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21 results on '"Zhu, Minqian"'

10. Anti-Inflammatory and Gut Microbiota Modulation Potentials of Flavonoids Extracted from Passiflora foetida Fruits

Author

Han, Xiangpeng, Song, Ya, Huang, Riming, Zhu, Minqian, Li, Meiying, Requena, Teresa, Wang, Hong, Han, Xiangpeng, Song, Ya, Huang, Riming, Zhu, Minqian, Li, Meiying, Requena, Teresa, and Wang, Hong

Abstract

This study aimed to explore the anti-inflammatory and gut microbiota modulation potentials of flavonoid-rich fraction (PFF) extracted from Passiflora foetida fruits. The results showed that PFF markedly reduced the production of nitric oxide (NO), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) in LPS-stimulated RAW 264.7 cells. Meanwhile, PFF treatment also effectively decreased the phosphorylation levels of MAPK, PI3K/Akt, and NF-κB signaling-pathway-related proteins (ERK, JNK, p38, Akt, and p65). Moreover, PFF had an impact on microbial composition and metabolites in a four-stage dynamic simulator of human gut microbiota (BFBL gut model). Specifically, PFF exhibited the growth-promoting ability of several beneficial bacteria, including Bifidobacterium, Enterococcus, Lactobacillus, and Roseburia, and short-chain fatty acid (SCFA) generation ability in gut microbiota. In addition, spectroscopic data revealed that PFF mainly contained five flavonoid compounds, which may be bioactive compounds with anti-inflammatory and gut microbiota modulation potentials. Therefore, PFF could be utilized as a natural anti-inflammatory agent or supplement to health products.

Published
2023

13. Immunological activity and gut microbiota modulation of pectin from kiwano (Cucumis metuliferus) peels

Author

Zhu, Minqian, Song, Ya, Martínez-Cuesta, M. Carmen, Peláez, Carmen, Li, Enru, Requena, Teresa, Wang, Hong, Sun, Yuanming, Guangdong Science and Technology Department, National Key Research and Development Program (China), Ministerio de Ciencia e Innovación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), and Agencia Estatal de Investigación (España)

Subjects
Health (social science), Kiwano, Immune-enhancing, Cucumis metuliferus, Plant Science, kiwano, pectin, immune-enhancing, microbiota simulation, Health Professions (miscellaneous), Microbiology, Microbiota simulation, Pectin, Food Science
Abstract

This article belongs to the Special Issue Analysis, Detection Technology and Safety Risk Assessment of Food Contaminants., For developing the recycling of fruit by-products from kiwano, a polysaccharide was extracted from kiwano (Cucumis metuliferus) peels, namely Cucumis metuliferus peels polysaccharide (CMPP), with the aim of investigating the potential beneficial effects. The composition of polysaccharides was analyzed by chemical methods. RAW264.7 macrophages cells and the microbiota dynamics simulator (BFBL gut model) were used for in vitro study. The result showed that CMPP mainly consists of glucuronic acid, arabinose, galactose and rhamnose. By intervening with RAW264.7 cells, CMPP promoted cell proliferation and showed immune-enhancing activity, which significantly (p < 0.05) induced the release of nitric oxide (NO), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) at a concentration of 50 μg/mL. In addition, CMPP had an impact on the composition of the gut bacteria, increasing the growth of Akkermansia, Bacteroides, Bifidobacterium, Feacalibacterium, and Roseburia. During the intake period, acetic, butyric and propionic acids were all increased, especially (p < 0.05) in the descending colon. Moreover, a decrease in ammonia concentration (10.17 ± 0.50 mM in the ascending colon, 13.21 ± 1.54 mM in the transverse colon and 13.62 ± 0.45 mM in the descending colon, respectively) was observed. In summary, CMPP can be considered as a pectin, showed immunological activity and function of gut microbiota modulation. This study could be the scientific basis of developing kiwano peels as beneficial to human health., This research was funded by the Lingnan Modern Agricultural Science and Technology Guangdong Laboratory independent scientific research project (NZ2021032), the Key Area R&D Program of Guangdong Province (NO. 2019B020211002), the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2017), and the International Cooperation Program of SCAU (NO. 2019SCAUGH03). This research was funded by the Spanish Ministry of Science and Innovation (grant numbers AGL2016-75951-R and PID2019-106071RB-I00)

Published
2022

21. Photo-Driven Delivery of 125 I-Labeled Nanomicelles for Nucleus-Targeted Internal Conversion Electron-Based Cancer Therapy.

Author

Qin Y, Shen M, Liu X, Gu J, Zhu M, and Yi X

Subjects
Animals, Antineoplastic Agents chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Chlorophyllides chemistry, Female, Iodine Radioisotopes, Lasers, Mammary Neoplasms, Experimental drug therapy, Mammary Neoplasms, Experimental pathology, Materials Testing, Mice, Mice, Inbred BALB C, Micelles, Optical Imaging, Photochemical Processes, Photosensitizing Agents chemistry, Antineoplastic Agents pharmacology, Cell Nucleus drug effects, Chlorophyllides pharmacology, Curcumin chemistry, Electrons, Nanoparticles chemistry, Photosensitizing Agents pharmacology
Abstract

As a kind of high linear energy transfer (LET) radiation, internal conversion electrons are emitted from some radionuclides, such as 125 I, triggering severe DNA damage to tumor cells when transported into the nucleus. Herein, we develop a curcumin-loaded nanomicelle composed of a photosensitizer chlorin e6 (Ce6) and amphiphilic poly(ethylene glycol) (poly(maleic anhydride- alt -1-octadecene)-poly(ethylene glycol) (C 18 -PMH-PEG)) to deliver 125 I into the nucleus under 660 nm laser irradiation, leading to the optimized imaging-guided internal conversion electron therapy of cancer. Ce6-containing nanomicelles (Ce6-C 18 -PEG) self-assemble with nucleus-targeted curcumin (Cur), obtaining Ce6-C 18 -PEG/Cur nanoparticles. After labeling Cur with 125 I, Ce6-C 18 -PEG/Cur enables single-photon emission computed tomography and fluorescence imaging of the tumor, serving as a guide for follow-up laser irradiation. Notably, the 660 nm laser-triggered photodynamic reaction of Ce6 optimizes the delivery of Ce6-C 18 -PEG/ 125 I-Cur at various stages, including tumor accumulation, cellular uptake, and lysosome escape, causing plenty of 125 I-Cur to enter the nucleus. By this strategy, Ce6-C 18 -PEG/ 125 I-Cur showed optimal antitumor efficacy and high biosafety in mice treated with local 660 nm laser irradiation using efficient energy deposition of internally converted electrons over short distances. Therefore, our work provides a novel strategy to optimize 125 I delivery for tumor treatment.

Published
2021
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