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Immediately following the discovery of the structure of DNA and the semi-conservative replication of the parental DNA sequence into two new DNA strands, it became apparent that DNA replication is organized in a temporal and spatial fashion during the S phase of the cell cycle, correlated with the large-scale organization of chromatin in the nucleus. After many decades of limited progress, technological advances in genomics, genome engineering, and imaging have finally positioned the field to tackle mechanisms underpinning the temporal and spatial regulation of DNA replication and the causal relationships between DNA replication and other features of large-scale chromosome structure and function. In this review, we discuss these major recent discoveries as well as expectations for the coming decade.

PurposeThe current study provides insights on the application of critical soft TQM practices in primary and secondary education and their impact on teachers' job satisfaction (TJS).Design/methodology/approachBased on a review of the literature related to TQM application in primary and secondary education, six soft TQM elements were traced as critical to the success of TQM implementation in the school environment: participation/involvement in continuous improvement, teamwork, empowerment, appraisal systems/recognition and reward for quality, training and development (T&D) and leadership (vision/commitment to quality culture). Moreover, their relationship to JS was theoretically founded and empirically tested. An online questionnaire was used as the research instrument. The participants were 200 primary and secondary public school teachers working in urban, semi urban and rural regions of Greece. After assessing the validity and reliability of the measurement scales, multiple regression analysis was applied to test the hypothesized relationships.FindingsThe research findings revealed that leadership and empowerment are the most highly implemented TQM practices in primary and secondary education. Moreover, participation/involvement, appraisal systems/recognition and rewards and leadership were the TQM elements that had a positive association with TJS.Practical implicationsThe outcomes of the study are of help to school principals and policy-makers in order to design and implement TQM policies that advance the quality of teaching and the effectiveness of processes in the primary and secondary education system, as well as to satisfy and motivate teachers for continuous improvement.Originality/valueThis was, to the best of our knowledge, the first study that has explored the impact of soft TQM elements on TJS.

PurposeThe present study focuses on the cost of quality (CoQ) based on which organizations can evaluate their quality-related activities in economic terms. The purpose of the study is to identify the CoQ practical implications as well as to group them into logical themes.Design/methodology/approachA systematic literature review (SLR) was conducted based on well-known academic publishers, such as Emerald Insight, Elsevier/ScienceDirect, SpringerLink, Taylor & Francis, Wiley and Scopus. Sixty-seven peer-reviewed journal articles in the field of CoQ were collected, which were published between 2010 and 2019. The “affinity diagram” was applied to group the practical implications identified into logical themes.FindingsA plethora of CoQ practical implications were identified and grouped into the following meaningful themes: benefits of CoQ measurement, effects of CoQ, business sectors measuring CoQ, factors influencing CoQ measurement, CoQ elements, future research in CoQ and the role of government.Research limitations/implicationsThe limited number of the publishers and keywords used to search for the articles of interest, as well as the subjectivity of grouping the large number of the practical implications into themes are the main limitations of the present study. These limitations constitute the basis upon which future literature review studies can be designed.Practical implicationsThe present study by presenting analytically and in summary (through the themes revealed) the CoQ practical implications, provides all the respective available literature in a single study for the benefit of practitioners and academics. Thus, clear and straightforward guidelines are given to practitioners with regard to CoQ issues and academics with regard to research topics of high interest.Originality/valueNo previous SLR study focusing on analyzing the practical implications of CoQ has been published so far.

ASARs are long noncoding RNA genes that control replication timing of entire human chromosomes in cis. The three known ASAR genes are located on human chromosomes 6 and 15, and are essential for chromosome integrity. To identify ASARs on all human chromosomes we utilized a set of distinctive ASAR characteristics that allowed for the identification of hundreds of autosomal loci with epigenetically controlled, allele-restricted behavior in expression and replication timing of coding and noncoding genes, and is distinct from genomic imprinting. Disruption of noncoding RNA genes at five of five tested loci resulted in chromosome-wide delayed replication and chromosomal instability, validating their ASAR activity. In addition to the three known essential cis-acting chromosomal loci, origins, centromeres, and telomeres, we propose that all mammalian chromosomes also contain “Inactivation/Stability Centers” that display allele-restricted epigenetic regulation of protein coding and noncoding ASAR genes that are essential for replication and stability of each chromosome.

