134 results on '"fennel oil"'
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2. A Thin-Layer Chromatography Method for the Determination of Essential Oil Components in Anise and Fennel Fruits
- Author
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E. P. Shefer, N. P. Antonova, I. M. Morgunov, S. S. Prokhvatilova, and M. S. Zotova
- Subjects
common anise fruits ,aniseed ,pimpinélla anísum ,common fennel fruits ,foenículum vulgáre ,anise oil ,fennel oil ,trans-anethole ,thin-layer chromatography ,state pharmacopoeia of the russian federation ,Medicine (General) ,R5-920 - Abstract
Scientific relevance. The State Pharmacopoeia of the Russian Federation, edition XIV, requires the identification of aniseed and fennel fruits by the same thin-layer chromatography (TLC) procedure using Sudan III and menthol. These markers are neither specific nor related to the therapeutic effects of these herbal drug products. The visual interpretation of chromatograms is complicated because of the low intensity of adsorption zones. Moreover, the corresponding compendial monographs do not characterise the adsorption zones specific to each of the plants. The most abundant component in aniseed and fennel essential oils, trans-anethole, would make a better reference standard from a methodological point of view.Aim. This study aimed to optimise the TLC procedure for essential oil determination in herbal drugs and herbal medicinal products of aniseed and fennel fruits and subsequently recommend it for inclusion in the relevant compendial monographs.Materials and methods. The study examined samples from several batches of herbal drugs, including aniseed and common fennel fruits, sourced from Russian manufacturers. The reference standards comprised commercial reagents, including trans-anethole, anise oil, and linalool, as well as fresh essential oils that had been steam distilled from the test samples in a Clevenger apparatus. The study was conducted by TLC. Sample preparation involved using Merck aluminium TLC plates, an IKA KS-501 digital orbital shaker, and a CAMAG Linomat 5 semi-automatic sample application system. The authors heated the plates in either a Binder ED53 drying oven or a CAMAG TLC plate heater. For visualisation, the authors selected a CAMAG TLC VISUALIZER 2 UV imaging and documentation system.Results. The informational and experimental research showed the feasibility of using trans-anethole as an identification reference standard for common anise and fennel fruits. The authors selected the optimal solvent for extracting active substances from the test products (hexane) and a detection reagent for improving visual evaluation of the chromatograms (1% sulfovanillin). The authors established characteristic adsorption zones for differentiating between aniseed and fennel fruits.Conclusions. The optimised procedure identifies the main components in the essential oils of aniseed and fennel fruits with a specific reference standard. This procedure may be recommended for inclusion in draft monographs for the corresponding herbal medicinal products.
- Published
- 2023
- Full Text
- View/download PDF
3. Comparison of the Effect of Fennel and Evening Primrose Oil on Menopausal Problems and Hormonal Levels: A Randomized Controlled Trial.
- Author
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Ghavi, Fatemeh, Shakeri, Fatemeh, Farahnaz, Heshmat, and Abdolahian, Somayeh
- Subjects
- *
RANDOMIZED controlled trials , *PRIMROSES , *FENNEL , *PETROLEUM , *ALTERNATIVE medicine - Abstract
Background: Using natural oral supplements is one of the methods of complementary medicine that has been widely welcomed in the last decade Since studies have reported contradictory results for effectiveness of herbal medicines during menopause and no other more effective herbal medicine has been suggested yet, the researchers of this study decided to compare the fennel and Evening Primrose Oil (EPO) and their effect on menopause problems and sex hormones. Materials and Methods: The present study was a triple-blinded, controlled clinical trial with 125 participants randomly assigned to. An intervention group received fennel, another intervention group received evening primrose oil, and the placebo group received placebo twice daily for 8 weeks. Pre-intervention and post-intervention results were obtained using hormonal assay and the Menopause Rating Scale (MRS). Results: In this study, the mean follicle-stimulating hormone (FSH) and estradiol levels changed significantly in the fennel and EPO groups compared to placebo (p < 0.001). The difference in the mean FSH score between the fennel group and EPO group was not significant (p = 0.304), but the difference in the mean estradiol level between these groups was significant (p = 0.043). Moreover, there was a significant difference in the mean MRS score between the intervention groups before the intervention (p < 0.05). However, the difference in the mean MRS score between the fennel and EPO groups was not significant after the intervention (p = 0.322). Conclusions: Consumption of fennel and EPO can significantly change FSH, estradiol, and psychological menopausal symptoms in postmenopausal women. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. Comparison of the effect of fennel and evening primrose oil on menopausal problems and hormonal levels: A randomized controlled trial
- Author
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Fatemeh Ghavi, Fatemeh Shakeri, Heshmat Farahnaz, and Somayeh Abdolahian
- Subjects
evening primrose oil ,fennel oil ,hormones ,menopause ,Nursing ,RT1-120 - Abstract
Background: Using natural oral supplements is one of the methods of complementary medicine that has been widely welcomed in the last decade Since studies have reported contradictory results for effectiveness of herbal medicines during menopause and no other more effective herbal medicine has been suggested yet, the researchers of this study decided to compare the fennel and Evening Primrose Oil (EPO) and their effect on menopause problems and sex hormones. Materials and Methods: The present study was a triple-blinded, controlled clinical trial with 125 participants randomly assigned to. An intervention group received fennel, another intervention group received evening primrose oil, and the placebo group received placebo twice daily for 8 weeks. Pre-intervention and post-intervention results were obtained using hormonal assay and the Menopause Rating Scale (MRS). Results: In this study, the mean follicle-stimulating hormone (FSH) and estradiol levels changed significantly in the fennel and EPO groups compared to placebo (p < 0.001). The difference in the mean FSH score between the fennel group and EPO group was not significant (p = 0.304), but the difference in the mean estradiol level between these groups was significant (p = 0.043). Moreover, there was a significant difference in the mean MRS score between the intervention groups before the intervention (p < 0.05). However, the difference in the mean MRS score between the fennel and EPO groups was not significant after the intervention (p = 0.322). Conclusions: Consumption of fennel and EPO can significantly change FSH, estradiol, and psychological menopausal symptoms in postmenopausal women.
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- 2023
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- View/download PDF
5. Histological and ultrastructural study on the pathogenicity of the fungicide cyproconazole and the probable protective influence of fennel oil extract on the adrenal cortex of adult rats.
- Author
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Aboelwafa, Hanaa R., Sakr, Inas H., Ramadan, Ramadan A., and Yousef, Hany N.
- Subjects
HISTOLOGY ,MICROBIAL virulence ,CYPROCONAZOLE ,FUNGICIDES ,FENNEL ,ADRENAL cortex - Abstract
Copyright of African Journal of Biological Sciences is the property of African Journal of Biological Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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6. Development and characterization of fennel oil-loaded alginate polymeric beads for larvicidal activity against Aedes agypti, Anopheles stephensi, and wild mosquito larvae.
- Author
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Ade, Megha, Sahoo, Debasish, Singh, Vandana, Saxena, Ankit, Shukla, Sanjeev K., and Yadav, Narayan Prasad
- Subjects
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ANOPHELES stephensi , *ESSENTIAL oils , *BASE oils , *AEDES , *MOSQUITOES , *SODIUM alginate - Abstract
The present work was aimed to prepare alginate-HPMC polymeric beads containing fennel oil and evaluate its potential as a controlled release system for larvicidal activity against Aedes agypti , Anopheles stephensi , and wild mosquito larvae. This study was carried out by emulsifying fennel oil with PEG 400 in an aqueous phase containing alginate and HPMC mixture and the fabrication of beads by an ionotropic gelation method using CaCl 2 as a cross-linker. The concentrations of sodium alginate, HPMC, and CaCl 2 were taken as process parameters. The fennel oil emulsion was characterized based on the oil droplet size (378 nm), polydispersity index (0.250), and viscosity (4518±269 cps at 100 rpm). The prepared beads were characterized by NMR, FTIR, and SEM for the confirmation of fennel oil entrapment in alginate beads and surface topographical study. The beads were further evaluated for %EE (79±0.22 %) loading capacity (78.56±0.309 %) and in-vitro drug release (91.66±0.47 % in 72 hours). The in-vivo larvicidal bioassay showed that the fennel oil-loaded alginate beads resulted in 100 % mortality of Aedes agypti , Anopheles stephensi , and wild mosquito larvae within 24 hours. These results confirm that the fennel oil-loaded alginate beads exhibited good entrapment efficiency, control release properties, and suitable larvicidal activity. [Display omitted] • Fennel essential oil has potent larvicidal efficacy against Aedes agypti , Anopheles stephensi , and wild mosquito larvae • The main concern utilizing fennel oil for larvicidal activity is that it is volatile and degrades quickly • Encapsulation of fennel essential oil reduces its volatilization and protects it from the external environment • Fennel oil-loaded polymeric beads composed of a mixture of sodium alginate and HPMC resulted in increased stability of fennel oil with prolonged-release properties to exert extended mosquito larvicidal activity [ABSTRACT FROM AUTHOR]
- Published
- 2024
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7. Nanostructured Lipid Carriers (NLC) for Biologically Active Green Tea and Fennel Natural Oils Delivery: Larvicidal and Adulticidal Activities against Culex pipiens.
- Author
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Radwan, Ibrahim Taha, Baz, Mohamed M., Khater, Hanem, and Selim, Abdelfattah M.
- Subjects
- *
CULEX pipiens , *GREEN tea , *ESSENTIAL oils , *TRANSMISSION electron microscopes , *FENNEL , *PARTICLE size distribution - Abstract
(1) Background: The control of mosquitoes with essential oils is a growing demand. (2) Methods: This study evaluated the novel larvicidal and adulticidal activity of fennel and green tea oils and their nanostructured lipid carriers (NLC) against Culex pipiens (C. pipiens) in the laboratory, field conditions and evaluated their effect against non-target organisms. SLN type II nanoformulations were synthesized and characterized using dynamic light scattering (DLS), zeta potential and transmission electron microscope. (3) Results: The synthesized NLCs showed spherical shaped, homogenous, narrow, and monomodal particle size distribution. The mortality percent (MO%) post-treatment (PT) with 2000 ppm for 24 h with fennel oil and NLC fennel (NLC-F) reached 85% (LC50 = 643.81 ppm) and 100% (LC50 = 251.71), whereas MO% for green tea oil and NLC green tea (NLC-GT) were 80% (LC50 = 746.52 ppm) and 100% (LC50 = 278.63 ppm), respectively. Field trial data showed that the larval reduction percent of fennel oil and NLC-F reached 89.8% and 97.4%, 24 h PT and the reduction percent of green tea oil and NLC-GT reached 89% and 93%, 24 h PT with persistence reached 8 and 7 days, for NLC-F and NLC-GT, respectively. The adulticidal effects showed that NLC-F and NLC-GT (100% mortality) were more effective than fennel and green tea oils (90.0% and 83.33%), with 24 h PT, respectively. Moreover, their reduction of adult density after spraying with LC95 X2 for 15 min, with fennel oil, NLC-F, and green tea oil, NLC-GT were 83.6%, 100%, 79.1%, and 100%, respectively, with persistence (>50%) lasting for three days. The predation rate of the mosquitofish, Gambusia affinis, and the bug, Sphaerodema urinator, was not affected in both oil and its NLC, while the predation rate of the beetle, Cybister tripunctatus increased (66% and 68.3%) by green tea oil and NLC-GT, respectively. (4) Conclusions: NLCs nanoformulation encapsulated essential oils was prepared successfully with unique properties of size, morphology, and stability. In vitro larvicidal and adulticidal effects against C. pipiens supported with field evaluations have been performed using essential oils and their nanoformulations. The biological evaluation of nanoformulations manifested potential results toward both larvicidal and adulticidal compared to the essential oils themselves, especially NLC encapsulated fennel oil which had promising larvicidal and adulticidal activity. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
8. Development of gel for Aedes aegypti repellent with combination of cinnamon oil (Cinnamomum burmannii Blume) and fennel oil (Foeniculum vulgare Mill)
- Author
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Sohipah Evah, Purba Anny Victor, and Djamil Ratna
- Subjects
gel ,aedes aegypti ,cinnamon oil ,fennel oil ,repellent ,Medicine - Abstract
Background/Aim: Aim of this study was to develop efficient mosquito repellent by combining fennel oil (Foeniculum vulgare Mill) and cinnamon oil (Cinnamomum burmannii Blume) in a gel preparation form. Methods: Effectiveness of each oil and its combination as viral repellents was tested by the World Health Organization's Pesticide Evaluation Scheme (WHOPES) method. Repellent was prepared in gel form. Evaluation of gel preparation included organoleptic properties, homogeneity, pH, viscosity, flow properties, acute skin irritation test and effectiveness test as mosquito repellent. Results: The mosquito protection test for cinnamon oil showed that cinnamon oil was most effective at concentration of 15 % (96.85 %), and fennel oil at 24 % concentration (79.26 %). Within 6 hours, gel made of 24 % fennel oil and 15 % cinnamon oil combination gave protection against 53.49 % mosquitoes. Conclusion: The combination of cinnamon oil and fennel oil can be formulated into gel form with satisfying physical and chemical characteristics and effectiveness against Aedes aegypti mosquitoes for 6 hours.
