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Several methods and catalysts have been investigated for eco-friendly ammonia (NH3) production under mild conditions in the past few decades. NH3 is important chemical fertilizer and now expecting as H2 carrier, and mainly synthesized by Haber-Bosch process under severe conditions (400 ℃, 20MPa). In contrast, nitrogenases, biocatalyst can activate N2 and H2O to form NH3 under ambient conditions in nature with a low synthesis rate. Herein we first reported photobiocatalytic NH3 production by the combination of cyanobacterial Anabaena variabilis as a whole-cell biocatalyst coupled with TiO2 as a photocatalyst in the existence of glycerol as a sacrificial reagent and viologens as an electron transfer mediator. Comparing with natural system, the formation rate of NH3 from a combination with inorganic photocatalyst was much increased by ca. 20.86 times. Biocatalytic reactions revealed that only reduced MV•+ passed into whole cells and transfer electrons to nitrogenase efficiently for NH3 production. The amount of intracellular [MoFe]-nitrogenase was increased in cyanobacteria cultivated in a nitrogen-deficient Allen & Arnon medium. The complete hybrid system produced NH3 with a maximum rate of 3.3 µM·g-1·h-1. This study is the first demonstration of the sustainable technology for solar-to-NH3 conversion as an energy carrier for a future carbon-neutral energy society.

To observe the radiological change and curative effect of cervical spondylosis treated with cervical vertebra pulling therapy in young people.A total of 65 patients(shedding in 5 patients and final inclusion in 60 patients) with cervical spondylosis who were treated from January 2018 to September 2019 were randomly divided into treatment group and control group according to the digital table method. There were 30 patients in treatment group, including 14 males and 18 females, aged from 20 to 44 years old with an average of(29.83±6.99) years, who were treated with cervical vertebra pulling therapy(once a week, 4 times in total). The control group consisted of 30 cases, 12 males and 18 females, aged from 18 to 43 years old with an average of (31.77±5.93) years, who received sitting traction therapy(once a week, 4 times in total). The changes of CSixty patients were followed up for (3.2±0.3) months. There were no significant differences in NRS, CCervical vertebra pulling method and cervical vertebra sitting traction can relieve the pain symptoms of patients with cervical spondylosis, but the effect of cervical vertebra pulling method is more durable;cervical vertebra pulling method can correct abnormal cervical sagittal parameters.

Metal oxynitrides are promising photocatalysts due to their narrow bandgap, but their lower stability compared to metal oxides is a drawback. The introduction of high-entropy alloys with entropy-stabilization features has shown high potential for various functional applications in recent years. By considering these two types of materials, we developed a high-entropy oxynitride for photocatalytic water splitting. The material, with a general composition of TiZrHfNbTaO6N3 and a d0 electronic configuration, showed a narrow bandgap of 1.6 eV, which is much lower than the bandgaps of relevant binary and high-entropy oxides. The material exhibited photocurrent generation and photocatalytic hydrogen production with high chemical stability, suggesting the high potential of high-entropy oxynitrides as advanced low-bandgap and stable photocatalysts.