PurposeThis paper explores how resilience may mitigate the impacts of a crisis and at the same time foster business excellence. Additionally, it seeks to analyze the role of HR department (HRD) in cultivating resilience and crisis awareness.Design/methodology/approachIn order for the authors to assess their hypotheses, a research model was conceptualized and tested by conducting an empirical study in Greek organizations that enlist the largest number of employees in Greece, belonging to various corporate sectors. Following the review of the relevant literature on resilience, business excellence and crisis management (CM), the research model and research hypotheses are presented.FindingsThe empirical section illustrates the statistical analysis of the collected data and the test of the research hypotheses. The authors managed to validate their research hypotheses through the research. The research demonstrated that promoting resilience and crisis awareness in a business excellence environment can reinforce the role of HRD aiming to overcome crises.Practical implicationsFollowing the research findings, the implications for managers and organizations are presented alongside with the research limitations. Managers and HRDs can review their mindset towards resilience. Thus, they may reevaluate their CM plans and processes according to the research findings.Originality/valueThe extended literature review proved that limited studies deal with the contribution of resilience regarding CM and business excellence. The originality of the present is to promote the cultivation of resilience in line with a high level of acquaintance with CM procedures to the dynamic role of HRD in terms of CM.

PurposeThe purpose of this paper is binary. At first, it explores the contribution of preoccupation with failure to total quality management (TQM) and crisis management (CM). Then, it analyzes how preoccupation with failure can advance the role of human resources department (HRD) in terms of CM.Design/methodology/approachThis paper consists of the theoretical and the empirical part. In the theoretical part an extended literature review takes place. In the empirical part, the research statistical analysis is presented. The research was conducted in organizations that employ the largest number of employees in Greece and represent various corporate sectors.FindingsThe research permitted the authors to confirm their research hypotheses. It presented how preoccupation with failure can advance continuous improvement and CM. Moreover, it illustrated the impact of failure to the key role of HRD against crises.Practical implicationsOrganizations and managers can reconsider their perspective towards failure. Additionally, they can review and redesign their TQM and CM procedures based on the research findings aiming to overcome crises.Originality/valueThe literature review indicated that limited research deals with the benefits of preoccupation with failure regarding TQM and CM. Specifically, the research advances the contribution of failure in relation with the level of CM intimacy to the role of HRD against crisis. The added value of the present is to make organizations and their top management realize the significance of failure and use it to promote learning, TQM and CM.

PurposeThe purpose of this paper is to develop an instrument that measures a set of dynamic drivers for managing innovation capability; and to validate this instrument in the agri-food sector.Design/methodology/approachBased on the innovation drivers identified after an extensive literature review, a measurement instrument was developed and then empirically validated through collecting preliminary data from 434 Greek agri-food companies. Exploratory factor analysis was applied, while their validity was confirmed through confirmatory factor analysis.FindingsThe analysis of the data confirms a valid measurement instrument of innovation drivers which consists of five drivers, namely, collaboration, environmental dynamism, knowledge orientation, quality orientation, and process management. The level of the five innovation drivers by the sample companies is deemed high, though not, however, excellent.Research limitations/implicationsA research challenge is to understand how the five innovation drivers are associated with agri-food business performance taking into consideration the role of environmental uncertainty. Moreover, it is worth validating this measurement instrument using multiple indicators for innovation drivers.Practical implicationsThe main contribution of this paper is that it develops a valid measurement instrument that can be used by agri-food companies as a self-assessment tool and a benchmarking tool. In doing so, suitable strategies can be selected in order for an agri-food to improve its innovation capability.Originality/valueThe proposed model provides plausible guidelines that advance innovation management research in the agri-food companies.

Retention of provisional substitute teachers (PSTs) in the teaching profession is an important and timely topic that relates to the sustainability of the schools’ work environment and teaching profession. The present study re-examines these issues using teacher job satisfaction (TJS) as a surrogate variable. More precisely, MUlti-criteria Satisfaction Analysis (MUSA) -a method that combines Multi-Criteria Decision and Importance-Performance Analysis- is applied to a data set of primary school substitute teachers from Greece to assess the contribution of schools’ performance on 5 important aspects of the school environment i.e., opportunities for self-fulfillment, work intensity/load, salary/income, leadership and collegial relations, to overall PSTs JS. The findings indicate that self-fulfillment and collegial relationships contribute the most to PST overall JS, whilst salary/income the least. The results further suggest that self-fulfillment is not only the facet of the work environment that PSTs value the most but also the strong point of the schools’ work environment. The study provides a new strategic perspective on TJS research, as well as evidence-based strategies for improving the quality of work life and attrition rate levels of substitute teachers. Moreover, the theoretical and practical implications of this study are presented and avenues for future research are highlighted.