- Published
- 2020
9. Quantification of Anethole in Fennel and Anise Essential Oils using Gas Chromatography and 1H-NMR-Spectroscopy
- Author
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Denisa Eglantina DUȚĂ, Alina CULEȚU, Mioara NEGOIȚĂ, and Valentin Ionescu
- Subjects
anethol ,anise oil ,fennel oil ,gc-ms ,nmr spectroscopy. ,Food processing and manufacture ,TP368-456 - Abstract
Nine essential oils from fennel (seeds and herbs) and anise (seeds) from different origins were analysed for density, refractive index and for a complete composition through GC-MS and 1H-NMR-spectroscopy. Anethole was the main compound identified in fennel and anise essential oils. Anethole content varied between 30 – 90% in fennel oils and between 80 – 99% in anise oils; anethole is often used as flavouring substance in foods with a good antimicrobial activity also. A positive correlation was found between anethole content determined by GC-MS and 1H-NMR (r = 0.8567 for fennel oils and r = 0.6986 for anise oils). The results showed different levels of anethole in oils (values ranged between 30.66 % and 99.24 %). Electronic nose was a very good and rapid method for discrimination of essential oils based on PCA (Principal Component Analysis) with discrimination index above 90 for both essential oils.
- Published
- 2019
- Full Text
- View/download PDF
10. Nanostructured Lipid Carriers (NLC) for Biologically Active Green Tea and Fennel Natural Oils Delivery: Larvicidal and Adulticidal Activities against Culex pipiens
- Author
-
Ibrahim Taha Radwan, Mohamed M. Baz, Hanem Khater, and Abdelfattah M. Selim
- Subjects
Culex pipiens ,green tea oil ,fennel oil ,nanostructured lipid carriers nanoformulations ,Organic chemistry ,QD241-441 - Abstract
(1) Background: The control of mosquitoes with essential oils is a growing demand. (2) Methods: This study evaluated the novel larvicidal and adulticidal activity of fennel and green tea oils and their nanostructured lipid carriers (NLC) against Culex pipiens (C. pipiens) in the laboratory, field conditions and evaluated their effect against non-target organisms. SLN type II nanoformulations were synthesized and characterized using dynamic light scattering (DLS), zeta potential and transmission electron microscope. (3) Results: The synthesized NLCs showed spherical shaped, homogenous, narrow, and monomodal particle size distribution. The mortality percent (MO%) post-treatment (PT) with 2000 ppm for 24 h with fennel oil and NLC fennel (NLC-F) reached 85% (LC50 = 643.81 ppm) and 100% (LC50 = 251.71), whereas MO% for green tea oil and NLC green tea (NLC-GT) were 80% (LC50 = 746.52 ppm) and 100% (LC50 = 278.63 ppm), respectively. Field trial data showed that the larval reduction percent of fennel oil and NLC-F reached 89.8% and 97.4%, 24 h PT and the reduction percent of green tea oil and NLC-GT reached 89% and 93%, 24 h PT with persistence reached 8 and 7 days, for NLC-F and NLC-GT, respectively. The adulticidal effects showed that NLC-F and NLC-GT (100% mortality) were more effective than fennel and green tea oils (90.0% and 83.33%), with 24 h PT, respectively. Moreover, their reduction of adult density after spraying with LC95 X2 for 15 min, with fennel oil, NLC-F, and green tea oil, NLC-GT were 83.6%, 100%, 79.1%, and 100%, respectively, with persistence (>50%) lasting for three days. The predation rate of the mosquitofish, Gambusia affinis, and the bug, Sphaerodema urinator, was not affected in both oil and its NLC, while the predation rate of the beetle, Cybister tripunctatus increased (66% and 68.3%) by green tea oil and NLC-GT, respectively. (4) Conclusions: NLCs nanoformulation encapsulated essential oils was prepared successfully with unique properties of size, morphology, and stability. In vitro larvicidal and adulticidal effects against C. pipiens supported with field evaluations have been performed using essential oils and their nanoformulations. The biological evaluation of nanoformulations manifested potential results toward both larvicidal and adulticidal compared to the essential oils themselves, especially NLC encapsulated fennel oil which had promising larvicidal and adulticidal activity.
- Published
- 2022
- Full Text
- View/download PDF
11. Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality
- Author
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Tharwat Imbabi, Islam Sabeq, Ali Osman, Kamal Mahmoud, Shimaa A. Amer, Aziza M. Hassan, Nikolay Kostomakhin, Walid Habashy, and Ahmed A. Easa
- Subjects
weaned rabbits ,fennel oil ,apoptosis ,gene expression ,meat quality ,Therapeutics. Pharmacology ,RM1-950 - Abstract
In the current study, fennel essential oil was used as an antibiotic alternative compared to gentamycin for enhancing the expression of apoptosis genes and antioxidant enzymes in weaned rabbits as well as meat quality and growth performance. The gene expression of the cell lymphoma 2 (BAX and BCL2), caspase3 (CASP3), and glutathione peroxidase (GPX1) were estimated in the liver tissue using qRT-PCR. A total of 45 Moshtohor weaned male rabbits aged four weeks were randomly allocated to control, T1, and T2 treatment groups; each consisted of 15 weaned male rabbits with five replicates. Rabbits in the T1 and T2 groups were orally supplied with 1 mL fennel oil and 1 mL gentamycin, respectively. Weaned rabbits under different treatments showed increased body weight (BW) at 8 and 12 weeks of age and average daily gain (ADG) at 4–8 and 4–12 weeks of age compared to the control group. Compared to the controls, the weaned rabbits supplemented with fennel oil and gentamycin had lower total cholesterol, triglyceride, and MDA. In addition, villus length, mRNA of BAX, BCL2, Casp3, and GPX were increased in the different treatments compared to the control. Furthermore, the meat of these rabbits was less tender, had a lower aerobic plate count (APC), pH, and was brighter and redder in color than the control. Under the conditions of the present study, the supplementation of weaned Moshtohor rabbits with fennel oil as a natural alternative for gentamycin enhanced feed conversion and daily gain through enhancing villus length and mucus thickness. Additionally, fennel essential oil reduces oxidative stress by increasing the antioxidant enzymes.
- Published
- 2021
- Full Text
- View/download PDF
12. Protective effects of fennel oil extract against sodium valproate-induced hepatorenal damage in albino rats
- Author
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Wael M. Al-Amoudi
- Subjects
Sodium valproate ,Fennel oil ,Liver ,Kidney ,Histology ,Antehole ,Biochemistry ,Biology (General) ,QH301-705.5 - Abstract
Foeniculum vulgare (Apiaceae) is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b.w fennel oil 3 days/week for 6 weeks. The biochemical analyses of hepatic enzymes were evaluated by estimating blood biomarkers of liver and renal damage along with histological examination. The results obtained from this work showed that treating animals with SVP lead to many histopathological alterations in the liver and kidney tissues. The effect appeared in the liver tissue include leukocyte infiltrations, cytoplasmic vacuolization of the hepatocytes, fatty degeneration and congestion of blood vessels. This commonly used chemical (SVP) caused some unwanted effects on the kidney cortex which histologically observed as degeneration in renal tubules, atrophy of the glomeruli and edema. Biochemical results also revealed an abnormal increase in the enzyme level of AST, SAT, ALP, bilirubin, creatinine and urea-nitrogen, with a noticed decrease in total protein content. However, the results of treated rats with SVP plus fennel oil showed some positive histopathological changes in both the liver and kidney tissues. These results have confirmed that fennel oil has positive effects on the histological structure of the liver and kidney and the biochemical levels of AST, ALT, ALP, bilirubin, total proteins, creatinine and urea. It is concluded that fennel oil has various pharmacological properties including antioxidant, anti-cancer activity, anti-inflammatory. These valuable effects might be due to the presence of aromatic compounds trans-anethole. This useful properties of fennel plant could be due to its antioxidant activity that prevents the toxicity of SVP.
- Published
- 2017
- Full Text
- View/download PDF
13. Bactericidal activity of some plant essential oils against Ralstonia solanacearum infection
- Author
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M. R.A. Tohamy, M. M. Atia, Rahma Abd-Elrahim, Mohamed A. Ali, and Mohamed M. A. Elashtokhy
- Subjects
Ralstonia solanacearum ,biology ,Bacterial wilt ,fungi ,food and beverages ,biology.organism_classification ,Cell wall ,Horticulture ,biology.protein ,Wheat germ oil ,Cultivar ,Fennel Oil ,General Agricultural and Biological Sciences ,Pathogen ,Peroxidase - Abstract
Potato plants and their tubers in Egypt are affected by one of the most renowned soil-borne pathogen, Ralstonia solanacearum, that caused brown rot in potato tubers and wilt in plants. There is no efficient therapeutic bactericide so; control of bacterial wilt is very rough. The study investigated three different concentrations of seven essential plant oils under in vitro and in vivo conditions as a result of their effects on Ralstonia solanacearum growth and their possibility use as potato seed pieces dressing for controlling bacterial wilt disease incidence. In vitro, anise oil at the three tested different concentrations (0.04, 0.07, and 0.14% vol/vol) was the most effective one inhibiting the growth of T4 and W9 isolates of Ralstonia solanacearum then pursued by thyme, lemongrass, and clove oils. On the other hand, rocket oil at the tested concentration was the least effective one followed by fennel oil. However, wheat germ oil was not completely effective. In vivo, experiment revealed that anise oil at the three concentrations significantly reduced disease incidence and severity in sponta and hermes potato cultivars and their effect was associated with increase of peroxidase, polyphenoloxidase, phenols and the foliar fresh weight of treated plants as well as the weight of tubers/plant followed by thyme and lemongrass oils compared to the infected untreated control. Morphological differences in bacterial cell structure have been observed using a transmission electron microscope (TEM). Anise oil at higher concentration caused of cell wall rupture and degraded cellular components.
