16 results on '"bone replacement graft"'
Search Results
2. Association Between Bone Graft Volume and Maxillary Sinus Membrane Elevation Height.
- Author
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Tetsuya Sonoda, Takehiro Harada, Nobuyuki Yamamichi, Monje, Alberto, and Hom-Lay Wang
- Subjects
SINUS augmentation ,BONE grafting ,MAXILLARY sinus surgery ,MAXILLARY sinus ,COMPUTED tomography ,ANATOMY - Abstract
Purpose: Maxillary sinus augmentation via crestal approach has been advocated as an alternative approach for sinus membrane elevation. Presently, no study has examined the relationship between the amount of bone grafting material placed and the final sinus membrane elevation height. Therefore, the present study was aimed at investigating the extent of sinus membrane elevation height depending on the amount of bone grafting material inserted as well as three-dimensionally assessing the likelihood of membrane perforation during membrane elevation. Materials and Methods: A total of 34 subjects (16 females and 18 males) with 61 crestal sinus elevation sites were recruited. The following changes in elevated sinus membrane area were recorded: vertical elevation height (VEH), buccopalatal elevation (BPE), and mesiodistal elevation (MDE). Cone beam computed tomography (CBCT) was used to measure the elevated height of the maxillary sinus floor at the initial examination, during surgery, and immediately after surgery. In addition, the VEH:BPE and VEH:MDE ratios at each site were calculated using CBCT to determine the probability of sinus membrane perforation. Results: In average, 0.1 mL of bone graft material placed elevated VEH an average of 3.5 mm, while 0.2 mL and 0.3 mL of graft placed elevated VEH 5 mm and 6 mm, respectively. Furthermore, it was demonstrated that the VEH:BPE and VEH:MDE ratios play a determinant role on membrane integrity. As such, a ratio greater than 1.0 may jeopardize membrane integrity, while a ratio ⩽ 0.8 might represent a lower risk of membrane perforation. Conclusion: An initial 0.1 mL of bone material filling can elevate sinus membrane vertically by 3.5 mm. To avoid sinus membrane perforation, a VEH:BPE or VEH:MDE ratio of ⩽ 0.8 should be obtained. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
3. Radiographic Evaluation of Regeneration Strategies for the Treatment of Advanced Mandibular Furcation Defects: A Retrospective Study
- Author
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Hsiang-Ling Huang, Yun-Han Ma, Che-Chang Tu, and Po-Chun Chang
- Subjects
periodontal regeneration ,furcation defects ,barrier membrane ,enamel matrix proteins ,bone replacement graft ,Chemical technology ,TP1-1185 ,Chemical engineering ,TP155-156 - Abstract
Teeth with furcation involvement (FI) present a higher risk of loss and are difficult to maintain. This study evaluated the efficacy of furcation defect regeneration (FDR) as a regeneration strategy. Pre-operative and 6-month postoperative radiographs were collected from patients receiving regeneration therapy for mandibular teeth with degree II and early degree III FI. The linear furcation involvement (LFI), ratio of LFI (RLI), LFI and RLI adjusted bythe alveolar bone crest (ABC), and radiographic intensity were assessed. The effects of demographic characteristics, regeneration treatment strategies, the relationship between furcation and ABC, and adjacent intrabony defect regeneration (AIDR) were evaluated using a generalized linear model and logistic regression. The results demonstrated that 1.5 mm adjusted LFI and 40% adjusted RLI were achieved in both pure furcation defects and combined furcation–angular defects by the combination of bone replacement grafts (BRG) and enamel matrix derivatives (EMD) or collagen membrane (CM); deproteinized bovine bone matrix (DBBM) showed a superior outcome among BRG. In combined furcation–angular defects, EMD appeared more beneficial than CM, and AIDR significantly promoted adjusted LFI and RLI. In conclusion, DBBM with EMD or CM was effective for FDR, and AIDR had a positive effect on FDR in the combined furcation–angular defect.
- Published
- 2022
- Full Text
- View/download PDF
4. Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration.
