17 results on '"Vetterlein, M. W."'
Search Results
2. Outcome groups and a practical tool to predict success of shock wave lithotripsy in daily clinical routine
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Hirsch, B., Abt, D., Güsewell, S., Langenauer, J., Betschart, P., Pratsinis, M., Vetterlein, M. W., Schmid, H. P., Wildermuth, S., and Zumstein, V.
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- 2021
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3. Vesico-urethral anastomotic stenosis following radical prostatectomy: a multi-institutional outcome analysis with a focus on endoscopic approach, surgical sequence, and the impact of radiation therapy
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Pfalzgraf, D., Worst, T., Kranz, J., Steffens, J., Salomon, G., Fisch, M., Reiß, C. P., Vetterlein, M. W., and Rosenbaum, C. M.
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- 2021
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4. Fistelchirurgie
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Rosenbaum, C. M., Vetterlein, M. W., and Fisch, M.
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- 2020
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5. Update on ureteral reconstruction 2024
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Hook, S., primary, Gross, A. J., additional, Netsch, C., additional, Becker, B., additional, Filmar, S., additional, Vetterlein, M. W., additional, Kluth, L. A., additional, and Rosenbaum, C. M., additional
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- 2023
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6. Wie werden der 10-Punkte-Plan des Deutschen Bundesministeriums für Gesundheit zur Bekämpfung resistenter Erreger und Maßnahmen des Antibiotic Stewardship wahrgenommen?: Eine fachübergreifende Analyse der Kenntnis deutscher Klinikärzte und Entwicklung einer urologischen Handlungsanweisung
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May, M., Vetterlein, M. W., Wagenlehner, F. M., Brookman-May, S. D., Gilfrich, C., Fritsche, H.-M., Spachmann, P. J., Burger, M., Schostak, M., Lebentrau, S., and MR2-Studiengruppe
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- 2017
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7. Is there evidence for a close connection between side of intravesical tumor location and ipsilateral lymphatic spread in lymph node-positive bladder cancer patients at radical cystectomy? Results of the PROMETRICS 2011 database
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May, M., Protzel, C., Vetterlein, M. W., Gierth, M., Noldus, J., Karl, A., Grimm, T., Wullich, B., Grimm, M. O., Nuhn, P., Bastian, P. J., Roigas, J., Hadaschik, B., Gilfrich, C., Burger, M., Fisch, M., Brookman-May, S., Aziz, A., Hakenberg, O. W., Bartsch, G., Bolenz, C., Buchner, A., Chun, F. K., Durschnabel, M., Ellinger, J., Fritsche, H. M., Froehner, M., Georgieva, G., Gilfrich, C., Gördük, M., Haferkamp, A., Hartmann, F., Herrmann, E., Hohenfellner, M., Janetschek, G., Keck, B., Kraischits, N., Krausse, A., Lusuardi, L., Martini, T., Mayr, R., Moritz, R., Müller, S. C., Novotny, V., Pahernik, S., Palisaar, R. J., Ponholzer, A., Pycha, A., Rink, M., Roghmann, F., Schmid, M., Schramek, P., Seitz, C., Shariat, S. F., Sikic, D., Stief, C. G., Syring, I., Vallo, S., Wagenlehner, F. M., Wirth, M. P., and the PROMETRICS 2011 Research Group
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- 2017
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8. Outcome groups and a practical tool to predict success of shock wave lithotripsy in daily clinical routine
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Hirsch, B., primary, Abt, D., additional, Güsewell, S., additional, Langenauer, J., additional, Betschart, P., additional, Pratsinis, M., additional, Vetterlein, M. W., additional, Schmid, H. P., additional, Wildermuth, S., additional, and Zumstein, V., additional
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- 2020
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9. Vesico-urethral anastomotic stenosis following radical prostatectomy: a multi-institutional outcome analysis with a focus on endoscopic approach, surgical sequence, and the impact of radiation therapy
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Pfalzgraf, D., primary, Worst, T., additional, Kranz, J., additional, Steffens, J., additional, Salomon, G., additional, Fisch, M., additional, Reiß, C. P., additional, Vetterlein, M. W., additional, and Rosenbaum, C. M., additional
