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This article looks back at ALIA's prediction from 2013 that 'library print and ebook collections will establish a 50:50 equilibrium by 2020 and that this balance will be maintained for the foreseeable future' in the light of the experience at Curtin University Library. It revisits the findings of an article on the same topic published in 2015, and documents the situation at Curtin University Library as at 2022. It describes changes in the ebook environment and user attitudes over the past 6 years, as well as developments in the Library's acquisition strategies and methods to increase ebook holdings, and the current state of the collection. The article finally provides a likely projection of the ebook and print book holdings situation at Curtin Library in 2050. [ABSTRACT FROM AUTHOR]

In the rapidly expanding field of e-commerce logistics, the optimisation of last-mile delivery solutions is paramount. This paper introduces a novel methodology that addresses this challenge by generating approximate Pareto fronts in a hybrid truck-drone delivery system. Specifically, we examine a generalized single truck multi-drone problem that allows multi-visit flight missions and rendezvous points distinct from launch locations. Our goal is providing decision-makers with a portfolio of optimal routing solutions that balance service time and environmental impact, criteria that are increasingly shaping decision-making in this domain. To achieve this, we introduce a bivector coding scheme inspired by flow-shop scheduling problems and implement a Simulated Annealing algorithm. This algorithm features an advanced stopping mechanism, negating the need for manual adjustments by utilizing a distinctive blend of a domination rate and a Kalman filter. Importantly, our framework employs an iterated greedy search algorithm to evolve from initial solutions towards identifying non-dominated solutions sets, which are then ranked using a hypervolume coefficient. To validate our methodology, we conduct a sensitivity analysis on two different size instances using a full factorial design of experiments. Our analysis reveals crucial insights into the impact of the number of drones, their autonomy, and their flight speed settings. From it, we conclude that it is a robust and adaptable framework for its practical application for obtaining Pareto fronts solutions among which picking the ultimate routing to be implemented. [ABSTRACT FROM AUTHOR]

Some human traits arise via organic evolution while others are acquired from the prevailing culture via a process of social learning. A mainstream interpretation is that evolution amounts to a change in the relative frequency of gene variants in a population and that culture coevolves at arm's length. Matters look different if one starts instead from the view that organisms are modified during evolution because of changes in gene expression as much as changes in the relative frequency of gene variants. Gene expression, i.e. generation of the product encoded by a gene, is not under genetic control, for it requires location- and time-specific triggers, which cannot be provided by genes. The genes present in an individual are present in every cell, hence at all locations in the individual's body and at all times during the individual's life. The necessary location- and time-specific triggers are provided internally by developmental events and conditions, or externally by environmental events and conditions, i.e. non-genetically. Socially-learned traits, having no special connection with genes, may nevertheless influence evolution, as for any trait. Like organic traits generally, socially-learned traits can be positively or negatively selected, for they similarly influence survival and reproduction. Like learned traits generally, they can play an important role in evolution by providing repeated selective pressure. The resulting evolutionary change typically affects an associated trait (e.g. adult ability to digest the sugar contained in milk), not the socially-learned trait itself (e.g. dairying), which continues under the influence of cultural processes of change. [ABSTRACT FROM AUTHOR]

Ecosystem engineers change the availability of resources for other species by forming new habitat or modifying existing habitat but, despite the diversity of avian ecosystem engineers, 80% of current literature focuses on mammals and invertebrates. Malleefowl Leipoa ocellata build large incubation mounds of soil and leaf-litter that are likely to provide habitat for invertebrates and vertebrates but use of their mounds by other vertebrates has never been quantified. Here, we examine vertebrate fauna visitation rates at Malleefowl mounds and non-mounds using camera-trap data collected by two citizen science projects. From 2012 to 2018, 20 active Malleefowl mounds and 16 non-mound sites were monitored over 31,913 hours and 225,144 hours, respectively. In total, we identified visits by 1724 birds, reptiles and mammals from 36 species. The mean number of vertebrate visits per 1000 hours of surveillance was around one and a half times and species richness five times that at mounds compared with non-mounds. Malleefowl mounds may enhance the availability of invertebrate prey for insectivorous birds and mammals, provide a favourable microclimate for reptiles to thermoregulate, and be signalling/social communication locations. Our results show that further research is warranted and suggest that conservation of Malleefowl may be important not only for the Malleefowl itself, but also for a suite of mallee birds and reptiles. [ABSTRACT FROM AUTHOR]

