1. Can zaprinast and avanafil induce the levels of angiogenesis, bone morphogenic protein 2, 4 and 7 in kidney of ovariectomised rats?
- Author
-
Huyut, Zübeyir, Bakan, Nuri, Yıldırım, Serkan, Akbay, Halil İbrahim, Huyut, Mehmet Tahir, Ahlatçı, Adem, and Uçar, Bünyamin
- Subjects
- *
VASCULAR endothelial growth factors , *NEOVASCULARIZATION , *ABDOMEN , *BONE morphogenetic proteins - Abstract
This study investigated effects of zaprinast and avanafil on angiogenesis, vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP) 2, 4 and 7. Female rats were randomly divided into four groups (n = 6). Sham; abdomen was approximately 2 cm opened and closed. Ovariectomised (OVX); abdomen was opened 2 cm and the ovaries were cut. OVX + zaprinast and OVX + avanafil groups; after the same procedure with OVX, 10 mg/kg zaprinast and avanafil were orally administered for 2 month, respectively. Angiogenesis and the levels of VEGF, BMP2, 4 and 7 were determined. VEGF, BMP2, 4 and 7 levels in OVX + zaprinast and especially OVX + avanafil groups were higher than the sham and OVX (p <.05). However, only VEGF and BMP2 levels in OVX + zaprinast group were significant according to sham (p <.05). Also, angiogenesis in OVX + zaprinast and OVX + avanafil groups was dominant according to sham and OVX (p <.05). Zaprinast and avanafil induced BMP2, 4 and 7 levels synergistically with increased VEGF and angiogenesis in renal tissue. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF