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1. Physicochemical and Microbiological Stability of a New Oral Clonidine Solution for Paediatric Use

Author

Verlhac Camille, Lannoy Damien, Bourdon Florence, Titecat Marie, Frealle Emilie, Nassar Carole, Berneron Christophe, and Odou Pascal

Subjects
clonidine, oral solution, drug stability, pediatric preparation, Therapeutics. Pharmacology, RM1-950, Pharmaceutical industry, HD9665-9675
Abstract

As many drugs are unavailable for paediatric use, hospital pharmacies are often required to develop suitable formulations themselves. Clonidine is commonly used in paediatrics (in severe hypertension, in opiate withdrawal syndrome, in tics and Gilles de la Tourette syndrome or in anaesthetic premedication) but no appropriate formulation has been drawn up. The aims of this work were to develop an oral solution of clonidine dedicated to children and to assess its physicochemical and microbiological stability.

Published
2018
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3. Multicenter Retrospective Study of Invasive Fusariosis in Intensive Care Units, France

Author

Demonchy, Jordane, Biard, Lucie, Clere-Jehl, Raphael, Wallet, Florent, Mokart, Djamel, Moreau, Anne-Sophie, Argaud, Laurent, Verlhac, Camille, Pene, Frederic, Lautrette, Alexandre, Bige, Naike, de Jong, Audrey, Canet, Emmanuel, Quenot, Jean-Pierre, Issa, Nahema, Zerbib, Yoann, Bouard, Ines, Picard, Muriel, and Zafrani, Lara

Subjects
Bacterial pneumonia -- Care and treatment, Mortality -- France, Hematopoietic stem cells -- Transplantation -- Health aspects, Pneumonia -- Care and treatment, Antifungal agents -- Health aspects, Hospital patients -- Care and treatment, Acute respiratory distress syndrome -- Care and treatment, Health
Abstract

Invasive fungal infections are common, and severe complications can occur in immunocompromised patients, especially in patients with hematologic malignancies who require intensive care unit (ICU) admission (2,2). Invasive fusariosis is [...]

Published
2024
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4. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Author

Souweine, Bertrand, Eisenmann, Nathanael, Quenot, Jean-Pierre, Seguin, Philippe, Asehnoune, Karim, Lasocki, Sigismond, Ferrandiere, Martine, Sossou, Achile, Langeron, Olivier, Leone, Marc, Dupont, Herve, Veber, Benoit, Ichai, Carole, Rimmelé, Thomas, Legay, François, Grelon, Fabien, Dahyot-Fizelier, Claire, Cayot, Sophie, Godet, Thomas, Guerin, Renaud, Verlhac, Camille, Chabanne, Russell, Cosserant, Bernard, Blondonnet, Raiko, Lautrette, Alexandre, Muller, Laurent, Massanet, Pablo, Boutin, Caroline, Barbar, Saber, Roger, Claire, Belafia, Fouad, Cisse, Moussa, Monnin, Marion, Conseil, Matthieu, Carr, Julie, De Jong, Audrey, Chanques, Gérald, Dargent, Auguste, Crozon, Thomas, Clauzel, Julien, Le Core, Marinne, Andreu, Pascal, Lebouvrier, Thomas, Launey, Yoann, Roquilly, Antoine, Cinotti, Raphael, Tellier, Anne-Charlotte, Barbaz, Mathilde, Cohen, Benjamin, Lemarche, Edouard, Bertrand, Pierre-Marie, Arbelot, Charlotte, Zieleskiewicz, Laurent, Hammad, Emmanuelle, Duclos, Garry, Calypso, Mathieu, Orban, Jean-Christophe, Quintard, Hervé, Assefi, Mona, Morel, Jerome, Molliex, Serge, Petitas, Frank, Nanadougmar, Hadanou, Jabaudon, Matthieu, Audard, Jules, Pereira, Bruno, Jaber, Samir, Lefrant, Jean-Yves, Futier, Emmanuel, Lambert, Céline, Bazin, Jean-Etienne, Bastarache, Julie A., Constantin, Jean-Michel, and Ware, Lorraine B.