- Author
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Sanz, Mariano, Dahlin, Christer, Apatzidou, Danae, Artzi, Zvi, Bozic, Darko, Calciolari, Elena, De Bruyn, Hugo, Dommisch, Henrik, Donos, Nikos, Eickholz, Peter, Ellingsen, Jan E., Haugen, Håvard J., Herrera, David, Lambert, France, Layrolle, Pierre, Montero, Eduardo, Mustafa, Kamal, Omar, Omar, and Schliephake, Henning
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BIOMATERIALS , *GUIDED bone regeneration , *PERIODONTICS , *BONE grafting , *BIOLOGICAL membranes , *CELLULAR therapy , *BIOCOMPATIBILITY , *OSTEOINDUCTION , *STEM cells , *BIOMECHANICS , *BIOMEDICAL materials , *BLOOD platelets , *BONE marrow transplantation , *BONE morphogenetic proteins , *BONE regeneration , *BONE resorption , *DENTAL technology , *ENDOSCOPIC surgery , *PERIODONTITIS , *ADULT education workshops , *SURFACE properties , *PHYSIOLOGY ,FACIAL bones injuries - Abstract
Background and Aims: To review the regenerative technologies used in bone regeneration: bone grafts, barrier membranes, bioactive factors and cell therapies. Material and Methods: Four background review publications served to elaborate this consensus report. Results and Conclusions: Biomaterials used as bone grafts must meet specific requirements: biocompatibility, porosity, osteoconductivity, osteoinductivity, surface properties, biodegradability, mechanical properties, angiogenicity, handling and manufacturing processes. Currently used biomaterials have demonstrated advantages and limitations based on the fulfilment of these requirements. Similarly, membranes for guided bone regeneration (GBR) must fulfil specific properties and potential biological mechanisms to improve their clinical applicability. Pre‐clinical and clinical studies have evaluated the added effect of bone morphogenetic proteins (mainly BMP‐2) and autologous platelet concentrates (APCs) when used as bioactive agents to enhance bone regeneration. Three main approaches using cell therapies to enhance bone regeneration have been evaluated: (a) "minimally manipulated" whole tissue fractions; (b) ex vivo expanded "uncommitted" stem/progenitor cells; and (c) ex vivo expanded "committed" bone‐/periosteum‐derived cells. Based on the evidence from clinical trials, transplantation of cells, most commonly whole bone marrow aspirates (BMA) or bone marrow aspirate concentrations (BMAC), in combination with biomaterial scaffolds has demonstrated an additional effect in sinus augmentation and horizontal ridge augmentation, and comparable bone regeneration to autogenous bone in alveolar cleft repair. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
5. Regeneration of alveolar ridge defects. Consensus report of group 4 of the 15th European Workshop on Periodontology on Bone Regeneration.
- Author
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Jepsen, Søren, Schwarz, Frank, Cordaro, Luca, Derks, Jan, Hämmerle, Christoph H. F., Heitz‐Mayfield, Lisa J., Hernández‐Alfaro, Federico, Meijer, Henny J. A., Naenni, Nadja, Ortiz‐Vigón, Alberto, Pjetursson, Bjarni, Raghoebar, Gerry M., Renvert, Stefan, Rocchietta, Isabella, Roccuzzo, Mario, Sanz‐Sánchez, Ignacio, Simion, Massimo, Tomasi, Cristiano, Trombelli, Leonardo, and Urban, Istvan
- Subjects
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BONE regeneration , *BONE abnormalities , *ALVEOLAR process surgery , *PERIODONTICS , *BONE grafting , *DENTAL implants , *TREATMENT effectiveness , *PERI-implantitis , *MAXILLA surgery , *BONE resorption , *JAW diseases , *ORAL surgery , *PERIODONTITIS , *PLASTIC surgery , *DENTAL radiography , *ADULT education workshops , *DISEASE complications , *DISEASE risk factors ,SURGICAL complication risk factors - Abstract
Background and Aims: Bone augmentation procedures to enable dental implant placement are frequently performed. The remit of this working group was to evaluate the current evidence on the efficacy of regenerative measures for the reconstruction of alveolar ridge defects. Material and Methods: The discussions were based on four systematic reviews focusing on lateral bone augmentation with implant placement at a later stage, vertical bone augmentation, reconstructive treatment of peri‐implantitis associated defects, and long‐term results of lateral window sinus augmentation procedures. Results: A substantial body of evidence supports lateral bone augmentation prior to implant placement as a predictable procedure in order to gain sufficient ridge width for implant placement. Also, vertical ridge augmentation procedures were in many studies shown to be effective in treating deficient alveolar ridges to allow for dental implant placement. However, for both procedures the rate of associated complications was high. The adjunctive benefit of reconstructive measures for the treatment of peri‐implantitis‐related bone defects has only been assessed in a few RCTs. Meta‐analyses demonstrated a benefit with regard to radiographic bone gain but not for clinical outcomes. Lateral window sinus floor augmentation was shown to be a reliable procedure in the long term for the partially and fully edentulous maxilla. Conclusions: The evaluated bone augmentation procedures were proven to be effective for the reconstruction of alveolar ridge defects. However, some procedures are demanding and bear a higher risk for post‐operative complications. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