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- 2020
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10. Postoperative Chemotherapy Bladder Instillation After Radical Nephroureterectomy: Results of a European Survey from the Young Academic Urologist Urothelial Cancer Group
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Florian Roghmann, Friedrich-Carl von Rundstedt, Wojciech Krajewski, Tom-Régis Dobé, Kees Hendricksen, Ettore Di Trapani, Evanguelos Xylinas, Malte W. Vetterlein, Francesco Soria, Paul Sargos, Andrea Necchi, Gianluigi Califano, Roland Seiler, Aidan P. Noon, Cédric Poyet, Benjamin Pradere, Simone Albisinni, Michael Rink, Idir Ouzaid, Andrea Mari, Atiqullah Aziz, Marco Moschini, Dobe, T. -R., Califano, G., von Rundstedt, F. -C., Ouzaid, I., Albisinni, S., Aziz, A., Di Trapani, E., Hendricksen, K., Krajewski, W., Mari, A., Moschini, M., Necchi, A., Noon, A. P., Poyet, C., Pradere, B., Rink, M., Roghmann, F., Sargos, P., Seiler, R., Soria, F., Vetterlein, M. W., Xylinas, E., University of Naples Federico II, European Institute of Oncology [Milan] (ESMO), Fondazione Ospedale San Camillo [Venezia] (IRCCS), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), University of Zurich, and Xylinas, Evanguelos
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2748 Urology ,medicine.medical_specialty ,Urology ,[SDV]Life Sciences [q-bio] ,610 Medicine & health ,lcsh:RC870-923 ,lcsh:RC254-282 ,030218 nuclear medicine & medical imaging ,law.invention ,Recurrence risk ,03 medical and health sciences ,0302 clinical medicine ,Single intravesical postoperative instillation ,Randomized controlled trial ,law ,Urothelial cancer ,Medicine ,Chemotherapy ,Statistical analysis ,Urothelial Cancer ,Patient summary ,Urothelial carcinoma ,Postoperative chemotherapy ,business.industry ,Radical nephroureterectomy ,Généralités ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,3. Good health ,Background level ,10062 Urological Clinic ,Settore MED/24 ,Upper tract urothelial carcinoma ,030220 oncology & carcinogenesis ,Intravesical recurrence ,business - Abstract
Background: Level 1 evidence supports the administration of single postoperative intravesical chemotherapy (pIVC) following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), in order to decrease intravesical recurrence risk. Objective: The Young Academic Urologist Urothelial Cancer Group aimed to investigate the use of pIVC in daily practice among European colleagues. Design, setting, and participants: An online survey was shared with European Association of Urology Section of Oncological Urology (ESOU) 2017 participants via e-mail. Submissions were accepted from April to June 2017. The topics for 15 questions of this survey included the habit of delivering pIVC, the choice of drug, its dosage, related doubts or concerns, reasons not to perform pIVC, knowledge of the evidence, and surgical preferences for RNU. Outcome measurements and statistical analysis: Survey software was used for analyses. Logistic regression analyses were used to investigate the association between surgeons’ experience and caseloads with pIVC utilization. Results and limitations: Overall, 127 responses were collected (11.6%). About half of the participants (47%) regularly administered pIVC following RNU. The drug most commonly utilized was mitomycin (85%); 82% adhered to the standard dosage of 40 mg. Different administration protocols were adopted: ≤48 h (39%), 7–10 postoperative days (35%), >10 d (11%), and intraoperatively (10%). The evidence was supported by prospective randomized clinical trials for only 65% of responders. Among interviewees who did not deliver pIVC, the most commonly reported reasons were lack of supporting data (55%), fear of potential side effects (18%), and organizational hurdles (15%). Conclusions: Our research highlights the limited use of pIVC following RNU for UTUC, raising the question of how the compliance with level 1 evidence in the urological community may be promoted. Patient summary: Level 1 evidence supports the administration of single postoperative intravesical chemotherapy (pIVC) following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), in order to decrease intravesical recurrence risk. The Young Academic Urologist Urothelial Cancer Group aimed to investigate the use of pIVC in daily practice among European colleagues. Our research highlights the limited use of pIVC (47%) following RNU for UTUC, raising the question of how the compliance with level 1 evidence in the urological community may be promoted., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2020
