11 results on '"ZUO-YUAN CHEN"'
Search Results
2. Association between interleukin-8 gene -251 A/T polymorphism and the risk of coronary artery disease: A meta-analysis
- Author
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Jun Wu, Zuo-Yuan Chen, Quan-Fang Zhang, Wenzhong Zhang, Wei Wang, Wugang Wang, Yan Cui, and Zhexun Lian
- Subjects
Oncology ,Adult ,Male ,medicine.medical_specialty ,China ,Heterozygote ,Genotype ,Coronary Artery Disease ,polymorphism ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Internal medicine ,medicine ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,030212 general & internal medicine ,Allele ,Acute Coronary Syndrome ,Genotyping ,Alleles ,Aged ,business.industry ,Homozygote ,Interleukin-8 ,Case-control study ,Heterozygote advantage ,General Medicine ,Odds ratio ,Middle Aged ,meta-analysis ,030220 oncology & carcinogenesis ,Meta-analysis ,Case-Control Studies ,Female ,Gene polymorphism ,business ,Polymorphism, Restriction Fragment Length ,Systematic Review and Meta-Analysis ,Research Article - Abstract
Background: The association between interleukin-8 (IL-8) gene polymorphism −251 A>T and susceptibility to coronary artery disease (CAD) has been investigated previously; however, results remain controversial. Thus, a meta-analysis was conducted to reassess the effects of this polymorphism on CAD risks. Methods: The PubMed, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for relevant studies published up to December, 2018. The pooled odds ratios (OR) were calculated using STATA 13.0 software for allelic (A vs T) as well as homozygote (AA vs TT), heterozygote (AT vs TT), recessive (AA vs AT + TT), and dominant (AA + AT vs TT) genotype models, respectively. Results: Ten case-control studies (3744 cases and 3660 controls) were included. Overall, a significant association of IL-8 gene −251 A > T polymorphism with an increased risk of CAD was only observed in the dominant genotype model (OR = 1.48), but not others. In the subgroup analysis, significantly increased risks were also found for Chinese (OR = 1.64), polymerase chain reaction-restriction fragment length polymorphism genotyping (OR = 1.61), acute coronary syndrome (ACS) type (OR = 1.92 for 3 datasets; OR = 1.88 for 4 datasets), high quality (OR = 1.64), and age/gender matching status (OR = 1.55) under the dominant model. Furthermore, significantly increased risks were also found for ACS type under allelic (OR = 1.32 for 3 datasets; OR = 127 for 4 datasets), homozygote (OR = 1.64 for 3 datasets; OR = 1.50 for 4 datasets), heterozygote (OR = 1.32 for 3 datasets; OR = 1.30 for 4 datasets), and recessive (OR = 1.40 for 3 datasets; OR = 1.28 for 4 datasets) models. Conclusion: This meta-analysis suggests that Chinese patients carrying −251A allele of IL-8 may have an increased risk for the development of CAD, especially ACS.
- Published
- 2019
3. RETRACTED: Two transition metal coordination polymers: Magnetic investigation and treatment activity on children chronic myocarditis by regulating the hs-cTnT expression
- Author
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Fang Wang, Yi An, Bin Yang, Xiao-Nan Dong, Shan Li, Zuo-Yuan Chen, Liang-Liang Fan, and Xia-Xia Wang
- Subjects
Coordination polymer ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Inorganic Chemistry ,Metal ,chemistry.chemical_compound ,Transition metal ,Annexin ,Materials Chemistry ,Physical and Theoretical Chemistry ,chemistry.chemical_classification ,Chemistry ,Ligand ,Polymer ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Solvent ,Crystallography ,visual_art ,Ceramics and Composites ,visual_art.visual_art_medium ,0210 nano-technology ,Single crystal - Abstract
In the current study, by solvothermal reaction of Cu(NO3)2·3H2O or Co(NO3)2·6H2O with the H4Tdada ligand in a mixed solvent of H2O and DMA, two novel coordination polymers (CPs) were prepared and their chemical formulae are {[(CH3)2NH2]2[Co(Tdada)](H2O)3}n (1) and {[Cu2(Tdada)(H2O)(DMA)](DMA)3}n (2, H4Tdada = 5,5′-((thiophene-2,5-dicarbonyl) bis(azanediyl)) diisophthalic acid). The single crystal X-diffraction studies show that compound 1 shows a 3D 2-fold interpenetrated framework with a 4-connected dia topology and compound 2 shows a non-interpenetrated framework with a 4-connected lon topology. The magnetic investigations indicate that the two compounds possess antiferromagnetic coupling between neighboring metallic ions, and the Curie-Weiss constant is −7.5 K for 1 and -6.04 K for 2, respectively. Their treatment activity on viral myocarditis was evaluated and the related mechanism was discussed at the same time. First of all, the Cell Counting Kit-8 was carried out to evaluate the toxicity of compounds 1 and 2. The Annexin V-FITC Apoptosis Detection Kit was conducted and the apoptosis of the virus infected cardiomyocytes was measured. In addition to this, the ELISA detection was used to measure the hs-cTnT in the cardiomyocytes after compound 1 or 2 treatment.
