Search

Abstract Background The long-term safety and efficacy of repeated applications of subliminal transscleral cyclophotocoagulation (SL-TSCPC) with a focus on cumulative energy was evaluated in glaucoma patients. Methods In this retrospective, multicentric study the data of a total of 82 eyes with various causes of glaucoma that were treated with a single or multiple applications of SL-TSCPC were collected. Treatments were performed under general or local anesthesia with an 810 nm diode laser. Power was 2000 mW; duty cycle, 31.3%; total treatment duration, 80–320 s; equaling a total energy of 50–200 J per treatment session. Fifty-five eyes (55 patients) presented for all follow-ups, and these eyes were selected for further statistical analysis. The mean age was 60.0 ± 17.1 years, and 22 (40%) of the patients were female. Intraocular pressure (IOP) and dependence on further glaucoma medication were evaluated at 12 months following the initial treatment. Results Eyes underwent 1 or 2 consecutive SL-TSCPC treatments. Median (min–max) baseline IOP of 34 (13–69) decreased to 21.5 (7–61), 22 (8–68), 20 (9–68), and 19.5 (3–60) mmHg at the 1, 3, 6, and 12-month postoperative timepoints respectively. The mean (± SD) IOP decrease at 12 months was 26 ± 27%, 39 ± 32%, and 49 ± 33% in the low (below 120 J, n = 18), medium (120–200 J, n = 24), and high (above 200 J, n = 13) cumulative energy groups respectively. At the 12-month timepoint, oral carbonic anhydrase use was discontinued in ¾ of the cases. Conclusions It was found that the repeated application of SL-TSCPC safely and efficiently decreases IOP in a Caucasian population with heterogenous causes of glaucoma, eyes with silicone oil responded to a greater extent. Inclusion of cumulative energy scales may contribute to better addressing repeated procedures in a standardized fashion.

The investigation results of magnetization, dynamic magnetic susceptibility and microstructure of samples of second generation high-temperature superconducting wires irradiated by Bi ions at room temperature with energy of 670 MeV and fluences of 1011 and 1012 cm–2 are presented. The dependences of the superconducting transition temperature and critical current density on the fluence have been determined. For the sample irradiated to fluence 1011 cm–2, an increase in the critical current density is observed compared to the control nonirradiated sample. The microstructure analysis of irradiated samples demonstrates the presence of amorphous tracks, which can act as effective pinning centers. [ABSTRACT FROM AUTHOR]

Copyright of Eurasian Physical Technical Journal is the property of E.A. Buketov Karaganda University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The electrical conductivity of GMZ grade graphite irradiated by fast neutrons with fluence of 2.22*1019 n/cm² in the temperature range of 298e448 K was studied. It is shown that the more neutrons fluence, than the more the electrical conductivity of the material decreases. [ABSTRACT FROM AUTHOR]

The shelf life of green chillies is very low due to high-water activity (aw = 0.90 ± 0.01). Balancing aw and moisture content is crucial for maintaining freshness, quality and extending shelf life of green chillies. To attain microbial and biochemical stability, the aw should be reduced to 0.6 and 0.3, respectively. Hence, a controlled drying process was introduced. The 0.6 aw (62 ℃/360 min + 35 ℃/60 min) and 0.3 aw (75 ℃/600 min + 40 ℃/240 min) green chillies improved bioactives retention, colour and texture; but could not completely prevent the growth of microorganisms. Therefore, post-drying, a decontamination process i.e., pulsed light (PL) treatment of 0.53 to 2.59 Jcm−2 (1.7–2.1 kV/120–360 s) was employed. Along with microbial decontamination and enzyme inactivation, PL preserved better physicochemical characteristics in 0.6 and 0.3 aw than 0.9 (fresh) green chillies. While, there is 89.8%, 89.0%, 88.8%, and 93.3% retention of phenolics, antioxidants, flavonoids, and capsaicinoids, respectively, in 0.3 aw green chillies at PL fluence of 2.59 J cm−2 fluence. Alongside, ascorbic acid, carotenoids, and chlorophyll showed 30%, 19%, and 26% loss, respectively, in 0.6 aw green chillies at 2.59 J cm−2. Drying followed by PL treatment ensured that the green chillies were safe for consumption, and met regulatory standards while maintaining their quality attributes. Therefore, integrated approach combining drying followed by PL decontamination would be the suitable method for preserving the quality of the green chillies. [ABSTRACT FROM AUTHOR]

