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p-Coumaric acid is derived from cinnamic acid and is one of the major compounds in the Brazilian green propolis extract. Studies have shown that both p-coumaric acid and cinnamic acid have promising antiproliferative effects. In this context, aiming to increase the complexity of these active natural products and their activities, we performed coupling reactions with propargylamine and benzylamine, as well as with threonine, phenylalanine and lysine amino acids, aiming to enhance their antiproliferative effects towards the hormone-dependent breast cancer MCF-7 cells. Overall, the p-coumaric acid coupling with L-threonine amino acid (compound 15) had the best selectivity index (SI = 5.1), with half-maximal inhibitory concentration of 39.6 ± 1 µM, showing a high selectivity against hormone-dependent breast cancer cell lines MCF-7 and low cytotoxicity against the normal breast cell lines MCF-10A. Thus, this new natural product derivative may represent a prototype for the future development of antiproliferative agents, especially against hormone-dependent breast cancer. [ABSTRACT FROM AUTHOR]

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of GeSec: Revista de Gestao e Secretariado is the property of Sindicato das Secretarias e Secretarios do Estado de Sao Paulo (SINSESP) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Lean is applied in automobile companies to reduce lead time and waste through value stream mapping. Industry 4.0 is a process of industrial systems revolution in companies driven by digitalization and data-oriented techniques. The combination of both is called Lean 4.0. In this sense, the purpose of this paper is to attend Ultra-Light Steel Auto-body (ULSAB) automotive requirements through Lean 4.0 framework applied in the fabrication of B-pillar by hot stamping. Optimization algorithms are important to simulate different scenarios and interact with these processes. The proposal was developed in the case study by assessments based on semi-structured questionnaires, analysis of records and documents. The findings showed overall equipment effectiveness (OEE) was increased by 41.5%. The contribution of this work was to meet ULSAB automotive requirements for hot stamping process by reducing vehicle weight while increasing structural strength. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Tecnologia Aplicada is the property of Faculdade Campo Limpo Paulista and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Manufacturing companies strive for ever-increasing competitiveness through productivity and quality. This goal can be achieved through the implementation of lean manufacturing and six sigma methodologies. Lean manufacturing adds value by reducing waste, while six sigma eliminates variability. In this context, this article proposes a new framework within Lean Six Sigma circumstances. The framework was proposed by means of an exhaustive literature review which identified the positive points of other Lean Six Sigma frameworks available on literature. The framework was applied to a case study, and the assessments were based on semi-structured questionnaires and analysis of records and documents. The implementation was carried out in a manufacturing company in Brazil, which belongs to an American-based multinational. In the case study described herein, the manufacturing company established the proposed framework to support the combination of lean manufacturing and six sigma and introduced an enterprise-wide culture of project through the proposed Lean Six Sigma framework, which resulted in significant benefits. [ABSTRACT FROM AUTHOR]

The present study describes a strategy for teaching and learning technical drawing, by enhancing students' skills in spatial perception. This strategy was proposed by means of literature review, which identified the strengths and weaknesses of technical drawing concepts up to date. This study allowed to construct a framework in which contains a general guide to address this strategy. It is a method in which students play an active role, initially manually sketching and on the drawing board before proceeding to the computer. The manual drawing was supported by origami systems, and Piaget's pedagogy to understand the space-plane relationship. From another point of view, it was used the problem-based learning on the drawing by computer to draw components that were drawn by hand. The research was conducted over two years in the course of industrial engineering. Purposive sampling was used to select 32 students participating in this research. The principal findings of this research concern the evolutionary learning of the orthogonal projections that enable students to draw objects in the plane that they first saw in the space. [ABSTRACT FROM AUTHOR]

Copyright of Em Pauta is the property of Editora da Universidade do Estado do Rio de Janeiro (EdUERJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study proposes an adaptability index system for product development to enhance engineering system management. The index system takes into account the need to reduce the time required to market new products. The adaptability index is defined by the relationship between the time to develop a current product and the time to develop a subsequent (next) one, so that the recommended index will be useful when a new product with shorter execution times than those of the previous one is introduced into the product design and manufacturing process. Implementing an adaptability system’s parameters are derived from responsiveness, competitiveness, engineering, and marketing activities as reflected in adaptability indices. The study’s methodology is case study through questionnaires, interviews, and records. The authors recommend increasing adaptability by reducing complexity through computer-integrated manufacturing, standardization, and others methodologies. The significant outcome based on the case study is the assessment that is enabled by the proposed adaptability index. This index will guide engineering companies in the selection of the most relevant development processes, protocols, production tools, and procedures aimed at reducing the time-to-market required to generate new products, thus allowing it to meet market demand, increase product diversification, and reduce product lifetimes. [ABSTRACT FROM AUTHOR]

Copyright of Revista da Associação Brasileira de Nutrição is the property of Associacao Brasileira de Nutricao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista da Associação Brasileira de Nutrição is the property of Associacao Brasileira de Nutricao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)