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11. The association of cigarette smoking and pathological response to neoadjuvant platinum-based chemotherapy in patients undergoing treatment for urinary bladder cancer - A prospective European multicenter observational study of the EAU Young Academic Urologists (YAU) urothelial carcinoma working group
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Jakub Dobruch, Morgan Rouprêt, Thomas Seisen, David D'Andrea, Karim Saba, Malte W. Vetterlein, Philipp Gild, Florian Roghmann, Laura S. Mertens, Nicolas von Landenberg, Pietro Grande, Shahrokh F. Shariat, Evanguelos Xylinas, Margit Fisch, Michael Rink, Evi Comploj, J. Anract, Kees Hendricksen, Paolo Gontero, Bas W.G. van Rhijn, Andrea Necchi, Roland Seiler, Cédric Poyet, Armin Pycha, Aidan P. Noon, Marcus G. Cumberbatch, University of Zurich, Rink, Michael, Gild, P., Vetterlein, M. W., Seiler, R., Necchi, A., Hendricksen, K., Mertens, L. S., Roghmann, F., Landenberg, N. V., Gontero, P., Cumberbatch, M., Dobruch, J., Seisen, T., Grande, P., D'Andrea, D., Anract, J., Comploj, E., Pycha, A., Saba, K., Poyet, C., van Rhijn, B. W., Noon, A. P., Roupret, M., Shariat, S. F., Fisch, M., Xylinas, E., Rink, M., and Urology
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Male ,medicine.medical_treatment ,Urologists ,030232 urology & nephrology ,Logistic regression ,Bladder cancer ,Cisplatin ,Neoadjuvant chemotherapy ,Radical cystectomy ,Smoking ,0302 clinical medicine ,Interquartile range ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,Prospective Studies ,610 Medicine & health ,Middle Aged ,Prognosis ,Combined Modality Therapy ,Neoadjuvant Therapy ,2746 Surgery ,Survival Rate ,Oncology ,030220 oncology & carcinogenesis ,Cohort ,Female ,2730 Oncology ,Algorithms ,medicine.medical_specialty ,Cystectomy ,Cigarette Smoking ,03 medical and health sciences ,Internal medicine ,Humans ,Aged ,business.industry ,Proportional hazards model ,Patient Selection ,Odds ratio ,medicine.disease ,10062 Urological Clinic ,Urinary Bladder Neoplasms ,Smoking cessation ,Surgery ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
Objective To prospectively study the impact of smoking on pathological response to neoadjuvant chemotherapy (NAC) in patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). Materials & methods We collected standard clinicopathological variables, including smoking status (never, former, current) in patients undergoing NAC and RC for UCB at 12 European tertiary care centers between 12/2013-12/2015. Clinicopathological variables were compared according to smoking status. Multivariable logistic regression models were built to assess the association of smoking status and a) complete (no residual disease), b) partial (residual, non-muscle invasive disease), c) no pathological response (residual muscle invasive or lymph node positive disease). Kaplan-Meier and Cox regression analyses were employed to study the impact of response to NAC on survival. Results and limitations Our final cohort consisted of 167 NAC patients with a median follow-up of 15 months (interquartile range (IQR) 9–26 months) of whom 48 (29%), 69 (41%), and 50 (30%) where never, former, and current smokers, respectively. Smoking was significantly associated with advanced age (p = 0.013), worse ECOG performance status (p = 0.049), and decreased pathological response to NAC (p = 0.045). On multivariable logistic regression analyses, former and current smoking status was significantly associated with lower odds of complete pathological response (odds ratio (OR) 0.37, 95% confidence interval (CI) 0.16–0.87, p = 0.023, and OR 0.34, 95% CI 0.13–0.85, p = 0.021), while current smoking status was significantly associated with a greater likelihood of no pathological response (OR 2.49, 95% CI 1.02–6.06, p = 0.045). Response to NAC was confirmed as powerful predictor of survival. Conclusions Smoking status is adversely associated with pathological response to NAC. Smokers should be informed about these adverse effects, counseled regarding smoking cessation, and possibly be considered for immunotherpeutics as they may be more effective in smokers.
