9 results on '"cribado sistemático"'
Search Results
2. Nutrition screening tools for risk of malnutrition among hospitalized patients: A protocol for systematic review and meta analysis
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Joan De Pedro-Gomez De Pedro-Gomez, Sergio Fresneda, Enrique Castro-Sánchez, Aina Yañez, Regina Cortes, and Miquel Bennasar-Veny
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Adult ,medicine.medical_specialty ,metanálisis como asunto ,Hospitalized patients ,humanos ,cribado sistemático ,MEDLINE ,CINAHL ,RT ,03 medical and health sciences ,0302 clinical medicine ,Meta-Analysis as Topic ,systematic review ,RA0421 ,medicine ,Humans ,Mass Screening ,hospitalización ,030212 general & internal medicine ,Protocol (science) ,business.industry ,screening ,Malnutrition ,General Medicine ,Grey literature ,adulto ,medicine.disease ,desnutrición ,Hospitalization ,meta-analysis ,Nutrition Assessment ,030220 oncology & carcinogenesis ,Meta-analysis ,Family medicine ,evaluación nutricional ,business ,RC - Abstract
Background: Malnutrition is a clinical problem with a high prevalence in hospitalized adult patients. Many nutritional screening tools have been developed but there is no consensus on which 1 is more useful. The purpose of this review protocol is to provide an overview of which nutritional screening tool is most valid to identify malnutritional risk in hospitalized adult patients and to analyze the sensitivity and specificity of the different tools. Methods: The protocol of this systematic review and meta-analysis was registered on the INPLASY website (https://inplasy.com/inplasy-2020-9-0028/)) and INPLASY registration number is INPLASY202090028. We will perform a systematic literature search of main databases: PubMed, EMBASE, CINAHL and Web of Science and the Cochrane database. Also, grey literature will be search. Peer-reviewed studies published in English, Portuguese or Spanish language will be selected. Screening of titles, abstract and full text will be assessed for eligibility by 2 independent blinded reviewers and any discrepancies will be resolved via consensus. After screening the studies, a meta-analysis will be conducted, if it is possible. Results: Results from this systematic review will help health professionals to identify malnutrition in hospitalized patients and to make decisions to prevent or treat it as well as provide new clues to researchers. Conclusion: Our systematic review will provide aknowledge about the most valid malnutrition risk screening tool in hospitalized adult patients., This study was funded by the College of Nursing of the Balearic Islands within the framework of Grants for Research Projects (grant Number COIBA-PI2018/0264). This project has been funded by the Carlos III Health Institute (Ministry of Economy and Competitiveness, Spain) through the Network for Prevention and Health Promotion in Primary Care (redIAPP, RD16/0007/008), and by European Union ERDF funds.
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- 2020
3. Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches
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Rosivaldo S. Borges, Luciane B. Silva, Jorddy Neves Cruz, Sirlene S. B. Ota, Kelton L. B. Santos, Franco Henrique Andrade Leite, Moysés Fagundes de Araújo Neto, Carlos Henrique Tomich de Paula da Silva, Ryan da Silva Ramos, Joaquín M. Campos, Cleison C. Lobato, Cleydson B. R. Santos, [Dos Santos,KLB, Cruz,JN, Silva,LB, Ramos,RS, Lobato,CC, Borges,RS, Santos,CBR] Laboratory of Modeling and Computational Chemistry, Department of Biological and Health Sciences, Federal University of Amapá, Macapá-AP, Brazil. [Dos Santos,KLB, Ota,SSB, Santos,CBR] Nucleus of Studies and Selection of Bioactive Molecules, Institute of Health Sciences, Federal University of Pará, Belém-PA, Brazil. [Neto,MFA, Leite,FHA, and ] Laboratory of Molecular Modeling, State University of Feira de Santana, Feira de Santana, Bahia, Brazil. [da SIlva,CHTP] Computational Laboratory of Pharmaceutical Chemistry, University of São Paulo, Ribeirão Preto-SP, Brazil. [da SIlva,CHTP] Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP, Brazil. [Campos,JM] Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, Institute of Biosanitary, Research ibs. Granada, University of Granada, Granada, Spain.