6. Efficacy of Guided Tissue Regeneration Using Frozen Radiation-Sterilized Allogenic Bone Graft as Bone Replacement Graft Compared with Deproteinized Bovine Bone Mineral in the Treatment of Periodontal Intra-Bony Defects: Randomized Controlled Trial
- Author
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Aniela Brodzikowska, Mariano Sanz, Bartłomiej Górski, and Marcin Szerszeń
- Subjects
guided tissue regeneration (GTR) ,allograft ,bone replacement graft ,periodontal regeneration ,General Medicine ,xenograft ,intra-bony defect ,periodontitis - Abstract
(1) Background: The aim of this study was to compare the clinical and radiographic outcomes of guided tissue regeneration (GTR) using two biomaterials as bone replacement grafts in the treatment of periodontal intra-bony defects. (2) Methods: Using a split-mouth design, 30 periodontal intra-bony defects were treated with either frozen radiation-sterilized allogenic bone grafts (FRSABG tests) or deproteinized bovine bone mineral (DBBM, controls) combined with a bioabsorbable collagen membrane in 15 patients. Clinical attachment level gains (CAL-G), probing pocket depth reductions (PPD-R), and radiographic changes in linear defect fill (LDF) were evaluated 12 months postoperatively. (3) Results: The CAL, PPD, and LDF values improved significantly in both groups 12 months after the surgery. However, in the test group, the PPD-R and LDF values were significantly higher compared to the controls (PPD-R 4.66 mm versus 3.57 mm, p = 0.0429; LDF 5.22 mm versus 4.33, p = 0.0478, respectively). Regression analysis showed that baseline CAL was a significant predictor for PPD-R (p = 0.0434), while the baseline radiographic angle was a predictor for CAL-G (p = 0.0026) and LDF (p = 0.064). (4) Conclusions: Both replacement grafts when used for GTR with a bioabsorbable collagen membrane yielded successful clinical benefits in teeth with deep intra-bony defects 12 months postoperatively. The use of FRSABG significantly enhanced PPD reduction and LDF.
- Published
- 2023
7. Surgical Treatment of Periodontal Diseases—a Review of Current Clinical Research
- Author
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Palaiologou, A. Archontia, Schiavo, Julie H., and Maney, Pooja
- Published
- 2019
- Full Text
- View/download PDF
8. Three-year results following regenerative periodontal surgery of advanced intrabony defects with enamel matrix derivative alone or combined with a synthetic bone graft.
- Author
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Hoffmann, Thomas, Al-Machot, Elyan, Meyle, Jörg, Jervøe-Storm, Pia-Merete, and Jepsen, Søren
- Subjects
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PERIODONTITIS , *PERIODONTITIS treatment , *HEALTH outcome assessment , *DENTAL enamel , *BONE grafting , *PATIENTS - Abstract
Objectives: This study aims to compare the clinical outcomes of a combination of enamel matrix derivatives (EMD) and a synthetic bone graft (biphasic calcium phosphate) with EMD alone in wide and deep one- and two-wall intrabony defects 36 months after treatment. Material and methods: Thirty patients with chronic periodontitis and one wide (≥ 2 mm) and deep (≥ 4 mm) intrabony defect had been recruited in three centres in Germany. During surgery, defects were randomly assigned to EMD/synthetic bone graft (SBG) (test) or EMD (control). Assessments at baseline, after 6, 12 and 36 months, included bone sounding, relative clinical attachment levels, probing pocket depths and recessions. Results: After 36 months, defects in both groups were significantly improved ( p < 0.001) with regard to defect fill, attachment gain and probing pocket reduction. In the EMD/SBG group, a mean defect fill of 2.6 mm (±1.7) was measured, and in the EMD group, the defect fill was 2.3 mm (±1.5). A mean gain in clinical attachment of 4.1 mm (±3.6) and 3.8 mm (±2.2) was observed in the test and in the control group, respectively. There were no statistically significant differences in any of the investigated parameters between the two treatment modalities. Conclusions: The clinical improvements of advanced intrabony defects obtained with both regenerative modalities could be maintained over a period of 3 years. The combination of EMD with SBG did not show any advantage compared to the use of EMD alone. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
9. Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration
- Author
