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Consumer reviews are an invaluable aid for businesses in obtaining consumers’ feedback to facilitate their marketing campaigns. However, the rapidly increasing number of consumer reviews makes it difficult for businesses to obtain a comprehensive view of consumer opinions about their products, especially about the highlighted product features. This study presents a framework to provide an understanding of how consumers’ feedback changes over time and what concerns consumers most. The framework presented here contributes to consumer review analysis in three ways. First, a novel model is proposed to extract the feature words that are semantically relevant to each highlighted product feature. Second, consumers’ feedback on each highlighted product feature is converted into a sentiment tendency graph, which may reflect how the feedback changes over time. Third, consumers’ feedback is also summarized, which may reveal what consumers appreciate and what concerns them most. The experimental results show that the proposed model can effectively extract the feature words for each highlighted feature of the product. Moreover, both sentiment tendency graphs and summaries could complement each other and provide a more detailed picture for consumers and manufacturers.

The rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color change enables label-free visual detection of G-quadruplexes, which is due to the disassembly of dye H-aggregates to monomers. This specific detection of G-quadruplex arises from its end-stacking interaction with G-quartet. On the basis of this universal indicator, a facile approach for large-scale identification of G-quadruplex was developed.

A series of isaindigotone derivatives and analogues were designed, synthesized and evaluated as dual inhibitors of cholinesterases (ChEs) and self-induced β-amyloid (Aβ) aggregation. The synthetic compounds had IC50 values at micro or nano molar range for cholinesterase inhibition, and some compounds exhibited strong inhibitory activity for AChE and high selectivity for AChE over BuChE, which were much better than the isaindigotone derivatives previously reported by our group. Most of these compounds showed higher self-induced Aβ aggregation inhibitory activity than a reference compound curcumin. The structure–activity relationship studies revealed that the derivatives with higher inhibition activity on AChE also showed higher selectivity for AChE over BuChE. Compound 6c exhibiting excellent inhibition for both AChE and self-induced Aβ aggregation was further studied using CD, EM, molecular docking and kinetics.

A tailor-made colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids was developed by incorporating a coumarin–hemicyanine fluorophore into an isaindigotone framework. The significant and distinct changes in both the color and fluorescence of this probe enable the label-free and visual detection of G-quadruplex structures.