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27 results on '"Woodling, Kellie"'

1. The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model

Author

Inselman, Amy L., primary, Masters, Elysia A., additional, Moore, Jalina N., additional, Agarwal, Rajiv, additional, Gassman, Audrey, additional, Kuijpers, Gemma, additional, Beger, Richard D., additional, Delclos, Kenneth B., additional, Swift, Sybil, additional, Camacho, Luísa, additional, Vanlandingham, Michelle M., additional, Sloper, Daniel, additional, Nakamura, Noriko, additional, Gamboa da Costa, Gonçalo, additional, Woodling, Kellie, additional, Bryant, Matthew, additional, Trbojevich, Raul, additional, Wu, Qiangen, additional, McLellen, Florence, additional, and Christner, Donna, additional

Published
2024
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3. Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents

Author

Camacho, Luísa, Lewis, Sherry M., Vanlandingham, Michelle M., Juliar, Beth E., Olson, Greg R., Patton, Ralph E., Gamboa da Costa, Gonçalo, Woodling, Kellie, Sepehr, Estatira, Bryant, Matthew S., Doerge, Daniel R., Basavarajappa, Mallikarjuna S., Felton, Robert P., and Delclos, K. Barry

Published
2016
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5. NIEHS/FDA CLARITY-BPA research program update

Author

Heindel, Jerrold J., Newbold, Retha R., Bucher, John R., Camacho, Luísa, Delclos, K. Barry, Lewis, Sherry M., Vanlandingham, Michelle, Churchwell, Mona I., Twaddle, Nathan C., McLellen, Michelle, Chidambaram, Mani, Bryant, Matthew, Woodling, Kellie, Costa, Gonçalo Gamboa da, Ferguson, Sherry A., Flaws, Jodi, Howard, Paul C., Walker, Nigel J., Zoeller, R. Thomas, Fostel, Jennifer, Favaro, Carolyn, and Schug, Thaddeus T.

Published
2015
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18. Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90

Author

Delclos, K. Barry, primary, Camacho, Luísa, additional, Lewis, Sherry M., additional, Vanlandingham, Michelle M., additional, Latendresse, John R., additional, Olson, Greg R., additional, Davis, Kelly J., additional, Patton, Ralph E., additional, Gamboa da Costa, Gonçalo, additional, Woodling, Kellie A., additional, Bryant, Matthew S., additional, Chidambaram, Mani, additional, Trbojevich, Raul, additional, Juliar, Beth E., additional, Felton, Robert P., additional, and Thorn, Brett T., additional

Published
2016
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19. Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: Gavage vs. feeding

Author

Sprando, Robert L., primary, Reimschuessel, Renate, additional, Stine, Cynthia B., additional, Black, Thomas, additional, Olejnik, Nicholas, additional, Scott, Michael, additional, Keltner, Zachary, additional, Bandele, Omari, additional, Ferguson, Martine, additional, Nemser, Sarah M., additional, Tkachenko, Andriy, additional, Evans, Eric, additional, Crosby, Tina, additional, Woodling, Kellie, additional, Loukotková, Lucie, additional, and da Costa, Gonçalo Gamboa, additional

Published
2012
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22. Acute and Chronic Effects of Oral Genistein Administration in Neonatal Mice1

Author

Cimafranca, Melissa A., primary, Davila, Juanmahel, additional, Ekman, Gail C., additional, Andrews, Rachel N., additional, Neese, Steven L., additional, Peretz, Jackye, additional, Woodling, Kellie A., additional, Helferich, William G., additional, Sarkar, Jhimly, additional, Flaws, Jodi A., additional, Schantz, Susan L., additional, Doerge, Daniel R., additional, and Cooke, Paul S., additional

Published
2010
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26. Intrinsic Resistance of Burkholderia cepaciaComplex to Benzalkonium Chloride

Author

Ahn, Youngbeom, Kim, Jeong Myeong, Kweon, Ohgew, Kim, Seong-Jae, Jones, Richard C., Woodling, Kellie, Gamboa da Costa, Gonçalo, LiPuma, John J., Hussong, David, Marasa, Bernard S., and Cerniglia, Carl E.