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- 2020
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12. Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases
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Gontero, P, Pisano, F, Palou, J, Joniau, S, Albersen, M, Colombo, R, Briganti, A, Pellucchi, F, Faba, OR, van Rhijn, BW, van de Putte, EF, Babjuk, M, Fritsche, HM, Mayr, R, Albers, P, Niegisch, G, Anract, J, Masson-Lecomte, A, De la Taille, A, Roupret, M, Peyronnet, B, Cai, T, Witjes, AJ, Bruins, M, Baniel, J, Mano, R, Lapini, A, Sessa, F, Irani, J, Brausi, M, Stenzl, A, Karnes, JR, Scherr, D, O'Malley, P, Taylor, B, Shariat, SF, Black, P, Abdi, H, Matveev, VB, Samuseva, O, Parekh, D, Gonzalgo, M, Vetterlein, MW, Aziz, A, Fisch, M, Catto, J, Pang, KH, Xylinas, E, Rink, M, Young Acad Urologists Urothel, Gontero, P., Pisano, F., Palou, J., Joniau, S., Albersen, M., Colombo, R., Briganti, A., Pellucchi, F., Faba, O. R., van Rhijn, B. W., van de Putte, E. F., Babjuk, M., Fritsche, H. M., Mayr, R., Albers, P., Niegisch, G., Anract, J., Masson-Lecomte, A., De la Taille, A., Roupret, M., Peyronnet, B., Cai, T., Witjes, A. J., Bruins, M., Baniel, J., Mano, R., Lapini, A., Sessa, F., Irani, J., Brausi, M., Stenzl, A., Karnes, J. R., Scherr, D., O'Malley, P., Taylor, B., Shariat, S. F., Black, P., Abdi, H., Matveev, V. B., Samuseva, O., Parekh, D., Gonzalgo, M., Vetterlein, M. W., Aziz, A., Fisch, M., Catto, J., Pang, K. H., Xylinas, E., and Rink, M.
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Nephrology ,Male ,medicine.medical_specialty ,Internationality ,Complications ,Urology ,medicine.medical_treatment ,Urinary Bladder ,030232 urology & nephrology ,Cystectomy ,Risk Assessment ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Postoperative Complications ,Internal medicine ,Medicine ,Humans ,Urinary diversion ,Aged ,Retrospective Studies ,Bladder cancer ,business.industry ,Radiation therapy ,Radical cystectomy ,Middle Aged ,medicine.disease ,Surgery ,Urinary Bladder Neoplasms ,030220 oncology & carcinogenesis ,Relative risk ,Abdominal Neoplasms ,Female ,business ,Complication - Abstract
Purpose: Conflicting evidence exists on the complication rates after cystectomy following previous radiation (pRTC) with only a few available series. We aim to assess the complication rate of pRTC for abdominal–pelvic malignancies. Methods: Patients treated with radical cystectomy following any previous history of RT and with available information on complications for a minimum of 1year were included. Univariable and multivariable logistic regression models were used to assess the relationship between the variable parameters and the risk of any complication. Results: 682 patients underwent pRTC after a previous RT (80.5% EBRT) for prostate, bladder (BC), gynecological or other cancers in 49.1%, 27.4%, 9.8% and 12.9%, respectively. Overall, 512 (75.1%) had at least one post-surgical complication, classified as Clavien ≥ 3 in 29.6% and Clavien V in 2.9%. At least one surgical complication occurred in 350 (51.3%), including bowel leakage in 6.2% and ureteric stricture in 9.4%. A medical complication was observed in 359 (52.6%) patients, with UTI/pyelonephritis being the most common (19%), followed by renal failure (12%). The majority of patients (86%) received an incontinent urinary diversion. In multivariable analysis adjusted for age, gender and type of RT, patients treated with RT for bladder cancer had a 1.7 times increased relative risk of experiencing any complication after RC compared to those with RT for prostate cancer (p = 0.023). The type of diversion (continent vs non-continent) did not influence the risk of complications. Conclusion: pRTC carries a high rate of major complications that dramatically exceeds the rates reported in RT-naïve RCs.
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- 2020
13. Cosmetic complications after anterior urethral surgery: a scoping review and photo collection.
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Chierigo F, Mantica G, Drocchi G, Madec FX, Verla W, Białek Ł, Adamowicz J, Cocci A, Frankiewicz M, Klemm J, Neuville P, Oszczudłowski M, Redmond EJ, Rosenbaum CM, Waterloos M, Vetterlein MW, and Campos-Juanatey F
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Introduction: Anterior urethroplasty is the gold standard for treating complex urethral strictures, primarily focusing on restoring urinary function. However, aesthetic complications, including penile curvature, scarring, and meatal deformities, can impact patient satisfaction, self-image, and quality of life. Despite their significance, cosmetic outcomes are underreported in the literature, affecting patient counseling and surgical planning., Objective: This scoping review aims to assess the prevalence, types, and contributing factors of cosmetic complications after anterior urethroplasty. A photographic collection of these complications is also presented to aid in clinical education., Materials and Methods: A systematic search of PubMed, Scopus, and Web of Science databases was performed, including studies from 2000 onward that report cosmetic outcomes in male adult patients post-urethroplasty. Following PRISMA guidelines, studies focusing on pediatric cases, case reports with fewer than 10 patients, and those lacking specific cosmetic data were excluded., Results: Of the 493 studies screened, 97 met the inclusion criteria, with only a minority (8 studies) explicitly discussing cosmetic complications. Reported issues varied widely, including penile curvature, skin tethering, hypertrophic scarring, meatal deformities, and penile shortening, underscoring the diversity of aesthetic challenges in urethral reconstruction., Conclusion: This review highlights the need for incorporating aesthetic considerations into surgical planning and patient counseling for anterior urethroplasty. Standardized metrics for evaluating cosmetic outcomes could improve patient satisfaction and the quality of care in urethral reconstruction., Competing Interests: Declaration of competing interest None., (Copyright © 2024 AEU. Published by Elsevier España, S.L.U. All rights reserved.)