- Published
- 2021
4. ATP-induced cardioprotection against myocardial ischemia/reperfusion injury is mediated through the RISK pathway
- Author
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Jun-Hua Fu, Ru-Yong Yao, Fang Wang, Zhexun Lian, Zuo-Yuan Chen, and Hui Xin
- Subjects
0301 basic medicine ,Cancer Research ,Ischemia ,030204 cardiovascular system & hematology ,Pharmacology ,Wortmannin ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,myocardial reperfusion injury ,medicine ,Protein kinase B ,Cardioprotection ,adenosine-5′-triphosphate-dependent potassium channels ,Kinase ,business.industry ,adenosine-5′-triphosphate ,General Medicine ,Articles ,medicine.disease ,Molecular biology ,Potassium channel ,030104 developmental biology ,chemistry ,Apoptosis ,reperfusion injury salvage kinase ,business ,Reperfusion injury - Abstract
The aim of the present study was to examine the post-infarct acute effect of adenosine-5'-triphosphate (ATP) on myocardial infarction (MI) size as well as its precise molecular mechanism. Sixty New Zealand white male rabbits were exposed to 40 min of ischemia followed by 180 min of reperfusion. The rabbits were intravenously administered 3 mg/kg of ATP (ATP group) or saline (control group) immediately after reperfusion and maintained throughout the first 30 min. The wortmannin+ATP, PD-98059+ATP, and 5-hydroxydecanoic acid (5-HD) sodium salt+ATP groups were separately injected with wortmannin (0.6 mg/kg), PD-98059 (0.3 mg/kg), and 5-HD (5 mg/kg) 5 min prior to ATP administration. MI size was calculated as the percentage of the risk area in the left ventricle. Myocardial apoptosis was determined using a TUNEL assay. Western blot analysis was performed to examine the levels of protein kinase B (Akt)/p-Akt and extracellular signal-regulated kinase (ERK)/p-ERK in the ischemic myocardium, 180 min after reperfusion. The infarct size was significantly smaller in the ATP group than in the control group (p
- Published
- 2016
5. Elevated Lipoprotein-Associated Phospholipase A2 Is Associated with Progression of Nonculprit Lesions after Percutaneous Coronary Intervention
- Author
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Wei-Qiang Kang, Rui Zhang, Hui-Ping Gong, Shanglang Cai, Song Liu, Hui Xin, Quan-Fang Zhang, Zhexun Lian, Zuo-Yuan Chen, Xian-feng Ning, and Zhi-Ming Ge
- Subjects
Male ,Acute coronary syndrome ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Coronary Angiography ,General Biochemistry, Genetics and Molecular Biology ,Body Mass Index ,Pathogenesis ,Percutaneous Coronary Intervention ,Internal medicine ,medicine ,Humans ,Acute Coronary Syndrome ,Phospholipids ,Aged ,Anthropometry ,business.industry ,Hydrolysis ,Lipoprotein-associated phospholipase A2 ,Percutaneous coronary intervention ,General Medicine ,Middle Aged ,medicine.disease ,Oxygen ,Stenosis ,Cholesterol ,1-Alkyl-2-acetylglycerophosphocholine Esterase ,Multivariate Analysis ,Conventional PCI ,Disease Progression ,Cardiology ,Female ,business ,Body mass index ,Biomarkers ,Follow-Up Studies ,Blood sampling - Abstract
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that hydrolyzes oxidized phospholipids to generate bioactive proatherogenic products. Nonculprit lesions have been assumed to contribute to the pathogenesis of recurrent acute coronary syndrome (ACS). The role of LP-PLA2 in the progression of nonculprit coronary lesions after successful percutaneous coronary intervention (PCI) remains unclear. Our study included 123 patients with ACS who underwent initial PCI and a long-term follow-up (mean interval, one year) with coronary angiography. Among them, 19 patients were diagnosed as the progression of nonculprit lesions, based on the presence of at least one of the following factors: (1) ≥ 10% reduction in the diameter of a preexisting ≥ 50% stenosis; (2) ≥ 30% reduction in the diameter of a < 50% stenosis; and (3) early-onset stenosis with ≥ 30% reduction in the diameter of a segment that was normal on the primary angiogram. Blood sampling was drawn from all patients at 12-14 hours after PCI. The ACS patients with progression had higher total cholesterol (4.47 ± 1.02 mmol/L vs. 3.59 ± 0.57 mmol/L, P < 0.05), higher levels of Lp-PLA2 activity (14.39 ± 6.13 nmol/min/ml vs. 8.86 ± 3.14 nmol/min/ml, P < 0.001) and a higher proportion of multi-vessel disease than those without progression. Multivariate logistic regression analysis showed that Lp-PLA2 activity (β = 0.024, P = 0.005) was an independent predictor for rapid progression of nonculprit coronary lesions. In conclusion, elevated Lp-PLA2 activity is associated with rapid progression of nonculprit coronary lesions in ACS patients who underwent PCI.