Published
2020
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5. Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome

Author

BOUCHANT, Louis, primary, GODET, Thomas, additional, ARPAJOU, Gauthier, additional, AUPETITGENDRE, Lucie, additional, CAYOT, Sophie, additional, GUERIN, Renaud, additional, JABAUDON, Matthieu, additional, VERLHAC, Camille, additional, BLONDONNET, Raiko, additional, BORAO, Lucile, additional, PEREIRA, Bruno, additional, CONSTANTIN, Jean-Michel, additional, BAZIN, Jean-Etienne, additional, FUTIER, Emmanuel, additional, and AUDARD, Jules, additional

Published
2024
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6. Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS

Author

Jabaudon, Matthieu, primary, Audard, Jules, additional, Pereira, Bruno, additional, Jaber, Samir, additional, Lefrant, Jean-Yves, additional, Blondonnet, Raiko, additional, Godet, Thomas, additional, Futier, Emmanuel, additional, Lambert, Céline, additional, Bazin, Jean-Etienne, additional, Bastarache, Julie A., additional, Constantin, Jean-Michel, additional, Ware, Lorraine B., additional, Souweine, Bertrand, additional, Eisenmann, Nathanael, additional, Quenot, Jean-Pierre, additional, Seguin, Philippe, additional, Asehnoune, Karim, additional, Lasocki, Sigismond, additional, Ferrandiere, Martine, additional, Sossou, Achile, additional, Langeron, Olivier, additional, Leone, Marc, additional, Dupont, Herve, additional, Veber, Benoit, additional, Ichai, Carole, additional, Rimmelé, Thomas, additional, Legay, François, additional, Grelon, Fabien, additional, Dahyot-Fizelier, Claire, additional, Cayot, Sophie, additional, Guerin, Renaud, additional, Verlhac, Camille, additional, Chabanne, Russell, additional, Cosserant, Bernard, additional, Lautrette, Alexandre, additional, Muller, Laurent, additional, Massanet, Pablo, additional, Boutin, Caroline, additional, Barbar, Saber, additional, Roger, Claire, additional, Belafia, Fouad, additional, Cisse, Moussa, additional, Monnin, Marion, additional, Conseil, Matthieu, additional, Carr, Julie, additional, De Jong, Audrey, additional, Chanques, Gérald, additional, Dargent, Auguste, additional, Crozon, Thomas, additional, Clauzel, Julien, additional, Le Core, Marinne, additional, Andreu, Pascal, additional, Lebouvrier, Thomas, additional, Launey, Yoann, additional, Roquilly, Antoine, additional, Cinotti, Raphael, additional, Tellier, Anne-Charlotte, additional, Barbaz, Mathilde, additional, Cohen, Benjamin, additional, Lemarche, Edouard, additional, Bertrand, Pierre-Marie, additional, Arbelot, Charlotte, additional, Zieleskiewicz, Laurent, additional, Hammad, Emmanuelle, additional, Duclos, Garry, additional, Calypso, Mathieu, additional, Orban, Jean-Christophe, additional, Quintard, Hervé, additional, Assefi, Mona, additional, Morel, Jerome, additional, Molliex, Serge, additional, Petitas, Frank, additional, and Nanadougmar, Hadanou, additional

Published
2020
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7. Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU

Author

Blet, Alice, De Roquetaillade, Charles, Hartmann, Oliver, Struck, Joachim, Mebazaa, Alexandre, Chousterman, Benjamin Glenn, Laterre, Pierre François, Berghe, Caroline, Dujardin, Marie France, Renard, Suzanne, Wittebole, Xavier, Collienne, Christine, Zapatero, Diego Castanares, Dugernier, Thierry, Vinetti, Marco, De Schryver, Nicolas, Thirifays, Anne, Mairesse, Jacques, Huberlant, Vincent, Petre, Hélène, Buelens, Isabelle, Henin, Pierre, Trine, Hugues, Laurent, Yves, Sébastien, Loix, Geukens, Paul, Kehl, Laurent, François, Bruno, Vignon, Philippe, Pichon, Nicolas, Begot, Emmanuelle, Fedou, Anne Laure, Chapellas, Catherine, Galy, Antoine, Rodier, Nicolas, Baudrillart, Ludmilla, Nouaille, Michelle, Laleu, Séverine, Mancia, Claire, Daix, Thomas, Bourzeix, Paul, Herafa, Isabelle, Duchambon, Anne Aurore, Lascarrou, Jean Baptiste, Fiancette, Maud, Colin, Gwenhael, Henry-Lagarrigue, Matthieu, Lacherade, Jean Claude, Lebert, Christine, Martin-Levfèvre, Laurent, Vinatier, Isabelle, Yehia, Aihem, Bachoumas, Konstantinos, Joret, Aurélie, Reignier, Jean, Rousseau, Cécille, Maquigneau, Natacha, Alcourt, Yolaine, Zinzonni, Vanessa Erragne, Deschamps, Angélique, Robert, Angelina, Mercier, Emmanuelle, Simeon-Vieules, Véronique, Aubrey, Aurélie, Mabilat, Christine, Garot, Denis, Ehrmann, Stephan, Legras, Annick, Jouan, Youenn, Dequin, Pierre François, Guillon, Antoine, Bodet-Contentin, Laetitia, Rouve, Emmannuelle, Salmon, Charlotte, Brick, Lysiane, Massat, Stéphanie, Desachy, Arnaud, Fally, Marie Anne, Robin, Laurence, Cracco, Christophe, Lafon, Charles, Calvat, Sylvie, Rouleau, Stéphane, Schnell, David, Lasocki, Sigismond, Fesard, Philippe, Leblanc, Damien, Bouhours, Guillaume, Chassier, Claire, Conte, Mathieu, Gaillard, Thomas, Denou, Floriane, Kerymel, Mathieu, Guyon, Marion, Loiez, Anthéa, Lebreton, Stéphanie, Meziani, Ferhat, Allam, Hayat, Chenaf, Samir, Rahmani, Hassène, Heenen, Sarah, Kummerlen, Christine, Delabranche, Xavier, Boivin, Alexandra, Clere-Jehl, Raphaël, Rabouël, Yannick, Pottecher, Julien, Bayer, Sophie, Metzger, Catherine, Hecketsweiler, Stéphane, Ludes, Pierre Olivier, Besancenot, Hortense, Dhif, Nadia, Freys, Guy, Lessinger, Jean Marc, Launoy, Anne, Ruimy, Aude, Meyer, Alain, Szozot, M., Deye, Nicolas, Gayat, Etienne, Fournier, Marie Céline, Abroug, Sarra, Louadah, Badr, Feliot, Elodie, Voicu, Sebastian, Malissin, Isabelle, Megarbane, Bruno, Manivet, Philippe, Victori, Gardianot, Kelly, Da Silva, La Foucher, Béatrice, Pierre, Valérie, Kerdjana, Lamia, Beeken, Thomas, Goury, Antoine, Garcon, Pierre, Gaugain, Samuel, Huot, Benjamin, Barthelemy, Romain, Soyer, Benjamin, Jacob, Laurent, Legrand, Matthieu, Fourniar, Marie Céline, Bonnet, Francine, Legall, Chloé, Oueslati, Haikel, Cupaciu, Alexandru, Manivat, Philippe, Louadeh, Badr, Sonneville, Romain, Letrou, Sophie, Bouadma, Lila, Mourvillier, Bruno, Deiler, Véronique, Magalhaes, Eric, Neuville, Mathilde, Timsit, Jean François, Radjou, Aguila, Gaudry, Stéphane, Dubief, Emeline, Messika, Jonathan, La Combe, Béatrice, Roux, Damien, Berquier, Guillaume, Laissi, Mohamed, Ricard, Jean Damien, Constantin, Jean Michel, Perbet, Sebastien, Delmas, Julie, Pascal, Julien, Cayot, Sophie, Guerin, Renaud, Jabaudon, Matthieu, Roszyk, Laurence, Rolhion, Christine, Bourdier, Justine, Lematte, Mathilde, Gouhier, Charlène, Verlhac, Camille, Godet, Thomas, Radji, Sophiano, Caumon, Elodie, Thibault, Sandrine, Marx, Nikolaus, Schuerholz, Tobias, Pezechk, Jessica, Feld, Florian, Brülls, Christian, Beeker, Thorben, Simon, Tim Philipp, Deisz, Robert, Schindler, Achim, Meier, Bianca, Janisch, Thorsten, Hohn, Andreas, Schedler, Dirk, Wetsch, Wolfgang, Schröder, Daniel, Meier-Hellmann, Andreas, Lucht, Alexander, Henker, Robert, Römmer, Magdalena, Meinig, Torsten, Zacharowski, Kai D., Meybohm, Patrick, Lindau, Simone, Mutlak, Haitham, Kluge, Stefan, Ringeis, Grit, Füllekrug, Birgit, Singer, Brigitte, Nierhaus, Axel, Bangert, Katrin, De Heer, Geraldine, Frings, Daniel, Fuhrmann, Valentin, Müller, Jakob, Schreiber, Jörg, Sensen, Barbara, Siedler, Stephanie, Siewecke, Annekatrin, Söffker, Gerold, Wichmann, Dominic, Kerinn, Mélanie, Jaschinski, Ulrich, Kreuser, Ilse, Zanquila, Marlene, Kortgen, Andreas, Bloos, Frank, Gonnert, Falk, Thomas-Rüddel, Daniel, Haucke, Anja, Kolanos, Steffi, Kohlberg, Karina Knuhr, Bloos, Petra, Schwope, Katrin, Di Somma, Salvatore, Rossella, Marino, Russo, Veronica, Simona, Santarelli, Bartoli, Christopher, Navarin, Sylvia, Bongiovanni, Cristina, Orru, Michela, Quatrocchi, Daniela, Zoccoli, Giada, Varchetta, Antonella, Antonelli, Massimo, De Pascale, Gennaro, Vallecoccia, Maria Sole, Cutuli, Salvatore Lucio, Digravio, Valentina, Quattrochi, Daniela, D'Arrigo, Sonia, Leone, Filippo Elvino, Beishuizen, Bert, Rinket, Martin, Border, Natalie, Bos-Burgmeijer, Mariska, Braad, Astrid, Papendorp, S., Vermeijden, J., Pickkers, Peter, Van De A, Marieke, Van Wezel, Helen, Heunks, Leo, Bordar, Natalie, Luijten-Arts, Chantal, Hoedemaekers, Astrid, Van Der Hoeven, Hans, Roovers, Noortje, Hemelaar, Pleun, Intensive care medicine, ACS - Pulmonary hypertension & thrombosis, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, and UCL - (SLuc) Service de soins intensifs