Observations on natural history are a useful but often overlooked branch of ecology. With the use of camera-traps, collection of data e.g. on breeding behaviour and success has never been easier, particularly when studying cryptic species. Additionally, camera-traps are well suited to citizen science because of their ease of operation and the ability to store and verify data. Malleefowl Leipoa ocellata breeding behaviour has previously been studied through direct observation or timelapse photography, resulting in small sample sizes and potentially biased observations. Using camera-trap data collected by citizen scientists, we examined the breeding behaviour of this species. We quantified the timing and duration of mound-tending activities at 20 mounds using camera surveillance for >30,000 hours (1250 days) over six breeding seasons. Time spent at the mound during five mound stages and visit frequencies by the male and female during each stage are reported. Female involvement at the mound was consistent, although males spent three times as long at the mound compared with females during egg-laying. On egg-laying days, females spent longer uncovering the mound, compared with covering the mound post egg-laying. Our findings confirm that both male and female Malleefowl spend a substantial amount of time constructing and maintaining their mound throughout the year and, most notably, that the female consistently participates in mound-tending. These insights are particularly valuable as our surveillance was over markedly longer time spans than previous studies that relied upon direct observation. [ABSTRACT FROM AUTHOR]

Behavioral mechanisms for avoiding inbreeding are common in the natural world and are believed to have evolved as a response to the negative consequences of inbreeding. However, despite a fundamental role in fitness, we have a limited understanding of the cues that individuals use to assess inbreeding risk, as well as the extent to which individual inbreeding behavior is repeatable. We used piecewise structural equation modeling of 24 years of data to investigate the causes and consequences of within- versus extra-group paternity in banded mongooses. This cooperatively breeding mammal lives in tight-knit social groups that often contain closely related opposite-sex breeders, so inbreeding can be avoided through extra-group mating. We used molecular parentage assignments to show that, despite extra-group paternity resulting in outbred offspring, within-group inbreeding occurs frequently, with around 16% litters being moderately or highly inbred. Additionally, extra-group paternity appears to be plastic, with females mating outside of their social group according to individual proxies (age and immigration status) and societal proxies (group size and age) of within-group inbreeding risk but not in direct response to levels of within-group relatedness. While individual repeatability in extra-group paternity was relatively low, female cobreeders showed high repeatability, suggesting a strong constraint arising from the opportunities for extra-group mating. The use of extra-group paternity as an inbreeding avoidance strategy is, therefore, limited by high costs, opportunity constraints, and the limited reliability of proxies of inbreeding risk. [ABSTRACT FROM AUTHOR]

In some animal species, individuals regularly breed with relatives, including siblings and parents. Given the high fitness costs of inbreeding, evolutionary biologists have found it challenging to understand the persistence of these inbred societies in nature. One appealing but untested explanation is that early life care may create a benign environment that offsets inbreeding depression, allowing inbred societies to evolve. We test this possibility using 21 years of data from a wild cooperatively breeding mammal, the banded mongoose, a species where almost one in ten young result from close inbreeding. We show that care provided by parents and alloparents mitigates inbreeding depression for early survival. However, as adults, inbred individuals provide less care, reducing the amount of help available to the next generation. Our results suggest that inbred cooperative societies are rare in nature partly because the protective care that enables elevated levels of inbreeding can be reduced by inbreeding depression. [ABSTRACT FROM AUTHOR]

Background: Improving the quality of care for patients who return home after a hospital stay is an international priority; however, few jurisdictions have engaged broadly with patients and caregivers to understand what most affects their experience transitioning home. We performed Ontario-wide group concept mapping, beginning with a brainstorming phase, to understand patient and caregiver priorities in the transition. Methods: We used group concept mapping to engage patients and caregivers who had lived experience transitioning from hospital to home in Ontario in the previous 3 years. We report on the first phase, brainstorming, conducted over 10 weeks beginning Jan. 11, 2018 via an online survey or facilitated group discussion. Participants responded to a single focal prompt: "When leaving the hospital for home, some thing(s) that affected the experience were: ____." The study team identified recurrent concepts and overarching themes. Patients and caregivers informed the study design, recruitment and data interpretation. Results: In all, 665 people (263 patients [39.5%], 352 caregivers [52.9%] and 50 people who were both patient and caregiver [7.5%]) participated in brainstorming online, and 71 people participated in 1 of 8 group discussions. Participants identified 6 key areas affecting their experience of transition from hospital to home: home and community care, the discharge process, medical follow-up after discharge, medications, patient and caregiver education, and the kindness and caring of the health care team in hospital. Most notable were challenges with the timeliness, sufficiency, reliability and consistency of publicly funded home care services. Interpretation: Patients and caregivers from across Ontario noted a range of issues affecting their experience transitioning from hospital to home, particularly the quality and sufficiency of publicly funded home care. Our findings will be used to inform a provincial quality standard on the transition from hospital to home. [ABSTRACT FROM AUTHOR]