Background: The long-term safety and efficacy of repeated applications of subliminal transscleral cyclophotocoagulation (SL-TSCPC) with a focus on cumulative energy was evaluated in glaucoma patients. Methods: In this retrospective, multicentric study the data of a total of 82 eyes with various causes of glaucoma that were treated with a single or multiple applications of SL-TSCPC were collected. Treatments were performed under general or local anesthesia with an 810 nm diode laser. Power was 2000 mW; duty cycle, 31.3%; total treatment duration, 80–320 s; equaling a total energy of 50–200 J per treatment session. Fifty-five eyes (55 patients) presented for all follow-ups, and these eyes were selected for further statistical analysis. The mean age was 60.0 ± 17.1 years, and 22 (40%) of the patients were female. Intraocular pressure (IOP) and dependence on further glaucoma medication were evaluated at 12 months following the initial treatment. Results: Eyes underwent 1 or 2 consecutive SL-TSCPC treatments. Median (min–max) baseline IOP of 34 (13–69) decreased to 21.5 (7–61), 22 (8–68), 20 (9–68), and 19.5 (3–60) mmHg at the 1, 3, 6, and 12-month postoperative timepoints respectively. The mean (± SD) IOP decrease at 12 months was 26 ± 27%, 39 ± 32%, and 49 ± 33% in the low (below 120 J, n = 18), medium (120–200 J, n = 24), and high (above 200 J, n = 13) cumulative energy groups respectively. At the 12-month timepoint, oral carbonic anhydrase use was discontinued in ¾ of the cases. Conclusions: It was found that the repeated application of SL-TSCPC safely and efficiently decreases IOP in a Caucasian population with heterogenous causes of glaucoma, eyes with silicone oil responded to a greater extent. Inclusion of cumulative energy scales may contribute to better addressing repeated procedures in a standardized fashion. [ABSTRACT FROM AUTHOR]

Cutlery and flatware designs are an everchanging phenomenon of the manufacturing industry. Worldwide hospitality businesses demand perpetual evolution in terms of aesthetics, designs, patterns, colours, and materials due to customers' demands, modernisation, and fierce competition. To thrive in this competitive market, modern fabrication techniques must be flexible, adoptive, fast, and cost effective. For decades, static designs and trademark patterns were achieved through moulds, limiting production to a single cutlery type per mould. However, with the advent of laser engraving and design systems, the whole business of cutlery production has been revolutionised. This study explores the possibility of creating diverse designs for stainless steel 304 flatware sets without changing the entire production process. The research analyses three key laser process parameters, power, scanning speed, and number of passes, and their impacts on the resulting geometry, depth of cut, surface roughness, and material removed. These parameters are comprehensively studied and analysed for steel and zirconia ceramic. The study details the effects of power, scanning speed, number of passages, and fluence on engraved geometry. Fluence (power*number of passages/scanning speed) positively influences outputs and presents a positive trend. Medium power settings and higher scanning speeds with the maximum number of passages produce high-quality, low-roughness optimised cavities with the ideal geometric accuracy for both materials. [ABSTRACT FROM AUTHOR]

The wettability of polymers is usually inadequate to ensure the appropriate spreading of polar liquids and thus enable the required adhesion of coatings. A standard ecologically benign method for increasing the polymer wettability is a brief treatment with a non-equilibrium plasma rich in reactive oxygen species and predominantly neutral oxygen atoms in the ground electronic state. The evolution of the surface wettability of selected aromatic polymers was investigated by water droplet contact angles deposited immediately after exposing polymer samples to fluxes of oxygen atoms between 3 × 1020 and 1 × 1023 m−2s−1. The treatment time varied between 0.01 and 1000 s. The wettability evolution versus the O-atom fluence for all aromatic polymers followed similar behavior regardless of the flux of O atoms or the type of polymer. In the range of fluences between approximately 5 × 1020 and 5 × 1023 m−2, the water contact angle decreased exponentially with increasing fluence and dropped to 1/e of the initial value after receiving the fluence close to 5 × 1022 m−2. [ABSTRACT FROM AUTHOR]

This study investigated the impact of pulsed light (PL) applied at a fluence of 4–12 J cm−2 (complying with U.S. Food and Drug Administration standards) on fresh‐cut watermelon, focusing on its efficacy in inactivating various food‐borne pathogenic gram‐positive (Escherichia coli and Staphylococcus aureus) and gram‐negative (Listeria monocytogenes and Salmonella) bacteria. The inactivation data were used to fit the log‐linear and Weibull kinetic models. Additionally, the impact of PL on physicochemical properties, lycopene content, total phenolic content, antioxidant activity, and pectin methylesterase (PME) residual activity (RA) was studied. The results demonstrated that the inactivation rate increases with the increase in fluence. Salmonella was most sensitive to PL, resulting in a reduction of 2.55 ± 0.08 log CFU g−1 and a higher kmax, whereas S. aureus was most resistant, with a reduction of 1.87 ± 0.24 log CFU g−1 and a lower kmax. The Weibull model was the best to predict the inactivation kinetics based on standard statistics and information theory criteria. For all assayed food‐borne pathogens, the inactivation curve showed non‐linearity with upward concavity except for L. monocytogenes, which followed a concave downward curve (β >1). Results showed that PL was effective in the retention of color, firmness, pH levels, total soluble solids, and titratable acidity, and also had a positive effect on enhancing the levels of essential components such as lycopene, total phenolic compounds, and antioxidant activity. Additionally, the PME RA significantly decreased with an increase in fluence due to structural modification. Therefore, PL can be explored to enhance fresh‐cut watermelon's safety and quality attributes. Practical Applications: The implementation of this research holds significant potential for practical benefits in the fresh‐cut fruit industry. The findings could revolutionize processing practices, ensuring enhanced microbial safety, enzyme inactivation, and an extended shelf‐life of fresh‐cut watermelon. The study strongly contributes to preserving the desirable texture, color, and overall quality of the product, enhancing the retention of lycopene and other valuable antioxidants by standardizing the pulsed light treatment parameters while adhering to U.S. Food and Drug Administration standards for food application. Moreover, this research will scientifically contribute to addressing the critical challenges of foodborne outbreaks in the fresh‐cut fruit sector while providing consumers with a healthy, convenient food choice. [ABSTRACT FROM AUTHOR]