Background Artemisinin-based combination therapy has become the preferred approach for treating malaria and has successfully reduced malaria-related mortality. Currently, the main source of artemisinin is Artemisia annua L., and thus, it is of strategic importance to enhance artemisinin contents in A. annua plants. Phytohormones and illumination are known to be important external environmental factor that can have notable effects on the production of secondary metabolite. The activities of different hormones can be influenced to varying degrees by light, and thus light and hormones may jointly regulate various processes in plants. Here, we performed transcriptome and metabolome analyses revealed that ultraviolet B irradiation and phytohormone gibberellins coordinately promoted the accumulation of artemisinin in Artemisia annua. Methods Artemisinin analysis was performed by ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UPLC-ESI-QqQ-MS/MS). RNA sequencing, GO and KEGG enrichment analysis were applied to analyzing the differentially expressed genes (DEGs) under ultraviolet B irradiation and gibberellins treatments. Weighted gene co-expression network (WGCNA) analyzed the genes in artemisinin‑related modules and identified candidate hub genes in these modules. Results In this study, we found that cross-talk between UV-B and GA induced processes leading to modifications in artemisinin accumulation. A total of 14,762 genes differentially expressed (DEGs) among different treatments were identified by transcriptome analysis. UV-B and GA treatments enhanced the accumulation of artemisinin by up-regulating the expression of the key artemisinin biosynthesis genes ADS and CYP71AV1. According to the high degree value and high expression level, a total of 84 co-expressed transcription factors were identified. Among them, MYB and NAC TFs mainly involved in regulating the biosynthesis of artemisinin. Weighted gene co-expression network analysis revealed that GA + UV in blue modules was positively correlated with artemisinin synthesis, suggesting that the candidate hub genes in these modules should be up-regulated to enhance artemisinin synthesis in response to GA + UV treatment. Conclusion Our study demonstrated the co-regulation of artemisinin biosynthetic pathway genes under ultraviolet B irradiation and phytohormone gibberellins treatment. The co-expression was analysis revealed that the selected MYB and NAC TFs might have regulated the artemisinin biosynthesis gene expression with ADS and CYP71AV1 genes. Weighted gene co-expression network analysis revealed that GA + UV treatment in blue modules was positively correlated with artemisinin synthesis. We established the network to distinguish candidate hub genes in blue modules might be up-regulated to enhance artemisinin synthesis in response to GA + UV treatment.

Background Labor represents a period of significant physical activity. Inefficient energy supply may delay labor process and even lead to cesarean delivery. Herein we investigated whether ingestion of a carbohydrate-rich beverage could reduce cesarean delivery in laboring women with epidural analgesia. Methods This multicenter randomized trial was conducted in obstetrician-led maternity units of nine tertiary hospitals in China. Primigravidae with single term cephalic pregnancy who were preparing for vaginal birth under epidural analgesia were randomized to intake a carbohydrate-rich beverage or commercially available low-carbohydrate beverages during labor. The primary outcome was the rate of cesarean delivery. Secondary outcomes included maternal feeling of hunger, assessed with an 11-point scale where 0 indicated no hunger and 10 the most severe hunger, and maternal and neonatal blood glucose after childbirth. Results Between 17 January 2018 and 20 July 2018, 2008 women were enrolled and randomized, 1953 were included in the intention-to-treat analysis. The rate of cesarean delivery did not differ between the two groups (11.3% [111/982] with carbohydrate-rich beverage vs. 10.9% [106/971] with low-carbohydrate beverages; relative risk 1.04, 95% CI 0.81 to 1.33; p = 0.79). Women in the carbohydrate-rich beverage group had lower subjective hunger score (median 3 [interquartile range 2 to 5] vs. 4 [2 to 6]; median difference − 1; 95% CI − 1 to 0; p < 0.01); their neonates had less hypoglycemia (1.0% [10/968] vs. 2.3% [22/956]; relative risk 0.45; 95% CI 0.21 to 0.94; p = 0.03) when compared with those in the low-carbohydrate beverage group. They also had higher rates of maternal hyperglycemia (6.9% [67/965] vs. 1.9% [18/953]; p < 0.01) and neonatal hyperglycemia (9.2% [89/968] vs. 5.8% [55/956]; p < 0.01), but none required special treatment. Conclusions For laboring primigravidae with epidural analgesia, ingestion of a carbohydrate-rich beverage compared with low-carbohydrate beverages did not reduce cesarean delivery, but relieved maternal hunger and reduced neonatal hypoglycemia at the expense of increased hyperglycemia of both mothers and neonates. Optimal rate of carbohydrate supplementation remains to be determined. Trial registration www.chictr.org.cn; identifier: ChiCTR-IOR-17011994; registered on 14 July 2017.

