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5. Thoughts on IMSI

Author

Palermo, Gianpiero D., Hu, Jennifer C. Y., Rienzi, Laura, Maggiulli, Roberta, Takeuchi, Takumi, Yoshida, Atsumi, Tanaka, Atsushi, Kusunoki, Hiroshi, Watanabe, Seiji, Neri, Queenie V., Rosenwaks, Zev, Racowsky, Catherine, editor, Schlegel, Peter N., editor, Fauser, Bart C., editor, and Carrell, Douglas T., editor

Published
2011
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18. Ergonomic study on a chair for watermelon tunnel cultivation

Author

KIKUCHI, Yutaka, primary, Teshima, Tsukasa, additional, MINAGAWA, Keiko, additional, SEKI, Ei, additional, OKADA, Shunsuke, additional, MATSUMOTO, Masahiro, additional, HARADA, Yasuhiro, additional, TANAKA, Masahiro, additional, KONYA, Hideyuki, additional, YAMASAKI, Hirofumi, additional, UMENO, Satoru, additional, TANAKA, Hiroaki, additional, NAKANISHI, Yumika, additional, NANBA, Shoko, additional, YOSHIDA, Atsumi, additional, FUJII, Akiko, additional, and SAWAGUCHI, Keita, additional

Published
2020
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22. Cover Image, Volume 39, Issue 6

Author

Nakamura, Shigeru, primary, Kobori, Yoshitomo, additional, Ueda, Yoshihiko, additional, Tanaka, Yoko, additional, Ishikawa, Hiromichi, additional, Yoshida, Atsumi, additional, Katsumi, Momori, additional, Saito, Kazuki, additional, Nakamura, Akie, additional, Ogata, Tsutomu, additional, Okada, Hiroshi, additional, Nakai, Hideo, additional, Miyado, Mami, additional, and Fukami, Maki, additional

Published
2018
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23. STX2 is a causative gene for nonobstructive azoospermia

Author

Nakamura, Shigeru, primary, Kobori, Yoshitomo, additional, Ueda, Yoshihiko, additional, Tanaka, Yoko, additional, Ishikawa, Hiromichi, additional, Yoshida, Atsumi, additional, Katsumi, Momori, additional, Saito, Kazuki, additional, Nakamura, Akie, additional, Ogata, Tsutomu, additional, Okada, Hiroshi, additional, Nakai, Hideo, additional, Miyado, Mami, additional, and Fukami, Maki, additional

Published
2018
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28. New molecular diagnostic kit to assess Y-chromosome deletions in the Japanese population

Author

Iijima, Masashi, Koh, Eitetsu, Izumi, Kouji, Taya, Masaki, Maeda, Yuji, Kyono, Kouichi, Yoshida, Atsumi, Namiki, Mikio, Iijima, Masashi, Koh, Eitetsu, Izumi, Kouji, Taya, Masaki, Maeda, Yuji, Kyono, Kouichi, Yoshida, Atsumi, and Namiki, Mikio

Abstract

Objectives: Deletions in the azoospermia factor regions are the most common known molecular genetic cause of human male infertility involving spermatogenetic failure. Testing for these deletions in Japanese DNA samples using conventional sequence-tagged site probes occasionally lead to considerable non-specific or faint products in the Japanese population. The aim of the present study was to evaluate the sensitivity and specificity of a newly developed kit for the detection of azoospermia factor microdeletions in the Japanese population. Methods: Sequence-tagged site probes were reselected and the Luminex suspension array assay was carried out. Validation was retrospectively carried out with 2014 DNA sequences with known microdeletions, which were divided into four categories. Results: Category1 deletions that corresponded to the conventional classification of azoospermia factor deletion were present in 83 men (4.2%), which can result in intrachromosomal homologous recombination. Kit data confirmed the presence of deletions of this type in DNA sequences known to harbor the azoospermia factor deletions. Category2 deletions involved cytogenetic abnormalities in 28 men (1.4%), whereas category3 deletions in 759 men (37.7%) were atypical classifications including the gr/gr deletion. As these deletions are thought to be a result of palindromic units and non-homologous recombination, these microdeletions might impact in the interpretation of some clinical findings. The rest of the 1145 cases (56.8%) were assigned to category4 as normal variants (polymorphism/no deletion). Conclusions: The present findings show that this new kit offers good sensitivity and specificity with the advantage of saving in terms of cost and time. © 2014 The Japanese Urological Association.

Published
2017

29. Placental oxidative stress and maternal endothelial function in pregnant women with normotensive fetal growth restriction.

Author

Yoshida, Atsumi, Watanabe, Kazushi, Iwasaki, Ai, Kimura, Chiharu, Matsushita, Hiroshi, and Wakatsuki, Akihiko

Subjects
*CELL receptors, *DNA, *ENDOTHELIUM, *FETAL growth retardation, *PLACENTA, *OXIDATIVE stress, *CASE-control method, *BLOOD
Abstract