Microbial contamination of dehydrated onion products is a challenge to the industry. The study focused on opting for a suitable drying condition for minced onion and exploring the decontamination efficacy of pulsed light (PL) treatment conditions for the dehydrated product. The minced onions were hot air dried at 55–75°C for 280 min. The drying condition selected was 195 min at 75°C with a final water activity of 0.5 and moisture content of 7% (wet basis [w.b.]). The weight losses, browning indexes (BI), shrinkage volumes (%), and thiosulfinate content were considered. The dehydrated product was exposed to PL treatment corresponding to an effective fluence range of 0.007–0.731 J/cm2. A fluence of 0.444 J/cm2 (1.8 kV for 150 s) achieved 5.00, 3.14, 2.96, and 2.98 log reduction in total plate count, yeast and mold count, Bacillus cereus 10876, and Escherichia coli ATCC 43888, respectively. The PL‐treated sample (0.444 J/cm2) produced a microbially safe product with no significant difference in the moisture contents (%w.b.) and water activity (aw) from the untreated dehydrated sample. Further, a 30.9% increase in the BI and a 4.25% depletion in thiosulfinate content were observed after PL treatment. An optimum drying combination (75°C for 195 min) of minced onion followed by decontamination using pulsed light treatment at 0.444 J/cm2 fluence satisfies the microbial safety and quality. Practical Application: Dehydrated minced onion can be used for dishes requiring low water content and short cooking time. It is helpful during shortages, high price fluctuations, and famines. [ABSTRACT FROM AUTHOR]

A comparative analysis of the diffuse reflectance spectra and their changes after irradiation with electrons with an energy of 30 keV of coatings based on polymethylphenylsiloxane resin and pigment powders of two-layer hollow ZnO/SiO2 particles is carried out. The analysis is performed in situ in the range of 250–2500 nm. The samples are irradiated using a Spectrum space-conditions simulator. The radiation resistance of the studied coatings based on two-layer hollow ZnO/SiO2 particles is estimated relative to coatings based on ZnO polycrystals by analyzing the difference diffuse reflectance spectra obtained by subtracting the spectra after irradiation from the spectra of the unirradiated samples. It is found that the intensity of the induced absorption bands in coatings based on hollow ZnO/SiO2 particles is less than in coatings based on ZnO microparticles, and the radiation resistance when estimating changes in the integral absorption coefficient of solar radiation (ΔαS) is twice as high. The increase in the radiation resistance is probably determined by the different nature of defect accumulation: in the case of solid microparticles, defects can accumulate inside grains; in hollow particles, the accumulation of defects can occur only within the thin shell of the sphere. [ABSTRACT FROM AUTHOR]

Ready‐to‐drink (RTD) mango beverage enriched with short‐chain fructooligosaccharides (scFOS) was developed to reduce added sugar and incorporate a soluble prebiotic fiber. The impact of pulsed light (PL) technology on microbial inactivation, enzyme activity, and quality attributes in scFOS‐enriched mango RTD beverages was investigated. Effective PL fluence of 0.12–1.2 J/cm2 was employed on mango beverage in order to maximize the retention of nutritional properties along with inactivation of microbial and enzymatic activity. There is complete inactivation of microbial load and enzymatic activity with 72.45, 84.17, 88, 78.79, and 77.63% retention of ascorbic acid, antioxidants, total phenolics, total flavonoids, and total carotenoids in 6% scFOS mango beverage at an effective fluence of 1.2 J/cm2. There is no wide change in TSS, pH, and TA in all the PL treatments. The scFOS increased viscosity, and it also protected bioactives, namely, carotenoids, ascorbic acid, and phenolics, from photoxidation caused by PL. Results showed that scFOS allowed a substantial reduction in added sugar and increased soluble fiber content in the beverage. Sensory score of 3 and 6% scFOS‐enriched beverages were closely comparable with control. The study showcases the potential of scFOS to enhance the nutritional profile of beverages. It also highlights the effectiveness of PL processing in pasteurization fruit beverages, meeting stakeholders' demands for microbial safety, enzymatic stability, and nutrient retention. Practical applications: The practical applications of this research hold significant promise for the food and beverage industry. The innovative formulations of ready‐to‐drink (RTD) mango beverages not only reduce added sugar by up to 52% but also increase fiber content from 0.6 to 6%, meeting consumer demands for healthier options. The integration of pulsed light technology effectively targets microbial and enzyme inactivation, complying with Food and Drug Administration standards and offering a viable processing method. The incorporation of short‐chain fructooligosaccharides enhances the protection of bioactive compounds during pulsed light treatment, ensuring higher retention of antioxidants, vitamins, and other valuable components. This advancement contributes to improved nutritional profiles while maintaining sensory appeal. These findings have the potential to revolutionize RTD beverage production, addressing health‐conscious consumer preferences, and enhancing product quality. [ABSTRACT FROM AUTHOR]

