1. Remnant cholesterol trajectory and subclinical arteriosclerosis: a 10-year longitudinal study of Chinese adults
- Author
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Ping-ting Yang, Li Tang, Sai-qi Yang, Qiu-ling Shi, Ya-qin Wang, Yue-xiang Qin, Jian-gang Wang, and Ying Li
- Subjects
Remnant cholesterol ,Subclinical atherosclerosis ,Trajectory ,Longitudinal cohort ,Cardiovascular disease ,Medicine ,Science - Abstract
Abstract We aimed to identify different trajectories of remnant cholesterol (RC) and investigate the association of RC trajectories with vascular endothelial function and atherosclerosis progression in a longitudinal cohort of the Chinese population. A total of 521 participants were included in the flow-mediated vasodilation (FMD) subcohort study, and 7775 participants were included in the brachial-ankle pulse wave velocity (baPWV) subcohort study. All participants had ≥ 3 medical examinations during the 10-year follow-up period. In the FMD subcohort study, three distinct RC trajectories were identified according to the RC range and changing pattern over time: “low” (57.58%), “moderate” (30.90%) and “high” (11.52%). The proportion of the three groups with vascular endothelial dysfunction (FMD 1400 cm/s) was 38.79%, 51.26% and 59.01% respectively. Taking the low group as a reference, participants in the moderate and high groups had over 1.46 and 2.16 times the odds of atherosclerosis (P
- Published
- 2024
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