Objective: The purpose of this study was to investigate the relationship between placental oxidative stress and maternal endothelial function in pregnant women with normotensive fetal growth restriction (FGR).Methods: We examined serum concentrations of oxygen free radicals (d-ROMs), maternal angiogenic factor (PlGF), and sFlt-1, placental oxidative DNA damage, and maternal endothelial function in 17 women with early-onset preeclampsia (PE), 18 with late-onset PE, 14 with normotensive FGR, and 21 controls. Flow-mediated vasodilation (FMD) was assessed as a marker of maternal endothelial function. Immunohistochemical analysis was performed to measure the proportion of placental trophoblast cell nuclei staining positive for 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage.Results: Maternal serum d-ROM, sFlt-1 concentrations, and FMD did not significantly differ between the control and normotensive FGR groups. The proportion of nuclei staining positive for 8-OHdG was significantly higher in the normotensive FGR group relative to the control group.Conclusions: Our findings demonstrate that, despite the presence of placental oxidative DNA damage as observed in PE patients, pregnant women with normotensive FGR show no increase in the concentrations of sFlt-1 and d-ROMs, or a decrease in FMD. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis

Author

Sugimoto, Kazuhiro, primary, Koh, Eitetsu, additional, Sin, Ho-Su, additional, Maeda, Yuji, additional, Narimoto, Kazutaka, additional, Izumi, Koji, additional, Kobori, Yoshitomo, additional, Kitamura, Eiko, additional, Nagase, Hiroki, additional, Yoshida, Atsumi, additional, and Namiki, Mikio, additional

Published
2009
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40. Single Nucleotide Polymorphism Analysis of the Folliclestimulating Hormone (FSH) Receptor in Japanese with Male Infertility: Identification of Codon Combination with Heterozygous Variations of the Two Discrete FSH Receptor Gene

Author

SHIMODA, Chiharu, primary, KOH, Eitetsu, additional, YAMAMOTO, Kenrou, additional, MATSUI, Futoshi, additional, SUGIMOTO, Kazuhiro, additional, SIN, Ho-su, additional, MAEDA, Yuji, additional, KANAYA, Jiro, additional, YOSHIDA, Atsumi, additional, and NAMIKI, Mikio, additional

Published
2009
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49. Features of constitutive gr/gr deletion in a Japanese population.

Author

Ho-Su Sin, Koh, Eitetsu, Shigehara, Kazuyoshi, Sugimoto, Kazuhiro, Maeda, Yuji, Yoshida, Atsumi, Kyono, Koichi, and Namiki, Mikio

Subjects
MALE infertility, Y chromosome, SPERMATOGENESIS, PHENOTYPES, GENETIC recombination, OLIGOSPERMIA, GENETICS
Abstract

BACKGROUND: The relationship between male infertility and gr/gr deletions that remove multiple genes of the Y chromosome varies among countries and populations. The aim of this study was to investigate the association between gr/gr deletions and spermatogenic phenotype in fertile and infertile Japanese men. METHODS: The subjects were screened by sequence-tagged site (STS) analysis to detect gr/gr deletions, and haplogroups were assigned using eight highly informative markers. In total, 395 infertile men and 377 fertile men (controls) participated in our study. Of the 772 subjects, 260 individuals carried confirmed gr/gr deletions and were used in further analysis of deletion subtype and gene copy number, specifically loss and gain of CDY1 and DAZ copies. These 260 subjects were divided into a control group (n = 131) all with normozoospermia, and an infertile group (n =129) with 89 infertile subjects exhibiting azoospermia (absence of sperm) and 40 exhibiting oligozoospermia (reduced sperm concentration). RESULTS: There were gr/gr deletions in 33.7% (260/772) of all subjects and the deletions were widespread in haplogroup D (86.2%). There were no significant differences in the frequency of gr/gr deletions between the infertile and control groups. The gr/gr deletion subtypes were not distributed randomly among haplogroups; the CDY1a + DAZ1/2 genes were deleted in 96.9% (217/224) of haplogroup D individuals, whereas the O lineage had a variety of gr/gr deletion types. The loss of CDY1a + DAZ1/2 was not associated with spermatogenic impairment in haplogroup D (P = 0.33). CONCLUSIONS: Taken together, gr/gr deletions in haplogroup D occur constitutively, are associated with the loss of CDY1a + DAZ1/2 and are phenotypically neutral. Further studies are needed to establish whether Y-linked compensatory factors outside the AZFc region can counteract the pathogenic effect of a gr/gr deletion in the D lineage. [ABSTRACT FROM AUTHOR]

Published
2010
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50. Structural abnormalities of autosomal chromosomes in the male partner do not influence fertilization and early development of embryos after intracytoplasmic sperm injection.

Author

Yoshida, Atsumi, Araki, Yasuhisa, Motoyama, Mitsuhiro, Kim, Sang-Yong, Sung, Hiro, Araki, Shigeo, Miura, Kazukiyo, Shirai, Masafumi, Yoshida, A, Araki, Y, Motoyama, M, Kim, S Y, Sung, H, Araki, S, Miura, K, and Shirai, M

Abstract

The objective of this study was to determine whether or not abnormalities in the autosomal structure of the male partner have any influence on fertilization and early embryo development after intracytoplasmic sperm injection (ICSI). Thirty-seven couples in whom the male partners were examined by the same andrologist were included in this study. Six couples (group I) in whom the male partner possessed autosomal structural abnormality underwent seven ICSI cycles. As a control group, 31 couples (group II) in which the male partner was karyotypically normal underwent 41 ICSI cycles. Although the normal fertilization rates seen in group I were significantly higher than those in group II (P < 0.05), there was no significant difference in the cleavage rates between the two groups. We did not perform the analysis of the female partner's chromosomes, but we surmise that structural autosomal abnormalities in the male partner do not adversely influence fertilization at ICSI and early development of embryos. [ABSTRACT FROM AUTHOR]

Published
1997
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