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Adenosine ,Molecular model ,Pharmaceutical Science ,Quantitative Structure-Activity Relationship ,Relación estructura-actividad cuantitativa ,Ligands ,Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Laboratory Chemicals::Ligands [Medical Subject Headings] ,Analytical Chemistry ,Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Structure-Activity Relationship::Quantitative Structure-Activity Relationship [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Molecular dynamics ,Simulación del acoplamiento molecular ,Drug Discovery ,Agonistas del receptor de adenosina A2 ,0303 health sciences ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Molecular::Molecular Dynamics Simulation [Medical Subject Headings] ,Chemistry ,Biological activity ,Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Purine Nucleosides::Adenosine [Medical Subject Headings] ,Molecular Docking Simulation ,INDÚSTRIA FARMACÊUTICA ,Cribado sistemático ,Chemistry (miscellaneous) ,Molecular Medicine ,BindingDB ,Pharmacophore ,Virtual screening ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Purinergic::Receptors, Purinergic P1::Receptors, Adenosine A2 [Medical Subject Headings] ,Quantitative structure–activity relationship ,Adenosine A2 Receptor Agonists ,030303 biophysics ,Computational biology ,Adenosine A2A receptor ,Molecular Dynamics Simulation ,Article ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Molecular::Molecular Docking Simulation [Medical Subject Headings] ,Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Purinergic Agents::Purinergic Agonists::Purinergic P1 Receptor Agonists::Adenosine A2 Receptor Agonists [Medical Subject Headings] ,lcsh:QD241-441 ,03 medical and health sciences ,lcsh:Organic chemistry ,Molecular insight ,Humans ,Physical and Theoretical Chemistry ,030304 developmental biology ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Purinergic::Receptors, Purinergic P1 [Medical Subject Headings] ,adenosine A2A receptor ,Receptors, Adenosine A2 ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Statistical::Linear Models [Medical Subject Headings] ,Organic Chemistry ,virtual screening ,Simulación de Dinámica Molecular ,Docking (molecular) ,molecular insight - Abstract
Adenosine Receptor Type 2A (A2AAR) plays a role in important processes, such as anti-inflammatory ones. In this way, the present work aimed to search for compounds by pharmacophore-based virtual screening. The pharmacokinetic/toxicological profiles of the compounds, as well as a robust QSAR, predicted the binding modes via molecular docking. Finally, we used molecular dynamics to investigate the stability of interactions from ligand-A2AAR. For the search for A2AAR agonists, the UK-432097 and a set of 20 compounds available in the BindingDB database were studied. These compounds were used to generate pharmacophore models. Molecular properties were used for construction of the QSAR model by multiple linear regression for the prediction of biological activity. The best pharmacophore model was used by searching for commercial compounds in databases and the resulting compounds from the pharmacophore-based virtual screening were applied to the QSAR. Two compounds had promising activity due to their satisfactory pharmacokinetic/toxicological profiles and predictions via QSAR (Diverset 10002403 pEC50 = 7.54407; ZINC04257548 pEC50 = 7.38310). Moreover, they had satisfactory docking and molecular dynamics results compared to those obtained for Regadenoson (Lexiscan®), used as the positive control. These compounds can be used in biological assays (in vitro and in vivo) in order to confirm the potential activity agonist to A2AAR, PROPESP/UFPA, National Council for Scientific and Technological Development (CNPq)
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- 2020
4. Prevalence of healthy lifestyles against cancer in Spanish women