Subjects
Male, medicine.medical_specialty, Multiple Organ Failure, MEDLINE, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Critical Care and Intensive Care Medicine, Sepsis, 03 medical and health sciences, Adrenomedullin, 0302 clinical medicine, Belgium, Germany, medicine, Research Letter, Humans, Lactic Acid, Hospital Mortality, Prospective Studies, Prospective cohort study, Aged, Netherlands, Proportional Hazards Models, Chi-Square Distribution, business.industry, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, lcsh:RC86-88.9, Length of Stay, Middle Aged, medicine.disease, Prognosis, Shock, Septic, Survival Analysis, 3. Good health, Hospitalization, Patient Outcome Assessment, Intensive Care Units, 030228 respiratory system, Italy, Shock (circulatory), Emergency medicine, Female, France, medicine.symptom, business, Biomarkers
Abstract

Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial.AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock.Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8).AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial.ClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015.

Published
2020
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8. Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Author

Mebazaa, Alexandre, Geven, Christopher, Bergmann, Andreas, Massat, Stéphanie, Desachy, Arnaud, Fally, Marie Anne, Robin, Laurence, Cracco, Christophe, Lafon, Charles, Calvat, Sylvie, Rouleau, Stéphane, Schnell, David, Lasocki, Sigismond, Antonelli, Massimo, Fesard, Philippe, Leblanc, Damien, Bouhours, Guillaume, Chassier, Claire, Conte, Mathieu, Gaillard, Thomas, Denou, Floriane, Kerymel, Mathieu, Guyon, Marion, Loiez, Anthéa, Beishuizen, Albertus, Lebreton, Stéphanie, Meziani, Ferhat, Allam, Hayat, Chenaf, Samir, Rahmani, Hassène, Heenen, Sarah, Kummerlen, Christine, Delabranche, Xavier, Boivin, Alexandra, Clere-Jehl, Raphaël, Constantin, Jean-Michel, Rabouël, Yannick, Pottecher, Julien, Bayer, Sophie, Metzger, Catherine, Hecketsweiler, Stéphane, Ludes, Pierre Olivier, Besancenot, Hortense, Dhif, Nadia, Freys, Guy, Lessinger, Jean-Marc, Damoisel, Charles, Launoy, Anne, Ruimy, Aude, Meyer, Alain, Szozot, M., Deye, Nicolas, Gayat, Etienne, Fournier, Marie-Céline, Abroug, Sarra, Louadah, Badr, Feliot, Elodie, Voicu, Sebastian, Malissin, I., Megarbane, Bruno, Manivet, Philippe, Victori, Gardianot, Kelly, Da Silva, La Foucher, Béatrice, Pierre, Valérie, Kerdjana, Lamia, Di Somma, Salvatore, Beeken, Thomas, Goury, Antoine, Garcon, Pierre, Gaugain, Samuel, Chousterman, Benjamin Glen, Huot, Benjamin, Barthelemy, Romain, Soyer, Benjamin, Jacob, Laurent, Legrand, Matthieu, Dugernier, Thierry, Bonnet, Francine, Legall, Chloé, Oueslati, Haikel, Cupaciu, Alexandru, Sonneville, Romain, Letrou, Sophie, Bouadma, Lila, François, Bruno, Mourvillier, Bruno, Deiler, Véronique, Magalhaes, Eric, Neuville, Mathilde, Timsit, Jean-François, Radjou, Aguila, Gaudry, Stéphane, Dubief, Emeline, Messika, Jonathan, La Combe, Béatrice, Gaudry, Stephane, Roux, Damien, Berquier, Guillaume, Laissi, Mohamed, Ricard, Jean-Damien, Perbet, Sebastien, Delmas, Julie, Pascal, Julien, Cayot, Sophie, Guerin, Renaud, Hollinger, Alexa, Huberlant, Vincent, Jabaudon, Matthieu, Roszyk, Laurence, Rolhion, Christine, Bourdier, Justine, Lematte, Mathilde, Gouhier, Charlène, Verlhac, Camille, Godet, Thomas, Radji, Sophiano, Caumon, Elodie, Lascarrou, Jean-Baptiste, Thibault, Sandrine, Marx, Nikolaus, Schuerholz, Tobias, Pezechk, Jessica, Feld, Florian, Brülls, Christian, Beeker, Thorben, Simon, Tim-Philipp, Deisz, Robert, Schindler, Achim, Marx, Gernot, Meier, Bianca, Janisch, Thorsten, Hohn, Andreas, Schedler, Dirk, Wetsch, Wolfgang, Schröder, Daniel, Meier-Hellmann, Andreas, Lucht, Alexander, Henker, Robert, Römmer, Magdalena, Mercier, Emmanuelle, Meinig, Torsten, Zacharowski, Kai