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4 results on '"cyclohexylethanoids"'

1. Cornus sanguinea Fruits: a Source of Antioxidant and Antisenescence Compounds Acting on Aged Human Dermal and Gingival Fibroblasts*.

Author

Iannuzzi, Anna Maria, Giacomelli, Chiara, De Leo, Marinella, Russo, Lara, Camangi, Fabiano, De Tommasi, Nunziatina, Braca, Alessandra, Martini, Claudia, and Trincavelli, Maria Letizia

Subjects
*CYTOKINES, *INTERLEUKINS, *FLAVONOIDS, *FIBROBLASTS, *ANTIOXIDANTS, *NUCLEAR magnetic resonance spectroscopy, *GENE expression, *FRUIT, *CELL proliferation, *MASS spectrometry, *DESCRIPTIVE statistics, *PLANT extracts, *MOLECULAR structure, *POLYMERASE chain reaction, *REACTIVE oxygen species, *DATA analysis software, *GINGIVA, *KERATINOCYTES, *HYDROGEN peroxide
Abstract

Five new compounds, a flavonol glycoside (1), a megastigmane (2), 2 cyclohexylethanoids (3, 4), and a phenylethanoid derivative (5), together with 15 known compounds (6 – 20) including flavonoid glycosides, cyclohexylethanoids, and phenolic compounds, have been isolated from Cornus sanguinea drupes. All the structures have been determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry data. The antioxidant capability of the most representative isolated compounds was evaluated in the hydrogen peroxide (H2 O2)-induced premature cellular senescence model of human dermal and gingival fibroblasts. Several derivatives counteracted the increase of reactive oxigen species (ROS) production in both cellular models. Among the most promising, compounds 8, 14 , and 20 were able to counteract cell senescence, decreasing the expression of p21 and p53. Furthermore, compound 14 decreased the expression of inflammatory cytokines (IL-6) in both cell models and counteracted the decrease of collagen expression induced by the H2 O2 in dermal human fibroblasts. These data highlight the anti-aging properties of several isolated compounds from C. sanguinea drupes, supporting its possible use in the cure of skin or periodontitis lesions. [ABSTRACT FROM AUTHOR]

Published
2021
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2. Cornus sanguinea Fruits: a Source of Antioxidant and Antisenescence Compounds Acting on Aged Human Dermal and Gingival Fibroblasts*.

Author

Iannuzzi, Anna Maria, Giacomelli, Chiara, De Leo, Marinella, Russo, Lara, Camangi, Fabiano, De Tommasi, Nunziatina, Braca, Alessandra, Martini, Claudia, and Trincavelli, Maria Letizia

Subjects
CYTOKINES, INTERLEUKINS, FLAVONOIDS, FIBROBLASTS, ANTIOXIDANTS, NUCLEAR magnetic resonance spectroscopy, GENE expression, FRUIT, CELL proliferation, MASS spectrometry, DESCRIPTIVE statistics, PLANT extracts, MOLECULAR structure, POLYMERASE chain reaction, REACTIVE oxygen species, DATA analysis software, GINGIVA, KERATINOCYTES, HYDROGEN peroxide
Abstract

Five new compounds, a flavonol glycoside (1), a megastigmane (2), 2 cyclohexylethanoids (3, 4), and a phenylethanoid derivative (5), together with 15 known compounds (6 – 20) including flavonoid glycosides, cyclohexylethanoids, and phenolic compounds, have been isolated from Cornus sanguinea drupes. All the structures have been determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry data. The antioxidant capability of the most representative isolated compounds was evaluated in the hydrogen peroxide (H2 O2)-induced premature cellular senescence model of human dermal and gingival fibroblasts. Several derivatives counteracted the increase of reactive oxigen species (ROS) production in both cellular models. Among the most promising, compounds 8, 14 , and 20 were able to counteract cell senescence, decreasing the expression of p21 and p53. Furthermore, compound 14 decreased the expression of inflammatory cytokines (IL-6) in both cell models and counteracted the decrease of collagen expression induced by the H2 O2 in dermal human fibroblasts. These data highlight the anti-aging properties of several isolated compounds from C. sanguinea drupes, supporting its possible use in the cure of skin or periodontitis lesions. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
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3. Cornus sanguinea Fruits: a Source of Antioxidant and Antisenescence Compounds Acting on Aged Human Dermal and Gingival Fibroblasts

Author

Chiara Giacomelli, Fabiano Camangi, Alessandra Braca, Claudia Martini, Lara Russo, Anna Maria Iannuzzi, Maria Letizia Trincavelli, Nunziatina De Tommasi, and Marinella De Leo

Subjects
Senescence, Antioxidant, antioxidant, medicine.medical_treatment, Cell, Pharmaceutical Science, Cornaceae, Antioxidants, Analytical Chemistry, Proinflammatory cytokine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cornus, Drug Discovery, medicine, Humans, cyclohexylethanoids, Hydrogen peroxide, 030304 developmental biology, Pharmacology, Periodontitis, chemistry.chemical_classification, 0303 health sciences, human fibroblasts, Organic Chemistry, Glycoside, Phenylethanoid, Cornus sanguinea, Hydrogen Peroxide, Fibroblasts, medicine.disease, medicine.anatomical_structure, Complementary and alternative medicine, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Fruit, Molecular Medicine, Cornus sanguinea, Cornaceae, cyclohexylethanoids, flavonol glycosides, antioxidant, human fibroblasts, flavonol glycosides
Abstract

Five new compounds, a flavonol glycoside ( 1), a megastigmane ( 2), 2 cyclohexylethanoids ( 3, 4), and a phenylethanoid derivative ( 5), together with 15 known compounds ( 6– 20) including flavonoid glycosides, cyclohexylethanoids, and phenolic compounds, have been isolated from Cornus sanguinea drupes. All the structures have been determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry data. The antioxidant capability of the most representative isolated compounds was evaluated in the hydrogen peroxide (H2O2)-induced premature cellular senescence model of human dermal and gingival fibroblasts. Several derivatives counteracted the increase of reactive oxigen species (ROS) production in both cellular models. Among the most promising, compounds 8, 14, and 20 were able to counteract cell senescence, decreasing the expression of p21 and p53. Furthermore, compound 14 decreased the expression of inflammatory cytokines (IL-6) in both cell models and counteracted the decrease of collagen expression induced by the H2O2 in dermal human fibroblasts. These data highlight the anti-aging properties of several isolated compounds from C. sanguinea drupes, supporting its possible use in the cure of skin or periodontitis lesions.

Published
2021

4. New cyclohexylethanoids from the leaves of Clerodendrum trichotomum.

Author

Xu, Rui-Lan, Wang, Rui, Ha, Wei, and Shi, Yan-Ping

Abstract

Highlights: [•] Two new cyclohexylethanoids were isolated and elucidated by extensive NMR experiments. [•] This series cyclohexylethanoids are characteristic of the Clerodendrum genus. [•] The new cyclohexylethanoids were evaluated for cytotoxicity against the A549 human tumor cell line. [Copyright &y& Elsevier]

Published
2014
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