1. In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent
- Author
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Cristina Delerue-Matos, Patrick Veras Quelemes, Alexandra Plácido, de Oliveira Rcm, de Almeida Mp, da Silva Da, Lustosa Akmf, de Almeida Leite Jrs, da Silva Fv, Oliveira Is, de Jesus Oliveira Ac, Amorim Adgn, Peter Eaton, and Repositório Científico do Instituto Politécnico do Porto
- Subjects
Male ,Nanoparticle ,Metal Nanoparticles ,02 engineering and technology ,01 natural sciences ,Silver nanoparticle ,Hydrogel, Polyethylene Glycol Dimethacrylate ,lcsh:Chemistry ,chemistry.chemical_compound ,antibacterial activity ,lcsh:QH301-705.5 ,Spectroscopy ,General Medicine ,021001 nanoscience & nanotechnology ,healing ,Computer Science Applications ,Anti-Bacterial Agents ,wounds ,Transmission electron microscopy ,Wounds ,Pseudomonas aeruginosa ,Silver nanoparticles ,0210 nano-technology ,Antibacterial activity ,Rheology ,medicine.drug ,Staphylococcus aureus ,silver nanoparticles ,Silver ,Healing ,Reducing agent ,Phthalic Acids ,Microbial Sensitivity Tests ,010402 general chemistry ,Catalysis ,Article ,Inorganic Chemistry ,Sodium borohydride ,Polymer chemistry ,medicine ,Animals ,Anacardium ,Physical and Theoretical Chemistry ,Particle Size ,Rats, Wistar ,Molecular Biology ,Wound Healing ,hydrogel ,cashew gum ,Organic Chemistry ,Cashew gum ,0104 chemical sciences ,Carboxymethyl cellulose ,Hydrogel ,chemistry ,Chemical engineering ,lcsh:Biology (General) ,lcsh:QD1-999 ,Carboxymethylcellulose Sodium ,Particle size - Abstract
Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles. The nanoparticles were prepared in the hydrogel in situ, utilizing two variants of cashew gum as a capping agent, and sodium borohydride as the reducing agent. This gum is non-toxic and comes from a renewable natural source. The particles and gel were thoroughly characterized through using rheological measurements, UV-vis spectroscopy, nanoparticles tracking analysis, and transmission electron microscopy analysis (TEM). Antibacterial tests were carried out, confirming antimicrobial action of the silver nanoparticle-loaded gels. Furthermore, rat wound-healing models were used and demonstrated that the gels exhibited improved wound healing when compared to the base hydrogel as a control. Thus, these gels are proposed as excellent candidates for use as wound-healing treatments.
- Published
- 2017
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