Abstract

ABSTRACTPharmaceutical products that are contaminated with Burkholderia cepaciacomplex (BCC) bacteria may pose serious consequences to vulnerable patients. Benzyldimethylalkylammonium chloride (BZK) cationic surfactants are extensively used in medical applications and have been implicated in the coselection of antimicrobial resistance. The ability of BCC to degrade BZK, tetradecyldimethylbenzylammonium chloride (C14BDMA-Cl), dodecyldimethylbenzylammonium chloride (C12BDMA-Cl), decyldimethylbenzylammonium chloride (C10BDMA-Cl), hexyldimethylbenzylammonium chloride, and benzyltrimethylammonium chloride was determined by incubation in 1/10-diluted tryptic soy broth (TSB) to determine if BCC bacteria have the ability to survive and inactivate these disinfectants. With BZK, C14BDMA-Cl, and C12BDMA-Cl, inhibition of the growth of 20 BCC strains was observed in disinfectant solutions that ranged from 64 to 256 µg/ml. The efflux pump inhibitor carbonyl cyanide m-chlorophenylhydrazone increased the sensitivity of bacteria to 64 µg/ml BZK. The 20 BCC strains grew well in 1/10-diluted TSB medium with BZK, C12BDMA-Cl, and C10BDMA-Cl; they absorbed and degraded the compounds in 7 days. Formation of benzyldimethylamine and benzylmethylamine as the initial metabolites suggested that the cleavage of the C alkyl-N bond occurred as the first step of BZK degradation by BCC bacteria. Proteomic data confirmed the observed efflux activity and metabolic inactivation via biodegradation in terms of BZK resistance of BCC bacteria, which suggests that the two main resistance mechanisms are intrinsic and widespread.IMPORTANCEBenzyldimethylalkylammonium chloride is commonly used as an antiseptic in the United States. Several recent microbial outbreaks were linked to antiseptics that were found to contain strains of the Burkholderia cepaciacomplex. Burkholderiaspecies survived in antiseptics, possibly because of the degradation of antiseptic molecules or regulation of relevant gene expression. In this study, we assessed the efflux pump and the potential of B. cepaciacomplex bacteria to degrade benzyldimethylalkylammonium chloride and improved our understanding of the resistance mechanisms, by using proteomic and metabolic information. To our knowledge, this is the first systematic report of the intrinsic mechanisms of B. cepaciacomplex strain resistance to benzyldimethylalkylammonium chloride, based on the metabolic and proteomic evidence for efflux pumps and the complete biodegradation of benzyldimethylalkylammonium chloride.

Published
2016
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27. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides.

Author

Xiaobo He, Qingsu Xia, Woodling, Kellie, Ge Lin, and Fu, Peter P.

Subjects
*ALKALOIDS, *BIOMARKERS, *BIOLOGICAL models, *CARCINOGENS, *DNA, *LIVER tumors, *OXIDES, *PLANTS, *RATS
Abstract

There are 660 pyrrolizidine alkaloids (PAs) and PA N-oxides present in the plants, with approximately half being possible carcinogens. We previously reported that a set of four PA-derived DNA adducts is formed in the liver of rats administered a series of hepatocarcinogenic PAs and a PA N-oxide. Based on our findings, we hypothesized that this set of DNA adducts is a common biological biomarker of PA-induced liver tumor formation. In this study, we determined that rat liver microsomal metabolism of five hepatocarcinogenic PAs (lasiocarpine, retrorsine, riddelliine, monocrotaline, and heliotrine) and their corresponding PA N-oxides produced the same set of DNA adducts. Among these compounds, lasiocarpine N-oxide, retrorsine N-oxide, monocrotaline N-oxide, and heliotrine N-oxide are for first time shown to be able to produce these DNA adducts. These results further support the role of these DNA adducts as potential common biomarkers of PA-induced liver tumor initiation. [ABSTRACT FROM AUTHOR]

Published
2017
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