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2 results on '"amitryptilin"'

1. Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins

Author

Radivoj Jadrić, Sabaheta Hasić, Emina Kiseljaković, Jovan Radovanović, Emina Ićindić-Nakaš, and Mira Winterhalter-Jadrić

Subjects
amitryptilin, beta-endorphins, rat, sera, brain, Biology (General), QH301-705.5
Abstract

The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.

Published
2006
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2. Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins

Author

Sabaheta Hasić, Jovan Radovanović, Radivoj Jadrić, Mira Winterhalter-Jadrić, Emina Kiseljaković, and Emina Ićindić-Nakas

Subjects
Drug, medicine.medical_specialty, endocrine system, Brain chemistry, Pro-Opiomelanocortin, media_common.quotation_subject, Amitriptyline, brain, Pharmacology, Antidepressive Agents, Tricyclic, sera, Article, chemistry.chemical_compound, beta-endorphins, Internal medicine, medicine, Animals, rat, Endorphins, Rats, Wistar, Beta (finance), amitryptilin, media_common, Brain Chemistry, lcsh:R5-920, business.industry, beta-Endorphin, General Medicine, Rats, Endocrinology, chemistry, Antidepressant, business, lcsh:Medicine (General), hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.

Published
2006

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