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Mariano Sanz, Christer Dahlin, Danae Apatzidou, Zvi Artzi, Darko Bozic, Elena Calciolari, Hugo De Bruyn, Henrik Dommisch, Nikos Donos, Peter Eickholz, Jan E. Ellingsen, Håvard J. Haugen, David Herrera, France Lambert, Pierre Layrolle, Eduardo Montero, Kamal Mustafa, Omar Omar, and Henning Schliephake
- Subjects
Bone Regeneration ,Consensus ,Barrier membrane ,Biocompatible Materials ,Bone morphogenetic protein ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Progenitor cell ,Bone regeneration ,Bone Transplantation ,business.industry ,Biomaterial ,030206 dentistry ,Alveolar Ridge Augmentation ,barrier membrane ,bio-absorbable ,bioactive agent ,biomaterials ,bone regeneration ,bone replacement graft ,cell therapies ,guided bone regeneration ,osteoconductive ,osteoinductive ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Transplantation ,Guided Tissue Regeneration, Periodontal ,Periodontics ,business ,Whole Bone Marrow ,Biomedical engineering - Abstract
Background and Aims To review the regenerative technologies used in bone regeneration: bone grafts, barrier membranes, bioactive factors and cell therapies. Material and Methods Four background review publications served to elaborate this consensus report. Results and Conclusions Biomaterials used as bone grafts must meet specific requirements: biocompatibility, porosity, osteoconductivity, osteoinductivity, surface properties, biodegradability, mechanical properties, angiogenicity, handling and manufacturing processes. Currently used biomaterials have demonstrated advantages and limitations based on the fulfilment of these requirements. Similarly, membranes for guided bone regeneration (GBR ) must fulfil specific properties and potential biological mechanisms to improve their clinical applicability. Pre‐clinical and clinical studies have evaluated the added effect of bone morphogenetic proteins (mainly BMP ‐2) and autologous platelet concentrates (APC s) when used as bioactive agents to enhance bone regeneration. Three main approaches using cell therapies to enhance bone regeneration have been evaluated: (a) “minimally manipulated” whole tissue fractions; (b) ex vivo expanded “uncommitted” stem/progenitor cells; and (c) ex vivo expanded “committed” bone‐/periosteum‐derived cells. Based on the evidence from clinical trials, transplantation of cells, most commonly whole bone marrow aspirates (BMA ) or bone marrow aspirate concentrations (BMAC ), in combination with biomaterial scaffolds has demonstrated an additional effect in sinus augmentation and horizontal ridge augmentation, and comparable bone regeneration to autogenous bone in alveolar cleft repair.
- Published
- 2019
10. A multi-centre randomized controlled clinical trial on the treatment of intra-bony defects with enamel matrix derivatives/synthetic bone graft or enamel matrix derivatives alone: results after 12 months.
- Author
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Meyle, Joerg, Hoffmann, Thomas, Topoll, Heinz, Heinz, Bernd, Al-Machot, Eli, Jervøe-Storm, Pia-Merete, Meiß, Christian, Eickholz, Peter, and Jepsen, Sören
- Subjects
- *
BONE substitutes , *HYPOTHESIS , *ANALYSIS of variance , *BONE resorption , *BONE grafting , *CALIBRATION , *CLINICAL trials , *COMPUTER software , *DENTAL enamel , *LONGITUDINAL method , *MEDICAL cooperation , *RESEARCH , *STATISTICAL sampling , *DENTAL radiography , *U-statistics , *SAMPLE size (Statistics) , *DATA analysis , *STATISTICAL significance , *HUMAN research subjects , *CASE-control method , *PATIENT selection , *THERAPEUTICS - Abstract
Objectives: Comparison of the clinical and radiographic outcomes of a combination of enamel matrix derivatives (EMD) and a synthetic bone graft (EMD/SBG) with EMD alone in wide (≥2 mm) and deep (≥4 mm) one- and two- wall intra-bony defects 12 months after treatment. Materials and Methods: Seventy-three patients with chronic periodontitis and one wide (≥2 mm) and deep (≥4 mm) intra-bony defect were recruited in five centres in Germany. During surgery, defects were randomly assigned to EMD/SBG (test) or EMD (control). Assessments at baseline, after 6 and 12 months included bone sounding, attachment levels, probing pocket depths, bleeding on probing, and recessions. Changes in defect fill were recorded radiographically. Results: Both treatment modalities led to significant clinical improvements. In the EMD/SBG group a mean defect fill of 2.7 ± 1.9mm was calculated, in the EMD group the defect fill was 2.8 ± 1.6 mm. A mean gain in clinical attachment of 1.7 ± 2.1mm in the test group and 1.9 ± 1.7mm in the control group after 1 year was observed. Radiographic analysis confirmed for both groups that deeper defects were associated with greater defect fill. Conclusion: The results show comparable clinical and radiographic outcomes following both treatment modalities 12 months after treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
11. Clinical outcomes after treatment of intra-bony defects with an EMD/synthetic bone graft or EMD alone: a multicentre randomized-controlled clinical trial.