- Published
- 2013
6. Effects of salvianolic acid B on cardiovascular endothelial cells and platelet activation in a rabbit model of ischemia-reperfusion
- Author
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Guo-xiong Dong, Ge-xin Liu, Zuo-yuan Chen, An-yong Zhang, Zhe-xun Lian, and Fu-guo Yang
- Subjects
medicine.medical_specialty ,Endothelium ,Ischemia ,Myocardial Reperfusion Injury ,Nitric Oxide ,Nitric oxide ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Platelet ,Platelet activation ,Endothelial dysfunction ,Benzofurans ,business.industry ,Endothelins ,Myocardium ,Endothelial Cells ,Platelet Activation ,medicine.disease ,P-Selectin ,medicine.anatomical_structure ,Endocrinology ,Complementary and alternative medicine ,chemistry ,Endothelium, Vascular ,Rabbits ,Endothelin receptor ,business ,Ligation - Abstract
OBJECTIVE To investigate the effects of salvianolic acid B (SA-B) on cardiovascular endothelial cell function and platelet activation during myocardial ischemia-reperfusion in rabbits. METHODS A total of 24 New Zealand white rabbits were randomly divided into sham-operated group, ischemia-reperfusion group (untreated group) and SA-B group. The hearts of rabbits in untreated group and SA-B group underwent half an hour of left anterior descending coronary artery (LADCA) occlusion via ligation technology, which was followed by 4 hours of reperfusion to prepared ischemia-reperfusion injury model in vivo. For sham-operated group, the animals were not subjected to occlusion of LADCA. In SA-B treatment group the rabbits were intravenously administered SA-B immediately after LADCA occlusion, and the other two groups were given normal saline in the same way instead of SA-B. The jugular vein bloods of animals were collected before LADCA ligation, half an hour after ligation and after 1-, 4-hour reperfusion, respectively. The content of plasma nitric oxide (NO) was determined by nitrate reductase process. Radioimmunoassay was applied to detect the endothelin (ET) content in plasma and the count of alpha-granule membrane protein-140 (GMP-140) on platelet surface to identify the activation of the platelet. RESULTS No significant difference was observed before and after sham LADCA occlusion in sham-operated group in the contents of NO and ET in plasma (P>0.05), neither was the count of GMP-140 on platelet surface (P>0.05). The content of NO in plasma detected 0.5 h after LADCA occlusion was significantly decreased in untreated group compared with the sham-operated group at the corresponding time, and they were also much lower than that before LADCA occlusion in the sham-operated group (P
- Published
- 2008
7. Transcatheter Treatment of Large Aortopulmonary Window: A Case Report
- Author
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Quansheng Xing, Zuo-Yuan Chen, Daxin Zhou, Qin Wu, Pin Sun, Zhexun Lian, Xiaxia Wang, Hui Xin, and Jidong Zhang
- Subjects
Cardiac Catheterization ,medicine.medical_specialty ,Aortopulmonary septal defect ,Septal Occluder Device ,business.industry ,Hypertension, Pulmonary ,medicine.medical_treatment ,medicine.disease ,Pulmonary hypertension ,Aortopulmonary Septal Defect ,Aortopulmonary window ,Surgery ,Shunt (medical) ,Young Adult ,Internal medicine ,MUSCULAR VENTRICULAR SEPTAL DEFECT ,medicine ,Cardiology ,Humans ,Female ,Cardiology and Cardiovascular Medicine ,business ,Cardiac catheterization - Abstract
Introduction: Aortopulmonary window (APW), a large aortopulmonary septal defect (APSD), is a serious and rare defect within congenital heart diseases. Case report: In this study, we reported an APW case with severe pulmonary arterial hypertension. This patient was successfully treated by transcatheter closure with a muscular ventricular septal defect (VSD) occluder. Conclusion: We had a successful experience with transcatheter closure of a large APW using a muscular VSD occluder. There was no residual shunt or complications during the 6-month follow-up.