D., Meybohm, Patrick, Lindau, Simone, Mutlak, Haitham, Kluge, Stefan, Ringeis, Grit, Füllekrug, Birgit, Singer, Brigitte, Nierhaus, Axel, Bangert, Katrin, de Heer, Geraldine, Frings, Daniel, Fuhrmann, Valentin, Müller, Jakob, Schreiber, Jörg, Sensen, Barbara, Siedler, Stephanie, Siewecke, Annekatrin, Söffker, Gerold, Pickkers, Peter, Wichmann, Dominic, Kerinn, Mélanie, Jaschinski, Ulrich, Kreuser, Ilse, Zanquila, Marlene, Kortgen, Andreas, Bloos, Frank, Gonnert, Falk, Thomas-Rüddel, Daniel, Haucke, Anja, Kolanos, Steffi, Kohlberg, Karina Knuhr, Bloos, Petra, Schwope, Katrin, Rossella, Marino, Russo, Veronica, Simona, Santarelli, Bartoli, Christopher, Navarin, Sylvia, Bongiovanni, Cristina, Orru, Michela, Quatrocchi, Daniela, Zoccoli, Giada, Varchetta, Antonella, de Pascale, Gennaro, Vallecoccia, Maria Sole, Cutuli, Salvatore Lucio, Digravio, Valentina, Laterre, Pierre-François, Quattrochi, Daniela, D'Arrigo, Sonia, Leone, Filippo Elvino, Beishuizen, Bert, Rinket, Martin, Border, Natalie, Bos-Burgmeijer, Mariska, Braad, Astrid, Papendorp, S., Cornet, Alexander, AdrenOSS-1 study investigators, Vermeijden, J., Trof, Ronald J., van de A, Marieke, Van Wezel, Helen, Heunks, Leo, Luijten-Arts, Chantal, Hoedemaekers, Astrid, van der Hoeven, Hans, Wittebole, Xavier, Laterre, Pierre François, Roovers, Noortje, Hemelaar, Pleun, Berghe, Caroline, Dujardin, Marie-France, Renard, Suzanne, Collienne, Christine, Zapatero, Diego Castanares, Vinetti, Marco, De Schryver, Nicolas, Thirifays, Anne, Mairesse, Jacques, Petre, Hélène, Buelens, Isabelle, Henin, Pierre, Trine, Hugues, Laurent, Yves, Sébastien, Loix, Geukens, Paul, Blet, Alice, Kehl, Laurent, Vignon, Philippe, Pichon, Nicolas, Begot, Emmanuelle, Fedou, Anne-Laure, Chapellas, Catherine, Galy, Antoine, Rodier, Nicolas, Baudrillart, Ludmilla, Nouaille, Michelle, Laleu, Séverine, Mancia, Claire, Daix, Thomas, Bourzeix, Paul, Herafa, Isabelle, Duchambon, Anne-Aurore, Lascarrou, Jean Baptiste, Fiancette, Maud, Colin, Gwenhael, Hartmann, Oliver, Henry-Lagarrigue, Matthieu, Lacherade, Jean-Claude, Lebert, Christine, Martin-Levèvre, Laurent, Vinatier, Isabelle, Yehia, Aihem, Bachoumas, Konstantinos, Joret, Aurélie, Reignier, Jean, Rousseau, Cécille, Scigalla, Paul, Maquigneau, Natacha, Alcourt, Yolaine, Zinzonni, Vanessa Erragne, Deschamps, Angélique, Robert, Angelina, Simeon-Vieules, Véronique, Aubrey, Aurélie, Mabilat, Christine, Garot, Denis, Struck, Joachim, Ehrmann, Stephan, Legras, Annick, Manikikian, Jouan, Youenn, Dequin, Pierre François, Guillon, Antoine, Bodet-Contentin, Laetitia, Rouve, Emmannuelle, Salmon, Charlotte, Brick, Lysiane, Department of Anaesthesiology and Critical Care and Burn Unit, St-Louis Hospital, Service de biochimie INSERM UMR-S942, Hôpital Lariboisière-APHP, Université Paris Diderot - Paris 7 (UPD7), Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal, Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cliniques universitaires St Luc [Bruxelles], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Adrenomed AG, Service de Médecine Intensive et Réanimation [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Génétique, Reproduction et Développement (GReD), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Department of Intensive Care, St-Pierre Hospital, Centre d'Investigation Clinique de Limoges (CIC1435), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Réanimation Médico-Chirurgicale [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Service de réanimation médicale [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Radboud university [Nijmegen], Hôpital Bichat - Claude Bernard, Université Catholique de Louvain = Catholic University of Louvain (UCL), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Intensive care medicine, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Limoges, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Radboud University [Nijmegen], and MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC)