- Published
- 2022
14. IN VITRO RESEARCH ON THE INHIBITORY EFFECTS OF FENNEL, SAGE AND SEABUCKTHORN ESSENTIAL OILS ON SOME FOOD SPOILAGE FUNGI.
- Author
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OLARU, Georgia and POPA, Elena Mona
- Subjects
ESSENTIAL oils ,FOOD spoilage ,FENNEL ,ASPERGILLUS niger ,TERPENES ,FLAVORING essences - Abstract
Essential oils from natural plants are antimicrobial agents that can be used to control food spoilage and pathogenic food; they have long been used as flavoring agents in beverages and food. The antimicrobial activity of essential oils is attributed to a number of small terpenoids and phenolic compounds that provide antifungal or antibacterial activity. The experimental research carried out in this work focus on the in vitro study of the antimicrobial effect of fennel and sage essential oils on two food spoilage molds with the evaluation of the minimal lethal concentration (MLC). The fungi used in experimental work were Aspergillus niger and Penicillum expansum from Faculty of Biotechnologies collection. Minimum lethal concentrations were determined using a modified disc diffusion method in agar after puncture the fungus in the center of the Petri dishes. Sage and fennel essential oils proved to be the strongest antifungic agents, the minimum volumes that inhibited the growth and development of two fungi ranging between 14 to 19 µL. Seabuckthorn essential oil, even in higher doses of 250-300 µL, did not show antifungal activity. [ABSTRACT FROM AUTHOR]
- Published
- 2019
15. Fennel Oil Treatment Mimics the Anti-Depressive and Anxiolytic Effects of Fluoxetine without Altering the Serum Cholesterol Levels in Rats.
- Author
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Perveen, Tahira, Emad, Shaista, Ahmad, Saara, Batool, Zehra, Yousuf, Sarwat, Sheikh, Sheeza, Qadeer, Sara, and Haider, Saida
- Abstract
Synthetic antidepressants are effective drugs for the treatment of psychiatric disorders. Along with the effectiveness these drugs are also associated with some side effects. Since ancient times herbs are used as medicinal purposes. One such herb is Fennel (Foeniculum vulgare). Fennel has many efficacious uses. It is a common herb and spice. It is used in many culinary purposes and also it has therapeutic purposes. In the present study antidepressant effects of fennel oil was monitored by comparing it with a synthetic antidepressant drug, fluoxetine. The rats were divided into three groups as control, drug and oil which were respectively treated with water, fluoxetine (0.3 mg/kg) and fennel oil (0.5 ml/day). The treatment was continued for three weeks. Struggling time in forced swim test (FST), number of square crossed in open field test (OFT) and time spent in open arm in elevated plus maze (EPM) was monitored weekly. Repeated administration of fennel oil for 3 weeks showed significant antidepressant- and anxiolytic-like effects in FST and EPM, respectively which were comparable to fluoxetine treated group. A significant increased cholesterol levels were observed in fluoxetine treated rats which was not observed in fennel oil treated rats. Therefore, repeated administration of fennel oil may exert antidepressive- and anxiolyticlike behaviors. These effects were found to be comparable to that of the clinically used synthetic drug, fluoxetine. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
16. Uji Aktivitas Penghambatan ?-Amylase Pada Ekstrak Etanol Daun Adas (Foeniculum vulgare Mill.) Menggunakan Elisa Reader
- Author
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Dwi Bagus Pambudi, Retno Aulia Maharisti, and Nuniek Nizmah Fajriyah
- Subjects
chemistry.chemical_classification ,Foeniculum ,biology ,Secondary metabolite ,biology.organism_classification ,Enzyme assay ,chemistry ,biology.protein ,medicine ,Monosaccharide ,Amylase ,Food science ,Fennel Oil ,Digestion ,medicine.drug ,Acarbose - Abstract
Adas telah dibudidayakan di Indonesia sebagai tanaman bumbu dan tanaman obat. Adas dapat menghasilkan minyak adas, yang merupakan hasil penyulingan dari serbuk buah adas yang kering dan masak, sedangkan daun adas lebih banyak dimasak untuk dijadikan sayur. Salah satu enzim yang berperan penting dalam pemecahan oligosakarida dan disakarida menjadi monosakarida sehingga siap untuk diabsorbsi adalah enzim ?-amilase. Penghambatan terhadap enzim ?-amilase dapat menunda dan memperlama waktu cerna karbohidrat, menyebabkan penurunan laju absorbsi glukosa dan mencegah peningkatan kadar plasma glukosa postpandrial. Tujuan penelitian ini untuk mengetahui ekstrak etanol daun adas (Foeniculum vulgare Mill.) memiliki aktivitas penghambatan enzim ?-amylase menggunakan Elisa Reader. Metode penelitian eksperimental diterapkan untuk menguji ekstrak etanol senyawa metabolit sekunder dari daun adas terhadap penghambatan aktivitas enzim ?-amilase. Hasil penelitian menunjukkan bahwa nilai IC50 pada ekstrak daun adas sebesar 7,87 ?g/mL sedangkan IC50 akarbose sebagai pembanding sebesar 14,80 ?g/mL. Sebagai kesimpulan, bahwa ekstrak etanol daun adas dapat digunakan dalam menurunkan kadar gula dalam darah.
- Published
- 2021
17. Protective effects of fennel oil extract against sodium valproate-induced hepatorenal damage in albino rats.
- Author
-
Al-Amoudi, Wael M.
- Abstract
Foeniculum vulgare (Apiaceae) is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b.w fennel oil 3 days/week for 6 weeks. The biochemical analyses of hepatic enzymes were evaluated by estimating blood biomarkers of liver and renal damage along with histological examination. The results obtained from this work showed that treating animals with SVP lead to many histopathological alterations in the liver and kidney tissues. The effect appeared in the liver tissue include leukocyte infiltrations, cytoplasmic vacuolization of the hepatocytes, fatty degeneration and congestion of blood vessels. This commonly used chemical (SVP) caused some unwanted effects on the kidney cortex which histologically observed as degeneration in renal tubules, atrophy of the glomeruli and edema. Biochemical results also revealed an abnormal increase in the enzyme level of AST, SAT, ALP, bilirubin, creatinine and urea-nitrogen, with a noticed decrease in total protein content. However, the results of treated rats with SVP plus fennel oil showed some positive histopathological changes in both the liver and kidney tissues. These results have confirmed that fennel oil has positive effects on the histological structure of the liver and kidney and the biochemical levels of AST, ALT, ALP, bilirubin, total proteins, creatinine and urea. It is concluded that fennel oil has various pharmacological properties including antioxidant, anti-cancer activity, anti-inflammatory. These valuable effects might be due to the presence of aromatic compounds trans -anethole. This useful properties of fennel plant could be due to its antioxidant activity that prevents the toxicity of SVP. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
18. IN VITRO SCREENING FOR INSECTICIDAL ACTIVITY OF NATURAL PLANT PROTECTION PRODUCTS AGAINST TROPINOTA (EPICOMETIS) HIRTA (PODA) (COLEOPTERA: CETONIIDAE).
- Author
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Atanasova, Daniela, Ganchev, Donyo, and Nenov, Neno
- Subjects
- *
PLANT protection , *INSECT pest control , *INSECTICIDES - Abstract
The insecticidal activity of newly created naturally friendly plant protection products based on plant essential oils emulsified with plant triglyceride oil-based soap were tested against adult individuals of Tropinota (Epicometis) hirta (Poda) under in vitro conditions. Four different plant protection products (ready to be used) on the base of lavender, tobacco, coriander and fennel oil were tested. The products were created at the University of Food Technologies - Plovdiv, Bulgaria. The trials revealed strong insecticidal action of the coriander and lavender oil-based products. Surprisingly, the formulation based on tobacco oil had no effect on T. hirta and neither did the fennel oil-based product. The products were tested for phytotoxicity on two cultivars (Golden Delicious and Jonagold) of fiveyear- old apple trees using in vitro insecticidal trial concentrations according to standard № 227 of the OECD. There were no phytotoxic effects of the concentrations used. [ABSTRACT FROM AUTHOR]
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- 2017
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19. Insecticidal and behavioral effects of some plant essential oils against Sitophilus granarius L. and Tribolium castaneum (Herbst)
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Mehmet Ali Teke and Çetin Mutlu
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0106 biological sciences ,biology ,Caryophyllene ,Plant Science ,Origanum ,Horticulture ,biology.organism_classification ,Ocimum ,01 natural sciences ,010602 entomology ,chemistry.chemical_compound ,Camphor ,Eucalyptol ,chemistry ,Lamiaceae ,Estragole ,Fennel Oil ,Agronomy and Crop Science ,010606 plant biology & botany - Abstract
Insecticidal, repellent and fumigant activities of Rosemary [Rosmarinus officinalis (Lamiaceae)], Daphne [Laurus nobilis (Lauraceae)], Echinacea (Echinacea purpurea (Asteraceae), Marjoram [Origanum majorana (Lamiaceae)], Basil [Ocimum basilicum (Lamiaceae)] and Fennel [Foeniculum vulgare (Apiaceae)] extracts were tested against Sitophilus granarius (Col.: Curculionidae) and Tribolium castaneum (Col.: Tenebrionidae) under laboratory conditions. The composition of essential oils extracted from the plants was also determined. Eucalyptol and Terpinyl acetate were the main components of Daphne oil. Similarly, the main components of Basil oil were Methyl cinnamate, Linalool and Eucalyptol, whereas Camphor and Eucalyptol were the main constituents of Rosemary oil. Likely, γ-Terpinene and β-Terpineol were the main components of Marjoram oil, while Estragole was the main component in Fennel oil. The β-Cubebene and Caryophyllene were the main components of Echinacea oil. Echinacea and Basil oils exhibited high contact toxicity against S. granarius. Basil oil caused 99.59% mortality of S. granarius 24 h after application, whereas Echinacea oil caused 99.59% mortality 72 h after application. In single-dose fumigant toxicity assays, Rosemary oil exhibited 58.41% fumigant activity against S. granarius after 24 h, whereas Fennel oil indicated 100% fumigant toxicity against T. castaneum. All essential oils showed repellent effects against both the pests. The essential oils caused 34.12–95.29% decrease in the progeny production of F1 generation of T. castaneum, while the decrease in the F1 generation of S. granarius ranged between 84.27 and 98.88%. It is concluded that essential oils of Fennel, Rosemary, Echinacea and Basil could potentially be used for the control of studied stored grain pests.
- Published
- 2020
20. FORMULASI TISU BASAH BAWANG MERAH (Allium Cepa var. Ascalonicum) DENGAN MINYAK ADAS (Oleum Foeniculum Vulgare) SEBAGAI KOMPRES DEMAM ALAMI
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Zulfa Nurani Alfiyyah, Dewi Ratnasari, and Yusi Helmiawati
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Foeniculum ,biology ,Organoleptic ,biology.organism_classification ,Oleum ,Tissue Preparation ,Horticulture ,chemistry.chemical_compound ,chemistry ,Allium ,Fennel Oil ,Medicinal plants ,Aroma ,Mathematics - Abstract
Latar Belakang: Demam adalah suatu keadaan dimana suhu tubuh diatas normal yaitu diatas 38°C. Demam dapat diredakan dengan pengobatan sintetis dan pengobatan tradisional, salah satu tanaman obat yang dapat digunakan dalam pengobatan tradisional untuk mengendalikan demam adalah bawang merah (Allium Cepa var. Ascalonicum). Tujuan Penelitian: Penelitian ini bertujuan untuk membuat tisu basah dari bawang merah (Allium Cepa var. Ascalonicum) dengan minyak adas (Oleum Foeniculum Vulgare) sebagai kompres demam instan atau siap pakai yang mengandung bahan alami. Metode: Penelitian ini menggunakan metode penelitian tindakan (Action Research) menggunakan instrumen penelitian berupa lembar observasi dan angket uji kesukaan. Sediaan dibuat dengan komposisi antara bawang merah : minyak adas (12:1, 12:2, 12:3). Hasil: Menunjukkan hasil sediaan tisu basah yang tahan lama dan stabil selama 3 minggu penyimpanan pada suhu ruangan 20°C-25°C secara uji organoleptik dengan proposi formula yang paling disukai responden adalah formula 3 dengan penambahan minyak adas sebanyak 3 ml yaitu aroma 84% dan warna 88%. Simpulan: Tisu basah stabil dalam penyimpanan selama 3 minggu pada suhu ruangan dan sediaan yang paling disukai oleh masyarakat yaitu formula ketiga dengan penambahan minyak adas sebanyak 3 ml.