- Published
- 2015
8. ATP-induced cardioprotection against myocardial ischemia/reperfusion injury is mediated through the RISK pathway.
- Author
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ZHE-XUN LIAN, FANG WANG, JUN-HUA FU, ZUO-YUAN CHEN, HUI XIN, and RU-YONG YAO
- Subjects
CORONARY heart disease prevention ,ADENOSINE triphosphatase ,MYOCARDIAL infarction ,MOLECULAR cardiology ,LABORATORY rabbits ,DRUG efficacy - Abstract
The aim of the present study was to examine the post-infarct acute effect of adenosine-5'-triphosphate (ATP) on myocardial infarction (MI) size as well as its precise molecular mechanism. Sixty New Zealand white male rabbits were exposed to 40 min of ischemia followed by 180 min of reperfusion. The rabbits were intravenously administered 3 mg/kg of ATP (ATP group) or saline (control group) immediately after reperfusion and maintained throughout the first 30 min. The wortmannin+ATP, PD-98059+ATP, and 5-hydroxydecanoic acid (5-HD) sodium salt+ATP groups were separately injected with wortmannin (0.6 mg/kg), PD-98059 (0.3 mg/kg), and 5-HD (5 mg/kg) 5 min prior to ATP administration. MI size was calculated as the percentage of the risk area in the left ventricle. Myocardial apoptosis was determined using a TUNEL assay. Western blot analysis was performed to examine the levels of protein kinase B (Akt)/ p-Akt and extracellular signal-regulated kinase (ERK)/p-ERK in the ischemic myocardium, 180 min after reperfusion. The infarct size was significantly smaller in the ATP group than in the control group (p<0.05). The infarct size-reducing effect of ATP was completely blocked by wortmannin, PD-98059 and 5-HD. Compared with the control group, cardiomyocyte apoptosis was significantly reduced in the ATP group, while this did not occur in the wortmannin+ATP, PD-98059+ATP and 5-HD+ATP groups. Western blot analysis revealed a higher myocardial expression of p-Akt and p-ERK 180 min following reperfusion in the ATP versus the control group. In conclusion, cardioprotection by postischemic ATP administration is mediated through activation of the reperfusion injury salvage kinase (RISK) pathway and opening of the mitochondrial ATP-dependent potassium channels. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
9. Atp-induced cardioprotection against myocardial ischemia/reperfusion injury is mediated through risk pathway
- Author
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F. Wang, Zuo-Yuan Chen, Zhexun Lian, Ru-Yong Yao, Jidong Zhang, Shanglang Cai, and Hui Xin
- Subjects
Cardioprotection ,TUNEL assay ,Kinase ,business.industry ,Ischemia ,Pharmacology ,medicine.disease ,Wortmannin ,chemistry.chemical_compound ,chemistry ,Apoptosis ,Anesthesia ,medicine ,Cardiology and Cardiovascular Medicine ,business ,Protein kinase B ,Reperfusion injury - Abstract
Objective: Adenosine-5'-triphosphate (ATP) has been reported to protect the heart from myocardial ischemia/reperfusion injury when administered at the onset of reperfusion and is as effective as mechanical postconditioning. However, whether the protective effect of postconditioning with ATP is mediated through the same signaling pathways as those of ischemic postconditioning is still unclear. We examined the postinfarct acute effect of ATP on myocardial infarct size and its precise molecular mechanism. Methods: Forty-eight New Zealand white male rabbits were exposed to 40 min of ischemia followed by 180 min of reperfusion. Rabbits were intravenously injected 3mg/kg of ATP (ATP group) or saline (control group) immediately after reperfusion within 30min. The wortmannin+ATP, PD-98059+ATP, and 5-hydroxydecanoic acid sodium salt (5-HD)+ATP groups were respectively injected with wortmannin [a phosphatidyl-inositol 3-kinase (PI3-kinase) inhibitor, 0.6 mg/kg], PD-98059 [an extracellular signal regulated protein kinase (ERK) inhibitor, 0.3 mg/kg], and 5-HD [a mitochondrial ATP-dependent K+ (KATP) channel blocker, 5 mg/kg] 5 min before ATP administration. Myocardial infarct size was calculated as a percentage of the risk area of the left ventricle. Myocardial apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) methods. Western blot analysis was performed to examine the signals such as protein kinase B (Akt) and extracellular signal-regulated protein kinase (ERK) in the ischemic myocardium after 180min of reperfusion. Results: The infarct size was significantly smaller in the ATP group (12.8±1.9%) than in the control group (29.1±2.9%). The infarct size-reducing effect of ATP was completely blocked by wortmannin (26.5±2.7%), PD-98059 (27.9±3.2%), and 5-HD (26.1±4.0%). Compared with control group, ATP group significantly reduced cardiomyocytes apoptosis (apoptotic index: 27.0±5.8% vs 10.3±6.0%, P