The mol­ecular and crystal structure of a new mononuclear neutral high-spin iron(III) complex with two different tridentate ligands has been studied by an X-ray diffraction analysis., The title neutral mononuclear complex, [1-(5-bromo-2-oxido­benzyl­idene)thio­semicarbazidato](4-bromo-2-{[2-(pyridin-2-yl)hydrazinyl­idene]meth­yl}pheno­lato)iron(III), [Fe(C8H6BrN3OS)(C12H9BrN3O)] (I), crystallizes in the monoclinic space group C 2/c and has two different planar tridentate ligands. The central FeIII ion is coordinated to three N, two O and one S atom, forming a distorted octa­hedral FeN3O2S coordination geometry. In the crystal, the complex mol­ecules are linked by N—H⋯O and N—H⋯N hydrogen bonds and π–π inter­actions into layers parallel to (100). Magnetic measurements show that the central FeIII ion is in the high-spin state; this is also supported by the bond distances around the FeIII ion.

Two new 2-arylbenzofurans, 2-(4-methoxyphenyl)-3,5-dimethylbenzofuran-7-ol (1) and 2-(4-methoxyphenyl)-3,5-dimethylbenzofuran-6-ol (2), were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-TMV and cytotoxicity activities. The results showed that compounds 1 and 2 exhibited high anti-TMV activities with inhibition rates of 29.2% and 30.8% at the concentration of 20 μM. These rates are close to that of positive control (31.1%). Compounds 1 and 2 also showed moderate to weak cytotoxicities against the tested human tumor cell lines with IC50 values in the range of 2.2–8.2 μM.

Two new isobenzofurans, 1-(3-hydroxypropanoyl)-2-methoxy-isobenzofuran-1(3H)-one (1) and 2-methoxy-1-prenyl-isobenzofuran-1(3H)-one (2), were isolated from the leaves of Yunnan local sun-cured tobacco. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their cytotoxicity. The results revealed that compound 1 exhibited cytotoxicity for NB4, A549, SHSY5Y, PC3, and MCF7 cells with IC50 values of 2.8, 5.4, 6.9, 3.8, and 4.9 μM, and compound 2 exhibited cytotoxicity for NB4, A549, SHSY5Y, PC3, and MCF7 cells with IC50 values of 6.6, 7.8, 9.4, 7.0, and 9.2 μM, respectively.

To investigate the technique, mechanism and clinical efficacy of manual reduction of WU medical school in the treatment of anterior glenohumeral dislocations.From January 2016 to December 2017, 181 patients with anterior glenohumeral dislocations were treated with our manual reduction, including 71 males and 110 females, ranging in age from 19 to 94 years old, with a mean age of(61.1±16.3) years old; 68 cases of subglenoid type, 93 cases of subcoracoid type and 20 cases of subclavian type. Constant score was used to evaluate limb function while the external fixation was removed.One hundred and fifty-seven patients achieved reduction at the first attempt and 23 patients achieved at the second time. There was no vascular damage, nerve damage or iatrogenic fracture accmpanied. The Constant score ranged from 75 to 100, with a mean score of 92.1±4.3. One hundred and sixty-eight patients were followed up, and the duration ranged from 12 to 24 months, with an average of (16.1±3.2) months, no recurrent dislocation occurred during the follow up period.The manual reduction of WU medical school in the treatment of anterior glenohumeral dislocations has high success rate and low complication rate, which is scientific, safe, standardized, easy to learn and worth promoting.

Dye-sensitized photocatalytic hydrogen production using a boron-dipyrromethene (BODIPY) organic material having a pyridyl group at the anchor site was investigated. Phenyl, carbazole, and phenothiazine derivatives were introduced into BODIPY dyes, and their photocatalytic activities were examined. Identification was performed by nuclear magnetic resonance (NMR), infrared (IR), mass (MS) spectra, and absorption spectra, and catalyst evaluation was performed by using visible-light irradiation and photocatalytic hydrogen production and photocurrent. These dyes have strong absorption at 600&ndash, 700 nm, suggesting that they are promising as photosensitizers. When the photocatalytic activity was examined, stable catalytic performance was demonstrated, and the activity of the Pt-TiO2 photocatalyst carrying a dye having a carbazole group was 249 &mu, mol/gcat&middot, h. Photocurrent measurements suggest that dye-sensitized photocatalytic activity is occurring. This result suggests that BODIPY organic materials with pyridyl groups as anchor sites are useful as novel dye-sensitized photocatalysts.