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Adela Castelló, Carmen Vidal, Carmen Sánchez-Contador, Carmen Santamariña, Carmen Pedraz-Pingarrón, Nuria Aragonés, Dolores Salas, Nieves Ascunce, Marina Pollán, Virginia Lope, María José Toribio, Beatriz Pérez-Gómez, Pilar Moreo, Ministerio de Sanidad y Política Social (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), and Federación Española de Cáncer de Mama
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0301 basic medicine ,consumo de alcohol ,cumplimiento del paciente ,humanos ,Breastfeeding ,lcsh:Medicine ,ejercicio físico ,Cancer prevention ,Body Mass Index ,Breast cancer screening ,0302 clinical medicine ,Risk Factors ,Neoplasms ,Prevalence ,Medicine ,Mass Screening ,lcsh:Science ,Early Detection of Cancer ,mediana edad ,neoplasias ,education.field_of_study ,anciano ,Multidisciplinary ,medicine.diagnostic_test ,dieta ,Incidence (epidemiology) ,Smoking ,prevalencia ,Middle Aged ,autoinforme ,detección precoz del cáncer ,Transgender hormone therapy ,Female ,Alcohol Drinking ,Population ,cribado sistemático ,Article ,03 medical and health sciences ,Cancer epidemiology ,Breast cancer ,Environmental health ,ingesta energética ,Humans ,factores de riesgo ,Healthy Lifestyle ,education ,Exercise ,Aged ,business.industry ,lcsh:R ,Body Weight ,índice de masa corporal ,peso corporal ,hábito de fumar ,medicine.disease ,Diet ,030104 developmental biology ,Cross-Sectional Studies ,Spain ,Patient Compliance ,lcsh:Q ,Self Report ,business ,Energy Intake ,Breast feeding ,030217 neurology & neurosurgery ,estudios transversales - Abstract
Modifying behavior towards healthier lifestyles could prevent a significant number of malignant tumors. We evaluated the prevalence of healthy habits against cancer in Spanish women free of this disease, taking as a reference the recommendations for cancer prevention included in the European Code Against Cancer (ECAC), and we explored the characteristics associated with it. Our population comprised 3,584 women recruited in a population-based cross-sectional study carried out in 7 breast cancer screening programs. Information was directly surveyed and used to calculate a score based on ECAC recommendations referred to bodyweight, physical activity, diet, breastfeeding, tobacco, alcohol and hormone replacement therapy use. The degree of adherence was estimated with a score that evaluated null (0 points), partial (0.5 points) and full adherence (1 point) of each specific recommendation. Associations were explored using binary and ordinal logistic regression models. The median score was 5.7 out of 9 points. Recommendations with lower adherence were those related to intake of red/processed meat and foods high in salt (23% of total adherence), physical activity (24%) and body weight (29%), and recommendations with greater adherence where those related to hormone replacement therapy use (91%), vegetable intake (84%), alcohol (83%) and tobacco (61%). Overall adherence was better among older women, parous women, and in those living in rural areas, and worse among women with higher caloric intake. These recommendations should be evaluated periodically. Screening programs can be an appropriate place to disseminate this information., This study was supported by the Spanish Public Health Research Fund (FIS PI060386 & PS09/0790); by the Spanish Ministry of Health, Social Policy and Equality (EC11-273), by the Carlos III Institute of Health (ISCIII) (AESI PI15CIII/00013); by the Spanish Ministry of Economy and Competitiveness, Juan de la Cierva de Incorporacion grant (IJCI-2014-20900); by the EPY 1306/06 Collaboration Agreement between Astra-Zeneca and the Carlos III Institute of Health; and a grant from the Spanish Federation of Breast Cancer patients (FECMA EPY 1169/10). The authors wish to thank the participants in the DDM-Spain study for their contribution to breast cancer research.
