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Your search keyword '"YAO Zhongpeng"' showing total 4 results
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4 results on '"YAO Zhongpeng"'

1. Influencing Factors in the Preparation of Polymethylsilsesquioxane Light Diffusing Agent.

Author

WANG Wenjin, YAO Zhongpeng, XIN Zijie, KUANG Jianguo, and ZHOU Lihua

Subjects
RAW materials, POLYCONDENSATION, ENVIRONMENTAL protection, POLYCARBONATES, MICROSPHERES
Abstract

Polymethylsilsesquioxane microspheres were synthesized by hydrolysis condensation with methyltrimethoxysilane as raw material. The effects of raw material ratio, hydrolysis time, hydrolysis pH, polycondensation time and polycondensation pH on particle size were discussed. The optimum synthesis conditions are as follows: the mass ratio of methyltrimethoxysilane to ultrapure water is 1: (7-8), hydrolysis time is 1 h, hydrolysis pH value is 5-6 polycondensation time is 2 h, and polycondensation pH value is 9. At the same time, the filtrate generated in the reaction process shall be reused as solvent to prepare polymethylsilsesquioxane microspheres, which achieves the goal of environmental protection. When polymethylsilsesquioxane microspheres are used as light diffusion agent of polycarbonate, the light diffusion plate has higher light transmittance and haze compared with the similar products in the market. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Blockade of OX40/OX40L pathway combined with ethylene-carbodiimide-fixed donor splenocytes induces donor-specific allograft tolerance in presensitized recipients

Author

Lai, Xingqiang, primary, Yao, Zhongpeng, additional, Ning, Fen, additional, Zhang, Lei, additional, Fang, Jiali, additional, Li, Guanghui, additional, Xu, Lu, additional, Xiong, Yunyi, additional, Liu, Luhao, additional, Chen, Rongxin, additional, Ma, Junjie, additional, and Chen, Zheng, additional

Published
2020
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3. Ethylene carbodiimide-fixed donor splenocytes combined with cordycepin induce long-term protection to mice cardiac allografts

Author

Lu Xu, Fang Jiali, Li Guanghui, Chen Zheng, Guo Yuhe, Wang Tiantian, Yao Zhongpeng, Ma Junjie, Zhang Lei, Ning Fen, and Lai Xingqiang

Subjects
Graft Rejection, Male, medicine.medical_treatment, education, Immunology, Ischemia, Anti-Inflammatory Agents, 030230 surgery, Pharmacology, Immunotherapy, Adoptive, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Splenocyte, Immune Tolerance, Immunology and Allergy, Medicine, Animals, Humans, Transplantation, Homologous, Secretion, Cells, Cultured, Carbodiimide, Transplantation, Mice, Inbred BALB C, Mice, Inbred C3H, Cordycepin, Deoxyadenosines, business.industry, Graft Survival, Ethylenes, equipment and supplies, medicine.disease, Combined Modality Therapy, Tissue Donors, Mice, Inbred C57BL, Carbodiimides, Disease Models, Animal, Cytokine, chemistry, Cytokines, Heart Transplantation, Tumor necrosis factor alpha, Cytokine secretion, business, Spleen, 030215 immunology
Abstract

Infusion of ethylene carbodiimide-fixed donor splenocytes (ECDI-SPs) is an effective method to induce donor-specific protection to allografts. However, the ischemia reperfusion (I/R) injury during transplant leads to abundant of pro-inflammatory cytokines, which negates the effect of ECDI-SPs. Therefore, suppressing pro-inflammatory cytokine secretion while promoting anti-inflammatory cytokine release would enhance the graft protective efficacy of ECDI-SPs. In this study, we aimed to determine the effect of ECDI-SPs combined with a short course of cordycepin (an anti-inflammatory agent) on the long-term outcomes of mice cardiac allografts. Our results demonstrated that ECDI-SPs combined with cordycepin significantly promoted mice cardiac allograft survival compared with ECDI-SPs monotherapy. This effect was accompanied by decreased production of pro-inflammatory cytokines (IL-1β, IL-6, IL-17 and TNFα), increased secretion of anti-inflammatory cytokines (IL-10 and TGFβ), inhibition of Th17 and expansion of Tregs, and prevention of I/R injury. We concluded that cordycepin appeared to enhance the effect of modulating cytokine profile and regulate the Teff:Treg balance so as to strengthen the graft protective effect of ECDI-SPs. Our study of ECDI-SPs combined with cordycepin may provide a promising approach for prolong allograft survival.

Published
2018

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