Malaria is one of the three most deadly diseases in the world. Artemisinin is the first line and effective drug for treating malaria, and only can be extracted from Artemisia annua. Therefore, it is of great significance to cultivate new varieties of A. annua with high artemisinin content. Based on the germplasm bank and the whole genome, transcriptome and genetic map, the authors can explore high-quality genes, stress-resistant genes and genetic markers which have been used for rapid breeding of superior varieties of A. annua. So these methods of molecular breeding will become the main breeding direction of A. annua in the future. The breeding times of new varieties of A. annua can be shortened with molecular breeding technology. Based on the genetic background and the current situation of molecular breeding of A. annua, the strategy and technical route of molecular breeding were discussed and worked out in this paper, which provided a guidance and scientific reference for molecular breeding of A. annua in the future.

Background Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Pancreatic adenocarcinoma is one of the most common malignancies associated with thromboembolic events. A clinical study showed that thromboembolic events were detected in 36% of patients diagnosed as having pancreatic cancer. Studies showed that gestational diabetes mellitus could be one of the important risk factors for pancreatic cancer. Case presentation Gestational diabetes mellitus is associated with increased risk of breast and pancreatic cancer. This case report describes a 29-year-old Chinese woman who presented with: gestational diabetes mellitus; International Society on Thrombosis and Haemostasis criteria suggested disseminated intravascular coagulation with a score of 5; hemolysis, elevated liver enzymes, low platelet count syndrome; and pulmonary hypertension. After an intravenous injection of fibrinogen, she gave birth to a normal baby and following delivery, her blood pressure reached 180/110 mmHg. Laboratory analysis results showed elevated lactic dehydrogenase, decreased platelets and fibrinogen, and urine protein was positive. She was transfused with fresh frozen plasma, blood coagulation factor, and fibrinogen. Subsequently, she was transferred to a maternity intensive care unit, where magnesium sulfate seizure prophylaxis was continued for 24 hours to keep her magnesium level at a low therapeutic range. However, continuous oxygen therapy was needed to maintain her oxygenation. Further laboratory investigations revealed elevated carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4. Positron emission tomography-computed tomography showed malignant carcinoma in the head of her pancreas with lymph node involvement along with bone, peritoneal, and left adrenal metastasis, as well as double lung lymphangitic carcinomatosis. Conclusion A differential diagnosis of digestive system neoplasm should be considered when a pregnant patient presents with gestational diabetes mellitus and disseminated intravascular coagulation, where the disseminated intravascular coagulation has no specific cause and cannot be readily resolved.

To compare the clinical effects between open reduction internal fixation and three-dimensional reduction with external fixation under analgesia in treating fresh thoracolumbar fractures, and explore the simple and effective method for thoracolumbar fractures.The clinical data of 40 patients with thoracolumbar fractures who met the inclusion and exclusion criteria in the department of orthopaedics affiliated to Suzhou Hospital of Nanjing University of Chinese Medicine from February 2013 to August 2017 were retrospectively analyzed. According to therapeutic methods, the patients were devided into treatment group and control group, 20 cases in each group. Treatment group was treated by three-dimensional reduction method and external fixation devices under analgesia, and control group was treated by open reduction and common spinal fixation system. In treatment group, there were 9 males and 11 females, aged from 26 to 68 years old with an average of (52.8±11.3) years; and in control group, there were 10 males and 10 females, aged from 26 to 64 years old with an average of(50.6±8.8) years. Anterior vertebral body compression(AVBC), Cobb angle and visual analogue scale(VAS) were measured and compared in two group.All 40 patients finished follow-up. The follow-up time in treatment group was 5 to 37 months with average of (16.1±8.8) months, in control group was 5 to 29 months with an average of(17.3±6.0) months. There was no significant difference between two groups(Clinical effect of two methods was similar in treating thoracolumbar fractures, but three-dimensional reduction and external fixation devices under analgesia has advantage of easy operation, smaller trauma and no need secondary surgery for removed internal fixation.