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- 2019
5. Accuracy of online survey assessment of mental disorders and suicidal thoughts and behaviors in Spanish university students. Results of the WHO World Mental Health- International College Student initiative
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Ballester, Laura, Alayo, Itxaso, Vilagut, Gemma, Almenara, Jose, Isabel Cebria, Ana, Echeburua, Enrique, Gabilondo, Andrea, Gili, Margalida, Lagares, Carolina, Antonio Piqueras, Jose, Roca, Miquel, Soto-Sanz, Victoria, Jesus Blasco, Maria, Castellvi, Pere, Forero, Carlos G., Bruffaerts, Ronny, Mortier, Philippe, Auerbach, Randy P., Nock, Matthew K., Sampson, Nancy, Kessler, Ronald C., Alonso, Jordi, UNIVERSAL Study Grp, and Biomedicina, Biotecnología y Salud Pública
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Male ,Diagnóstico clínico ,Social Sciences ,Mental disorders ,Anxiety ,Global Health ,neuropsychiatric interview mini ,0302 clinical medicine ,Surveys and Questionnaires ,evaluación de riesgos ,Psychology ,Estudiants universitaris -- Salut mental ,estudios de cohortes ,Suicidal ideation ,Salut mental ,psychiatric-disorder ,Depression ,adulto ,adulto joven ,Suicide ,Mental illness ,Physical Sciences ,Medicine ,Science & Technology - Other Topics ,Estudiants universitaris -- Conducta suïcida ,Generalized anxiety disorder ,Universities ,Science ,cribado sistemático ,education ,universidades ,Neuropsychiatric Disorders ,diagnostic-tests ,World Health Organization ,Risk Assessment ,03 medical and health sciences ,Humans ,Students ,1st onset ,Mass screening ,Survey Research ,Science & Technology ,Mood Disorders ,Biology and Life Sciences ,medicine.disease ,Diagnòstic clínic ,030227 psychiatry ,Mood disorders ,Depressió ,Mathematics ,validity ,Emotions ,humanos ,College students -- Mental health ,adolescente ,Surveys ,Cohort Studies ,sistemas en línea ,screening scales ,Depresión ,Medicine and Health Sciences ,Mass Screening ,ideación suicida ,030212 general & internal medicine ,Major depressive episode ,Multidisciplinary ,Applied Mathematics ,Simulation and Modeling ,face-to-face ,Clinical diagnosis ,Diagnostic and Statistical Manual of Mental Disorders ,Multidisciplinary Sciences ,Behavioral disorders ,Research Design ,Trastornos mentales ,Female ,Mental health ,medicine.symptom ,Algorithms ,Research Article ,Clinical psychology ,Adult ,Adolescent ,Models, Psychological ,Research and Analysis Methods ,Neuroses ,Online Systems ,Suicidal Ideation ,Salud mental ,Young Adult ,algoritmos ,Mental Health and Psychiatry ,College students -- Suicidal behavior ,medicine ,business.industry ,Panic disorder ,global burden ,dsm-iv ,Diagnostic medicine ,Hypomania ,Trastorns mentals ,estudiantes ,business ,Malalties mentals ,Anxiety disorders - Abstract
Objective To assess the accuracy of WMH-ICS online screening scales for evaluating four common mental disorders (Major Depressive Episode[MDE], Mania/Hypomania[M/H], Panic Disorder[PD], Generalized Anxiety Disorder[GAD]) and suicidal thoughts and behaviors[STB] used in the UNIVERSAL project. Methods Clinical diagnostic reappraisal was carried out on a subsample of the UNIVERSAL project, a longitudinal online survey of first year Spanish students (18-24 years old), part of the WHO World Mental Health-International College Student (WMH-ICS) initiative. Lifetime and 12month prevalence of MDE, M/H, PD, GAD and STB were assessed with the Composite International Diagnostic Interview-Screening Scales [CIDI-SC], the Self-Injurious Thoughts and Behaviors Interview [SITBI] and the Columbia-Suicide Severity Rating Scale [C-SSRS]. Trained clinical psychologists, blinded to responses in the initial survey, administered via telephone the Mini-International Neuropsychiatric Interview [MINI]. Measures of diagnostic accuracy and McNemar chi(2) test were calculated. Sensitivity analyses were conducted to maximize diagnostic capacity. Results A total of 287 students were included in the clinical reappraisal study. For 12-month and lifetime mood disorders, sensitivity/specificity