Subjects
Male, medicine.medical_treatment, [SDV]Life Sciences [q-bio], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Medical and Health Sciences, law.invention, Adrenomedullin, 0302 clinical medicine, Belgium, law, Germany, Medicine, Hospital Mortality, Prospective Studies, Netherlands, Outcome, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Hematology, Middle Aged, Prognosis, Shock, Septic, Intensive care unit, 3. Good health, Hospitalization, Intensive Care Units, Infectious Diseases, Italy, Anesthesia, outcome, biomarker, Female, SOFA score, France, medicine.symptom, Infection, Multiple Organ Failure, Sepsis, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Clinical Research, Biomarker, Sepsis-2, Sepsis-3, Aged, Biomarkers, Chi-Square Distribution, Humans, Length of Stay, Patient Outcome Assessment, Proportional Hazards Models, Survival Analysis, Settore MED/41 - ANESTESIOLOGIA, AdrenOSS-1 study investigators, Lactic Acid, Renal replacement therapy, business.industry, Septic shock, Research, Inflammatory and immune system, Organ dysfunction, 030208 emergency & critical care medicine, lcsh:RC86-88.9, medicine.disease, Emergency & Critical Care Medicine, Good Health and Well Being, Blood pressure, business
Abstract

Background Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5–148.1 pg/ml]. Initial SOFA score was 7 [IQR 5–10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9–2.9]; adjusted HR 1.6 [CI 1.1–2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5–9.8). Conclusions AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015. Electronic supplementary material The online version of this article (10.1186/s13054-018-2243-2) contains supplementary material, which is available to authorized users.