- Published
- 2013
10. Successful off-pump device closure of an isolated perimembraneous ventricular septal defect using a series of six occluders in a 5 kg infant via a minimally invasive approach
- Author
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Zuo-Yuan Chen, Yueyi Ren, Silin Pan, Qin Wu, and Quansheng Xing
- Subjects
Heart Septal Defects, Ventricular ,medicine.medical_specialty ,Systolic Murmurs ,Heart disease ,Septal Occluder Device ,business.industry ,Coronary Artery Bypass, Off-Pump ,Infant ,medicine.disease ,Transoesophageal echocardiography ,Sternotomy ,Pneumonia ,Blood pressure ,Cardiothoracic ratio ,Internal medicine ,medicine.artery ,Pulmonary artery ,Circulatory system ,medicine ,Cardiology ,Humans ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
A 3-month-old female of 5 kg presented with a 4.23 mm isolated perimembranous ventricular septal defect (pmVSD) which was confirmed by transoesophageal echocardiography (TEE) ( Panel A ). Before that, she had suffered from pneumonia twice. Systolic murmurs of Grade 3 could be heard in the third intercostal space, with intense pulmonary second heart sound. As determined with transthoracic echocardiography (TTE) analysis, the dimensions of the pmVSD were 4.5 mm, with enlarged left atria and ventricles. A 46 mmHg pulmonary artery systolic pressure was estimated by TTE. Cardiomegaly (cardiothoracic ratio: 0.65) and pulmonary congestion were demonstrated on chest X-ray film. All the above features strongly indicated …
- Published
- 2010
11. Elevated Lipoprotein-Associated Phospholipase A2 Is Associated with Progression of Nonculprit Lesions after Percutaneous Coronary Intervention.
- Author
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Hui Xin, Hui-Ping Gong, Shang-Lang Cai, Xian-Feng Ning, Song Liu, Zuo-Yuan Chen, Zhe-Xun Lian, Rui Zhang, Quan-Fang Zhang, Wei-Qiang Kang, and Zhi-Ming Ge
- Abstract
Lipoprotein-associated phospholipase A2 (Lp-PLA
2 ) is an enzyme that hydrolyzes oxidized phospholipids to generate bioactive proatherogenic products. Nonculprit lesions have been assumed to contribute to the pathogenesis of recurrent acute coronary syndrome (ACS). The role of LP-PLA2 in the progression of nonculprit coronary lesions after successful percutaneous coronary intervention (PCI) remains unclear. Our study included 123 patients with ACS who underwent initial PCI and a long-term follow-up (mean interval, one year) with coronary angiography. Among them, 19 patients were diagnosed as the progression of nonculprit lesions, based on the presence of at least one of the following factors: (1) ≥ 10% reduction in the diameter of a preexisting ≥ 50% stenosis; (2) ≥ 30% reduction in the diameter of a < 50% stenosis; and (3) early-onset stenosis with ≥ 30% reduction in the diameter of a segment that was normal on the primary angiogram. Blood sampling was drawn from all patients at 12-14 hours after PCI. The ACS patients with progression had higher total cholesterol (4.47 ± 1.02 mmol/L vs. 3.59 ± 0.57 mmol/L, P < 0.05), higher levels of Lp-PLA2 activity (14.39 ± 6.13 nmol/min/ml vs. 8.86 ± 3.14 nmol/min/ml, P < 0.001) and a higher proportion of multi-vessel disease than those without progression. Multivariate logistic regression analysis showed that Lp-PLA2 activity ( β = 0.024, P = 0.005) was an independent predictor for rapid progression of nonculprit coronary lesions. In conclusion, elevated Lp-PLA2 activity is associated with rapid progression of nonculprit coronary lesions in ACS patients who underwent PCI. [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
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