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Copyright of Ciencia, Cuidado e Saude is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated the potential of host defense peptides clavanins A, MO, and LL-37 in in vitro osteoclastogenesis. Methods: RAW 264.7 cultures were stimulated with recombinant of receptor activator of nuclear factor kappa B ligand in the presence of different tested concentrations of host defense peptides, besides calcium hydroxide and doxycycline. Cellular viability, nitric oxide production, and a number of differentiated osteoclast-like cells were also evaluated. Results: Results showed that none of the substances were cytotoxic, except for 128 μg.mL-1 of doxycycline after 3 days. Host defense peptides, calcium hydroxide, and doxycycline did not interfere in nitric oxide production or downregulated it. An exception was observed in the presence of 2 μg.mL-1 of doxycycline, in which nitric oxide production was up-regulated. All host defense peptides were capable of reducing osteoclast-like cell differentiation. Conclusion: Host defense peptides clavanins A and MO demonstrated to be potential suppressors of osteoclastogenesis in vitro without interfering in cellular viability and nitric oxide production. These promising results need to be further analyzed in in vivo models of bone resorption. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Pesquisa: Cuidado é Fundamental is the property of Revista de Pesquisa: Cuidado e Fundamental Online and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Brasileira de Pesquisa em Turismo is the property of Associacao Nacional de Pesquisa e Pos-Graduacao em Turismo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Orthokeratinized odontogenic cyst (OOC) is a pathologic entity that was once described as an uncommon variation of odontogenic keratocyst, although the 2005 World Health Organization classification considers this as distinct pathologic entity due to its diverse biological behaviors. Literature on OOC describes a greater prevalence in White men aged 30 years and older and reports its low growth rate and aggressiveness as responsible for the lower recurrence rate. Because of its asymptomatic clinical course, the diagnosis may be delayed, increasing morbidity associated with the disease. The objective is to present a case of a distinguished OOC in the mandibular posterior region of a 30-year-old woman who presented with a significant odontogenic infection associated to the pathologic cavity, which was not noted before. The lesion was treated with enucleation and the mandible was reinforced using internal rigid fixation. After 1 year of follow-up there are no signs of recurrence. [ABSTRACT FROM AUTHOR]

Congenital epulis is a rare, benign soft tissue condition with a female preponderance that is only seen in newborns. It arises from the alveolar mucosa and occurs more frequently in the maxilla and protrudes out of the infant's mouth. This condition may interfere with feeding, lip closure, or respiration and even potentially obstruct the airway. This work presents the case of a female infant with a solid ovoid mass protruding from the oral cavity. Treatment of this lesion was surgical, and histopathologic examination confirmed clinical diagnosis of congenital epulis. Postsurgical follow-up was without complications; examination of the infant 2 months later revealed no sign of recurrence. [ABSTRACT FROM AUTHOR]

Copyright of Interface - Comunicação, Saúde, Educação is the property of Fundacao UNI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ciencia, Cuidado e Saude is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ciencia, Cuidado e Saude is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de Economia e Administração is the property of INSPER Instituto de Ensino e Pesquisa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

An 83-year-old light brown man was attended complaining of "pain on the right side of the mouth" for 1 year with difficulty feeding and chewing pain. Anamnesis revealed stage IV chronic renal disease, myocardial revascularization surgery, gastritis, depression, allergic rhinitis, recent weight loss, and previous smoking stopped 20 years ago. The extraoral examination showed facial asymmetry due to a swelling in the right mandibular body covered by normal skin. Intraoral examination evidenced an exophytic ulcer on the right edentulous mandibular alveolar ridge, extending from the parasymphysis to inferior retromolar region with verrucous aspect and irregular borders, hardened and painful to the palpation, and 7 × 3 cm in its largest diameter. Smear cytolopathology and incisional biopsy were performed. Diagnostic hypothesis was squamous cell carcinoma. The cytopathologic study revealed atypical cells strongly suggestive of malignant neoplasm. Histopathologic analysis confirmed the final diagnosis of moderately differentiated squamous cell carcinoma. The patient was referred for cancer treatment. [ABSTRACT FROM AUTHOR]