Motivation: Clustered DNA-lesions are predominantly induced by ionizing radiation, particularly by high-LET particles, and considered as lethal damage. Quantification of this specific type of damage as a function of radiation parameters such as LET, dose rate, dose, and particle type can be informative for the prediction of biological outcome in radiobiological studies. This study investigated the induction and complexity of clustered DNA damage for three different types of particles at an LET range of 0.5–250 keV/µm. Methods: Nanometric volumes (36.0 nm3) of 15 base-pair DNA with its hydration shell was modeled. Electron, proton, and alpha particles at various energies were simulated to irradiate the nanometric volumes. The number of ionization events, low-energy electron spectra, and chemical yields for the formation of °OH, H°, e a q − , and H2O2 were calculated for each particle as a function of LET. Single- and double-strand breaks (SSB and DSB), base release, and clustered DNA-lesions were computed from the Monte-Carlo based quantification of the reactive species and measured yields of the species responsible for the DNA lesion formation. Results: The total amount of DNA damage depends on particle type and LET. The number of ionization events underestimates the quantity of DNA damage at LETs higher than 10 keV/µm. Minimum LETs of 9.4 and 11.5 keV/µm are required to induce clustered damage by a single track of proton and alpha particles, respectively. For a given radiation dose, an increase in LET reduces the number of particle tracks, leading to more complex clustered DNA damage, but a smaller number of separated clustered damage sites. Conclusions: The dependency of the number and the complexity of clustered DNA damage on LET and fluence suggests that the quantification of this damage can be a useful method for the estimation of the biological effectiveness of radiation. These results also suggest that medium-LET particles are more appropriate for the treatment of bulk targets, whereas high-LET particles can be more effective for small targets. [ABSTRACT FROM AUTHOR]

Abstract Laser-induced graphene (LIG) is a three-dimensional graphene structure fabricated through the irradiation of a polymer substrate with laser energy (or fluence, equivalently). This methodology offers a cost-effective and facile means of producing 3D nanostructures, yielding graphene materials characterized by extremely high surface area and superior electrical properties, rendering them advantageous for various electrochemical applications. Nonetheless, it is imperative to acknowledge that the structures and material properties of LIG are subject to substantial variations contingent upon processing parameters, thereby underscoring the necessity for systematic inquiry and systematic comprehension of processing conditions, such as fluence and multi-passing, and resultant outcomes. Herein, we explored the impact of different laser fluence levels on the structural and material properties of LIG. We, especially, focused on how laser fluence affected substrate temperature and found that it caused polyimide (PI) substrate pyrolysis, resulting in changes in 3D structures and material density to LIG properties. We also investigated the effects of a multi-passing process on 3D LIG structures and material qualities, varying fluences, and temperature fluctuations. Lastly, we assessed electrochemical properties using LIGs produced under different conditions as working electrodes, leading to distinct impedance profiles and cyclic voltammetry (CV) curves. These variations were linked to the unique structural and material characteristics of the LIG samples.

Motivation: Clustered DNA-lesions are predominantly induced by ionizing radiation, particularly by high-LET particles, and considered as lethal damage. Quantification of this specific type of damage as a function of radiation parameters such as LET, dose rate, dose, and particle type can be informative for the prediction of biological outcome in radiobiological studies. This study investigated the induction and complexity of clustered DNA damage for three different types of particles at an LET range of 0.5–250 keV/µm. Methods: Nanometric volumes (36.0 nm3) of 15 base-pair DNA with its hydration shell was modeled. Electron, proton, and alpha particles at various energies were simulated to irradiate the nanometric volumes. The number of ionization events, low-energy electron spectra, and chemical yields for the formation of °OH, H°, eaq−, and H2O2 were calculated for each particle as a function of LET. Single- and double-strand breaks (SSB and DSB), base release, and clustered DNA-lesions were computed from the Monte-Carlo based quantification of the reactive species and measured yields of the species responsible for the DNA lesion formation. Results: The total amount of DNA damage depends on particle type and LET. The number of ionization events underestimates the quantity of DNA damage at LETs higher than 10 keV/µm. Minimum LETs of 9.4 and 11.5 keV/µm are required to induce clustered damage by a single track of proton and alpha particles, respectively. For a given radiation dose, an increase in LET reduces the number of particle tracks, leading to more complex clustered DNA damage, but a smaller number of separated clustered damage sites. Conclusions: The dependency of the number and the complexity of clustered DNA damage on LET and fluence suggests that the quantification of this damage can be a useful method for the estimation of the biological effectiveness of radiation. These results also suggest that medium-LET particles are more appropriate for the treatment of bulk targets, whereas high-LET particles can be more effective for small targets.