- Author
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Jepsen, S., Topoll, H., Rengers, H., Heinz, B., Teich, M., Hoffmann, T., Al-Machot, E., Meyle, J., and Jervøe-Storm, P.-M.
- Subjects
- *
PERIODONTITIS , *MICROSURGERY , *WOUND care , *DENTAL fillings , *PERIODONTICS , *DENTISTRY - Abstract
Objectives: Comparison of the outcomes of a combination of an enamel matrix derivative and a synthetic bone graft (EMD/SBC) with EMD alone in wide intra-bony defects. Material and Methods: Seventy-three patients with chronic periodontitis were recruited in five centres in Germany. All patients had one wide intra-bony defect of ⩾4 mm. Surgical procedures involved microsurgical technique and the modified papilla preservation flap. After debridement, defects were randomly assigned to EMD/SBC (test) or EMD (control). Assessments at baseline and after 6 months included bone sounding, attachment levels, probing pocket depths, bleeding on probing and recessions. Early wound-healing, adverse effects and patients' perceptions were also recorded. Results: Both treatment modalities led to significant clinical improvements. Change in bone fill 6 months after surgery was 2.0 mm (± 2.1) in the test group and 2.1 mm (± 1.2) in the control group. A gain in clinical attachment of 1.3 mm (± 1.8) in the test group and 1.8 mm (± 1.6) in the control group was observed. One week after surgery, primary closure was maintained in 95% of the test sites and 100% of the control sites. No differences in patients' perceptions were found. Conclusion: The results of the present study showed similar clinical outcomes following both treatment modalities. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
12. Guided tissue regeneration/deproteinized bovine bone mineral or papilla preservation flaps alone for treatment of intrabony defects. II: radiographic predictors and outcomes.
- Author
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Liñares, Antonio, Cortellini, Pierpaolo, Lang, Niklaus P., Suvan, Jean, and Tonetti, Maurizio S.
- Subjects
- *
GUIDED tissue regeneration , *ORAL diseases , *PERIODONTITIS , *SURGICAL flaps , *MULTIVARIATE analysis , *CLINICAL trials , *DENTAL radiography - Abstract
Objectives: This study reports the secondary analysis of a randomized-controlled clinical trial designed to assess the efficacy of deproteinized bovine mineral and a collagen membrane in the treatment of intrabony defects. The specific aims of this report are (1) to analyse the radiographic bone changes 1 year after therapy and (2) to assess the association between radiographic defect angle and treatment outcomes. Materials and Methods: Baseline and 12-month radiographs were collected from 120 patients with advanced chronic periodontitis from 10 centres in seven countries as part of a multi-centre clinical trial. All patients had at least one intrabony defect ⩾3 mm in depth. The treatment consisted of simplified or modified papilla preservation flaps to access the defect. After debridement of the area, a deproteinized bovine mineral and a collagen membrane were applied in the test subjects, and omitted in the controls. Main outcome measures were radiographic bone fill and defect resolution 1 year after surgery. Results: One hundred and twenty pairs of radiographs were obtained, of which 110 pairs were measurable (57 tests and 53 controls). One year after treatment, radiographic resolution of the intrabony component was significantly higher in the test group (3.2±1.7 mm) when compared with the controls (1.7±1.9 mm). Multivariate analysis indicated that the treatment and the baseline radiographic depth of the intrabony defect significantly influenced the radiographic bone fill of the intrabony defect 1 year following treatment. The percentage of resolution of the defect was influenced by the treatment provided and the baseline plaque score. The baseline radiographic defect angle did not show a significant impact on the clinical and radiographic outcomes. Conclusions: Regenerative periodontal surgery with a deproteinized bovine bone mineral and a collagen membrane offered additional benefits in terms of radiographic resolution of the intrabony defect and predictability of outcomes with respect to papilla preservation flaps alone. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
13. Comparison of Bone Grafting Materials in Human Extraction Sockets: Clinical, Histologic, and Histomorphometric Evaluations.
