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Background: Breast cancer (BC) patients have a greater risk of developing thyroid cancer (TC) than the general population. Similarly, TC patients are more likely to develop BC, suggesting an underlying common etiology. In this study, we sought to identify the potential cross-talking pathway and related molecular mechanisms conferring to the sequential development of BC and TC.Methods: We first used Multiple Primary-Standardized Incidence Ratios (MP-SIR) Program of SEER*Stat to calculate SIR to confirm the relationship between BC and TC. Then the RNA-seq was downloaded from The Cancer Genome Atlas (TCGA). And we built a co-expression network via Weighted Gene Co-expression Network Analysis (WGCNA) and obtained the most significant modules. The key genes were obtained by differential gene expression (DGE) analysis and WGCNA analysis. Furthermore, String database and Cytoscape software were used to construct protein-protein interactions (PPI), and defined the maximum Maximal Clique Centrality (MCC) value as hub gene.Then we performed prognosis analysis on the hub genes and obtained the prognostic genes of BC and TC. Finally, gene set enrichment analysis (GSEA) was used to investigate the molecular pathways associated with prognostic gene expressed both in BC and TC.Results: From the SEER database, we found that the risk of developing BC in TC patients was SIR 1.12, 95% CI [1.07, 1.18], and the risk of developing BC in TC patients was SIR 1.29, 95% CI [1.23, 1.26]. Fifty-nine key genes obtained by differential expression analysis and WGCNA identify that PI3K/AKT was the most enriched pathway in BC and TC. In addition, the Recombinant Fibulin 5 (FBLN5) was shown to be of significant prognostic value for both BC and TC and was down-regulated in BC and TC tissues. GSEA demonstrated that FBLN5 enrichment pathways associated with BC and TC mainly included: B cell receptor signaling pathway, steroid hormone biosynthesis, and pathways in cancer.Conclusions: The PI3K/AKT signaling is most co-enriched pathway in BC and TC. FBLN5 is the most relevant prognostic gene and an underlying common tumor suppressor in both BC and TC, with down-stream pathways involving immunity, hormone biosynthesis and carcinogenesis.

This paper explores the next stage of GaN power devices with 2-level integration of peripheral low voltage active and passive devices. The 1st level consists of protection/control/driving circuits, which potentially improves the performance and overcomes the challenges to the power devices. The 2nd level integration has high-low side on-chip integration on a 100V technology platform. The challenge of channel modulation due to substrate bias sharing is effectively eliminated by the invented new scheme. The system efficiency of DC-DC buck converter using such scheme is enhanced with lower on-state resistance and good stability.

To explore clinical effects of internal fixation in treating displaced clavicle fracture combined with coracoid process.From January 2005 to July 2012, 9 patients with displaced clavicle fracture combined with coracoid process were treated by internal fixation. Among them, there were 6 males and 3 females with an average age of 40.1 (ranged from 20 to 57) years old. According to Eyres classification: 3 cases were type II B, 1 case was type II A, 3 cases were type III B, and 2 cases were type V A. All patients had history of injury, and diagnosed as coracoid fracture X-ray and CT before operation. Herscovici criteria was used to evaluate function of shoulders joint after operation.Seven of 9 patients were followed up from 6 to 18 (averaged 11) months. The incisions were healed at stage I, coracoid process obtained bony healing, and reduction of acromioclavicular joint well. According to Herscovici criteria, 6 patients got excellent results and 1 in good.Internal fixation for the treatment of displaced clavicle fracture combined with coracoid process could restore physiological anatomical position of coracoid process, and benefit for recovery of limb function.

A new high voltage tolerant (HVT) electro-static discharge (ESD) design adopts one forward biased P+/N-well diode in series of one stacked NMOS, called the diode-stacked NMOS, is proposed to reduce the total capacitance and maintain the high ESD performance. The device has been implemented in 0.18 μm CMOS logic technologies and finds the measured human body model and machine-model ESD levels of the HVT pin exceed 6 kV and 550 V, respectively, while the measured input capacitance is only 250 fF.

This paper demonstrates an advanced 1.1um pixel backside illuminated CMOS image sensor with a 3D stacked architecture. The carrier wafer in conventional BSI is replaced by ASIC wafer, which contains a part of periphery circuit and is connected to the sensor wafer through bonding technology. With proper layout design and process improvement, the impact of 3D connection (Through Via, TV) on the sensor performance can be significantly minimized. In addition, for the first time, the degradation of stacked pixel performance during the folded circuit operation under sensor array is found and improved. The final stacked sensor exhibits the comparable pixel performances to conventional BSI. Furthermore, stacked architecture provides the opportunity to enhance sensor performance by the separate process tuning for sensor wafers (without any effect on ASIC wafers), leading to a further improvement of dark performance.

In this paper, current methods about perceptual hashing were deeply researched and the defects of them were analyzed. Principles and characters of discrete cosine transform, Watson visual model and chaotic model were introduced in details. A new method about perceptual image hashing which combined the characteristics of the three models was designed. This method use discrete cosine transform to feature extraction from image, eigenvector was handled by contrast sensitivity table, Logistic equation was used as chaos sequence generator to encrypt and at last the prediction differential method was used to quantization coding. Experimental results indicated that the method could resist the content-preserving modifications, and possessed strong robustness, safety and retrieval ability, and the collision rate decreases to level 10− 7. Therefore, this technique has the applied value in image authentication, copyright protection, image security and content-based image retrieval and so on.

With the development of the internet and computer technology, the image protection becomes more and more important. In order to strengthen the robust and safety of the image protection , this paper mainly improve the encryption algorithm of harsh sequence and propose the theory of using chaos theory to encrypt the image protection through analyzing the basic feature of the chaos theory. It also proposes new image protection solution by using encryption matrix methods, Pseudo random sequence block and image scrambling method in the image protection experiment. The experiment shows that these methods have better usefulness, safety and versatility which can satisfy the needs of image data encryption and image safety.

Backside Illumination (BSI) sensor with excellent optical performance has become the main-stream CMOS image sensor process. This work addressed the key factors and issues for 300mm BSI technology, including wafer distortion, silicon thickness variation, backside junction formation and dielectric film structure, thermal annealing and so on. It is demonstrated that with the optimized key process, a high performance 0.9um BSI pixel with low noise can be fabricated.

A switched beam technique applied to UHF band RFID reader is proposed. The proposed switched beam circuit composed of power divider, phase shifter, and beam controlling logic circuit is implemented on a 1x2 array antenna, and resulted in a -30 to 30 degrees beam switching range in three discrete angles. This capability not only enhances the sensing range and distance but also reduces the possible EMI interference. In addition, this array antenna can help effectively cancel or attenuate mutual interference among tags through antenna arrays directivity. These advantages provided by the antenna array greatly improve the performance of a RFID system in terms of scan efficiency and read rate, which makes RFID applications even more appealing.

A vehicle management system based on UHF band RFID technology is proposed. This system is applied for vehicle entering/leaving at road gates. The system consists of tag-on-car, reader antenna, reader controller, and the monitoring and commanding software. It could effective control the vehicles passing through road gate and record the vehicles' data. The entering time, leaving time, and tag number of each vehicle are all recorded and saved for further processing. By the benefit of UHF band long distance sensing ability, within nine meter the distance between vehicle and reader antenna, the signal can be accurately detected even the vehicle's speed at nearly 30 km/hr. The monitoring and commanding software can not only identify car owners' identities but also determine the gate to open or not. The accessories: video recording and pressure sensing components are flexible to add for enhancing the system's performance. This system has been tested in many field tests and the results shown that it is suitable for vehicle management and the related applications.