Laser-induced graphene (LIG) is a three-dimensional graphene structure fabricated through the irradiation of a polymer substrate with laser energy (or fluence, equivalently). This methodology offers a cost-effective and facile means of producing 3D nanostructures, yielding graphene materials characterized by extremely high surface area and superior electrical properties, rendering them advantageous for various electrochemical applications. Nonetheless, it is imperative to acknowledge that the structures and material properties of LIG are subject to substantial variations contingent upon processing parameters, thereby underscoring the necessity for systematic inquiry and systematic comprehension of processing conditions, such as fluence and multi-passing, and resultant outcomes. Herein, we explored the impact of different laser fluence levels on the structural and material properties of LIG. We, especially, focused on how laser fluence affected substrate temperature and found that it caused polyimide (PI) substrate pyrolysis, resulting in changes in 3D structures and material density to LIG properties. We also investigated the effects of a multi-passing process on 3D LIG structures and material qualities, varying fluences, and temperature fluctuations. Lastly, we assessed electrochemical properties using LIGs produced under different conditions as working electrodes, leading to distinct impedance profiles and cyclic voltammetry (CV) curves. These variations were linked to the unique structural and material characteristics of the LIG samples. [ABSTRACT FROM AUTHOR]

Laser fenestration in stapedotomy has thermal effect to the vestibule. To evaluate the role of energy density (fluence) in the severity of postoperative vestibular symptoms. The retrospective chart-review study included 84 patients with otosclerosis that underwent primary laser stapedotomy. Surgical outcomes, including nystagmus, and subjective vestibular symptoms during one-month follow-up, were compared between potassium titanyl phosphate (KTP) and CO2 laser. According to this study and literature, we assessed the relationship between laser parameters and the incidence of persistent vestibular symptoms lasting more than one week after surgery. The KTP and CO2 laser group included 48 and 36 patients, respectively. Fluence was different between the KTP (637 J/cm2) and CO2 (141 J/cm2) laser (p <.001). The KTP group showed gradual decrease in dizziness during one-month observation period, while the CO2 group exhibited a steep recovery curve in the first postoperative week (9 and 4 d of duration, respectively). The incidence of persistent vestibular symptoms was correlated with both fluence (r = 0.80, p =.01) and spot size (r = −0.74, p =.01). Appropriate setting of parameters with lower fluence is desirable for the efficiency and safety of laser stapedotomy. Abbreviations: ABG: air-bone gap; SD: standard deviation. [ABSTRACT FROM AUTHOR]

Abstract—The implantation of aluminum ions into the surface layer of a VT6 titanium alloy and the deposition of an aluminum thin film on the alloy surface by magnetron sputtering with subsequent ion-beam mixing by argon ions are studied. The evolution of the composition of the ion-alloyed layer in the VT6 titanium alloy after aluminum-ion implantation is demonstrated. [ABSTRACT FROM AUTHOR]

Copyright of Eurasian Physical Technical Journal is the property of E.A. Buketov Karaganda University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Pectin methyl esterase (PME) is responsible for the destabilization of clouds in sweet orange juice. The study aims to optimize pulsed light (PL) and ultrasound (US) treatments for the maximum inactivation of PME in sweet orange juice. A central composite design was used for PL treatments (2.5 -2.9 kV for 200–300 s) and US treatments (40- 120 W for 2–10 min). The numerical optimization predicted 98.5% inactivation of PME in the juice after 283 s PL exposure at 2.84 kV (2711 J/cm2). US optimized condition was 108 W for 9 min with 82.5% PME inactivation. The first-order rate constants for PL-induced PME inactivation varied from 0.0033 to 0.0159 s−1, whereas, for the US, the range was 0.00126 to 0.0015 s−1. The impact of PL and US treatments in series on various quality attributes of the juice was assessed. PL exposure at 2.4 kV for 180 s [1278 J/cm2; the highest intensity of PL] followed by US treatment for 360 s at 80 W [1.14 W/mL; the highest intensity of US] resulted in 98.3% PME inactivation, > 5-log reduction in natural microbiota, 5% loss in vitamin C, 1.7% loss in antioxidant capacity, and 99.4% retention in phenolics in the juice. The sequence of PL or US had minimal impact on enzyme inactivation and bioactive degradation in the juice. The PL-optimized processing also led to more than 5.0 log reductions in natural microflora. However, the preliminary sensory acceptance, color difference, and bioactive retention of the sample treated at the highest intensity of PL+US were superior to the PL-optimized juice. [ABSTRACT FROM AUTHOR]

Laser-based light sources have fostered innovative developments in biomedical and biosensor fields. However, laser-induced damage to optical components is a limitation for designing and implementing highly sensitive biosensors, necessitating the development and characterization of suitable optical components. Microscope glass slides are among the most extensively used optical units in this field. This study investigated the laser-induced damage threshold (LIDT) of high-quality microscope glass slides obtained from three different vendors. An S-on-1 protocol following the ISO 21254 series standards was adopted to ensure a meaningful comparative analysis. Multiple laser pulses at a constant fluence (at the three laser wavelengths most widely used in biosensors) were used for LIDT tests. An automated test bench was developed and employed to minimize the influence of human factors on the test results. The fatigue damage mechanism was observed in all the samples. The findings revealed good consistency among LIDT values within and across batches from the same vendor. However, a notable discrepancy was observed when comparing the results of slides obtained from different vendors, with threshold values differing by up to two-fold. This study emphasizes the need to carefully consider the glass material source when selecting microscope glass slides for laser-sensitive applications. [ABSTRACT FROM AUTHOR]

The establishment of a possible connection between neutrino emission and gravitational-wave (GW) bursts is important to our understanding of the physical processes that occur when black holes or neutron stars merge. In the Daya Bay experiment, using the data collected from December 2011 to August 2017, a search was performed for electron-Antineutrino signals that coincided with detected GW events, including GW150914, GW151012, GW151226, GW170104, GW170608, GW170814, and GW170817. We used three time windows of 10, 500, and 1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino candidates. The detected electron-Antineutrino candidates were consistent with the expected background rates for all the three time windows. Assuming monochromatic spectra, we found upper limits (90% confidence level) of the electron-Antineutrino fluence of (1.13-2.44)×1011 cm-2 at 5 MeV to 8.0×107 cm-2 at 100 MeV for the three time windows. Under the assumption of a Fermi-Dirac spectrum, the upper limits were found to be (5.4-7.0)×109 cm-2 for the three time windows.