were 67%/88.6% and 65%/73.3%, respectively. For 12-month and lifetime anxiety disorders, these were 76.8%/86.5% and 59.6%/71.1%, and for 12-month and lifetime STB, 75.9%/94.8% and 87.2%/86.3%. For 12-month and lifetime mood disorders, anxiety disorders and STB, positive predictive values were in the range of 18.1-55.1% and negative predictive values 90.2-99.0%; likelihood ratios positive were in the range of 2.1-14.6 and likelihood ratios negative 0.1-0.6. All outcomes showed adequate areas under the curve [AUCs] (AUC> 0.7), except M/H and PD (AUC = 0.6). Post hoc analyses to select optimal diagnostic thresholds led to improved concordance for all diagnoses (AUCs> 0.8). Conclusion The WMS-ICS survey showed reasonable concordance with the MINI telephone interviews performed by mental health professionals, when utilizing optimized cut-off scores. The current study provides initial evidence that the WMS-ICS survey might be useful for screening purposes., This project was supported by: Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III FEDER (PI13/00343); Ministerio de Sanidad, Servicios Sociales e Igualdad, Plan Nacional Sobre Drogas PNSD (exp.2015I015); and from the DIUE of the Generalitat de Catalunya (2017SGR452). L. Ballester was supported by FPU grant (FPU15/05728); M. J. Blasco was supported byRio Hortega grant (CM14/00125); P. Castellvi and P. Mortier were supported by a Sara Borrell grant (CD12/00440, and CD18/00049, resp.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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- 2019
6. Hospital Epidemics Tracker (HEpiTracker): Description and pilot study of a mobile app to track COVID-19 in hospital workers
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Aurelio Morales, Josep Muncunill, Alberto Fernández-Villar, Álvaro de Astorza, Julio Ancochea, Bernardino Alcázar-Navarrete, Carlos Catalina, Borja G. Cosío, Marcos Maroto, Sara Lumbreras, José María Alzaga, Eloy Ferreras, Celia de Lara, Carlos Alberto Valdivia, Xavier Basagaña, David Gómez Quilón, Luis Pérez de Llano, Dolors Carnicer-Pont, Esteve Fernández, Cecilia Soriano, Lorena Vega-Piris, Joan B. Soriano, Arturo García, María Lobo, Carlos Del Rio-Bermudez, UAM. Departamento de Medicina, and Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)
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Male ,Aplicacions mòbils ,020205 medical informatics ,Health Status ,humanos ,coronavirus ,epidemias ,Pilot Projects ,pandemias ,02 engineering and technology ,Body Temperature ,0302 clinical medicine ,Pandemic ,0202 electrical engineering, electronic engineering, information engineering ,Mass Screening ,Medicine ,030212 general & internal medicine ,app ,mediana edad ,Workers ,Surveillance ,proyectos piloto ,e-medicine ,Mobile apps ,estado de salud ,Middle Aged ,adulto ,Mobile Applications ,Telemedicine ,Hospitals ,Test (assessment) ,Population Surveillance ,surveillance ,language ,Female ,aplicaciones en aparatos electrónicos portátiles ,Public aspects of medicine ,RA1-1270 ,Coronavirus Infections ,infecciones por Coronavirus ,telemedicina ,Adult ,medicine.medical_specialty ,Monitoring ,Coronavirus disease 2019 (COVID-19) ,Medicina ,Pneumonia, Viral ,cribado sistemático ,MEDLINE ,Health Informatics ,Context (language use) ,Disclosure ,temperatura corporal ,Betacoronavirus ,03 medical and health sciences ,divulgación ,E-medicine ,vigilancia de la población ,Humans ,Epidemics ,Personal ,Pandemics ,Original Paper ,SARS-CoV-2 ,business.industry ,Public Health, Environmental and Occupational Health ,COVID-19 ,neumonía ,Pneumonia ,language.human_language ,Coronavirus ,Personnel, Hospital ,monitoring ,Spain ,Family medicine ,Symptoms ,symptoms ,Portuguese ,App ,business - Abstract
