1. Outcomes of adolescent and young patients with hepatocellular carcinoma after curative liver resection: a retrospective study.
- Author
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Zhang, Zheng-Yun, Guan, Jiao, Wang, Xin-Ping, Hao, Di-Si, and Zhou, Zun-Qiang
- Subjects
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HEPATOCELLULAR carcinoma , *PORTAL vein , *PROGRESSION-free survival , *TEENAGERS , *DEATH rate , *LIVER surgery - Abstract
Background: The risk of HCC is documented to be age-related. The outcomes of young HCC patients on postoperative prognosis are not well understood. The study aims to compare the characteristic differences between adolescent and young (AYA) and non-AYA HCC patients. Methods: We performed a retrospective analysis of the clinical and pathological findings and the survival of 243 HCC patients who underwent operations between 2007 and 2018. Results: The AYA group had a higher AFP level and a higher prevalence of family history of HCC or other cancers than the non-AYA group (P < 0.01 and P < 0.05). AYA patients had more unfavorable pathological characteristics including bigger lesion size, microvascular invasion, portal vein invasion, and hepatic capsule invasion. They also had a more unfavorable Edmondson grade and less tumor capsule formation (P < 0.01). Age was an independent predictor of survival in HCC patients. AYA patients had poorer disease-free and overall survival than non-AYA patients did (P < 0.01). Patients under 30 years old had an even poorer disease-free survival than those aged 30–40 (P = 0.047). Conclusions: AYA patients exhibited a higher recurrence rate and disease-related death rate with more unfavorable pathological characteristics. Enhanced follow-up for young HCC patients should be applied. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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