This paper has presented a bandgap reference circuit with high-order temperature compensation. The compensation technique is achieved by using MOS transistor operating in sub-threshold region for reducing high-order TC of Vbe. The circuit is designed in 0.18¦Ìm CMOS process. Simulation results show that the proposed circuit achieves 4.2 ppm/¡æ with temperature from-55 to 125 ¡æ, which is only a third than that of first-order compensated bandgap reference.

This paper discussed a input buffer structure with replica load, analysed its theory of improving input signal linearity and decreasing distortion, gived some circuit embodiments, one of which was used for a 12-bit 500MSPS SHA-less ADC based on BiCMOS technolgy, Spurious Free Dynamic Range (SFDR) reached above 90dB with a 250MHz input signal.

An analysis of the output impedance of the reference buffer for pipelined ADC is presented is this paper. To achieve high performance of the reference buffer, damping network has added in. The output impedance of buffer amplifier is made equal to the resistance of the damping network. As a result, the effective impedance is made independent of frequency. Spectre simulation with 14-bit 250MSPS pipelined ADC loads, the results show the settling time can be achieved 1.2 ns with 0.0023% precision, and the noise floor per bin is-114dB with the power consumption is 42.3mW. The reference buffer can meet the requirement of 14-bit up to 800MSPS pipelined ADC.

A reaction of SmCl3·6H2O and Hpytza (Hpytza = 5-(3-pyridyl) tetrazole-2-acetic acid) under the presence of KOH, produced a novel coordination compound, [Sm(pytza)2Cl(H2O)2] (1). This compound was structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. Compound 1 reveals an 1D structure via its bridging pytza ligand and simultaneously shows a specific and good catalytic behavior for the photo-polymerization of vinyl monomers. Furthermore, the high molecular weight polymers with narrow polydispersity were obtained, and the polymerization showed controlled characteristics. The catalyst can be isolated from polymer products easily and reused for at least 10 times.

Kyphoplasty has been proven to be an efficient method to relieve patient suffering from osteoporotic vertebral compression fractures (OVCFs). Because of its technological superiority, unilateral kyphoplasty consumes less operative time and bone cement than traditional bilateral kyphoplasty. However, there is controversy about which method is most efficient in the treatment of OVCFs. Thus, an overall analysis should be performed to shed light on the facts corroborating both procedures.To evaluate the safety and efficacy of unipedicular kyphoplasty versus bipedicular kyphoplasty in treating OVCFs.Inclusion criteria were randomized controlled trials focusing on comparing unilateral versus bilateral balloon kyphoplasty in treatment of OVCFs. The exclusion criteria contained infection, neoplastic etiology, traumatic fracture, neural compression, neurological deficit, spinal stenosis, previous surgery at the involved vertebral body, long-term use of steroids, and kyphoplasty with other invasive or semi-invasive intervention treatment. Retrospective studies, reviews, technology introductions, and biochemical trials were also excluded.The PubMed MEDLINE, Cochrane Library, Web of Science, and EMBASE were systematic searched. Only randomized controlled trials published up to June 2015 comparing unilateral kyphoplasty with bilateral kyphoplasty in treatment of OVCFs were identified.Two researchers independently screeded the works for inclusion and data extraction. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system was used to assess the methodological quality and evidence synthesis.Six articles with 563 patients were enrolled in this study. Results showed that the unilateral approach required less surgical time (MD, -23.19; 95% CI, [-27.08, -19.31]; P0.00001) and cement consumption (MD, -2.07; 95% CI, [-2.23, -1.91]; P0.00001), as well as a reduced cement leakage ratio (RR, 0.59; 95% CI, [0.35, 0.99]; P0.05) and improved short-term general health (MD, 1.48; 95% CI, [0.02, 2.93], P0.05). No significant difference was found in the visual analog scale score (short-term and long-term), Oswestry Disability Index score (mid-term and long-term) kyphotic angle reduction, restoration rate of anterior vertebral height, vertebral height loss rate, postoperative adjacent-level fractures, or in other assessments of 36-Item Short Form Health Survey parameters (short-term and long-term).Only 6 studies were included, so that the sample size was still relatively small and publication bias could not be revealed in this study. Observation time of some data was inconsistent. All of these problems could influence the reliability of the results.Both unilateral kyphoplasty and bilateral kyphoplasty are safe and effective treatments for OVCFs. However, when operative time, cement volume, cement leakage, short-term general health, radiation dose, and hospitalization costs are taken into consideration, unilateral kyphoplasty may be the better choice. Yet, more high-quality RCTs with long-term follow-up are still required to make the final conclusion.Key words: Kyphoplasty, unilateral approach, bilateral approach, osteoporotic vertebral compression fractures, meta-analysis.