- Published
- 2020
21. Response of Fennel (Foeniculum vulgare, Mill) plants to foliar application of moringa leaf extract and benzyladenine (BA)
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S. S.A. Abdel-Rahman and A.A.S. Abdel-Kader
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0106 biological sciences ,Limonene ,Foeniculum ,biology ,Vegetative reproduction ,fungi ,food and beverages ,Plant Science ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Moringa ,010404 medicinal & biomolecular chemistry ,Horticulture ,chemistry.chemical_compound ,chemistry ,Chavicol ,Myrcene ,Estragole ,Fennel Oil ,010606 plant biology & botany - Abstract
The aim of this study was to investigate the influence of foliar application of Moringa oleifera leaf extracts (control, 2.5% and 5% aqueous MLE, 2.5% and 5% ethanolic MLE) and/or benzyladenine (control, 50, 100 and 200 ppm BA) on the growth, fruit and oil yield and its main components and chemical constituents of fennel (Foeniculum vulgare, Mill.) plants. The obtained results revealed that treated fennel plants with MLE and/or BA resulted in a significant increase in the vegetative growth, number of umbels/plant, fruit and oil yield per plant and feddan as well as total carbohydrates in fruits, chlorophyll a, b and carotenoids, nitrogen, phosphorus and potassium contents in leaves compared to untreated plants. Generally, the application of moringa leaf extracts was more effective than BA treatments. The individual treatment of aqueous MLE at 5% or BA at 100 ppm gave the best results of the previous mentioned characteristics followed by 5% ethanolic MLE or 50 ppm BA compared to the control and the rest of tested individual ones. The highest values of all studied parameters were obtained by using 5% aqueous or ethanolic MLE combined with 100 ppm BA. The increments were 91.1% and 85.3% in fruit yield/feddan, 52.5% and 46.3% in volatile oil percentage and 192.4% and 172.0% in oil yield/feddan, respectively over the control. The G.C. analysis of the volatile oil showed that the major component of volatile oil was methyl chavicol (estragole) with concentration range from 77.5% to 87.3%. The minor compounds were myrcene and limonene. The best treatment for decreasing the concentration of methyl chavicol (77.5%), which is undesirable component in fennel oil resulted from the combination of 5% aqueous MLE plus 100 ppm BA. Therefore, it could be recommended that spraying fennel plants with 5% aqueous MLE plus 100 ppm BA for obtaining higher vegetative growth, fruit and oil yield.
- Published
- 2020
22. Attractant Effect of Eucalyptus globulus (Labill) and Foeniculum vulgare (Mill.) Essential Oils on Aegorhinus superciliosus (Guérin) (Coleoptera: Curculionidae)
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Leonardo Bardehle, Betania Pacheco, Eduardo Fuentes, Leonardo Salas, Jocelyne Tampe, and Andrés Quiroz
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0106 biological sciences ,Foeniculum ,Soil Science ,04 agricultural and veterinary sciences ,Plant Science ,Biology ,biology.organism_classification ,01 natural sciences ,Fenchone ,chemistry.chemical_compound ,Horticulture ,Eucalyptol ,chemistry ,Eucalyptus oil ,Eucalyptus globulus ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,Estragole ,Fennel Oil ,Agronomy and Crop Science ,Anethole ,010606 plant biology & botany - Abstract
Currently, the use of essential oils for behavioral manipulation of insects is being investigated for its potential application in integrated pest management programs. Thus, we identified the chemical composition of Eucalyptus globulus (Labill) and Foeniculum vulgare Mill. essential oils and evaluated its effect on the Aegorhinus superciliosus behavior, an important fruit tree pest in the south of Chile. The oils were analyzed by gas chromatography coupled with mass spectrometry and then were evaluated in olfactometric bioassays in order to establish whether they have any effect on the insect behavior. Finally, we determined the electrophysiological activities associated with behavior studies using electroantennography. The GC-MS analysis indicated the presence of 17 compounds from eucalyptus oil being its major constituent’s eucalyptol (63.6%) and α-pinene (18.9%). For fennel oil, 16 volatile constituents were identified, being anethole (50.8%), estragole (19.5%), and fenchone (11.1%) the dominant compounds. The olfactometric bioassays revealed that eucalyptus oil was attractive for both sexes of A. superciliosus whereas fennel oil was only attractive to the females (P ≤ 0.05). The main compounds, eucalyptol and anethole, were attractive to females (P ≤ 0.05) and electrophysiologically active for both sexes of the insect. In conclusion, the components attractive identified in the present study could be the starting point for the development of effective attractant lures for controlling the raspberry weevil in southern Chile.
- Published
- 2020
23. Development of gel for Aedes aegypti repellent with combination of cinnamon oil (Cinnamomum burmannii Blume) and fennel oil (Foeniculum vulgare Mill)
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Ratna Djamil, Evah Sohipah, and Anny Purba Victor
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gel ,repellent ,biology ,Traditional medicine ,Foeniculum ,cinnamon oil ,lcsh:R ,fungi ,lcsh:Medicine ,Cinnamomum burmannii ,fennel oil ,Aedes aegypti ,030204 cardiovascular system & hematology ,biology.organism_classification ,03 medical and health sciences ,0302 clinical medicine ,aedes aegypti ,Fennel Oil ,030217 neurology & neurosurgery ,Cinnamon Oil - Abstract
Background/Aim: Aim of this study was to develop efficient mosquito repellent by combining fennel oil (Foeniculum vulgare Mill) and cinnamon oil (Cinnamomum burmannii Blume) in a gel preparation form. Methods: Effectiveness of each oil and its combination as viral repellents was tested by the World Health Organization's Pesticide Evaluation Scheme (WHOPES) method. Repellent was prepared in gel form. Evaluation of gel preparation included organoleptic properties, homogeneity, pH, viscosity, flow properties, acute skin irritation test and effectiveness test as mosquito repellent. Results: The mosquito protection test for cinnamon oil showed that cinnamon oil was most effective at concentration of 15 % (96.85 %), and fennel oil at 24 % concentration (79.26 %). Within 6 hours, gel made of 24 % fennel oil and 15 % cinnamon oil combination gave protection against 53.49 % mosquitoes. Conclusion: The combination of cinnamon oil and fennel oil can be formulated into gel form with satisfying physical and chemical characteristics and effectiveness against Aedes aegypti mosquitoes for 6 hours.
- Published
- 2020
24. Quantification of Anethole in Fennel and Anise Essential Oils using Gas Chromatography and 1H-NMR-Spectroscopy
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Valentin Ionescu, Mioara Negoiță, Alina Culețu, and Denisa Eglantina Duță
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1h nmr spectroscopy ,Chromatography ,lcsh:TP368-456 ,Chemistry ,anethol ,fennel oil ,gc-ms ,General Medicine ,nmr spectroscopy ,chemistry.chemical_compound ,lcsh:Food processing and manufacture ,Gas chromatography ,anise oil ,Anethole - Abstract
Nine essential oils from fennel (seeds and herbs) and anise (seeds) from different origins were analysed for density, refractive index and for a complete composition through GC-MS and 1H-NMR-spectroscopy. Anethole was the main compound identified in fennel and anise essential oils. Anethole content varied between 30 – 90% in fennel oils and between 80 – 99% in anise oils; anethole is often used as flavouring substance in foods with a good antimicrobial activity also. A positive correlation was found between anethole content determined by GC-MS and 1H-NMR (r = 0.8567 for fennel oils and r = 0.6986 for anise oils). The results showed different levels of anethole in oils (values ranged between 30.66 % and 99.24 %). Electronic nose was a very good and rapid method for discrimination of essential oils based on PCA (Principal Component Analysis) with discrimination index above 90 for both essential oils.
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- 2019
25. Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality
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Ali Osman, Ahmed A Easa, Aziza M. Hassan, Kamal Emam Mahmoud, Walid S. Habashy, Shimaa A. Amer, Nikolay Kostomakhin, Islam I. Sabeq, and Tharwat A. Imbabi
- Subjects
GPX1 ,Antioxidant ,Physiology ,medicine.medical_treatment ,Clinical Biochemistry ,RM1-950 ,Biology ,medicine.disease_cause ,Biochemistry ,Feed conversion ratio ,Article ,law.invention ,meat quality ,chemistry.chemical_compound ,Animal science ,law ,medicine ,Fennel Oil ,Molecular Biology ,Essential oil ,chemistry.chemical_classification ,Triglyceride ,Glutathione peroxidase ,apoptosis ,fennel oil ,Cell Biology ,chemistry ,weaned rabbits ,gene expression ,Therapeutics. Pharmacology ,Oxidative stress - Abstract
In the current study, fennel essential oil was used as an antibiotic alternative compared to gentamycin for enhancing the expression of apoptosis genes and antioxidant enzymes in weaned rabbits as well as meat quality and growth performance. The gene expression of the cell lymphoma 2 (BAX and BCL2), caspase3 (CASP3), and glutathione peroxidase (GPX1) were estimated in the liver tissue using qRT-PCR. A total of 45 Moshtohor weaned male rabbits aged four weeks were randomly allocated to control, T1, and T2 treatment groups, each consisted of 15 weaned male rabbits with five replicates. Rabbits in the T1 and T2 groups were orally supplied with 1 mL fennel oil and 1 mL gentamycin, respectively. Weaned rabbits under different treatments showed increased body weight (BW) at 8 and 12 weeks of age and average daily gain (ADG) at 4–8 and 4–12 weeks of age compared to the control group. Compared to the controls, the weaned rabbits supplemented with fennel oil and gentamycin had lower total cholesterol, triglyceride, and MDA. In addition, villus length, mRNA of BAX, BCL2, Casp3, and GPX were increased in the different treatments compared to the control. Furthermore, the meat of these rabbits was less tender, had a lower aerobic plate count (APC), pH, and was brighter and redder in color than the control. Under the conditions of the present study, the supplementation of weaned Moshtohor rabbits with fennel oil as a natural alternative for gentamycin enhanced feed conversion and daily gain through enhancing villus length and mucus thickness. Additionally, fennel essential oil reduces oxidative stress by increasing the antioxidant enzymes.