- Author
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Thompson, Dennis M., Rohrer, Michael D., and Prasad, Hari S.
- Subjects
BONE grafting ,DENTAL implants ,BONE growth ,DENTAL extraction ,CIGARETTE smokers ,LONGITUDINAL method ,EQUIPMENT & supplies - Abstract
Copyright of Implant Dentistry is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2006
- Full Text
- View/download PDF
14. Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone.
- Author
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Tonetti, Maurizio S., Cortellini, Pierpaolo, Lang, Niklaus P., Suvan, Jean E., Adriaens, Patrick, Dubravec, Dominik, Fonzar, Alberto, Fourmousis, Ioannis, Rasperini, Giulio, Rossi, Roberto, Silvestri, Maurizio, Topoll, Heinz, Wallkamm, Beat, and Zybutz, Michael
- Subjects
- *
PERIODONTAL pockets , *GUIDED tissue regeneration , *CLINICAL trials , *SURGICAL flaps , *PERIODONTITIS , *HEALTH outcome assessment - Abstract
Tonetti MS, Cortellini P, Lang NP, Suvan JE, Adriaens P, Dubravec D, Fonzar A, Fourmousis I, Rasperini G, Rossi R, Silvestri M, Topoll H, Wallkamm B, Zybutz M: Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial. J Clin Periodontol 2004; 31: 770–776. doi: 10.1111/j.1600-051X.2004.00562.x.© Blackwell Munksgaard, 2004. This prospective multicenter randomized controlled clinical trial was designed to compare the clinical outcomes of papilla preservation flap surgery with or without the application of a guided tissue regeneration (GTR)/bone replacement material. One hundred and twenty-four patients with advanced chronic periodontitis were recruited in 10 centers in seven countries. All patients had at least one intrabony defect of ⩾3 mm. The surgical procedures included access for root instrumentation using either the simplified or the modified papilla preservation flap in order to obtain optimal tissue adaptation and primary closure. After debridement, the regenerative material was applied in the test subjects, and omitted in the controls. At baseline and 1 year following the interventions, clinical attachment levels (CALs), probing pocket depths (PPDs), recession, full-mouth plaque scores and full-mouth bleeding scores (FMBS) were assessed. One year after treatment, the test defects gained 3.3±1.7 mm of CAL, while the control defects yielded a significantly lower CAL gain of 2.5±1.5 mm. Pocket reduction was also significantly higher in the test group (3.7±1.8 mm) when compared with the controls (3.2±1.5 mm). A multivariate analysis indicated that the treatment, the clinical centers, baseline PPD and baseline FMBS significantly influenced CAL gains. Odds ratios (ORs) of achieving above-median CAL gains were significantly improved by the test procedure (OR=2.6, 95% CI 1.2–5.4) and by starting with deeper PPD (OR=1.7, 1.3–2.2) but were decreased by receiving treatment at the worst-performing clinical center (OR=0.9, 0.76–0.99). The results of this trial indicated that regenerative periodontal surgery with a GTR/bone replacement material offers an additional benefit in terms of CAL gains, PPD reductions and predictability of outcomes with respect to papilla preservation flaps alone. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
15. Regeneration of alveolar ridge defects. Consensus report of group 4 of the 15th European Workshop on Periodontology on Bone Regeneration
- Author
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Mario Roccuzzo, Cristiano Tomasi, Søren Jepsen, Massimo Simion, Frank Schwarz, Jan Derks, Ignacio Sanz-Sánchez, Federico Hernández-Alfaro, Stefan Renvert, Nadja Naenni, Henny J. A. Meijer, Gerry M. Raghoebar, Lisa J. A. Heitz-Mayfield, Leonardo Trombelli, Isabella Rocchietta, Alberto Ortiz-Vigón, Luca Cordaro, Istvan A. Urban, Christoph H. F. Hämmerle, Bjarni E. Pjetursson, Man, Biomaterials and Microbes (MBM), Personalized Healthcare Technology (PHT), University of Zurich, and Jepsen, Søren
- Subjects