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- 2024
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14. The use of robotic surgery for the management of urethral strictures and bladder neck contractures: A systematic review.
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Mantica G, Chierigo F, Białek Ł, Madec FX, Frankiewicz M, Verla W, Redmond EJ, Rosenbaum CM, Cocci A, Campos-Juanatey F, Oszczudłowski M, Adamowicz J, Terrone C, and Vetterlein MW
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Objective: The aim of this systematic review is to offer a comprehensive view of the current use of robotic surgery for the treatment of urethral strictures and bladder neck contractures., Methods: A systematic review of the current literature was conducted through the Medline and NCBI PubMed, Embase databases in December 2023. Keywords used were "robotic" and "robotic-assisted" combined with "urethroplasty", "urethral stricture", and "bladder neck contracture". All papers published after 2000, concerning studies conducted on humans for urethral strictures and bladder neck contractures managed with robotic surgery were considered for the review. Only procedures involving a direct approach to urethra/bladder neck and/or graft harvesting for urethroplasty have been included., Results: A total of 275 articles were evaluated after the strategy search and only 11 articles were considered eligible for the final analysis. The studies included a series of between a minimum of 1 and a maximum of 104 patients, for a total of 203 patients. The robotic surgery was performed mainly for the treatment of bladder neck contracture and posterior urethra. In some reports, the robotic system was used for graft harvesting, subsequently used with an open perineal technique. The follow-up presented in the different studies is very heterogeneous. However, most studies have high success rates, with recurrence and redo surgery rates generally below 20%. Likewise, post-procedure incontinence rates are low., Conclusions: The outcomes presented in the literature, combined with the minimally invasive nature, suggest a possible growing role for robotic surgery in the coming years in the treatment of these diseases., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 AEU. Published by Elsevier España, S.L.U. All rights reserved.)
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- 2024
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15. Oral care pathways after oral mucosal graft harvesting: a systematic review.
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Frankiewicz M, Adamowicz J, Białek L, Campos-Juanatey F, Chierigo F, Cocci A, Madec FX, Mantica G, Oszczudłowski M, Redmond EJ, Rosenbaum CM, Verla W, Waterloos M, Jobczyk M, Kałużny A, Vetterlein MW, and Matuszewski M
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Introduction: Oral mucosal grafts are essential in reconstructive urology, particularly for urethral and genital defects. Advances in harvesting and implantation techniques have been made, yet perioperative care remains crucial for optimal outcomes. This systematic review explores postoperative care pathways following oral mucosal graft harvesting to consolidate knowledge, identify best practices, and highlight research gaps., Objective: The review aims to identify optimal care pathways, compare different oral care approaches, and address research gaps., Methods: A systematic literature search was conducted using PubMed, Scopus, and Web of Science databases without time constraints. Key search terms included "oral mucosal graft", "oral care pathways", "OMG post-operative care", "BMG", "LMG", and "OMG graft harvesting". Selection followed PRISMA guidelines. Inclusion criteria focused on studies addressing oral mucosal grafts in reconstructive urology and associated perioperative care, excluding non-English articles, case reports, and editorials., Results: The review underscores the suitability of oral mucosa for grafting due to properties like excellent vascularization and minimal immunogenicity. Comparisons among graft harvesting sites reveal differences in tissue quality, ease of harvest, and donor site morbidity. Non-closure techniques generally result in less postoperative pain and quicker healing, though closure might better control bleeding and infection. Despite common complications such as mild trismus and altered chewing efficiency, patient satisfaction remains high., Conclusions: Effective management of oral mucosal grafts harvesting emphasizes tailored perioperative care to minimize complications and enhance recovery. Further research should focus on long-term oral morbidity, standardized care protocols, and patient-reported outcomes to improve care pathways and surgical results., Competing Interests: Declaration of competing interest No conflicts of interest are reported by the authors., (Copyright © 2024 The Authors. Published by Elsevier España, S.L.U. All rights reserved.)