- Published
- 2021
26. Efficacy of Natural Formulation Containing Activated Charcoal, Calcium Sennosides, Peppermint Oil, Fennel Oil, Rhubarb Extract, and Purified Sulfur (Nucarb®) in Relieving Constipation
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Kamran Hassan, Muhammad Irfan, Maroof Vaince, Sidra Memon, Adnan Maqsood, Ambreen Aslam, Nabeel Amaan, Adeel Qamar, Umair Akram, and Rashid Ali
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tenesmus ,Abdominal pain ,Constipation ,laxatives ,Traditional medicine ,business.industry ,General Engineering ,Gastroenterology ,constipation ,Sennosides ,Bedtime ,Bloating ,Activated charcoal ,nucarb ,medicine ,Internal Medicine ,Defecation ,Fennel Oil ,medicine.symptom ,business ,Family/General Practice ,natural medicine - Abstract
Introduction Long-term use of laxatives may have side effects such as bloating, allergic reaction, abdominal pain, metabolic disturbances, and hepatotoxicity. In this study, we have compared the efficacy of herbal medicine Nucarb, a combination of activated charcoal, calcium sennosides, peppermint oil, fennel oil, rhubarb extract, and purified sulfur, in relieving constipation. Methods This longitudinal study was conducted in multiple cities of Pakistan from April 2021 to June 2021. A total of 1000 patients, of either gender between age group 18 and 75 years, with complete spontaneous bowel movement of less than or equal to two times per week, were enrolled in the study. Participants were prescribed two tablets of Nucarb once daily (OD) at bedtime for the first seven days, followed by one tablet of Nucarb OD at bedtime for the following seven days. They were asked to return for follow-up after 14 days. Results There was a statistically significant improvement in all six components of constipation. After 14 days, the severity of constipation reduced by 80.70%, the sensation of straining was reduced by 72.69%, and the feeling of incomplete evacuation was reduced by 71.87%. There was no adverse event reported. Conclusion Nucarb is efficacious in reducing the severity of constipation, sensation of straining, bloating and abdominal pain, feeling of incomplete evacuation, and difficulty in passing gas. Since it is a herbal product, it can be safely used in all populations.
- Published
- 2021
27. SYNTHESIS OF THIOMETHYLATED CALIX[4]RESORCINARENE BASED ON FENNEL OIL VIA CHLOROMETHYLATION
- Author
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Suryadi Budi Utomo, Jumina Jumina, Dwi Siswanta, Mustofa Mustofa, and Naresh Kumar
- Subjects
fennel oil ,chloromethylation ,tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene ,flattened partial cone ,crown ,Chemistry ,QD1-999 - Abstract
A research has been conducted to synthesize thiomethylated-C-4-methoxyphenylcalix[4]resorcinarene using fennel oil as a starting material. The synthesis was carried out in four steps i.e. (1) oxidation of anethole to yield p-anisaldehyde, (2) HCl-catalyzed condensation of p-anisaldehyde with resorcinol, (3) chloromethylation of C-4-methoxyphenylcalix[4]resorcinarene with paraformaldehyde and HCl in the presence of ZnCl2 to yield tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene, and (4) reaction of tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene with thiourea followed by hydrolysis with sodium hydroxide solution to yield tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene. The prepared compounds were characterized based on melting point, FT-IR, and NMR spectrometers. According to the analysis of 1H-NMR spectrometer, C-4-methoxyphenylcalix[4]resorcinarene and tetrakis-chloromethyl-C-4-methoxyphenylcalix[4]resorcinarene were observed in the chair or flattened partial cone conformation, while tetrakis-thiomethyl-C-4-methoxyphenylcalix[4]resorcinarene tend to exist in the crown or cone conformation.
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- 2011
- Full Text
- View/download PDF
28. Chemical Composition and Antimicrobial and Cytotoxic Activities of Foeniculum vulgare Mill Essential Oils
- Author
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Abdolmajid Ghasemian, Ali-H Al-Marzoqi, Seyyed Khalil Shokouhi Mostafavi, Maryam Teimouri, and Yasemin Khudiar Alghanimi
- Subjects
Foeniculum ,Herbal Medicine ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Anti-Infective Agents ,law ,Oils, Volatile ,Humans ,Medicine ,Fennel Oil ,Essential oil ,Limonene ,Apiaceae ,biology ,Traditional medicine ,business.industry ,Gastroenterology ,biology.organism_classification ,Antimicrobial ,Fenchone ,Anti-Bacterial Agents ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Gas chromatography ,business - Abstract
Foeniculum vulgare (F. vulgare) Mill, commonly known as fennel, belongs to the Umbelliferae (Apiaceae) family, biennial or perennial herbs disseminated in Mediterranean region and central Europe. This herbal medicine (HM) is considered as a traditional HM, and its parts have been studied. In this survey, essential oils from seeds collected from three various regions (Kerman, Golestan, and East Azerbaijan Provinces) of Iran were prepared with hydro-distillation and their components were analyzed with gas chromatography (GC) and chromatography time-of-flight mass spectrometry (GC/MS). Antimicrobial and cytotoxic activities of the essential oils were examined with disk-diffusion method on Muller–Hinton agar and Subaru-dextrose Agar, respectively. Additionally, the MTT assay was assessed on breast cancer cell line (MCF-7). The expression of apoptosis-related genes, Bax and Bcl2, was determined using quantitative real-time PCR (RT-qPCR). The major fractions of essential oils identified by GC and GC/MS included trans-anethole (78.47%, 49.64%, 78.68%), fenchone (10.5%, 8.4%, and 10.2%), and limonene (5.9%, 6.70%, and 5.6%), respectively. Fennel oil collected from three various places exerted inhibitory effects on the bacterial growth and higher cytotoxic effects on MCF-7 cancer cell line. In addition, the essential oil increased the expression of Bax, but decreased Bcl2 gene expression significantly (P
- Published
- 2019
29. Can Mesenchymal Stem Cell Transplantation and Fennel Ingestion Alter the Histology of Senile Diabetic Rat Ovary?
- Author
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Fatma S. Abdel Aal, Mona Mohamed Abd Elgalil, and Hekmat Sorour
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business.industry ,Mesenchymal stem cell ,Physiology ,Ovary ,medicine.disease ,Obesity ,Transplantation ,Menopause ,medicine.anatomical_structure ,Diabetes mellitus ,Medicine ,Stem cell ,Fennel Oil ,business - Abstract
Background: The relation between menopausal status and diabetes mellitus remains controversial. However, clinical trials suggest that menopause would speed the progression to diabetes. Reproductive tract dysfunction is a recognized consequence of diabetes obesity syndrome (DOS). Therefore, a possible association between obesity, diabetes mellitus and abnormalities of female reproductive function may occur. Nowadays traditional medicinal plants and spices are commonly used for their possible effects as hypoglycaemic, antidiabetic and folliculogenic agents instead of using synthetic drugs. Recent studies suggest that bone marrow stem cells (BMSCs) are promising grafts to treat a variety of diseases, including reproductive dysfunction.Aim of the work: The objective of this study was to evaluate the therapeutic implication of MSCs and fennel ingestion on ovarian diabetically induced senile rats.Materials & Methods: 24 senile female albino rats were used in this study. They were divided into 4 equal groups: control group, diabetic group, diabetic/MSCs group and diabetic/ MSCs /fennel oil group. Treatments were continued for 8 weeks, and ovarian samples were collected for histological, immunohistochemical and ultrastructure studies.Blood glucose levels were estimated and serum hormonal analyses were performed.Results: Induction of diabetes caused variable sizes of typical ovarian follicular cysts and elevation of blood glucose level. Stem cell transplantation showed some amelioration in the ovarian structure and blood glucose level. Administration of both MSCs and fennel oil had the ability to lower the blood glucose level and restore ovarian structure in diabetic rats.Conclusion: The use of MSCs in regenerative medicine and tissue engineering makes them a promising therapy to treat diabetes mellitus complications. Fennel essential oil could be given to diabetic patients to ameliorate diabetes in addition to its use as a fertility enhancing agent.
- Published
- 2019
30. Alternaria Spots in Tomato Leaves Differently Delayed by Four Plant Essential Oil Vapours
- Author
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Yeon Sook Jo, Dong Hyun Ryoo, Hyun Ji Kwon, Young Hee Lee, Jeum Kyu Hong, Seog Won Chang, Chang-Jin Park, and Ji Hwan Jung
- Subjects
0106 biological sciences ,Plant Science ,01 natural sciences ,Biochemistry ,Alternaria alternata ,Tomato ,law.invention ,law ,Disease management ,Plant essential oil vapour ,Leaf spot ,lcsh:Agriculture (General) ,Fennel Oil ,Molecular Biology ,Essential oil ,Cinnamon Oil ,biology ,fungi ,food and beverages ,Alternaria ,biology.organism_classification ,lcsh:S1-972 ,Fungicide ,010602 entomology ,Horticulture ,Germination ,Eco-Friendly ,Agronomy and Crop Science ,010606 plant biology & botany ,Biotechnology - Abstract
Alternaria leaf spot disease has been a concern during a tomato production in greenhouse. In vitro antifungal activities of vapours of four plant essential oils, cinnamon oil, fennel oil, origanum oil and thyme oil, were investigated during in vitro conidial germination and mycelial growth of Alternaria alternata causing the tomato leaf spots to find eco-friendly alternatives for chemical fungicides. The four plant essential oils showed different antifungal activities against in vitro conidial germination of A. alternata in dose-dependent manners, and cinnamon oil vapour was most effective to suppress the conidial germination. The four plant essential oils showed similar antifungal activities against the in vitro mycelial growth of A. alternata in dose-dependent manners, but low doses of thyme oil vapour slightly increased in vitro mycelial growth of A. alternata. Necrotic lesions on the A. alternata-inoculated tomato leaves were reduced differently depending on kinds and concentrations of plant essential oils. Delayed conidial germination and germ-tube elongation of A. alternata were found on the tomato leaves treated with cinnamon oil and origanum oil vapours at 6 hpi. These results suggest that volatiles from cinnamon oil and origanum oil can be provided as alternatives to manage Alternaria leaf spot during the tomato production eco-friendly.