The wettability of polymers is usually inadequate to ensure the appropriate spreading of polar liquids and thus enable the required adhesion of coatings. A standard ecologically benign method for increasing the polymer wettability is a brief treatment with a non-equilibrium plasma rich in reactive oxygen species and predominantly neutral oxygen atoms in the ground electronic state. The evolution of the surface wettability of selected aromatic polymers was investigated by water droplet contact angles deposited immediately after exposing polymer samples to fluxes of oxygen atoms between 3 × 1020 and 1 × 1023 m−2s−1. The treatment time varied between 0.01 and 1000 s. The wettability evolution versus the O-atom fluence for all aromatic polymers followed similar behavior regardless of the flux of O atoms or the type of polymer. In the range of fluences between approximately 5 × 1020 and 5 × 1023 m−2, the water contact angle decreased exponentially with increasing fluence and dropped to 1/e of the initial value after receiving the fluence close to 5 × 1022 m−2.

To evaluate corneal stiffening of porcine corneas induced by corneal crosslinking (CXL) with constant irradiance as a function of total fluence. Ninety corneas from freshly enucleated porcine eyes were divided into five groups of 18 eyes. Groups 1–4 underwent epi-off CXL using a dextran-based riboflavin solution and an irradiance of 18 mW/cm2, group 5 served as the control group. Groups 1 to 4 were treated with a total fluence of 20, 15, 10.8, and 5.4 J/cm2, respectively. Thereafter, biomechanical measurements were performed on 5 mm wide and 6 mm long strips using an uniaxial material tester. Pachymetry measurements were performed on each cornea. At 10% strain, the stress was 76, 56, 52, and 31% higher in groups 1–4, respectively compared to the control group. The Young's modulus was 2.85 MPa for group 1, 2.53 MPa for group 2, 2.46 MPa for group 3, 2.12 MPa for group 4, and 1.62 MPa for the control group. The difference between groups 1 to 4 and the control group 5 were statistically significant (p = <0.001; p = <0.001; p = <0.001; p = 0.021). In addition, group 1 showed significantly more stiffening than group 4 (p = <0.001), no other significant differences were found. Pachymetry measurements revealed no statistically significant differences among the five groups. Additional mechanical stiffening can be achieved by increasing the fluence of the CXL. There was no threshold detected up to 20 J/cm2. A higher fluence could compensate the weaker effect of accelerated or epi-on CXL procedures. [ABSTRACT FROM AUTHOR]

Procedures are developed for accelerated laboratory tests of spacecraft polymers for resistance to long-term exposure to hyperthermal atomic oxygen (AO) with the use of high-energy AO ions of a rarefied plasma and Kapton-H polyimide as the reference material. The parameters that characterize physico-chemical, thermo-optical, and aerodynamic AO – Kapton-H interaction (surface roughness, solar absorptance, and normal infrared emittance) are determined at different values of the AO fluence. To do this, use was made of the data of tests onboard spacecraft in the Earth's atmosphere and the authors and others' laboratory tests. The normal and the tangential momentum transfer coefficient and the energy transfer coefficient are reported as a function of the AO bombardment angle. The obtained data on the AO-induced degradation of the parameters that characterize AO–polyimide dynamic interaction allow one to predict the behavior of the polyimide thermo-optical and aerodynamic properties during a long-term service in the Earth's upper atmosphere and ionosphere. • Physical modeling conditions for spacecraft – atomic oxygen interaction are given. • Atomic oxygen to polyimide momentum and energy transport coefficients are measured. • Atomic oxygen induced polyimide degradation parameters are determined. [ABSTRACT FROM AUTHOR]

The implantation of argon ions in a grade 1420 aluminum alloy is studied. The optimum mode allowing the maximum alloy softening is shown to be Е = 36 keV, j = 300 μA/cm2, and Φ = 4.9 × 1017 cm–2 (irradiation time of 7 min). An increase in the ion current density by a factor of 1.5 (up to 450 μA/cm2) causes about a twofold reduction of the irradiation time, while maintaining near the same softening level, namely, σu = 351 MPa, σ0.2 = 161 MPa, and δ = 19.8%, at a lower fluence of 3.7 × 1017 cm–2. [ABSTRACT FROM AUTHOR]

