1. MDSCs in infectious diseases: regulation, roles, and readjustment
- Author
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Natalie E. Nieuwenhuizen, Ana E. Sousa, Margarida Saraiva, Cornelia Gujer, Christian Münz, Yahya Sohrabi, Thalia Garcia-Tellez, Peter Delputte, Benoit Favier, Anca Dorhoi, Anurag Singh, Annabel F. Valledor, Estibaliz Glaría, Michaela Müller-Trutwin, Gennadiy Zelinskyy, Jan Ehrchen, Friedrich-Loeffler-Institut (FLI), Universität Greifswald - University of Greifswald, Max Planck Institute for Infection Biology (MPIIB), Max-Planck-Gesellschaft, University of Barcelona, Institute of Biomedicine - IBUB [Barcelona, Spain], HIV, Inflammation et persistance, Institut Pasteur [Paris], Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Tübingen, Westfälische Wilhelms-Universität Münster (WWU), Universität Zürich [Zürich] = University of Zurich (UZH), Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), Czech Academy of Sciences [Prague] (CAS), Universidade de Lisboa (ULISBOA), University of Antwerp (UA), This work was supported by European Cooperation in Science and Technology (COST) and the COST Action BM1404 Mye-EUNITER (http://www.mye-euniter.eu). COST is part of the European Union Framework Programme Horizon 2020. Estibaliz Glaría is supported by a fellowship from the University of Barcelona (Ajuts de Personal Investigador predoctoral en Formació, APIF), Thalia Garcia-Tellez is supported by the Institut Carnot Pasteur Maladie Infectieuses (ANR 11-CARN 017-01) as part of the Pasteur—Paris University (PPU) International PhD Program and by Sidaction., We thank Ronnie Grant (University of Edinburgh) for figure editing., HIV, Inflammation et persistance - HIV, Inflammation and Persistence, Institut Pasteur [Paris] (IP), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Universidade do Porto = University of Porto, Universidade de Lisboa = University of Lisbon (ULISBOA), University of Zurich, and Dorhoi, Anca
- Subjects
Cancer Research ,Virus oncogènics ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,MDSC ,Medizin ,Disease ,Mye-EUNITER ,10263 Institute of Experimental Immunology ,[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity ,0302 clinical medicine ,Immunology and Allergy ,1306 Cancer Research ,Molecular Targeted Therapy ,Pathogen ,Myeloid regulatory cells ,Immunosuppression ,Infeccions ,3. Good health ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Oncology ,Acute Disease ,Host-Pathogen Interactions ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,2723 Immunology and Allergy ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,2730 Oncology ,Disease Susceptibility ,Infection ,Oncovirus ,Immunology ,Virulence ,610 Medicine & health ,Biology ,Infections ,Communicable Diseases ,Immunomodulation ,03 medical and health sciences ,medicine ,Animals ,Humans ,2403 Immunology ,Immunosupressió ,Myeloid-Derived Suppressor Cells ,Oncogenic viruses ,Multicellular organism ,Chronic Disease ,Myeloid cells ,570 Life sciences ,biology ,Human medicine ,Biomarkers ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,030215 immunology - Abstract
International audience; Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.
- Published
- 2019