Peri-implantitis ,Sinus Floor Augmentation ,Consensus ,bone replacement graft ,sinus floor ,complications ,elevation ,medicine.medical_treatment ,Dentistry ,610 Medicine & health ,consensus statement ,bone augmentation ,10068 Clinic of Reconstructive Dentistry ,03 medical and health sciences ,0302 clinical medicine ,bone regeneration ,dental implants ,Alveolar Process ,Alveolar ridge ,Medicine ,030212 general & internal medicine ,Bone regeneration ,Dental implant ,Sinus (anatomy) ,Bone Transplantation ,Augmentation procedure ,business.industry ,Dental Implantation, Endosseous ,ridge augmentation ,Alveolar Ridge Augmentation ,030206 dentistry ,Periodontology ,adverse events ,medicine.anatomical_structure ,PERI-IMPLANT DISEASES ,barrier membrane ,guided bone regeneration ,Periodontics ,business ,3506 Periodontics ,biomaterials ,peri-implantitis - Abstract
BACKGROUND AND AIMS: Bone augmentation procedures to enable dental implant placement are frequently performed. The remit of this working group was to evaluate the current evidence on the efficacy of regenerative measures for the reconstruction of alveolar ridge defects.MATERIAL AND METHODS: The discussions were based on four systematic reviews focusing on lateral bone augmentation with implant placement at a later stage, vertical bone augmentation, reconstructive treatment of peri-implantitis associated defects, and long-term results of lateral window sinus augmentation procedures.RESULTS: A substantial body of evidence supports lateral bone augmentation prior to implant placement as a predictable procedure in order to gain sufficient ridge width for implant placement. Also, vertical ridge augmentation procedures were in many studies shown to be effective in treating deficient alveolar ridges to allow for dental implant placement. However, for both procedures the rate of associated complications was high. The adjunctive benefit of reconstructive measures for the treatment of peri-implantitis-related bone defects has only been assessed in a few RCTs. Meta-analyses demonstrated a benefit with regard to radiographic bone gain but not for clinical outcomes. Lateral window sinus floor augmentation was shown to be a reliable procedure in the long-term for the partially and fully edentulous maxilla.CONCLUSIONS: The evaluated bone augmentation procedures were proven to be effective for the reconstruction of alveolar ridge defects. However, some procedures are demanding and bear a higher risk for postoperative complications. This article is protected by copyright. All rights reserved.
- Published
- 2019
16. Radiographic Evaluation of Regeneration Strategies for the Treatment of Advanced Mandibular Furcation Defects: A Retrospective Study.
- Author
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Huang HL, Ma YH, Tu CC, and Chang PC
- Abstract
Teeth with furcation involvement (FI) present a higher risk of loss and are difficult to maintain. This study evaluated the efficacy of furcation defect regeneration (FDR) as a regeneration strategy. Pre-operative and 6-month postoperative radiographs were collected from patients receiving regeneration therapy for mandibular teeth with degree II and early degree III FI. The linear furcation involvement (LFI), ratio of LFI (RLI), LFI and RLI adjusted bythe alveolar bone crest (ABC), and radiographic intensity were assessed. The effects of demographic characteristics, regeneration treatment strategies, the relationship between furcation and ABC, and adjacent intrabony defect regeneration (AIDR) were evaluated using a generalized linear model and logistic regression. The results demonstrated that 1.5 mm adjusted LFI and 40% adjusted RLI were achieved in both pure furcation defects and combined furcation-angular defects by the combination of bone replacement grafts (BRG) and enamel matrix derivatives (EMD) or collagen membrane (CM); deproteinized bovine bone matrix (DBBM) showed a superior outcome among BRG. In combined furcation-angular defects, EMD appeared more beneficial than CM, and AIDR significantly promoted adjusted LFI and RLI. In conclusion, DBBM with EMD or CM was effective for FDR, and AIDR had a positive effect on FDR in the combined furcation-angular defect.
- Published
- 2022
- Full Text
- View/download PDF
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