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Your search keyword '"Xu, Yao-Jun"' showing total 11 results
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11 results on '"Xu, Yao-Jun"'

5. Three new lanostane triterpenoids and two new amides from Alternaria sp. with NLRP3 inflammasome inhibitory activity

Author

Bi, De-Wen, Feng, Jian, Pang, Wen-Hui, Yang, Peng-Yun, Xu, Yao-Jun, Zeb, Muhammad Aurang, Wang, Meng-Ru, Zhang, Xing-Jie, Li, Xiao-Li, Zhang, Rui-Han, Wang, Wei-Guang, and Xiao, Wei-Lie

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

Three new lanostane triterpenoids (1-3) along with two new amides fatty compounds (4-5) were isolated from the ethyl acetate extract of a culture of the endophytic fungus Alternaria sp. gx-2. Their structures were identified by 1D and 2D NMR spectral data and HRESIMS. Compounds 1-12 were evaluated for their anti-inflammatory and tyrosinase inhibition activities. The isolated compounds did not show inhibitory activities at a concentration of 100 μM against tyrosinase, while under the concentration of 10 μM, the release of lactate dehydrogenase (LDH) inhibition rate of compound 1 was 54.45%, indicating that compound 1 had moderate anti-inflammatory activity on the activation of NLRP3 inflammasome.

Published
2023

7. Ainslides A−F, Six Sesquiterpenoids Isolated from Ainsliaea pertyoides and Their NLRP3‐Inflammasome Inhibitory Activity

Author

Zhang, Jing‐Jing, primary, Xu, Yao‐Jun, additional, Li, Rui, additional, Zhang, Yu, additional, Yue, Chen‐Fang, additional, Bi, De‐Wen, additional, Cheng, Bin, additional, Wu, Xue‐Wen, additional, Zhang, Rui‐Han, additional, Zhang, Xing‐Jie, additional, Li, Xiao‐Li, additional, and Xiao, Wei‐Lie, additional

Published
2022
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11. Ainslides A-F, Six Sesquiterpenoids Isolated from Ainsliaea pertyoides and Their NLRP3-Inflammasome Inhibitory Activity.

Author

Zhang JJ, Xu YJ, Li R, Zhang Y, Yue CF, Bi DW, Cheng B, Wu XW, Zhang RH, Zhang XJ, Li XL, and Xiao WL

Subjects
Inflammasomes, Molecular Structure, NLR Family, Pyrin Domain-Containing 3 Protein, Asteraceae chemistry, Sesquiterpenes chemistry, Sesquiterpenes pharmacology
Abstract

Six new sesquiterpenoids, named as ainslides A-F (1-6), including one carotene-type sesquiterpene (1), one eudesmane (2), four guaianolides (3-6), together with eight known sesquiterpenoids (7-14), were purified from the whole plants of Ainsliaea pertyoides. The structures of these sesquiterpenoids were characterized based on spectroscopic methods including 1D and 2D NMR, HR-ESI-MS, UV, and IR spectra, together with ECD calculations and X-ray diffraction experiments. The anti-inflammatory activity of all the isolated compounds was screened and compounds 3 and 7-13 exhibited NLRP3-inflammasome inhibitory activity with IC 50 values of 1.80-4.33 μM., (© 2022 Wiley-VHCA AG, Zurich, Switzerland.)

Published
2022
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