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7. Re-Os Isotope Dating of Molybdenite from the Shapoling Mo Deposit, East Qinling and Its Implication for Identification of Late Jurassic Mo Mineralization

Author

YUE Su-wei, DENG Xiao-hua, YAO Jun-ming, and SUN Ya-li

Subjects
molybdenite, re-os isotopic dating, shapoling mo deposit, east qinling orogenic belt, Geology, QE1-996.5, Ecology, QH540-549.5
Abstract

The Shapoling Mo deposit is located in the Xiong'er rock mass of the southern margin of the North China Craton. The deposit is hosted in a contact zone between granite and wallrocks of the Taihua Soupergroup, which is a recently found discovered vein dissemination type deposit in East Qinling. The ore-bodies are associated with quartz veins and controlled by subsidiary faults. The mineralization styles include veinlet and disseminated types. In order to determine the age of the Shapoling Mo deposit, Re-Os isotopic dating of molybdenite was conducted. Six molybdenite samples yielded Re-Os ages ranging from 158.3±1.5 Ma to 160.7±1.2 Ma, with a weighted mean age of 160±1 Ma (2σ, MSWD=2.1). The Re-Os age shows that the Mo mineralization occurred during the late Jurassic, earlier than the formation of Huashan rock mass (about 30 Ma). In addition, one molybdenite sample in Huashan rock mass yielded a Re-Os age of 130.5±1.0 Ma, which is in accordance with the age of the Huashan pluton and molybdenite age (125.4-129.4 Ma) reported by a previous study. In conclusion, the Shapoling deposit contains two episodes of Mo mineralization from the early Cretaceous and late Jurassic periods. Combining this with geological characteristics and tectonic-metallogenic evolution, it is suggested that Huashan rock mass, granite porphyry, and related hydrothermal deposits in the Xiong'er terrain are the products of extrusion to extension transition during continent-continent collision in the Qinling orogenic belt.

Published
2017
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10. Necator americanus: Optimization of the golden hamster model for testing anthelmintic drugs

Author

Jian Xue, Xiao Shuhua, Bin Zhan, Qiang Huiqing, Peter J. Hotez, Yao Jun-Ming, and Ricardo Toshio Fujiwara

Subjects
Male, Veterinary medicine, Necator americanus, Immunology, Pyrantel Pamoate, Physiology, Phenylenediamines, Biology, Albendazole, Tribendimidine, Necatoriasis, Deworming, Sex Factors, Cricetinae, parasitic diseases, medicine, Animals, Anthelmintic, Anthelmintics, Mesocricetus, Infectious dose, Age Factors, General Medicine, biology.organism_classification, Disease Models, Animal, Infectious Diseases, Erythrocyte Count, Female, Parasitology, medicine.drug
Abstract

Laboratory golden hamsters (Mesocricetus auratus) were infected with Necator americanus under several different parasite and host conditions to optimize the model for testing anthelminthic drugs. The results confirmed that male hamsters were more susceptible to infection than females. Host age in the range of 5-15 weeks was not a factor that impacted on adult worm burden, and similar worm burdens were achieved using doses of 150, 250 or 500 N. americanus L3 (NaL3). The largest numbers of adult hookworms were recovered on days 21-28 post-infection, with a significant decrease at days 40-50 post-infection. Therefore adult worm recovery is maximal approximately 11-18 days prior to patency and host blood loss. From these studies a drug evaluation protocol was developed using 150 NaL3 as the infectious dose and then evaluating the anthelminthic effects of the drugs albendazole, tribendimidine, and pyrantel pamoate on days 21-28 post-infection. The model confirms the anthelminthic activity of albendazole, tribendimidine, and pyrantel pamoate and has the potential as a laboratory animal model to detect emerging drug resistance.

Published
2005

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