- Published
- 2018
31. Assessment of Fennel Oil Microfluidized Nanoemulsions Stabilization by Advanced Performance Xanthan Gum
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José Muñoz, Luis A. Trujillo-Cayado, José A. Carmona, Pablo Ramírez, Rubén Llinares, and Universidad de Sevilla. Departamento de Ingeniería Química
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Health (social science) ,Materials science ,nanoemulsion ,Plant Science ,engineering.material ,lcsh:Chemical technology ,01 natural sciences ,Health Professions (miscellaneous) ,Microbiology ,Homogenization (chemistry) ,Essential oil ,Article ,essential oil ,hydrocolloid ,0404 agricultural biotechnology ,Hydrocolloid ,Rheology ,Nanoemulsion ,medicine ,lcsh:TP1-1185 ,Response surface methodology ,Fennel Oil ,Microfluidization ,010401 analytical chemistry ,04 agricultural and veterinary sciences ,040401 food science ,0104 chemical sciences ,Chemical engineering ,Emulsion ,engineering ,rheology ,Biopolymer ,Xanthan gum ,Food Science ,medicine.drug ,Stabilizer (chemistry) ,microfluidization - Abstract
In this work, nanoemulsion-based delivery system was developed by encapsulation of fennel essential oil. A response surface methodology was used to study the influence of the processing conditions in order to obtain monomodal nanoemulsions of fennel essential oil using the microchannel homogenization technique. Results showed that it was possible to obtain nanoemul-sions with very narrow monomodal distributions that were homogeneous over the whole observation period (three months) when the appropriate mechanical energy was supplied by microfluidization at 14 MPa and 12 passes. Once the optimal processing condition was established, nanoemulsions were formulated with advanced performance xanthan gum, which was used as both viscosity modifier and emulsion stabilizer. As a result, more desirable results with enhanced physical stability and rheological properties were obtained. From the study of mechanical spectra as a function of aging time, the stability of the nanoemulsions weak gels was confirmed. The mechanical spectra as a function of hydrocolloid concentration revealed that the rheological properties are marked by the biopolymer network and could be modulated depending on the amount of added gum. Therefore, this research supports the role of advanced performance xanthan gum as a stabilizer of microfluidized fennel oil-in-water nanoemulsions. In addition, the results of this research could be useful to design and formulate functional oil-in-water nanoemulsions with potential application in the food industry for the delivery of nutraceuticals and antimicrobials. Ministerio de Economía y Competitividad CTQ2015-70700-P
- Published
- 2021
32. Acaricidal activity of Foeniculum vulgare against Rhipicephalus annulatus is mainly dependent on its constituent from trans-anethone
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Saleh Al-Quraishy, Abdel-Azeem S. Abdel-Baki, Waleed M. Arafa, Ahmed O. Hassan, Asmaa A. Kamel, Shawky M. Aboelhadid, and Atalay Sokmen
- Subjects
Life Cycles ,Foeniculum ,Physiology ,Eggs ,Disease Vectors ,medicine.disease_cause ,Biochemistry ,law.invention ,Toxicology ,chemistry.chemical_compound ,Larvae ,Medical Conditions ,Ticks ,Filter Paper ,Reproductive Physiology ,law ,Plant Products ,Medicine and Health Sciences ,Public and Occupational Health ,Rhipicephalus annulatus ,Protease Inhibitor Therapy ,Multidisciplinary ,biology ,Essential Oils ,Eukaryota ,Agriculture ,Vaccination and Immunization ,Glutathione ,Fenchone ,Laboratory Equipment ,Infectious Diseases ,Acetylcholinesterase ,Engineering and Technology ,Medicine ,Research Article ,Arthropoda ,Death Rates ,Science ,Immunology ,Antiretroviral Therapy ,Equipment ,Tick ,Antiviral Therapy ,Population Metrics ,Arachnida ,Infestation ,parasitic diseases ,Oils, Volatile ,Rhipicephalus ,medicine ,Animals ,Fennel Oil ,Essential oil ,Ixodes ,Population Biology ,Acaricide ,fungi ,Organisms ,Biology and Life Sciences ,biology.organism_classification ,Invertebrates ,Agronomy ,Species Interactions ,chemistry ,Fruit ,Preventive Medicine ,Peptides ,Zoology ,Developmental Biology ,Crop Science - Abstract
Globally, the economic losses due to hard ticks infestation and the control of the associated diseases have been calculated at USD $13.9–18.7 billion per year. The economic impact is related to its direct damage to the skins, blood loss, anemia, severe immunological reactions and indirect losses that related to the effects of hemoparasites, cost of treatment for clinical cases and expenses incurred in the control of ticks. The current study evaluated the acaricidal activities of fennel Foeniculum vulgare essential oil and its main components; trans-anethole and fenchone; against R. annulatus. GC–MS analysis revealed that this oil contained 16 components representing 99.9% of the total identified compounds with E-anethole being the predominant component(64.29%), followed by fenchone (9.94%). The fennel oil and trans-anethole showed significant acaricidal activities. The LC50 of the fennel oil was attained at concentrations of 12.96% for adult ticks and 1.75% for tick larvae meanwhile the LC50 of trans-anethole was reached at concentrations of 2.36% for adult tick and 0.56% for tick larvae. On the contrary, fenchone showed no any significant adulticidal activities and its LC50 attained at a concentration of 9.11% for tick larvae. Regarding repellence activities, trans-anethole achieved 100% repellency at the concentration of 10% while fennel showed 86% repellency at the same concentration. Fenchone showed no repellency effect. Treatment of larvae with fennel, trans-anethole, and fenchone LC50 concentrations significantly inhibited the acetylcholinesterase activity. Meanwhile, glutathione s-transferase activity was significantly decreased in fennel treated larvae but no significant effect was found in the larvae of trans-anethole and fenchone groups. These results indicate that the acaricide effect of fennel oil may attributed to its high content of trans-anethole. This was supported by potent adulticidal, larvicidal, and repellency effects of trans-anethole against Rhipeciphalus annulatus tick and therefore it could be included in the list of acaricide of plant origin.
- Published
- 2021
33. Effects of Supplementary Fennel (Foeniculum vulgare) Essential Oil of Diet on Growth, Survival, Body Composition and Hematological Parameters of Rutilus frisii kutum Fry.
- Author
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Mahdavi, S., Yeganeh, S., Firouzbakhsh, F., and Janikhalili, KH.
- Abstract
The effects of fennel essential oil (Foeniculum vulgare) at 5 levels of 0 (control), 100, 200, 400 and 600 mg per kg. of diet on growth performance, survival, body composition and hematological parameters of the Caspian kutum fry, Rutilus frisii kutum, were investigated in a 60-days feeding trial. No significant differences in the growth related parameters and survival were observed among treatments (p>0.05). The highest level of fat was observed in 100 mg fennel essential oil (p<0.05). The highest level of white blood cells was observed in 100 mg and the highest levels of red blood cells, hematocrite and hemoglobin were observed in 400 mg; the lowest level of MCV was observed in the control. No significant differences were observed in other parameters such as MCH and MCHC. In conclusion, fennel essential oil had no significant effect on the growth related parameters of the Caspian kutum fry, but 100 mg of fennel essential oil/kg diet would play an important role in promoting immune system of the fish by increasing the white and red blood cells. [ABSTRACT FROM AUTHOR]
- Published
- 2014
34. Foeniculum vulgare Mill. (Apiaceae/Umbelliferae)
- Author
-
Shahid Akbar
- Subjects
Apiaceae ,food.ingredient ,biology ,Foeniculum ,Traditional medicine ,business.industry ,biology.organism_classification ,Fenchone ,chemistry.chemical_compound ,food ,chemistry ,Herb ,Medicine ,Estragole ,Fennel Oil ,business ,Emmenagogue ,Anethole - Abstract
It is universally known as fennel and by more than 100 other names, and has been used medicinally throughout the world since ancient times. Hippocrates and Dioscorides mentioned fennel as diuretic and emmenagogue, and the juice was supposed to sharpen the eyesight. As one of the ancient Saxon people’s nine sacred herbs, fennel was credited with the power to cure, and was valued as a magic herb. In the Middle Ages it was draped over doorways on Midsummer’s Eve to protect the household from evil spirits. It is one of the most commonly consumed herb by more than a quarter of Italian pregnant women every day for at least 3 months during pregnancy, and one of the most frequently quoted plants in The Chilandar Medical Codex, the best preserved medieval Serbian manuscript on European medical science from the 12th to 15th centuries. In Europe and Mediterranean countries, fennel is traditionally used as antispasmodic, diuretic, anti-inflammatory, analgesic, secretomotor, secretolytic, galactagogue, as eye lotion, and antioxidant remedy and integrator; topically, fennel powder is used as a poultice for snakebites. In Portugal, it is highly recommended for treatment of diabetes, bronchitis and chronic coughs, and for kidney stones. In Unani medicine, it is used to open liver and spleen obstructions, relieve flatulent colic, and to induce diuresis and menstruation. In traditional Iranian medicine, it has been used for the treatment of inflammatory bowel diseases. Boiled or roasted roots are used for the treatment of gonorrhea in East Africa. In TCM, it is used to relieve chills, abdominal distension, vomiting and diarrhea. Fennel infusion is approved for GI disorders use in Europe since Nov. 2005 by the HMPC of the European Medicines Agency. Fennel contains d-pinene, camphene, d-α-phellandrene, dipentine, anethole, fenchone, methyl chavicol, aldehydes, and anisic acid. Bergapten, columbianetin, osthenol, psoralen, scoparone seselin, vanillin, β-sistosterol and stigmasterol have also been identified in fruits. In general, fennel oil extracted by either distillation-extraction or supercritical fluid extraction shows similar compositions, with trans-anethole, estragole, and fenchone as the main components.
- Published
- 2020
35. Immunological Stimulant Effect of Linseed Oil and Fennel Oil Supplemented Diet on Broilers
- Author
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Ibrahim S. Zahran, Ibrahim Said Abu-Alya, Sherif M. Shawky, Khalid M. Gaafar, Said I. Fathalla, and Mohamed K. Hussein
- Subjects
food.ingredient ,food ,General Veterinary ,Linseed oil ,Chemistry ,Animal Science and Zoology ,Food science ,Fennel Oil - Published
- 2020
36. Can yeast extract and chitosan-oligosaccharide improve fruit yield and modify the pharmaceutical active ingredients of organic fennel?
- Author
-
Abdel-Nasser A. El-Sheshtawy, Rasha S. El-Serafy, Ibrahim Al-Ashkar, and Abeer A. Dahab
- Subjects
Foeniculum ,biology ,food and beverages ,Raw material ,biology.organism_classification ,law.invention ,chemistry.chemical_compound ,Ingredient ,chemistry ,law ,Yeast extract ,Estragole ,Food science ,Fennel Oil ,Agronomy and Crop Science ,Essential oil ,Anethole - Abstract
Fennel is one of the most significant medicinal and aromatic herbs. It is used as a culinary ingredient and has an essential role as a raw material in the pharmaceutical industry. Many researchers across the world are working to increase the active components in the essential oil of medicinal and aromatic plants under organic farming. Growth promoters are one of the most effective methods for stimulating secondary metabolite production under organic agriculture. The objectives of this study were to investigate how foliar sprays of yeast extract (Y) and/or chitosan-oligosaccharide (CHO) affected the growth and yield of organic fennel (Foeniculum vulgare spp. vulgare Mill.) and if these applications can stimulate the production of pharmaceutical active ingredients in fennel fruits. Fennel foliage was subjected to foliar spray of Y at concentrations of 0 (Y0), 2 (Y1), and 4 (Y2) g L−1, and CHO at concentrations of 0 (CHO0), 60 (CHO1), and 120 (CHO2) mg L−1 twice. The results revealed that both Y and CHO treatments promoted growth parameters and leaf pigments content. Total phenols and nutritional content (N, P, K, Ca, and Mg) in fennel fruits were also improved. Furthermore, Y and CHO treatments enhanced fruit and oil productivity. Foliar spraying with Y and/or CHO, as well as their combination, resulted in significant modification in main pharmacological active components in fennel essential oil. Treated plants with Y1 had the lowest proportion of estragole (24.61 %), an undesirable component in fennel oil, and the highest concentration of anethole (64.50 %), which improved the oil quality. While treated plants with CHO1 or CHO2 displayed an increase in estragole content by about 33.34 and 46.59 % compared with Y1-plants, respectively. These new findings demonstrated that applying Y2 or CHO at both levels not only increased fennel growth and yield, but also contributed to increasing estragole and decreasing anethole concentration, and both had a negative impact on essential oil quality. However, applying Y1 enhanced fennel productivity as well as essential oil quality.