This paper has proposed an efficient direct torque control strategy based on space vector modulation (SVM-DTC) for dual three-phase permanent magnet synchronous motor (DTP-PMSM), which is implemented in a synchronous reference frame aligned with the machine stator flux vector. This strategy adopts the space vector modulation technique to compensate for the stator flux error, and then the continuous smooth response of the vector control and the rapid response of direct torque control are both achieved. Simulation studies of a 3KW DTP-PMSM are carried out. Simulation results show the improvement of the torque response, decrease of the torque ripple, the higher steady performance and better flux waveform.

In this paper, a kind of novel DAC architecture is proposed. Compared to the traditional DAC architecture, the proposed is a multistage one. In order to improve precision, we use a kind of feedback bias circuit, which can minimize the effect of the base currents. A 16-bit DAC transistor-level circuit is implemented in 0.18um SiGe process. The simulation results show that the DAC using the proposed architecture has higher resolution, and better static and dynamic performances than the traditional one.

Reaction of 5-[N-acetato(4-pyridyl)]tetrazolate (a4-ptz) potassium salt with lanthanide(III) chlorides, produced three new coordination compounds, [Ln(a4-ptz)2(H2O)4]·Cl·2H2O (Ln = La(1), Eu(2) and Tb(3)). These compounds were characterized by elemental analysis, IR spectroscopy, and single-crystal X-ray diffraction. Complexes 1–3 displayed 1-D structures. Luminescences of 1–3 were investigated at room temperature in the solid state.

Trichloroethylene (TCE) is known to induce allergic contact dermatitis and subsequent occupational medicamentosa-like dermatitis (OMLD) with multi-system injuries, including liver, kidney, and skin injuries. However, the mechanisms underlying immune system dysfunction that result in organ injury have not yet been clearly elucidated. In the present study, we measured the levels of secreted cytokines by effect or T cells in TCE-treated guinea pigs to better understand the contribution of allergic disorders in renal injuries. We immunized guinea pigs with trichloroethylene using the Guinea Pig Maximization Test (GPMT) and scored the inflammation on the guinea pigs' skin. The kidney function and ultra-structural changes in the kidneys were detected using biochemical methods and electron microscopy. The deposition of cytokines was determined using immunohistochemistry. The sensitization rate was 63.16% in the TCE-sensitized groups. The electron microscopy results showed tubular epithelial cell mitochondrial swelling, vacuolar degeneration, and atrophy of the microvillus in the sensitized groups. A high degree of cytokine deposition was observed in the renal tubular proximal epithelial cells in the TCE-sensitized groups. As observed in this study, the variation in the level of immune system activation not only indicates that TCE can largely magnify the immune reaction but also suggests a potential role of immune dysfunction in renal impairment.

