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Objective To investigate the effect of blood pressure patterns on memory function in patients with Parkinson's disease (PD). Methods A total of 68 PD patients were collected from the Department of Neurology of Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) between August 2018 and July 2021. All patients received 24 h ambulatory blood pressure monitoring (ABPM) and were divided into reverse dipping group (n=17), reduced dipping group (n=30), normal group (n=17), and extreme dipping group (n=4) according to the reduction rate of nocturnal systolic blood pressure; nocturnal hypertension group (n=37) and non⁃nocturnal hypertension group (n=31) according to nocturnal blood pressure. Global cognitive function was assessed by Mini⁃Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Memory function was evaluated by Logical Memory Test (LMT), Auditory Verbal Learning Test (AVLT) and Digit Span Test (DST). Results Among the 4 groups with different blood pressure pattern, statistical significances were found in duration (χ2=8.599, P=0.035), AVLT imediate 3 (F=3.100, P=0.033) and AVLT delayed (χ2=7.828, P=0.050). Pairwise comparison showed that the duration was longer in the reverse dipping group (Z=4.224, P=0.043) and the normal group (Z=4.821, P=0.028) than in the reduced dipping group; the AVLT imediate 3 of the reverse dipping group was lower than that of the normal group (t=⁃2.028, P=0.048) and the extreme dipping group (t=⁃2.673, P=0.010); the AVLT imediate 3 of the reduced dipping group was lower than that of the extreme dipping group (t=2.554, P=0.013). Compared with non⁃nocturnal hypertension group, the morbidity of hypertension was higher (χ2=6.399, P=0.011) and the duration was longer (Z=⁃2.008, P=0.045) in the nocturnal hypertension group. There was no significant difference in memory function between 2 groups (P＞0.05, for all). Conclusions PD patients with reverse dipping blood pressure pattern are more likely to influence cognitive function, especially in memory function. Continuous blood pressure monitoring should be performed in PD patients.

doi：10.3969/j.issn.1672⁃6731.2021.07.013

Objective To explore the expression of protein arginine deiminases (PADs) and protein arginine methyltransferases (PRMTs) in hepatocellular carcinoma, and to analyze whether the level of protein citrullination catalyzed by PADs is related to the expression of PRMTs. Methods The mRNA transcription of PADs and PRMTs in hepatoma cells was detected by quantitative PCR and the protein expression of PADs, citrullinated proteins and PRMTs was detected by Western blot. The mRNA correlation between PADs and PRMTs in liver cancer tissues in TCGA database was analyzed by bioinformatics, and the expressions of PADs, citrullinated proteins and PRMTs in liver cancer tissues was detected by immunohistochemistry. Results Compared with normal liver cell LX-2, the mRNA transcription of PAD2 and PRMT1 in Huh7 cells was higher (P＜0.001), and that of PAD4, PRMT1, PRMT5 and PRMT7 in HepG2 cells was higher (P＜0.01). The protein level of PAD2 and PAD4 in HepG2 and Huh7 was significantly higher than those in LX-2 (P＜0.01). The expression level of citrullinated protein in HepG2 and Huh7 was lower than that in LX-2. The expression of PADs and PRMTs in hepatocellular carcinoma was stronger than that in adjacent tissues, and the expression of citrullinated proteins was almost negative. There were positive correlation between PAD2 and all PRMTs in clinical sample database (P＜0.05). Conclusions The expression of PADs is high in hepatocellular carcinoma, whereas the expression of citrullinated proteins is low, which may be affected by the competition of PRMTs enzyme highly expressed in cells.

Cognitive decline is one of the greatest concerns for patients with Parkinson's disease (PD) and their care partners. Repetitive transcranial magnetic stimulation (rTMS) is a nonpharmacological treatment option used to improve cognitive function in PD, but its efficacy is unclear. We performed a meta-analysis to determine whether rTMS improves cognition in PD patients. Eligibility criteria (PICOS) were as follows: (1) 'P': The patients participating were diagnosed with idiopathic PD; (2) 'I': Intervention using rTMS; (3) 'C': Sham stimulation as control; (4) 'O': The outcome of the study included cognitive evaluations; (5) 'S': The study adopted randomized controlled design. The standardized mean difference (SMD) of change of score was applied to measure efficacy, and we used Version 2 of the Cochrane tool to assess risk of bias. Twelve studies met the inclusion criteria. Compared with sham-controlled group, the pooled result showed a non-significant short-term effect of rTMS on global cognition (SMD: −0.15, 95% CI: −0.59 to 0.29, I2 = 36.7%), executive function (SMD: 0.03, 95% CI: −0.21 to 0.26, I2 = 0.0%), and attention and working memory (SMD: 0.05, 95% CI: −0.25 to 0.35, I2 = 0.0%). Long-term outcomes were either shown to be statistically nonsignificant. Based on a limited number of studies, rTMS fails to improve cognition in PD. We call for additional high-quality randomized controlled trials with adequate sample sizes to determine the efficacy of rTMS. [ABSTRACT FROM AUTHOR]

Aims: The aim of this research was to investigate the alterations in functional brain networks and to assess the relationship between depressive impairment and topological network changes in Parkinson's disease (PD) patients with depression (DPD). Methods: Twenty‐two DPD patients, 23 PD patients without depression (NDPD), and 25 matched healthy controls (HCs) were enrolled. All participants were examined by resting‐state functional magnetic resonance imaging scans. Graph theoretical analysis and network‐based statistic methods were used to analyze brain network topological properties and abnormal subnetworks, respectively. Results: The DPD group showed significantly decreased local efficiency compared with the HC group (P =.008, FDR corrected). In nodal metrics analyses, the degree of the right inferior occipital gyrus (P =.0001, FDR corrected) was positively correlated with the Hamilton Depression Rating Scale scores in the DPD group. Meanwhile, the temporal visual cortex, including the bilateral middle temporal gyri and right inferior temporal gyrus in the HC and NDPD groups and the left posterior cingulate gyrus in the NDPD group, was defined as hub region, but not in the DPD group. Compared with the HC group, the DPD group had extensive weakening of connections between the temporal‐occipital visual cortex and the prefrontal‐limbic network. Conclusions: These results suggest that PD depression is associated with disruptions in the topological organization of functional brain networks, mainly involved the temporal‐occipital visual cortex and the posterior cingulate gyrus and may advance our current understanding of the pathophysiological mechanisms underlying DPD. [ABSTRACT FROM AUTHOR]