6 results on '"Zu-hai Zhang"'
Search Results
2. A diagnosis model of dementia via machine learning
- Author
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Ming Zhao, Jie Li, Liuqing Xiang, Zu-hai Zhang, and Sheng-Lung Peng
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dementia ,machine learning ,bagging ,principal component analysis ,diagnosis model ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
As the aging population poses serious challenges to families and societies, the issue of dementia has also received increasing attention. Dementia detection often requires a series of complex tests and lengthy questionnaires, which are time-consuming. In order to solve this problem, this article aims at the diagnosis method of questionnaire survey, hoping to establish a diagnosis model to help doctors make a diagnosis through machine learning method, and use feature selection method to select important questions to reduce the number of questions in the questionnaire, so as to reduce medical and time costs. In this article, Clinical Dementia Rating (CDR) is used as the data source, and various methods are used for modeling and feature selection, so as to combine similar attributes in the data set, reduce the categories, and finally use the confusion matrix to judge the effect. The experimental results show that the model established by the bagging method has the best effect, and the accuracy rate can reach 80% of the true diagnosis rate; in terms of feature selection, the principal component analysis (PCA) has the best effect compared with other methods.
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- 2022
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3. Recent advances on micro-invasive glaucoma surgery
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Guo-Jin Zuo and Zu-Hai Zhang
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micro-invasive ,glaucoma surgery ,intraocular pressure ,Ophthalmology ,RE1-994 - Abstract
Glaucoma is the second major causes of blindness after cataract. The conventional trabeculectomy and shunt implantation is still the most common surgical procedure in treatment of glaucoma. However, the limitations of the treatments are the security and failure rate. Micro-invasive glaucoma surgery(MIGS)is an emerging category which shares the following five characteristics compared with traditional glaucoma surgery:(1)an interno microincision,(2)micro-invasion,(3)definite curative effect,(4)high safety, and(5)rapid recovery. moreover, it can also reduce the use of glaucoma medication after operation. This kind of surgery can be conducted in three different space, such as Schlemm canal, the suprachoroidal space, and the subconjunctival space. This article reviews briefly the new techniques of micro-invasive glaucoma surgery.
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- 2017
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- View/download PDF
4. Clinical study on the optic nerve protection of calcium dobesilate in treating glaucoma
- Author
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Yan-Ni Zhu, Yan-Jie Bai, Yan-Hua Zhu, Jia-Hua Fang, and Zu-Hai Zhang
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calcium dobesilate ,glaucoma ,optic nerve ,Ophthalmology ,RE1-994 - Abstract
AIM:To observe the protective effect of calcium dobesilate on optic nerve of glaucoma patients whose intraocular pressure has been under control through operation.METHODS: A total of 78 inpatients(89 eyes)with glaucoma in this hospital from January, 2011 to February, 2012 were enrolled. All patients were randomly divided into treatment group and control group with 6 months in a course. The visual acuity, visual field(mean sensibility, MS), and intraocular pressure were measured at the experiment onset and 6 months later to evaluate the clinical effect.RESULTS: There were no statistically significant differences in the visual acuity, intraocular pressure between the two groups neither at the experiment onset nor after 6 months(P>0.05). The mean sensibility(MS)of the treatment group was obviously improved(14.56±5.03 vs 18.9±5.77, Pvs 13.48±4.69). There are statistically significant difference between the treatment group and the control group. Compared to the ratio of improvement, stability, and deterioration in the control group(10.3%, 48.7%, 41.0%), the indexes were changed obviously in the treatment group(64.1%, 28.2%, 7.7%,PCONCLUSION:Calcium dobesilate can improve mean retinal sensitivity and protect the optic nerve in glaucoma patients whose intraocular pressure has been controlled.
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- 2013
- Full Text
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5. Survey and analysis of the application feasibility of PBL teaching mode in ophthalmology class
- Author
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Nian-Yi Song, Yue-Sha Yuan, Yan-Hua Zhu, Xu-Tao Chen, and Zu-Hai Zhang
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ophthalmology ,problem-based learning ,teaching mode ,Ophthalmology ,RE1-994 - Abstract
AIM: To explore the application feasibility of problem-based learning(PBL)teaching mode in ophthalmology class in medical colleges of China.METHODS: Totally 157 students of class 2009 in Yangtze University majoring in clinical medicine were surveyed by questionnaires.RESULTS: The survey showed that 77.9% of students thought that traditional teaching methods of ophthalmology classes were quite satisfying. 82.8% of them considered it necessary to introduce the new teaching mode. 83.4% of them would choose PBL teaching mode between the traditional teaching mode and PBL teaching mode. 56.6% of them thought that PBL teaching mode was conducive to students' self-learning ability. The subjective and objective conditions made the exploration of PBL teaching modes feasible. However, there were disadvantages of PBL teaching mode. 73.1% of students thought the school teaching facilities were not enough, 78.6% of students thought that only part of the content of ophthalmology teaching was suitable for using PBL teaching mode.CONCLUSION: PBL teaching mode should be continuously explored and studied in the future ophthalmology teaching, in order to create suitable for China's national conditions of ophthalmology teaching mode.
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- 2013
- Full Text
- View/download PDF
6. Neuroprotective Effects of Bis(7)-tacrine in a Rat Model of Pressure-Induced Retinal Ischemia
- Author
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Zhi-gang Lu, Li Xu, Qi Wang, Jia-hua Fang, Jing-bo Li, and Zu-Hai Zhang
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Male ,Retinal Ganglion Cells ,Biophysics ,Ischemia ,Pharmacology ,Biochemistry ,Neuroprotection ,Retinal ganglion ,Rats, Sprague-Dawley ,Optic neuropathy ,chemistry.chemical_compound ,Retinal Diseases ,Electroretinography ,Pressure ,medicine ,Animals ,Retina ,medicine.diagnostic_test ,business.industry ,Retinal ,Cell Biology ,General Medicine ,medicine.disease ,Rats ,Disease Models, Animal ,Neuroprotective Agents ,medicine.anatomical_structure ,chemistry ,Anesthesia ,Tacrine ,Tumor Suppressor Protein p53 ,business ,medicine.drug - Abstract
The retinal ischemia-reperfusion model has been studied extensively and is an ideal animal model for studying clinical situations such as acute glaucoma and optic neuropathy. Our previous reports showed that bis(7)-tacrine had neuroprotective effects against glutamate-induced retinal ganglion cells damage through the drug's anti-NMDA receptor effects. Here, we investigated whether bis(7)-tacrine protects the retina from ischemic injury in a rat model. Retinal ischemia was induced by raising the intraocular pressure to 120 mmHg for 90 min. Rats received intraperitoneal injections of 0.2 mg/kg bis(7)-tacrine or saline at 30 min before ischemia, and then twice a day after retinal ischemia. Morphometric evaluation showed that bis(7)-tacrine dramatically reduced the retinal damage compared with the control group. Moreover, bis(7)-tacrine suppressed ischemia-induced reductions in a- and b-wave amplitudes of electroretinography. Protein levels of p53, the tumor suppressor gene known to induce apoptosis, were increased after ischemic injury, and treatment with bis(7)-tacrine reduced the expression of the protein. Our results suggest that bis(7)-tacrine has a neuroprotective effect against ischemic injury in the rat retina, possibly through the drug's anti-apoptotic effects. Bis(7)-tacrine may potentially be useful as a therapeutic drug in the management of ischemic retinal diseases.
- Published
- 2013
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