Reaction of MCl 2 ·4H 2 O (M = Zn, Cd, Mn) with [3-(2-pyridyl)-1-pyrazolyl] acetic acid (Hpypza) produced four new M(II)/pypza complexes, [Zn(pypza)Cl] 2 ( 1 ), [Cd(pypza)Cl] n ( 2 ), [Mn(pypza)Cl] 2 ( 3 ), [Mn(pypza)Cl] n ( 4 ). These compounds were structurally characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. The complexes 1 , 3 featured dinuclear structures and complexes 2 , 4 showed 1D chains. Compounds 1 – 4 were self-assembled to form supramolecular structures through hydrogen bonds interactions. Furthermore, the luminescence properties of 1 – 4 were investigated at room temperature in the solid state.

Four alkaline earth metal-organic frameworks, [Mg(H2O)6] · (pmtz)2 (1), [Ca(pmtz) 2(H2O)3] · H2O (2), [Sr(pmtz)2(H2O)4] (3), and [Ba(pmtz)2(H2O)2] · 4H2O (4) [pmtz = 5-(pyrimidyl)tetrazole anion], were synthesized and characterized by elemental analysis, IR spectroscopy, and X-ray crystallography. The crystal structures reveal that 1–3 are mononuclear while 4 displays a 2-D layer structure by bis(bidentate) bridging pmtz−. The luminescence properties of 1–4 were investigated in the solid state at room temperature.

To identify the pathogens causing root rot disease on Ligusticum chuanxiong from the main producing areas in Sichuan, and to provide gist of management of this disease in the future.The diseased rhizomes of Ligusticurn chuanxiong with root rot symptom were sampled in two main producing areas in Sichuan. According to Koch's postulate, the pathogenicity on Ligusticum chuanxiong rhizomes of the isolates was confirmed. The representative isolates were identified based on their morphological characteristics and ribosomal DNA internal transcribed spacer(rDNA-ITS) sequences.The isolates(f2-16, 3-2, f4-19 and f5-7)which caused root rot disease held high homology reached 99%, 99%, 100% and 100% respectively, when compared with GenBank sequences GQ229075, JQ796755, JN232136 and FJ481024.The causing agents of root rot disease on Ligusticum chuanxiong belong to Fusarium solani, Fusarium oxysporum, Plectosphaerella cucumerina and Phoma glomerata. Pathogens from different regions are varied.

In order to investigate the content and distribution of available element in the rhizonsphere soil of the growing areas of Salvia miltiorrhiza Bunge, the contents of available element (N,P,K,B,Cu,Zn,Fe,Mn) in 26 soil samples were tested and evaluated. The results showed that the contents of available P and Fe were very plentiful, available K, Cu and Zn were rich, available N and Mn were deficient, available B was extremely deficient in all growing areas of S. miltiorrhiza of eight provinces in China. The correlation analysis showed that the contents of eight kinds of available elements were varying degree correlation. The stepwise regression analysis between the contents of available elements of rhizonsphere soil and ten kinds of active ingredients of Danshen (Salviae Miltiorrhizae Radix et Rhizoma) were researched. The results showed that the rates of contribution of available N,B,Mn and Fe to quality of Danshen were relatively large and they were the significant factors, and the other factors did not show statistical significance. The recommended fertilizing strategies is that the usage of N,B and Mn fertilizers should be controlled according to different stages of growth of S. miltiorrhiza, and P fertilizer should be reduced in all growing areas of S. miltiorrhiza.