Published
2018
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10. Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Author

Mebazaa, Alexandre, Geven, Christopher, Hollinger, Alexa, Wittebole, Xavier, Chousterman, Benjamin Glen, Blet, Alice, Gayat, Etienne, Hartmann, Oliver, Scigalla, Paul, Struck, Joachim, Bergmann, Andreas, Antonelli, Massimo, Beishuizen, Albertus, Constantin, Jean-Michel, Damoisel, Charles, Deye, Nicolas, Di Somma, Salvatore, Dugernier, Thierry, François, Bruno, Gaudry, Stephane, Huberlant, Vincent, Lascarrou, Jean-Baptiste, Marx, Gernot, Mercier, Emmanuelle, Oueslati, Haikel, Pickkers, Peter, Sonneville, Romain, Legrand, Matthieu, Laterre, Pierre-François, AdrenOSS-1 Study Investigators, Laterre, Pierre François, Berghe, Caroline, Dujardin, Marie-France, Renard, Suzanne, Collienne, Christine, Zapatero, Diego Castanares, Vinetti, Marco, De Schryver, Nicolas, Thirifays, Anne, Mairesse, Jacques, Petre, Hélène, Buelens, Isabelle, Henin, Pierre, Trine, Hugues, Laurent, Yves, Sébastien, Loix, Geukens, Paul, Kehl, Laurent, Vignon, Philippe, Pichon, Nicolas, Begot, Emmanuelle, Fedou, Anne-Laure, Chapellas, Catherine, Galy, Antoine, Rodier, Nicolas, Baudrillart, Ludmilla, Nouaille, Michelle, Laleu, Séverine, Mancia, Claire, Daix, Thomas, Bourzeix, Paul, Herafa, Isabelle, Duchambon, Anne-Aurore, Lascarrou, Jean Baptiste, Fiancette, Maud, Colin, Gwenhael, Henry-Lagarrigue, Matthieu, Lacherade, Jean-Claude, Lebert, Christine, Martin-Levèvre, Laurent, Vinatier, Isabelle, Yehia, Aihem, Bachoumas, Konstantinos, Joret, Aurélie, Reignier, Jean, Rousseau, Cécille, Maquigneau, Natacha, Alcourt, Yolaine, Zinzonni, Vanessa Erragne, Deschamps, Angélique, Robert, Angelina, Simeon-Vieules, Véronique, Aubrey, Aurélie, Mabilat, Christine, Garot, Denis, Ehrmann, Stephan, Legras, Annick, Manikikian, Jouan, Youenn, Dequin, Pierre François, Guillon, Antoine, Bodet-Contentin, Laetitia, Rouve, Emmannuelle, Salmon, Charlotte, Brick, Lysiane, Massat, Stéphanie, Desachy, Arnaud, Fally, Marie Anne, Robin, Laurence, Cracco, Christophe, Lafon, Charles, Calvat, Sylvie, Rouleau, Stéphane, Schnell, David, Lasocki, Sigismond, Fesard, Philippe, Leblanc, Damien, Bouhours, Guillaume, Chassier, Claire, Conte, Mathieu, Gaillard, Thomas, Denou, Floriane, Kerymel, Mathieu, Guyon, Marion, Loiez, Anthéa, Lebreton, Stéphanie, Meziani, Ferhat, Allam, Hayat, Chenaf, Samir, Rahmani, Hassène, Heenen, Sarah, Kummerlen, Christine, Delabranche, Xavier, Boivin, Alexandra, Clere-Jehl, Raphaël, Rabouël, Yannick, Pottecher, Julien, Bayer, Sophie, Metzger, Catherine, Hecketsweiler, Stéphane, Ludes, Pierre