1. Standardised exercise training is feasible, safe and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension - results from a large European multicentre randomised controlled trial
- Author
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Andrew J. Peacock, Elena Jurevičienė, Gabor Kovacs, Sofia Viamonte, Alberto M. Marra, Antonio Cittadini, Heleen Demeyer, Christina A. Eichstaedt, Anna Agnese Stanziola, Ekkehard Grünig, Eglė Palevičiūtė, Frits M.E. Franssen, Robert Nechwatal, Maurizio Bussotti, Silvia Ulrich, Marinella Sommaruga, Mário Santos, Joan Albert Barberà, Isabel Blanco, Martin Johnson, Lina Gumbiene, Stefano Ghio, Stéphanie Saxer, Nicola Benjamin, Anton Vonk Noordegraaf, Abílio Reis, Eduardo Bossone, Martijn A. Spruit, Marion Delcroix, Horst Olschewski, Alison MacKenzie, Pulmonologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Grünig, Ekkehard, Mackenzie, Alison, Peacock, Andrew J, Eichstaedt, Christina A, Benjamin, Nicola, Nechwatal, Robert, Ulrich, Silvia, Saxer, Stéphanie, Bussotti, Maurizio, Sommaruga, Marinella, Ghio, Stefano, Gumbiene, Lina, Palevičiūtė, Eglė, Jurevičienė, Elena, Cittadini, Antonio, Stanziola, Anna A, Marra, Alberto M, Kovacs, Gabor, Olschewski, Horst, Barberà, Joan-Albert, Blanco, Isabel, Spruit, Martijn A, Franssen, Frits M E, Vonk Noordegraaf, Anton, Reis, Abílio, Santos, Mário, Viamonte, Sofia Gonçalve, Demeyer, Heleen, Delcroix, Marion, Bossone, Eduardo, Johnson, Martin, Pulmonary medicine, and ACS - Pulmonary hypertension & thrombosis
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Male ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,QUALITY-OF-LIFE ,law ,Exercise programme ,Medicine and Health Sciences ,Clinical endpoint ,Prospective Studies ,Exercise Tolerance ,Rehabilitation ,Middle Aged ,Europe ,medicine.anatomical_structure ,Female ,Chronic thromboembolic pulmonary hypertension ,Cardiology and Cardiovascular Medicine ,WALK TEST ,Adult ,medicine.medical_specialty ,Hypertension, Pulmonary ,END-POINT ,Pulmonary arterial pressure ,Pulmonary hypertension ,CAPACITY ,03 medical and health sciences ,Walking distance ,Internal medicine ,BENEFITS ,medicine ,Humans ,Pulmonary rehabilitation ,In patient ,Exercise ,Aged ,Lung ,Surrogate endpoint ,business.industry ,EFFICACY ,medicine.disease ,Confidence interval ,030228 respiratory system ,Chronic Disease ,Usual care ,Quality of Life ,Physical therapy ,business - Abstract
Aims This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Methods and results For the first time a specialized PAH/CTEPH rehabilitation programme was implemented in 11 centres across 10 European countries. Out of 129 enrolled patients, 116 patients (58 vs. 58 randomized into a training or usual care control group) on disease-targeted medication completed the study [85 female; mean age 53.6 ± 12.5 years; mean pulmonary arterial pressure 46.6 ± 15.1 mmHg; World Health Organization (WHO) functional class II 53%, III 46%; PAH n = 98; CTEPH n = 18]. Patients of the training group performed a standardized in-hospital rehabilitation with mean duration of 25 days [95% confidence interval (CI) 17–33 days], which was continued at home. The primary endpoint, change of 6-min walking distance, significantly improved by 34.1 ± 8.3 m in the training compared with the control group (95% CI, 18–51 m; P Conclusion This is the first multicentre and so far the largest randomized, controlled study on feasibility, safety, and efficacy of exercise training as add-on to medical therapy in PAH and CTEPH. Within this study, a standardized specialized training programme with in-hospital start was successfully established in 10 European countries.
- Published
- 2020
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