Objectives. Active inflammatory responses play an important role in the pathogenesis of depression. We hypothesized that the rapid antidepressant effect of ketamine is associated with the down-regulation of pro-inflammatory mediators. Methods. Forty-eight rats were equally randomized into six groups (a control and five chronic unpredictable mild stress (CUMS) groups) and given either saline or 10 mg/kg ketamine, respectively. The forced swimming test was performed, and the hippocampus was subsequently harvested for the determination of levels of interleukin (IL)-1β, IL-6, tumour necrosis factor-α (TNF-α), indoleamine 2,3-dioxygenase (IDO), kynurenine (KYN), and tryptophan (TRP). Results. CUMS induced depression-like behaviours and up-regulated the hippocampal levels of IL-1β, IL-6, TNF-α, IDO, and the KYN/TRP ratio, which were attenuated by a sub-anaesthetic dose of ketamine. Conclusion. CUMS-induced depression-like behaviours are associated with a reduction in hippocampal inflammatory mediators, whereas ketamine’s antidepressant effect is associated with a down-regulation of pro-inflammatory cytokines in the rat hippocampus.

Objectives: To compare the effects of regular intermittent bolus versus continuous infusion for epidural labor analgesia on maternal temperature and serum interleukin-6 (IL-6) level. Methods: This randomized trial was performed in Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, China between October 2012 and February 2014. Either regular intermittent bolus (RIB, n=66) or continuous infusion (CI, n=66) was used for epidural labor analgesia. A bolus dose (10 ml of 0.08% ropivacaine + 0.4 µg·ml-1 sufentanil) was manually administrated once an hour in the RIB group, whereas the same solution was continuously infused at a constant rate of 10 ml·h-1 in the CI group. Maternal tympanic temperature and serum IL-6 level were measured hourly from baseline to one hour post partum. The incidences of fever (≥38ºC) were calculated. Results: The incidence of maternal fever was similar between the 2 groups. There was a rising trend in mean temperature over time in both groups, but no statistical difference was detected between the groups at respective time points; maternal serum IL-6 showed similar changes. Conclusion: Compared with continuous infusion, regular intermittent bolus presents with the same incidence of maternal fever for epidural labor analgesia. Interleukin-6 elevation could be involved in mean maternal temperature increase.

Radar networking via various technical measures to improve the ability of the radar system of four anti-jam. Repressive noise because the need to launch multi -orient and large scope interference, power limits become a problem. In this paper on the basis of the characteristics of radar networking and interference power problem presents a measure contain distributed repressive interference and False track interference. Compared with the traditional high-power way of interference, distributed interference has big range interference section, close advantage and can change the shape of the exposure when changing the jammers distribution. Adaptive wave form technology can realize the jamming signal of time and space launch asynchronous, making that the jammer can simultaneously implementation to different radars of radar net false track deceptive jamming be possible. Through the simulation analysis, the composite interference of the distributed repressive interference and false track interference for netted radar can effectively reduce the oppressive interference power, and form an effective interference.

A novel volume estimator is proposed to solve the problem of 2-dimensional hyperbolic location, which is unlike most of previous methods focusing on solving the hyperbolic or spherical interpolation equations. The source coordinate are expressed as linear combination of the coordinates of the base stations and the weight vector is estimated as the singular vector corresponding to the minimum singular value of a matrix obtained from range-difference measurements. Simulation results show that the proposed estimator is superior to both the spherical interpolation method and Chan's method.

The asymmetric unit of the title compound, [Zn(C3H7NO)2(H2O)4][Zn(C13H10N2O5)Cl]2, is composed of a single anion and half a cation. The ZnII atom in the monoanion has a distorted triganol–pyramidal geometry, being coordinated by three O atoms and one N atom from one 2-{3-[2-(carboxylatomethoxy)phenyl]pyrazol-1-yl}acetate ligand and one Cl atom. In the dication, the ZnII atom is located on an inversion center and is coordinated by six O atoms in a slightly distorted octahedral geometry. In the crystal, the ions are linked by O—H...O hydrogen bonds, forming a two-dimensional network lying parallel to the ab plane. There are also C—H...O and C—H...Cl interactions present, which lead to the formation of a three-dimensional structure.