- Published
- 2021
37. Differential Inhibitory Activities of Four Plant Essential Oils on In Vitro Growth of Fusarium oxysporum f. sp. fragariae Causing Fusarium Wilt in Strawberry Plants
- Author
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Su Hyeon Kim, Sang Woo Lee, Jin Young Park, Yong-Chull Jeun, Na Hee Kim, and Jeum Kyu Hong
- Subjects
0106 biological sciences ,biology ,plant essential oil ,synergistic ,food and beverages ,lcsh:Plant culture ,biology.organism_classification ,Fusarium oxysporum f. sp. fragariae ,01 natural sciences ,volatile ,Fusarium wilt ,Conidium ,Horticulture ,Germination ,010608 biotechnology ,Fusarium oxysporum ,Spore germination ,lcsh:SB1-1110 ,Fennel Oil ,Agronomy and Crop Science ,Mycelium ,Cinnamon Oil ,antifungal ,010606 plant biology & botany ,Research Article - Abstract
The objective of this study was to determine inhibitory activities of four volatile plant essential oils (cinnamon oil, fennel oil, origanum oil and thyme oil) on in vitro growth of Fusarium oxysporum f. sp. fragariae causing Fusarium wilt of strawberry plants. Results showed that these essential oils inhibited in vitro conidial ger mination and mycelial growth of F. oxysporum f. sp. fragariae in a dose-dependent manner. Cinnamon oil was found to be most effective one in suppressing co nidial germination while fennel oil, origanum oil and thyme oil showed moderate inhibition of conidial ger mination at similar levels. Cinnamon oil, origanum oil and thyme oil showed moderate antifungal activities against mycelial growth at similar levels while fennel oil had relatively lower antifungal activity against mycelial growth. Antifungal effects of these four plant essential oils in different combinations on in vitro fungal growth were also evaluated. These essential oils demonstrated synergistic antifungal activities against conidial ger mination and mycelial growth of F. oxysporum f. sp. fragariae in vitro. Simultaneous application of origanum oil and thyme oil enhanced their antimicrobial activi ties against conidial germination and fungal mycelial growth. These results underpin that volatile plant es sential oils could be used in eco-friendly integrated dis ease management of Fusarium wilt in strawberry fields.
- Published
- 2017
38. Ovarian cytoarchitectual changes following fennel ingestion in senile diabetic albino rat
- Author
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Hekmat Ahmed-Sorour, Fatma S. Abdel Aal, and Mona Abd-Elgalil
- Subjects
business.industry ,Physiology ,Ovary ,medicine.disease ,Obesity ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Diabetes mellitus ,medicine ,Ingestion ,Folliculogenesis ,Risk factor ,Fennel Oil ,business ,030217 neurology & neurosurgery ,Hormone - Abstract
Introduction: Postmenopausal obesity sounds an alarm for women’s health, since it serves as a predominant risk factor for many chronic diseases leading to reduced life expectancy and increased health problems.The relation between menopausal status and diabetes mellitus remains controversial. Reproductive tract dysfunction is a recognized consequence of diabetes obesity syndrome (DOS). Therefore, a possible association between obesity, diabetes mellitus and abnormalities of female reproductive function in several respects may occur.Nowadays traditional medicinal plants and spices are commonly used for their possible effects as hypoglycaemic, antidiabetic and folliculogenic agents instead of using synthetic drugs.Aim: The objective of this study was to evaluate the therapeutic implication of fennel ingestion in ovarian changes in diabetically induced senile rats.Materials and Methods: A total of 24 senile female albino rats were divided into 4 equal groups: control group, fennel oil receiving group, diabetic group and diabetic/fennel oil ingested group. Treatments were continued for 8 weeks, then ovarian samples were collected from all rats for histological, immunohistochemical and ultra-structural studies. Blood glucose levels were measured to confirm hyperglycemia and to follow the disease progression. Serum analyses for hormonal assay were also estimatedResults: STZ injection caused typical ovarian follicular cysts of variable sizes together with elevation of blood glucose level. Fennel oil administration to diabetes-induced group showed some amelioration in the ovarian structure and blood glucose level.Conclusion: Fennel essential oil could ameliorate diabetes with its use as a fertility enhancing agent. Fennel has folliculogenesis effect consistent with its use in folk medicine as a fertility enhancing agent.
- Published
- 2017
39. Protective effect of fennel oil on cyclophosphamide inhibited spermatogenesis and induced oxidative stress in albino rats
- Author
-
Somaya Y. Shalaby, Saber A. Sakr, and Rawan H. Beder
- Subjects
medicine.medical_specialty ,Endocrinology ,Cyclophosphamide ,Apoptosis ,Chemistry ,Internal medicine ,medicine ,Fennel Oil ,medicine.disease_cause ,Spermatogenesis ,Testosterone ,Oxidative stress ,medicine.drug - Published
- 2017
40. Can yeast extract and chitosan-oligosaccharide improve fruit yield and modify the pharmaceutical active ingredients of organic fennel?
- Author
-
El-Serafy, Rasha S., El-Sheshtawy, Abdel-Nasser A., Dahab, Abeer A., and Al-Ashkar, Ibrahim
- Subjects
- *
YEAST extract , *ESSENTIAL oils , *AROMATIC plants , *FENNEL , *OIL wells , *PLANT growth , *ORGANIC farming , *FRUIT yield - Abstract
• Foeniculum vulgare was subjected to foliar spray of yeast and chitosan-oligosaccharide cultivated under organic farming. • Yeast and chitosan-oligosaccharide improve plant growth, fruit, and oil output. • Yeast increases trans-anethole and decreases estragole proportions of essential oils. • Chitosan-oligosaccharide decreases trans-anethole and increases estragole proportions of essential oils. • Yeast is encouraged to increase plant growth and fruit yield and improve essential oil quality. Fennel is one of the most significant medicinal and aromatic herbs. It is used as a culinary ingredient and has an essential role as a raw material in the pharmaceutical industry. Many researchers across the world are working to increase the active components in the essential oil of medicinal and aromatic plants under organic farming. Growth promoters are one of the most effective methods for stimulating secondary metabolite production under organic agriculture. The objectives of this study were to investigate how foliar sprays of yeast extract (Y) and/or chitosan-oligosaccharide (CHO) affected the growth and yield of organic fennel (Foeniculum vulgare spp. vulgare Mill.) and if these applications can stimulate the production of pharmaceutical active ingredients in fennel fruits. Fennel foliage was subjected to foliar spray of Y at concentrations of 0 (Y0), 2 (Y1), and 4 (Y2) g L−1, and CHO at concentrations of 0 (CHO0), 60 (CHO1), and 120 (CHO2) mg L−1 twice. The results revealed that both Y and CHO treatments promoted growth parameters and leaf pigments content. Total phenols and nutritional content (N, P, K, Ca, and Mg) in fennel fruits were also improved. Furthermore, Y and CHO treatments enhanced fruit and oil productivity. Foliar spraying with Y and/or CHO, as well as their combination, resulted in significant modification in main pharmacological active components in fennel essential oil. Treated plants with Y1 had the lowest proportion of estragole (24.61 %), an undesirable component in fennel oil, and the highest concentration of anethole (64.50 %), which improved the oil quality. While treated plants with CHO1 or CHO2 displayed an increase in estragole content by about 33.34 and 46.59 % compared with Y1-plants, respectively. These new findings demonstrated that applying Y2 or CHO at both levels not only increased fennel growth and yield, but also contributed to increasing estragole and decreasing anethole concentration, and both had a negative impact on essential oil quality. However, applying Y1 enhanced fennel productivity as well as essential oil quality. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
41. Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality.
- Author
-
Imbabi, Tharwat, Sabeq, Islam, Osman, Ali, Mahmoud, Kamal, Amer, Shimaa A., Hassan, Aziza M., Kostomakhin, Nikolay, Habashy, Walid, and Easa, Ahmed A.
- Subjects
MEAT quality ,ESSENTIAL oils ,FENNEL ,RABBITS ,ANTIOXIDANTS ,GLUTATHIONE peroxidase - Abstract
In the current study, fennel essential oil was used as an antibiotic alternative compared to gentamycin for enhancing the expression of apoptosis genes and antioxidant enzymes in weaned rabbits as well as meat quality and growth performance. The gene expression of the cell lymphoma 2 (BAX and BCL2), caspase3 (CASP3), and glutathione peroxidase (GPX1) were estimated in the liver tissue using qRT-PCR. A total of 45 Moshtohor weaned male rabbits aged four weeks were randomly allocated to control, T1, and T2 treatment groups; each consisted of 15 weaned male rabbits with five replicates. Rabbits in the T1 and T2 groups were orally supplied with 1 mL fennel oil and 1 mL gentamycin, respectively. Weaned rabbits under different treatments showed increased body weight (BW) at 8 and 12 weeks of age and average daily gain (ADG) at 4–8 and 4–12 weeks of age compared to the control group. Compared to the controls, the weaned rabbits supplemented with fennel oil and gentamycin had lower total cholesterol, triglyceride, and MDA. In addition, villus length, mRNA of BAX, BCL2, Casp3, and GPX were increased in the different treatments compared to the control. Furthermore, the meat of these rabbits was less tender, had a lower aerobic plate count (APC), pH, and was brighter and redder in color than the control. Under the conditions of the present study, the supplementation of weaned Moshtohor rabbits with fennel oil as a natural alternative for gentamycin enhanced feed conversion and daily gain through enhancing villus length and mucus thickness. Additionally, fennel essential oil reduces oxidative stress by increasing the antioxidant enzymes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
42. Effect of Different Terpene-Containing Essential Oils on Percutaneous Absorption of Trazodone Hydrochloride Through Mouse Epidermis.
- Author
-
Das, Malay K., Bhattacharya, A., and Ghosal, Saroj K.
- Subjects
- *
ESSENTIAL oils , *TRANSDERMAL medication , *SKIN absorption , *TERPENES , *DRUG delivery systems - Abstract
The aim of our study was to investigate the enhancing effect of several essential oils in the percutaneous absorption of trazodone hydrochloride (TZN). For this purpose, fennel oil, eucalyptus oil, citronella oil, and mentha oil were applied on the skin membrane in three different ways: included in the transdermal device, as a pretreatment, or both. To investigate the effect of penetration enhancers used in this study on the percutaneous absorption of TZN through mouse epidermis, Keshary-Chien diffusion cells were employed. The receptor phase was constantly stirring saline phosphate buffer of pH 7.4 at 37 ± 1°C. Results showed that pretreatment of skin with essential oils increases the flux values of TZN compared with the values obtained when the same essential oils were included in the transdermal devices. The percutaneous penetration flux for TZN was increased with skin pretreatment by 10% essential oils in the following order: fennel oil > eucalyptus oil > citronella oil > mentha oil. The amount of TZN retained in the skin after pretreatment with essential oils was found to be very similar in all cases and much higher than in the experiments without skin pretreatment. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
43. Histological and Histochemical Studies on the Protective Effect of Fennel Oil on the Formaldehyde-Induced Hepatotoxicity in Male Rabbits
- Author
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Rania A. Ahmed and Reham M. Noeim
- Subjects
Andrology ,Abnormal sperm morphology ,chemistry.chemical_compound ,Morphology (linguistics) ,chemistry ,Formaldehyde ,Fennel Oil ,Cytotoxicity - Published
- 2017
44. Effect of Some Essential Oils and Natural Botanical Extracts on Food Consumption and Some Physiological Aspects of Mulberry Silkworm, Bombyx mori L
- Author
-
Eman Hassan and Marwa Moustafa
- Subjects
biology ,Bombyx mori ,Chemistry ,Hemolymph ,Food consumption ,Instar ,Ingestion ,Body substance ,Food science ,Silkworm larvae ,Fennel Oil ,biology.organism_classification - Abstract
The effects of different concentrations of marjoram oil, thyme oil, (1%, 0.5%, and 0.25%) and their botanical extracts (2%, 1%, and 0.5%) as a nutritional additives offered to silkworm larvae during the 4th and 5th larval instars on food consumption, Approximate weight of digested food (A.D), Approximate digestibility (A.D%), efficiency of conversion of food ingested to body substance (E.C.I%), and efficiency of conversion of food digested to body substance (E.C.D%) were studied. Also, to determine their effects on total carbohydrates and total protein in larval haemolymph. Results showed significant variation in most of the studied parameters of oils and botanical extracts different concentrations compared to control; E.C.D% was found maximum with 0.5% marjoram oil (74.995%) and thyme oil (71.465%), in the botanical extracts 2% of both thyme, and marjoram exhibited the highest ratio (63.170% and 60.975%), respectively compared with control which recorded the minimum (38.830%). The efficiency with which the ingested food is converted into body substances (E.C.I%) 0.5% of marjoram and thyme oils showed the highest efficiency of conversion (21.000% and 20.555%), respectively compared to (13.445%) for the control. 2% of both thyme (19.960%) and marjoram extract (18.845%) showed also the highest ECI% while the control recorded the least result. The highest AD% was shown by control group (43.185%) and AD of the control group exhibited the highest among them (3.400 gm). Results revealed a significant variation between the both larval instars in most parameters. The quantity of food consumed in both oils and extracts varied significantly between the both instars with no significant values among different concentrations of them. Total protein exhibited the highest value when feeding larvae on mulberry leaves supplemented with 0.5% of both marjoram and thyme oils (41.067 and 39.867 mg/ml haemolymph), respectively, and 2% of both thyme and marjoram extracts (36.9 and 36.567 mg/ml haemolymph), respectively while the control group showed the minimum value (22.633 mg/ml haemolymph). The same trend was observed for total carbohydrates. It can be concluded that mulberry leaves fortified with different concentrations of marjoram and thyme oils and extracts were proved to be more efficient in rearing mulberry silkworm as it improved food acquisition, high ingestion, high (E.C.I & E.C.D) and low (A.D),also it increased protein and carbohydrates metabolism.