Many important physical problems, such as fluid structure interaction or conjugate heat transfer, require numerical methods that compute boundary derivatives or uxes to high accuracy. This paper proposes a novel approach to calculating accurate approximations of boundary derivatives of elliptic problems. We describe a new continuous finite element method based on p-refinement of cells adjacent to the boundary that increases the local degree of the approximation. We prove that the order of the approximation on the p-refined cells is, in 1D, determined by the rate of convergence at the mesh vertex connecting the higher and lower degree cells and that this approach can be extended, in a restricted setting, to 2D problems. The proven convergence rates are numerically verified by a series of experiments in both 1D and 2D. Finally, we demonstrate, with additional numerical experiments, that the p-refinement method works in more general geometries. [ABSTRACT FROM AUTHOR]

Introduction: Since the introduction of major trauma centres and regional trauma networks in 2012, management of splenic injury has shifted, with non-operative management now favoured. For those requiring intervention, splenic artery embolisation is well established as a first-line treatment in all but the most severely injured. Follow-up is variable, with few guidelines, highlighting the paucity of data addressing the need for further imaging and antimicrobial prophylaxis. This review was undertaken to assess practice and outcomes at our centre in the context of the contemporary literature. Methods: This retrospective study captured splenic embolisations over five years (January 2012–December 2016). CRIS interventional radiology codes were used to retrieve embolisation cases and Trauma Audit and Research Network and hospital event statistics data were used to identify all cases of traumatic splenic injury and to identify splenectomy and non-operative management patients. Outcomes were compared with available standards from different sources. Results: Over the study period 176 splenic injuries were identified, of which 122 underwent non-operative management, 28 were laparotomy first, and 26 undergoing embolisation with an increased trend to an 'embolisation-first' approach over this time. In the embolisation group, the age range was 16–79 yr (mean 41), 18 were male and the median time to intervention was 2 h 9 min (range 1.1–171 h), with eight following failed non-operative management. The proportion of proximal versus selective embolisation versus both was 10:14:1 and the predominant mechanism was coiling. One patient was not embolised due to absence of contrast extravasation on initial angiogram and two proceeded to splenectomy due to failure of splenic artery embolisation. There were complications in six patients: five ongoing left upper quadrant pain, one infected haematoma requiring drainage, two chest infections with pleural effusions, one of which required drainage. There were two deaths from other injuries. Fifteen of the 25 patients who underwent splenic artery embolisation had follow-up imaging, seven did not and three were excluded due to splenectomy and/or death; five patients were vaccinated according to the hospital splenectomy protocol, and six received prophylactic antibiotics. Conclusion: Our data show that non-operative management is the mainstay of treatment for the majority of splenic injury patients. Serious complications are not common but variation does exist in follow-up. The changing management trends are in line with national data. These findings will help to further implement and develop local protocols but more work is required to address splenic function after embolisation and the requirement for antimicrobial prophylaxis. [ABSTRACT FROM AUTHOR]

The transport of biomolecules across cell boundaries is central to cellular function. While structures of many membrane channels are known, the permeation mechanism is known only for a select few. Molecular dynamics (MD) is a computational method that can provide an accurate description of permeation events at the atomic level, which is required for understanding the transport mechanism. However, due to the relatively short time scales accessible to this method, it is of limited utility. Here, we present a method for all-atom simulation of electric field-driven transport of large solutes through membrane channels, which in tens of nanoseconds can provide a realistic account of a permeation event that would require a millisecond simulation using conventional MD. In this method, the average distribution of the electrostatic potential in a membrane channel under a transmembrane bias of interest is determined first from an all-atom MD simulation. This electrostatic potential, defined on a grid, is subsequently applied to a charged solute to steer its permeation through the membrane channel. We apply this method to investigate permeation of DNA strands, DNA hairpins, and α-helical peptides through α-hemolysin. To test the accuracy of the method, we computed the relative permeation rates of DNA strands having different sequences and global orientations. The results of the G-SMD simulations were found to be in good agreement in experiment. [ABSTRACT FROM AUTHOR]