Simple Summary: There are no effective treatments for patients with cancers that induce airway narrowing via extrinsic pressure to the bronchus (i.e., extrinsic malignant central airway obstruction—MCAO). The effects of these cancerous tumors must be quickly alleviated to allow normal breathing and delay disease progression. Currently, stents are used to keep the airway open, but stents do not halt the progression of the cancerous tumor that can crush the stent. We have shown that interstitial photodynamic therapy (I-PDT) can be a safe and beneficial treatment option for patients with extrinsic MCAO. Image-based pre-treatment planning is critical for patient safety and tumor response in I-PDT. Herein, we present and validate novel image-based computer optimization methods for guiding light administration in I-PDT of extrinsic MCAO, based on a rate-based light dose metric. We demonstrate the benefit of our approach in data from representative patients with extrinsic MCAO who were treated with I-PDT. There are no effective treatments for patients with extrinsic malignant central airway obstruction (MCAO). In a recent clinical study, we demonstrated that interstitial photodynamic therapy (I-PDT) is a safe and potentially effective treatment for patients with extrinsic MCAO. In previous preclinical studies, we reported that a minimum light irradiance and fluence should be maintained within a significant volume of the target tumor to obtain an effective PDT response. In this paper, we present a computational approach to personalized treatment planning of light delivery in I-PDT that simultaneously optimizes the delivered irradiance and fluence using finite element method (FEM) solvers of either Comsol Multiphysics® or Dosie™ for light propagation. The FEM simulations were validated with light dosimetry measurements in a solid phantom with tissue-like optical properties. The agreement between the treatment plans generated by two FEMs was tested using typical imaging data from four patients with extrinsic MCAO treated with I-PDT. The concordance correlation coefficient (CCC) and its 95% confidence interval (95% CI) were used to test the agreement between the simulation results and measurements, and between the two FEMs treatment plans. Dosie with CCC = 0.994 (95% CI, 0.953–0.996) and Comsol with CCC = 0.999 (95% CI, 0.985–0.999) showed excellent agreement with light measurements in the phantom. The CCC analysis showed very good agreement between Comsol and Dosie treatment plans for irradiance (95% CI, CCC: 0.996–0.999) and fluence (95% CI, CCC: 0.916–0.987) in using patients' data. In previous preclinical work, we demonstrated that effective I-PDT is associated with a computed light dose of ≥45 J/cm2 when the irradiance is ≥8.6 mW/cm2 (i.e., the effective rate-based light dose). In this paper, we show how to use Comsol and Dosie packages to optimize rate-based light dose, and we present Dosie's newly developed domination sub-maps method to improve the planning of the delivery of the effective rate-based light dose. We conclude that image-based treatment planning using Comsol or Dosie FEM-solvers is a valid approach to guide the light dosimetry in I-PDT of patients with MCAO. [ABSTRACT FROM AUTHOR]

Gold nanoparticles are widely used in laser biomedical applications due to their favorable properties, mainly localized plasmon resonance. However, laser radiation can cause a change in the shape and size of plasmonic nanoparticles, thus resulting in an unwanted reduction of their photothermal and photodynamic efficiency due to a drastic alteration of optical properties. Most previously reported experiments were carried out with bulk colloids where different particles were irradiated by different numbers of laser pulses, thus making it difficult to accurately evaluate the laser power photomodification (PM) threshold. Here, we examine the one-shot nanosecond laser-pulse PM of bare and silica-coated gold nanoparticles moving in a capillary flow. Four types of gold nanoparticles, including nanostars, nanoantennas, nanorods, and SiO2@Au nanoshells, were fabricated for PM experiments. To evaluate the changes in the particle morphology under laser irradiation, we combine measurements of extinction spectra with electron microscopy. A quantitative spectral approach is developed to characterize the laser power PM threshold in terms of normalized extinction parameters. The experimentally determined PM threshold increases in series were as follows: nanorods, nanoantennas, nanoshells, and nanostars. An important observation is that even a thin silica shell significantly increases the photostability of gold nanorods. The developed methods and reported findings can be useful for the optimal design of plasmonic particles and laser irradiation parameters in various biomedical applications of functionalized hybrid nanostructures. [ABSTRACT FROM AUTHOR]

The effect of a fluence of electrons with an energy of 30 keV in the range of (1–7) × 1016 cm–2 on the concentration of color centers in micron-sized hollow particles of aluminum oxide is studied in comparison with bulk Al2O3 microparticles. The analysis is carried out in situ according to diffuse reflection spectra in the range from 250 to 2500 nm. The radiation resistance of the studied microspheres is estimated relative to Al2O3 microparticles from analysis of the difference spectra of diffuse reflection obtained by subtracting the spectra after irradiation from the spectra of nonirradiated samples. Changes in the difference spectra of diffuse reflection of aluminum-oxide microparticles and microspheres show that with an increase in the electron fluence, the induced absorption increases throughout the entire spectrum. It is established that the radiation resistance of aluminum-oxide microspheres to the action of electrons with an energy of 30 keV at a fluence of (1–7) × 1016 cm–2 is greater than the radiation resistance of Al2O3 microparticles. An increase in the radiation resistance of hollow aluminum-oxide particles is due to a low concentration of radiation-induced defects in the anion sublattice. [ABSTRACT FROM AUTHOR]