Olivier, Besancenot, Hortense, Dhif, Nadia, Freys, Guy, Lessinger, Jean-Marc, Launoy, Anne, Ruimy, Aude, Meyer, Alain, Szozot, M., Fournier, Marie-Céline, Abroug, Sarra, Louadah, Badr, Feliot, Elodie, Voicu, Sebastian, Malissin, I., Megarbane, Bruno, Manivet, Philippe, Victori, Gardianot, Kelly, Da Silva, La Foucher, Béatrice, Pierre, Valérie, Kerdjana, Lamia, Beeken, Thomas, Goury, Antoine, Garcon, Pierre, Gaugain, Samuel, Huot, Benjamin, Barthelemy, Romain, Soyer, Benjamin, Jacob, Laurent, Bonnet, Francine, Legall, Chloé, Cupaciu, Alexandru, Letrou, Sophie, Bouadma, Lila, Mourvillier, Bruno, Deiler, Véronique, Magalhaes, Eric, Neuville, Mathilde, Timsit, Jean-François, Radjou, Aguila, Gaudry, Stéphane, Dubief, Emeline, Messika, Jonathan, La Combe, Béatrice, Roux, Damien, Berquier, Guillaume, Laissi, Mohamed, Ricard, Jean-Damien, Perbet, Sebastien, Delmas, Julie, Pascal, Julien, Cayot, Sophie, Guerin, Renaud, Jabaudon, Matthieu, Roszyk, Laurence, Rolhion, Christine, Bourdier, Justine, Lematte, Mathilde, Gouhier, Charlène, Verlhac, Camille, Godet, Thomas, Radji, Sophiano, Caumon, Elodie, Thibault, Sandrine, Marx, Nikolaus, Schuerholz, Tobias, Pezechk, Jessica, Feld, Florian, Brülls, Christian, Beeker, Thorben, Simon, Tim-Philipp, Deisz, Robert, Schindler, Achim, Meier, Bianca, Janisch, Thorsten, Hohn, Andreas, Schedler, Dirk, Wetsch, Wolfgang, Schröder, Daniel, Meier-Hellmann, Andreas, Lucht, Alexander, Henker, Robert, Römmer, Magdalena, Meinig, Torsten, Zacharowski, Kai D., Meybohm, Patrick, Lindau, Simone, Mutlak, Haitham, Kluge, Stefan, Ringeis, Grit, Füllekrug, Birgit, Singer, Brigitte, Nierhaus, Axel, Bangert, Katrin, De Heer, Geraldine, Frings, Daniel, Fuhrmann, Valentin, Müller, Jakob, Schreiber, Jörg, Sensen, Barbara, Siedler, Stephanie, Siewecke, Annekatrin, Söffker, Gerold, Wichmann, Dominic, Kerinn, Mélanie, Jaschinski, Ulrich, Kreuser, Ilse, Zanquila, Marlene, Kortgen, Andreas, Bloos, Frank, Gonnert, Falk, Thomas-Rüddel, Daniel, Haucke, Anja, Kolanos, Steffi, Kohlberg, Karina Knuhr, Bloos, Petra, Schwope, Katrin, Rossella, Marino, Russo, Veronica, Simona, Santarelli, Bartoli, Christopher, Navarin, Sylvia, Bongiovanni, Cristina, Orru, Michela, Quatrocchi, Daniela, Zoccoli, Giada, Varchetta, Antonella, De Pascale, Gennaro, Vallecoccia, Maria Sole, Cutuli, Salvatore Lucio, Digravio, Valentina, Quattrochi, Daniela, D'Arrigo, Sonia, Leone, Filippo Elvino, Beishuizen, Bert, Rinket, Martin, Border, Natalie, Bos-Burgmeijer, Mariska, Braad, Astrid, Papendorp, S., Cornet, Alexander, Vermeijden, J., Trof, Ronald J., Van De A, Marieke, Van Wezel, Helen, Heunks, Leo, Luijten-Arts, Chantal, Hoedemaekers, Astrid, Van Der Hoeven, Hans, Roovers, Noortje, and Hemelaar, Pleun

Subjects
3. Good health
Abstract

Critical care 22(1), 354 (2018). doi:10.1186/s13054-018-2243-2

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