This paper introduces a sharp-interface approach to simulating fluid-structure interaction (FSI) involving flexible bodies described by general nonlinear material models and across a broad range of mass density ratios. This new flexible-body immersed Lagrangian-Eulerian (ILE) scheme extends our prior work on integrating partitioned and immersed approaches to rigid-body FSI. Our numerical approach incorporates the geometrical and domain solution flexibility of the immersed boundary (IB) method with an accuracy comparable to body-fitted approaches that sharply resolve flows and stresses up to the fluid-structure interface. Unlike many IB methods, our ILE formulation uses distinct momentum equations for the fluid and solid subregions with a Dirichlet-Neumann coupling strategy that connects fluid and solid subproblems through simple interface conditions. As in earlier work, we use approximate Lagrange multiplier forces to treat the kinematic interface conditions along the fluid-structure interface. This penalty approach simplifies the linear solvers needed by our formulation by introducing two representations of the fluid-structure interface, one that moves with the fluid and another that moves with the structure, that are connected by stiff springs. This approach also enables the use of multi-rate time stepping, which allows us to use different time step sizes for the fluid and structure subproblems. Our fluid solver relies on an immersed interface method (IIM) for discrete surfaces to impose stress jump conditions along complex interfaces while enabling the use of fast structured-grid solvers for the incompressible Navier-Stokes equations. The dynamics of the volumetric structural mesh are determined using a standard finite element approach to large-deformation nonlinear elasticity via a nearly incompressible solid mechanics formulation. This formulation also readily accommodates compressible structures with a constant total volume, and it can handle fully compressible solid structures for cases in which at least part of the solid boundary does not contact the incompressible fluid. Selected grid convergence studies demonstrate second-order convergence in volume conservation and in the pointwise discrepancies between corresponding positions of the two interface representations as well as between first and second-order convergence in the structural displacements. The time stepping scheme is also demonstrated to yield second-order convergence. To assess and validate the robustness and accuracy of the new algorithm, comparisons are made with computational and experimental FSI benchmarks. Test cases include both smooth and sharp geometries in various flow conditions. We also demonstrate the capabilities of this methodology by applying it to model the transport and capture of a geometrically realistic, deformable blood clot in an inferior vena cava filter. • This paper introduces a sharp-interface fluid-flexible structure interaction approach for general nonlinear material models. • We incorporate the domain solution flexibility of immersed methods with an accuracy comparable to body-fitted methods. • The partitioned formulation allows for various mass density ratios and the use of multi-rate time-stepping. • We demonstrate the application of this method to the transport and capture of a blood clot in an inferior vena cava filter. • Our approach can be viewed as a distributed Lagrange multipliers scheme with interfacial (rather than volumetric) coupling. [ABSTRACT FROM AUTHOR]

We have conducted a density functional theory investigation into the gas-phase reactivity of small gold cluster ions in the interest of understanding gold cluster reactivity in several catalytic systems. Previously unreported geometries for Au[sup -, sub 9] and Au[sup -, sub 10] anions are obtained and reported from geometry optimizations. Predicted values of the vertical detachment energy match well with experiment, as does a rough simulation of its ultraviolet photoelectron spectrum—we found that comparison of predicted spectra with experimental data is a more sensitive analysis of geometry differences. Several binding sites for O[sub 2] with different energies are identified on Au[sup -, sub 10], but we show that the strongest binding site and orientation is predicted by frontier orbital theory. In addition, weakly stable adsorbed states for O[sub 2] on the anion clusters Au[sup -, sub 9], Au[sup -, sub 10], and Au[sup -, sub 11] are predicted in agreement with frontier orbital theory. The calculated binding energies are consistent with the experimentally observed patterns in adsorption of O[sub 2] on anionic Au clusters. The binding energy for O[sub 2] to Au[sup -, sub 10] was calculated to be 19 kcal/mol, higher than for O[sub 2] to either Au[sup -, sub 9] (4 kcal/mol) or Au[sup -, sub 11] (5 kcal/mol), and the calculated O-O bond length was found to increase from its gas-phase value of 1.27 angstroms to 1.38 angstroms when adsorbed on the Au[sup -, sub 10] cluster, approaching the calculated bond length of 1.41 angstroms for the gas-phase superoxide ion O[sup -, sub 2]. [ABSTRACT FROM AUTHOR]

Assessing collections, services and operations to ensure that the needs and expectation of clients are met and to optimise return on investment is an essential part of all library management. I Assessing academic library performance i presents a readable and nuanced introduction to library assessment backed up by recent scholarship and a compelling selection of case studies, which would be valuable to any library manager. [Extracted from the article]

Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral therapy. We used integration site analysis to ask if there is a similar clonal expansion of SIV infected cells in macaques. We show that the distribution of HIV and SIV integration sites in vitro is similar and that both viruses preferentially integrate in many of the same genes. We obtained approximately 8000 integration sites from blood samples taken from SIV-infected macaques prior to the initiation of ART, and from blood, spleen, and lymph node samples taken at necropsy. Seven clones were identified in the pre-ART samples; one persisted for a year on ART. An additional 100 clones were found only in on-ART samples; a number of these clones were found in more than one tissue. The timing and extent of clonal expansion of SIV-infected cells in macaques and HIV-infected cells in humans is quite similar. This suggests that SIV-infected macaques represent a useful model of the clonal expansion of HIV infected cells in humans that can be used to evaluate strategies intended to control or eradicate the viral reservoir. [ABSTRACT FROM AUTHOR]