- Published
- 2017
45. Antifungal Effects of Foeniculum vulgare Mill. Herb Essential Oil on the Phenotypical Characterizations of Alternaria alternata Kessel
- Author
-
Esmaeil Mahmoudi
- Subjects
0106 biological sciences ,Foeniculum ,biology ,Organic Chemistry ,Conidiation ,04 agricultural and veterinary sciences ,biology.organism_classification ,040401 food science ,01 natural sciences ,Biochemistry ,Alternaria alternata ,Fenchone ,Analytical Chemistry ,law.invention ,chemistry.chemical_compound ,Horticulture ,0404 agricultural biotechnology ,chemistry ,law ,Botany ,Estragole ,Fennel Oil ,Mycelium ,Essential oil ,010606 plant biology & botany - Abstract
The fungitoxicity of Foeniculum vulgare herb essential oil was evaluated by mycelial growth inhibition assessment in medium culture. The radial growth of the Alternaria alternata was completely inhibited at the oil levels of 500 and 300 ppm in poisoned food and volatile activity assessments, respectively. Microscopic observations using Light Microscope showed morphogenic changes in the test fungus with 300 ppm of the oil. These changes included a significant loss of conidiation, decrease hyphal diameter and induce cytoplasm condensation. The treatment with the oil also resulted in a highly lobate and bulbous anomalous structure on the hyphal tips. Essential oil of F. vulgare at 500 ppm effectively reduced the percentage of rotted tomatoes in in vivo. Gas chromatography-mass spectrometry analysis of the Fennel oil revealed that it was considered of 25 monoterpenoid compounds of which trans-anethole, estragole, and fenchone as the major components. Findings of the current study suggest that essentia...
- Published
- 2017
46. Evaluation of Six Plant Essential Oils against Three Stored Product Insects and Their Effects on the Haemogram under Laboratory Conditions
- Author
-
Abir A. Gad, Amany M. H. Abu-Shall, M.E. Tawfeek, and M. Mohey
- Subjects
Citronella oil ,biology ,fungi ,Cinnamomum verum ,Nigella sativa ,General Medicine ,biology.organism_classification ,law.invention ,Toxicology ,law ,Myristica fragrans ,Nutmeg oil ,Fennel Oil ,Cinnamon Oil ,Essential oil - Abstract
The effect of six plant essential oils against three stored grain insects, Sitophilus oryzae, Rhizopertha dominica andTribolium castaneum were studied under laboratory conditions. The tested oils are namely, fennel oil (Foeniculumvulgare), caraway oil (Carum carvi), cinnamon oil (Cinnamomum verum), citronella oil (Cymbopogon winterianus),nutmeg oil (Myristica fragrans) and black cumin oil (Nigella sativa). The result showed that increasing of the oilconcentration and exposure times significantly increased the mortality percentage.Generally, the toxicity of essential oils at all tested concentrations increased with the increasing of exposure time. So,the results indicated that toxicity of all tested essential oil against the three stored grain insects at the high concentrationwas recorded high mortality faster than low concentration.The tested essential oils significantly decreased the different haemocyte counts in tested insects, cinnamon oilmarkedly increased the haemocyte surface areas in the tested insects especially the surface area of oenocytoides in T.castaneum.The recorded results indicate that the essential oils of fennel, caraway, cinnamon and citronella could be applicable tothe management of S. oryzae, R. dominica and T. castaneum adults.
- Published
- 2017
47. Ameliorative Effect of Fennel Oil on Cyclophosphamide Induced Hepatotoxicity in Albino Rats
- Author
-
Saber A. Sakr, Somaya Y. Shalaby, and Rawan H. Beder
- Subjects
Cyclophosphamide ,Traditional medicine ,apoptosis ,fennel oil ,General Medicine ,Biology ,liver ,antioxidants ,Apoptosis ,cardiovascular system ,medicine ,Fennel Oil ,medicine.drug - Abstract
Cyclophosphamide (CPA) is an alkylating agent widely used as an anticancer and immunosuppressive drug. Fennel (Foeniculum vulgare Mill) essential oil is a traditional medicine used against many diseases. The present work studied the effect of fennel oil against liver damage induced by the anticancer drug, cyclophosphamide (CPA) in albino rats. Animals were divided into 4 groups: group1: control, group2: orally given fennel oil (1 ml/kg body weight once a week for six weeks), group3: treated with CPA (15 mg/kg body weight once a week for six weeks) and group4: treated with CPA and fennel oil. The liver removed for histological and immunohistochemical preparation. Blood was collected and sera were prepared for biochemical analysis. The results revealed that CPA caused histological alterations in the liver including degeneration of hepatic cells, cytoplasmic vacuolation, fatty infiltration and congestion of blood vessels. Immunohistochemical observations revealed that both cell proliferation marker Ki67 and apoptotic marker caspase-3 were increased. Biochemical results revealed increase in the liver enzymes activity ALT and AST. Treating rats with CPA and fennel oil caused an improvement in the histological structure of the liver and decreased Ki67 and caspase-3. Moreover, ALT and AST activity appeared with normal value. It is concluded that administration of fennel oil exhibited ameliorative effect against CPA-induced hepatic toxicity in albino rats. This effect may be attributed to the antioxidant property of fennel oil.
- Published
- 2017
48. Cyclophosphamide Induced Histologial and Immunohistochemical Alterations in Kidney of Albino Rats: The Ameliorative Effect of Fennel Oil
- Author
-
Saber A. Sakr and Ferial A. El-messady
- Subjects
Creatinine ,medicine.medical_specialty ,Kidney ,Chemotherapy ,Cyclophosphamide ,business.industry ,medicine.medical_treatment ,Nitrogen mustard ,Nephrotoxicity ,chemistry.chemical_compound ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Internal medicine ,cardiovascular system ,Urea ,Medicine ,heterocyclic compounds ,Fennel Oil ,business ,medicine.drug - Abstract
Cyclophosphamide (CPA) is a nitrogen mustard alkylating agent from the oxazaphosphorine group. It is used as an anticancer, anti-neoplastic agents and immunosuppressive agent widely used in chemotherapy. Fennel oil is traditionally used as a treatment for different diseases. The present work studied the effect of Fennel oil on CPA-induced nephrotoxicity in albino rats. Male albino rats were divided into 4 groups; gp1; control, gp2: Each rat was orally given Fennel oil (1 ml/kg body weight once a week for six weeks), gp3: animals were each orally treated with CPA at a dose of 15mg/kg body weight once a week for six weeks, gp4: CPA plus Fennel oil treated group. The obtained results showed that CPA induced histopathological alterations in the kidney including intertubular leucocytic infiltrations,congestion of blood vessels, degeneration of renal tubules and atrophy of glomeruli. Immunohistochemical observations revealed increase in expression of PCNA, caspase-3 and α -SMA. In addition, creatinine and urea levels increased in sera of treated rats. Treating rats with CPA and fennel oil caused an improvement in the histological structure of the kidney and decreased PCNA, caspase-3 and α-SMA. Moreover, creatinine and urea values were decreased. In conclusion, fennel oil showed ameliorative effect against nephrotoxicity of CPA due to its antioxidant activity.
- Published
- 2017
49. Aromatic factors of anti-platelet aggregation in fennel oil.
- Author
-
Yoshioka, Masanori and Tamada, Terumi
- Subjects
- *
ESSENTIAL oils , *BLOOD platelet aggregation , *ASPIRIN , *TERPENES , *ARTERIOSCLEROSIS - Abstract
In order to develop an ideal drug against arteriosclerosis, we tried to find anti-platelet aggregation factors in fennel oil among conventional essential oils: the reason for the investigation was that anethole, the main constituent of fennel oil, resembled eugenol, which was described as having both anti-bacterial and anti-platelet activities. Fennel oil, its constituents and related compounds were examined to find those that would inhibit aggregation of rabbit platelets induced by ADP, collagen or arachidonic acid. Fennel oil, anethole and estragole were proved to be good inhibitors, as effective as aspirin, against platelet aggregation with three types of inducers while p-anisidine was effective on two types. Judging from these experiments and review, we concluded that anethole was the main inhibitor in the fennel oil against platelet aggregation. [ABSTRACT FROM AUTHOR]
- Published
- 2005
50. Repellency of aerosol and cream products containing fennel oil to mosquitoes under laboratory and field conditions.
- Author
-
Soon-II Kim, Kyu-Sik Chang, Young-Cheol Yang, Byung-Seok Kim, and Young-Joon Ahn
- Subjects
AEROSOLS ,MOSQUITOES ,CITRONELLA oil ,GERANIUMS ,AEDES aegypti - Abstract
The repellency of fennel (Foeniculum vulgare Miller)-containing products (5% aerosol and 8% cream) against mosquitoes was compared with those of citronella oil, geranium oil and deer, as well as three commercial repellents, Baby Keeper® cream containing IR3535, MeiMei® cream containing citronella and geranium oils, and Repellan S® aerosol containing 19% N,N-diethyl-m-toluamide (deet) under laboratory and field conditions. In a laboratory study with female Aedes aegypti (L), fennel oil exhibited good repellency in a release-in-cage test and repellency in skin and patch tests of the oil was comparable with those of citronella and geranium oils. In paddy field tests with five human volunteers, 5% and 8% fennel oil-containing aerosol and cream produced 84% and 70% repellency, respectively, at 90 min after exposure, whereas Baby Keeper cream and MeiMei cream gave 71% and 57% repellency at 90m in after exposure, respectively, and Repellan S aerosol gave 89% repellency at 210 min. The species and ratio of mosquitoes collected were the genera Culex (44.1%), Anopheles (42.2%), Aedes (7.8%) and Armigeres (5.9%). Fennel oil-containing products could be useful for protection from humans and domestic animals from vector-borne diseases and nuisance caused by mosquitoes. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
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