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2 results on '"cicatricialalopecia"'

1. Inflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans

Author

Alexia Eyraud, Brigitte Milpied, Denis Thiolat, Anne-Sophie Darrigade, Katia Boniface, Alain Taïeb, and Julien Seneschal

Subjects
folliculitisdecalvans, cicatricialalopecia, inflammasomeactivation, treatment, immunomodulatingtherapy, Dermatology, RL1-803
Abstract

Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and included 17 patients with FD with available biopsies. Disease activity (stable vs. active) was defined clinically and histologically. Immunostaining was performed using antibodies directed against NALP1, NALP3, IL-1β, IL-8, and MxA on FD skin biopsies. Results were compared with normal controls and lichen planopilaris. Eleven patients had active disease and 6 had stable disease. NALP1, NALP3, and IL-1β expression were significantly increased in hair follicles in FD compared with controls and lichen planopilaris. This study highlights the predominant immune signal associated with inflammasome activation in FD, suggesting the use of IL-1β blockade in FD.

Published
2018
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2. Inflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans

Author

Brigitte Milpied, Alain Taïeb, Anne-Sophie Darrigade, Katia Boniface, Denis Thiolat, Julien Seneschal, and Alexia Eyraud

Subjects
Male, Myxovirus Resistance Proteins, Pathology, Inflammasomes, Biopsy, Interleukin-1beta, NALP3, Scarring alopecia, Pathogenesis, 030207 dermatology & venereal diseases, 0302 clinical medicine, lcsh:Dermatology, Medicine, treatment, biology, medicine.diagnostic_test, inflammasomeactivation, Interleukin, Inflammasome, General Medicine, Middle Aged, Immunohistochemistry, immunomodulatingtherapy, 030220 oncology & carcinogenesis, Female, Folliculitis decalvans, Hair Follicle, medicine.drug, Adult, medicine.medical_specialty, NLR Proteins, Dermatology, 03 medical and health sciences, Young Adult, Immune system, NLR Family, Pyrin Domain-Containing 3 Protein, Humans, Adaptor Proteins, Signal Transducing, Aged, Retrospective Studies, Folliculitis, Scalp, business.industry, Interleukin-8, folliculitisdecalvans, lcsh:RL1-803, medicine.disease, Scalp Dermatoses, cicatricialalopecia, biology.protein, business, Apoptosis Regulatory Proteins, Biomarkers
Abstract

Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and included 17 patients with FD with available biopsies. Disease activity (stable vs. active) was defined clinically and histologically. Immunostaining was performed using antibodies directed against NALP1, NALP3, IL-1β, IL-8, and MxA on FD skin biopsies. Results were compared with normal controls and lichen planopilaris. Eleven patients had active disease and 6 had stable disease. NALP1, NALP3, and IL-1β expression were significantly increased in hair follicles in FD compared with controls and lichen planopilaris. This study highlights the predominant immune signal associated with inflammasome activation in FD, suggesting the use of IL-1β blockade in FD.

Published
2018

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