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1. Distortion-dependent unhooking of interstrand cross-links in mammalian cell extracts

Author

Smeaton, Michael B., Hlavin, Erica M., Mason, Tracey McGregor, Noronha, Anne M., Wilds, Christropher J., and Miller, Paul S.

Subjects
DNA replication -- Research, Proteins -- Crosslinking, Proteins -- Research, Cell research, Biological sciences, Chemistry
Abstract

Interstrand cross-linked (ICL) linear DNA duplexes are used to examine cross-link processing in mammalian whole-cell extracts. The results have shown that in DNA not undergoing transcription or replication, distortions induced by the presence of an ICL has contributed to initial cross-link recognition and processing.

Published
2008

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