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8 results on '"Zhang, Yuan-Ning"'

5. Localized expression of human BMP-7 by BM-MSCs enhances renal repair in an in vivo model of ischemia-reperfusion injury

Author

Liu Yong-Liang, Wang Xiang-Wei, Jia Wei-Sheng, Fang Zhen-qiang, Zhang Yuan-Ning, Ye Bing-Wei, Yi Shan-Hong, Gang Ye, and Chen Wei

Subjects
Kidney, biology, Mesenchymal stem cell, Ischemia, Renal function, Cell Biology, medicine.disease, Andrology, Superoxide dismutase, Bone morphogenetic protein 7, Transplantation, medicine.anatomical_structure, Immunology, Genetics, medicine, biology.protein, Reperfusion injury
Abstract

Ischemia and subsequent reperfusion (I/R) damage kidney tubular cells and consequently impair renal function. Rabbit bone marrow mesenchymal stem cells (BM-MSCs) expressing human bone morphogenic protein-7 (hBMP-7) regenerated tubular cells and improved renal function in a kidney I/R model. Rabbits were injected immediately after I/R with one of the following: (i) hBMP-7-transduced BM-MSCs (BM-MSCshBMP-7); (ii) enhanced green fluorescent protein–transduced BM-MSCs (BM-MSCsEGFP); or (iii) PBS. The activity of superoxide dismutase (SOD) was higher, and the amount of malondialdehyde (MDA) was lower in the BM-MSCshBMP-7 group than in the BM-MSCsEGFP group. Both the BM-MSCshBMP-7 group and the BM-MSCsEGFP group had higher SOD activity and lower amounts of MDA than the PBS group. Bcl-2- and Bcl-2-associated X protein levels, and other variables, indicated the regeneration of the kidney in both experimental groups. However, the BM-MSCs hBMP-7 group showed higher activity than the BM-MSCsEGFP group, indicating that the combined strategy of BM-MSC transplantation with hBMP-7 gene therapy could be a useful approach for the treatment of renal IRI.

Published
2011

6. Localized expression of human BMP-7 by BM-MSCs enhances renal repair in an in vivo model of ischemia-reperfusion injury

Author

Fang, Zhen-Qiang, Ye, Bing-Wei, Liu, Yong-Liang, Wang, Xiang-Wei, Yi, Shan-Hong, Zhang, Yuan-Ning, Jia, Wei-Sheng, Chen, Wei, and Gang, Ye

Subjects
Superoxide Dismutase, Bone Morphogenetic Protein 7, Gene Expression, Bone Marrow Cells, Mesenchymal Stem Cells, Kidney, Mesenchymal Stem Cell Transplantation, Malondialdehyde, Reperfusion Injury, Animals, Humans, Rabbits, Cells, Cultured, Cell Proliferation
Abstract

Ischemia and subsequent reperfusion (I/R) damage kidney tubular cells and consequently impair renal function. Rabbit bone marrow mesenchymal stem cells (BM-MSCs) expressing human bone morphogenic protein-7 (hBMP-7) regenerated tubular cells and improved renal function in a kidney I/R model. Rabbits were injected immediately after I/R with one of the following: (i) hBMP-7-transduced BM-MSCs (BM-MSCshBMP-7); (ii) enhanced green fluorescent protein-transduced BM-MSCs (BM-MSCsEGFP); or (iii) PBS. The activity of superoxide dismutase (SOD) was higher, and the amount of malondialdehyde (MDA) was lower in the BM-MSCshBMP-7 group than in the BM-MSCsEGFP group. Both the BM-MSCshBMP-7 group and the BM-MSCsEGFP group had higher SOD activity and lower amounts of MDA than the PBS group. Bcl-2- and Bcl-2-associated X protein levels, and other variables, indicated the regeneration of the kidney in both experimental groups. However, the BM-MSCs (hBMP-7) group showed higher activity than the BM-MSCsEGFP group, indicating that the combined strategy of BM-MSC transplantation with hBMP-7 gene therapy could be a useful approach for the treatment of renal IRI.

Published
2012

8. [Prophylactic effect of inductive intravesical instillation of Bacillus Calmette-Guerin on postoperative recurrence of bladder cancer].

Author

Yi SH, Ye G, Wang XW, Jin HS, Zhang YN, and Yan ZL

Subjects
Adjuvants, Immunologic administration & dosage, Adjuvants, Immunologic adverse effects, Adjuvants, Immunologic therapeutic use, Administration, Intravesical, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Phytogenic administration & dosage, Antineoplastic Agents, Phytogenic adverse effects, Antineoplastic Agents, Phytogenic therapeutic use, BCG Vaccine administration & dosage, BCG Vaccine adverse effects, Camptothecin administration & dosage, Camptothecin adverse effects, Camptothecin therapeutic use, Carcinoma, Transitional Cell surgery, Cystectomy, Female, Fever chemically induced, Follow-Up Studies, Humans, Male, Middle Aged, Urinary Bladder Neoplasms surgery, BCG Vaccine therapeutic use, Camptothecin analogs & derivatives, Carcinoma, Transitional Cell drug therapy, Neoplasm Recurrence, Local prevention & control, Urinary Bladder Neoplasms drug therapy
Abstract

Background & Objective: Intravesical instillation is an important adjuvant therapy on preventing postoperative recurrence of superficial bladder transitional cell carcinoma, but the recurrence rate is still high. This study was to evaluate the prophylactic effect of intravesical instillation of hydroxycamptothecin (HYD) plus bacillus Calmette-Guerin (BCG) on postoperative recurrence of bladder transitional cell cancer., Methods: A total of 45 bladder cancer patients who underwent TURBT or partial cystectomy were divided into two groups: 24 patients in combination group received single intravesical instillation of HYD in Week 1 after operation and regular intravesical instillation of BCG since Week 2; 21 patients in BCG group received regular intravesical instillation of BCG since Week 1 after operation. All the patients were followed up for 24 months., Results: Three patients had recurrence at 2, 10, and 12 months after operation individually in BCG group; no recurrence developed in combination group. The recurrence rate was significantly higher in BCG group than in combination group (14.28% vs. 0, P<0.05). No serious adverse events and complication developed in both groups., Conclusion: Early use of single intravesical instillation of HYD plus subsequent regular intravesical instillation of BCG is markedly effective for preventing postoperative recurrence of bladder transitional cell cancer, with few adverse events.

Published
2008

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