Background: Hospital workers have been the most frequently and severely affected professional group during the COVID-19 pandemic, and have a big impact on transmission. In this context, innovative tools are required to measure the symptoms compatible with COVID-19, the spread of infection, and testing capabilities within hospitals in real time. Objective: We aimed to develop and test an effective and user-friendly tool to identify and track symptoms compatible with COVID-19 in hospital workers. Methods: We developed and pilot tested Hospital Epidemics Tracker (HEpiTracker), a newly designed app to track the spread of COVID-19 among hospital workers. Hospital staff in 9 hospital centers across 5 Spanish regions (Andalusia, Balearics, Catalonia, Galicia, and Madrid) were invited to download the app on their phones and to register their daily body temperature, COVID-19–compatible symptoms, and general health score, as well as any polymerase chain reaction and serological test results. Results: A total of 477 hospital staff participated in the study between April 8 and June 2, 2020. Of note, both health-related (n=329) and non–health-related (n=148) professionals participated in the study; over two-thirds of participants (68.8%) were health workers (43.4% physicians and 25.4% nurses), while the proportion of non–health-related workers by center ranged from 40% to 85%. Most participants were female (n=323, 67.5%), with a mean age of 45.4 years (SD 10.6). Regarding smoking habits, 13.0% and 34.2% of participants were current or former smokers, respectively. The daily reporting of symptoms was highly variable across participating hospitals; although we observed a decline in adherence after an initial participation peak in some hospitals, other sites were characterized by low participation rates throughout the study period. Conclusions: HEpiTracker is an already available tool to monitor COVID-19 and other infectious diseases in hospital workers. This tool has already been tested in real conditions. HEpiTracker is available in Spanish, Portuguese, and English. It has the potential to become a customized asset to be used in future COVID-19 pandemic waves and other environments., This project received unconditional help from Chiesi España SAU
- Published
- 2020
7. Barriers to and discourses about breast cancer prevention among immigrant women in Spain: a qualitative study
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Magdalena Esteva, Aina Mascaro, Maria de Lluc Bennasar, Clara Vidal, Carmen Sánchez-Contador, Barbara Villalonga, and Sebastià March
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Health Knowledge, Attitudes, Practice ,humanos ,Immigration ,neoplasias de la mama ,Health Services Accessibility ,Breast cancer screening ,0302 clinical medicine ,prevention ,Mass Screening ,Medicine ,030212 general & internal medicine ,lenguaje ,mediana edad ,Early Detection of Cancer ,Qualitative Research ,Language ,media_common ,anciano ,medicine.diagnostic_test ,social position ,Communication Barriers ,General Medicine ,Middle Aged ,detección precoz del cáncer ,030220 oncology & carcinogenesis ,emigrantes e inmigrantes ,Female ,Public Health ,investigación cualitativa ,Thematic analysis ,immigration ,mammography ,media_common.quotation_subject ,cribado sistemático ,Emigrants and Immigrants ,Language barrier ,factores socioeconómicos ,Breast Neoplasms ,Social class ,03 medical and health sciences ,Breast cancer ,gender and health ,Humans ,Aged ,Cancer prevention ,business.industry ,Research ,medicine.disease ,Country of origin ,culture ,Socioeconomic Factors ,barreras de comunicación ,Spain ,mamografía ,business ,Demography - Abstract
Objectives To identify knowledge, barriers and discourses about breast cancer screening in Spain among female immigrants from low-income countries and native Spanish women from a low socioeconomic class. Design Qualitative interview study with thematic analysis interpreted using cultural mediators. Setting Mallorca, Spain. Participants Thirty-six in-depth interviews, using cultural mediators, of immigrant women living in Mallorca who were 50-69years old and were from Maghreb, Sub-Saharan Africa, Eastern Europe, Latin America, China or were native to Spain and from a low socioeconomic class. Results We analysed the interviews to assess breast cancer perceptions and beliefs, discourses about breast cancer prevention and barriers to accessing breast cancer prevention programmes. Although the women reported an association of breast cancer with death, they acknowledged the effectiveness of early detection. They also exhibited reluctance to talk about cancer. Discourses about cancer prevention tended to be proactive or fatalistic, depending on the woman's country of origin. For all women, fear of results and lack of time were barriers that limited participation in breast cancer prevention programmes. Language barriers, frequent changes of residence and fear due to status as an irregular (undocumented) immigrant were barriers specific to immigrant women. Conclusions The culture of origin affects whether an immigrant has a fatalistic or proactive approach toward breast cancer screening. Immigrants from low-income countries and Spanish natives from a low socioeconomic class experience barriers in access to breast cancer screening. Frequently changing homes is also a barrier for immigrant women., This study was financed with a grant from the Ministry of Health, Carlos III Institute (ISCIII), PI08/90628. It also received the support of the Health Promotion and Preventive Activities-Primary Health Care Network (redIAPP), sustained by the Ministry of Health, ISCIII and cofinanced by ERDF funds (RETIC RD06/0018, RD12/0005/0011, RD16/0007). This project was also supported by the Balearic Islands Health Research Institute (IdISBa).
- Published
- 2018
8. Association between the Adherence to the International Guidelines for Cancer Prevention and Mammographic Density
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Adela Castelló, Leandro Prieto, María Ederra, Dolores Salas-Trejo, Carmen Vidal, Carmen Sánchez-Contador, Carmen Santamariña, Carmen Pedraz, Pilar Moreo, Nuria Aragonés, Beatriz Pérez-Gómez, Virginia Lope, Jesús Vioque, Marina Pollán, DDM-Spain research group, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo (España), and Federación Española de Cáncer de Mama
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medicine.medical_specialty ,cumplimiento del paciente ,Cross-sectional study ,humanos ,cribado sistemático ,Population ,Physical activity ,lcsh:Medicine ,neoplasias de la mama ,Breast Neoplasms ,Breast cancer ,Risk Factors ,Environmental health ,factores de riesgo ,Medicine ,Humans ,Mass Screening ,lcsh:Science ,education ,Mammary Glands, Human ,Mass screening ,Breast Density ,Gynecology ,education.field_of_study ,Multidisciplinary ,Cancer prevention ,business.industry ,lcsh:R ,MAMMOGRAPHIC DENSITY ,medicine.disease ,Postmenopause ,Cross-Sectional Studies ,Spain ,postmenopausia ,Patient Compliance ,lcsh:Q ,Smoking status ,Female ,business ,estudios transversales ,Research Article - Abstract
Introduction Mammographic density (MD) is considered a strong predictor of Breast Cancer (BC). The objective of the present study is to explore the association between MD and the compliance with the World Cancer Research Fund and the American Institute for Cancer Research (WCRF/AICR) recommendations for cancer prevention. Methods Data of 3584 women attending screening from a population-based multicenter cross-sectional study (DDM-Spain) collected from October 7, 2007 through July 14, 2008, was used to calculate a score that measures the level of compliance with the WCRF/AICR recommendations: R1)Maintain adequate body weight; R2)Be physically active; 3R)Limit the intake of high density foods; R4)Eat mostly plant foods; R5)Limit the intake of animal foods; R6)Limit alcohol intake; R7)Limit salt and salt preserved food intake; R8)Meet nutritional needs through diet. The association between the score and MD (assessed by a single radiologist using a semi-quantitative scale) was evaluated using ordinal logistic models with random center-specific intercepts adjusted for the main determinants of MD. Stratified analyses by menopausal status and smoking status were also carried out. Results A higher compliance with the WCRF/AICR recommendations was associated with lower MD (OR1-unit increase = 0.93 95%CI:0.86;0.99). The association was stronger in postmenopausal women (OR = 0.91 95%CI:0.84;0.99) and nonsmokers (OR = 0.87;95%CI:0.80;0.96 for nonsmokers, OR = 1.01 95%CI:0.91;1.12 for smokers, P-interaction = 0.042). Among nonsmokers, maintaining adequate body weight (OR = 0.81 95%CI:0.65;1.01), practicing physical activity (OR = 0.68 95%CI:0.48;0.96) and moderating the intake of high-density foods (OR = 0.58 95%CI:0.40;0.86) and alcoholic beverages (OR = 0.76 95%CI:0.55;1.05) were the recommendations showing the strongest associations with MD. Conclusions postmenopausal women and non-smokers with greater compliance with the WCRF/AICR guidelines have lower MD. These results may provide guidance to design specific recommendations for screening attendants with high MD and therefore at higher risk of developing BC., This study was supported by FIS PI060386 FIS (Health Research Fund) Research Grant; EC11-273 Research Grant from the Spanish Ministy of Health; CD110/00018 FIS Sara Borrell contract; FECMA 485 EPY 1170-10 grant from the Spanish Federation of Breast Cancer Patients.
- Published
- 2015
9. Determinants of non attendance to mammography program in a region with high voluntary health insurance coverage
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Magdalena Esteva, Francisca Collado, Alfonso Leiva, Carmen Sánchez-Contador, and Joana Ripoll
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medicine.medical_specialty ,humanos ,estudios de casos y controles ,cribado sistemático ,neoplasias de la mama ,Breast Neoplasms ,Non attendance ,Insurance Coverage ,Interviews as Topic ,Breast cancer screening ,análisis de regresión ,Environmental health ,entrevistas como asunto ,Epidemiology ,medicine ,Health insurance ,Mammography ,Humans ,Mass Screening ,skin and connective tissue diseases ,mediana edad ,Aged ,anciano ,Insurance, Health ,medicine.diagnostic_test ,business.industry ,lcsh:Public aspects of medicine ,Public health ,Public Health, Environmental and Occupational Health ,lcsh:RA1-1270 ,Middle Aged ,Patient Acceptance of Health Care ,Family medicine ,Case-Control Studies ,Regression Analysis ,Female ,mamografía ,Biostatistics ,business ,Research Article - Abstract
Background High participation rates are needed to ensure that breast cancer screening programs effectively reduce mortality. We identified the determinants of non-participation in a public breast cancer screening program. Methods In this case-control study, 274 women aged 50 to 64 years included in a population-based mammography screening program were personally interviewed. Socio-demographic characteristics, health beliefs, health service utilization, insurance coverage, prior mammography and other preventive activities were examined. Results Of the 192 cases and 194 controls contacted, 101 and 173, respectively, were subsequently interviewed. Factors related to non-participation in the breast cancer screening program included higher education (odds ratio [OR] = 5.28; 95% confidence interval [CI95%] = 1.57–17.68), annual dental checks-ups (OR = 1.81; CI95%1.08–3.03), prior mammography at a private health center (OR = 7.27; CI95% 3.97–13.32), gynecologist recommendation of mammography (OR = 2.2; CI95%1.3–3.8), number of visits to a gynecologist (median visits by cases = 1.2, versus controls = 0.92, P = 0.001), and supplemental private insurance (OR = 5.62; CI95% = 3.28–9.6). Among women who had not received a prior mammogram or who had done so at a public center, perceived barriers were the main factors related to non-participation. Among women who had previously received mammograms at a private center, supplemental private health insurance also influenced non-participation. Benign breast symptoms increased the likelihood of participation. Conclusion Our data indicate that factors related to the type of insurance coverage (such as prior mammography at a private health center and supplemental private insurance) influenced non-participation in the screening program.
- Published
- 2008
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