1. Mn(II)-Based Lipidic Nanovesicles as High-Efficiency MRI Probes
- Author
-
Gabriele A. Rolla, Mauro Botta, Lorenzo Tei, Enzo Terreno, Lucas W. E. Starmans, Gilberto Mulas, and Carlos F. G. C. Geraldes
- Subjects
liposomes ,Relaxometry ,Liposome ,Chemistry ,Biochemistry (medical) ,amphiphilic chelating ligands ,relaxometry ,Biomedical Engineering ,Nanoparticle ,Nanotechnology ,General Chemistry ,Biomaterials ,Core (optical fiber) ,manganese ,nanoparticles ,Amphiphile - Abstract
Although nowadays there is a renewed and growing interest in Mn-based contrast agents, there are only few studies dealing with Mn-based lipophilic nanoparticles and how they may be optimized as MRI contrast agents. Three amphiphilic paramagnetic Mn(II) complexes based on derivatives of EDTA and 1,4-DO2A were used for the preparation of lipidic nanoparticles. The length and position of the aliphatic chains were found to control whether either vesicular liposomes, nonvesicular bicelles, or a mixture of both was produced as well as the size and morphology of phospholipid-based self-assembling nanoaggregates. These differences determine whether hydrophilic Gd-based contrast agents or fluorescent dyes can be entrapped in the aqueous core of the nanoaggregate. Structural characterization was performed by cryo-TEM. Detailed
- Published
- 2020