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- 2024
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16. Long term outcomes from uncorrected hypospadias: a scoping review.
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Bohane E, Murphy M, Chierigo F, Mantica G, Adamowicz J, Campos-Juanatey F, Cocci A, Frankiewicz M, Rosenbaum CM, Verla W, Waterloos M, Białek Ł, Madec FX, Oszczudłowski M, Vetterlein MW, and Redmond EJ
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Introduction: The goal of hypospadias repair is to optimize urinary and sexual function, improve cosmesis and minimise the psychosocial effects associated with a penile anomaly. However, a lack of clarity exists regarding the role of surgery in milder hypospadias where the anomaly is inconspicuous and there is no anticipated impact on function. The aim of this study was to review the long term functional, cosmetic and psychosocial outcomes in men with uncorrected hypospadias. This information may be helpful for parents who are burdened with deciding the correct treatment for their child's hypospadias., Methods: A scoping review of PubMed, EMBASE, and CINAHL + databases was performed in adherence with PRISMA guidelines. Eight studies were identified for inclusion in the review., Results: Men with mild uncorrected hypospadias have similar functional outcomes to those without hypospadias, preferring to void standing and reporting similar IPSS scores. However, those with severe untreated hypospadias experience significant urinary difficulties, higher IPSS scores, and are more likely to sit when voiding. They reported worse SHIM scores, more ventral curvature, and greater difficulty with intercourse. Most men with incidentally identified hypospadias are unaware of their condition and are satisfied with their penile appearance. There was no difference in the attainment of psychosocial milestones between men with uncorrected hypospadias versus no hypospadias., Conclusion: There is a lack of research regarding the experiences of adult men with uncorrected hypospadias. However, there is some evidence to support the non-operative management of mild hypospadias. Therefore, the decision to defer surgery in infancy should balance parental wishes and physician guidance, particularly in cases where the risk of functional impairment is low., Competing Interests: Declaration of competing interest No conflicts of interest are reported by the authors., (Copyright © 2024. Published by Elsevier España, S.L.U.)
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- 2024
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17. Long-term functional success and patient-reported outcomes after female one-stage buccal mucosal graft urethroplasty.
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Klemm J, Marks P, Schulz RJ, Filipas DK, Stelzl DR, Dahlem R, Fisch M, and Vetterlein MW
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Introduction and Objectives: Female urethral strictures are a rare condition that significantly impacts patients' quality of life. Patient-reported outcomes are crucial, yet data regarding sexual function and treatment satisfaction are scarce. We aimed to provide insights from a reconstructive referral center., Patients and Methods: We conducted a retrospective analysis of women treated with ventral onlay one-stage buccal mucosa graft urethroplasty for urethral strictures between 2009-2023. We assessed objective (retreatment-free survival, ΔQmax) and subjective outcomes (validated patient-reported outcomes)., Results: Of 12 women, 83% and 17% had iatrogenic and idiopathic strictures, respectively. Median number of prior interventions was 6. Strictures were located meatal and mid-urethral in 25% and 75%, respectively, 22% had the bladder neck involved. Median graft length was 2 cm. At median follow-up of 66 months, 33% of patients underwent stricture retreatment, but only one case occurred within the first 2 years postoperatively. The median improvement in maximum flow rate (ΔQmax) was 10 ml/s. Median International Consultation on Incontinence Questionnaire Female Lower Urinary Tract Symptoms Modules (ICIQ-FLUTS) scores were 8 for filling symptoms, 6 for voiding symptoms, and 3 for incontinence symptoms. Median ICIQ-FLUTSsex score was 4. Higher scores indicate a higher symptom burden. Median ICIQ-Satisfaction outcome and satisfaction scores were 18 and 7, respectively, reflecting high treatment satisfaction., Conclusions: Buccal mucosal graft urethroplasty by ventral onlay for female urethral strictures yields effective, durable, and positively received outcomes. However, larger studies across multiple institutions are necessary to further assess its efficacy, especially regarding patient-reported experiences and sexual function., (Copyright © 2024 The Author(s). Published by Elsevier España, S.L.U. All rights reserved.)
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- 2024
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