The shortening of the minority carrier lifetime is the main reason for the degradation of the electrical performance of solar cells; therefore, it is particularly important to evaluate the minority carrier lifetime of inverted metamorphic triple junction (IMM3J) GaInP/GaAs/InGaAs solar cells. We evaluate the minority carrier lifetime of each subcell of IMM3J solar cells before and after 2 MeV proton irradiation by the electroluminescence (EL) method. Before proton irradiation, the minority carrier lifetimes of the GaInP, GaAs, and InGaAs subcells were 6.99 × 10−9 s, 3.09 × 10−8 s, and 2.31 × 10−8 s, respectively. After proton irradiation, the minority carrier lifetime of GaInP, GaAs, and InGaAs subcells degraded significantly. When the proton fluence was 2 × 1012 cm−2, the minority carrier lifetimes of the GaInP, GaAs, and InGaAs subcells degraded to 1.63 × 10−10 s, 1.56 × 10−11 s, and 1.65 × 10−10 s, respectively. These results provide a reference for predicting the degradation of the short-circuit current and open-circuit voltage of each subcell. [ABSTRACT FROM AUTHOR]

• Prepare the sensors by separately implanting Ag and Au ions into SiO 2 wafers. • Study the roles of Ag ion energy and Au ion fluence in preparing the sensors. • Demonstrate the key role of a single nanocomposite surface layer. • Reveal the importance of interparticle interaction. • Discuss the roles of size and spatial distributions of metal nanoparticles. The Ag ions with the same fluence and different energies as well as the Au ions with the same energy and different fluences were separately implanted into SiO 2 wafers to prepare Ag-E30, Ag-E40, Ag-E50, Au-F6.0, Au-F4.5, and Au-F3.0 samples as the candidates for the localized surface plasmon resonance sensor. The prepared samples' structural and optical properties were studied in depth. The results revealed that among Ag-E30, Ag-E40, and Ag-E50 samples, Ag-E40 sample had a single nanocomposite surface layer, and its characteristic reflection peak linearly depended in position on the refractive index of overlay owing to the stronger interparticle interaction. For Au-F6.0, Au-F4.5, and Au-F3.0 samples, they all featured a single nanocomposite surface layer and showed a linear dependence of the characteristic reflection peak's position and the overlay's refractive index. Considering the cost of preparation, Au-F3.0 sample should be an optimal sensor although its refractive index sensitivity was slightly smaller. [ABSTRACT FROM AUTHOR]

Background: Intensity-modulated radiation therapy (IMRT) may have too many peaks and valleys, making the treatment plan undeliverable. When there are too many fluency differences between adjacent pixels in the X or Y directions, the X and Y smoothing factors are utilized as weighting factors to penalize this behavior. Generally, a high degree of complexity is accompanied by many monitor units (MUs), large number of segments, small sized segments, and complex segment shapes. The degree of plan delivery uncertainty can all increase with a higher detailed fluence map. Aim: This study aims to evaluate the dosimetric effects of various smoothing levels on the planning target volume (PTV) and organs at risk (OARs) for cervix cancer. Materials and Methods: IMRT treatment plans were re-optimized by combining several values of the X and Y penalty between 0 and 100. The dose–volume histogram assessed various dosimetric indicators for PTV and OARs. Additionally, gamma passing rates were evaluated and noted as an indicator of the complex treatment plan. Results: At X = 60, Y = 60 fluence map penalty, the conformity index (CI) value reached its highest value of 0.996 ± 0.004. At X = 0, Y = 0, the homogeneity index (HI) was determined to have a maximum value of 0.0628 ± 0.0235. The highest and lowest MU values were 2424.30 ± 471.12 and 1087.80 ± 91.57, respectively, with X = 0, Y = 0 and X = 100, Y = 100. At X = 100, Y = 100, the gamma passing rate reaches its highest value of 99.28% ± 0.44% and minimum value of 85.93% ± 3.87% at X = 0, Y = 0. Conclusion: The CI and HI values showed no discernible fluctuation, and the OAR doses were barely affected as smoothing was increased. When the smoothing factor was raised, the number of MUs sharply dropped, and a decrease in the number of segments and higher gamma passing rates were also seen.

A study was undertaken to model the UV-C inactivation kinetics and determine the fluences required for the incremental inactivation of several strains of Cronobacter spp. suspended in clear phosphate-buffered saline (PBS). In total, 13 strains of Cronobacter spp. were individually suspended in PBS and treated with UV-C doses of 0, 2, 4, 6, 8, and 10 mJ cm−2 with a collimated beam device emitting UV-C at 253.7 nm. The log reduction from each treatment was identified using the plate count method and plotted against the UV-C dose and then curve fitted using several mathematical models. The UV-C dose required for incremental inactivation of each isolate was determined using both linear and nonlinear regression. For the 13 strains tested, a UV-C dose of 10 mJ cm−2 inactivated between 3.66 ± 0.101 and 5.04 ± 0.465 log CFU mL−1. The survival behavior of all strains was best fitted to the Weibull+tail model, with correlation coefficients between 97.17 and 99.71%, and was used to determine the fluences required for incremental inactivation. The UV-C fluences needed to inactivate 1 log (D10-value) of Cronobacter spp. in buffer were between 3.53 and 5.50 mJ cm−2, whereas a fluence greater than 6.57 mJ cm−2 was required to achieve a 4-log inactivation. A clear understanding of the UV-C dose-response of several strains of Cronobacter spp. lays the foundation to design effective UV-based disinfection systems. [ABSTRACT FROM AUTHOR]

Background: Intensity-modulated radiation therapy (IMRT) may have too many peaks and valleys, making the treatment plan undeliverable. When there are too many fluency differences between adjacent pixels in the X or Y directions, the X and Y smoothing factors are utilized as weighting factors to penalize this behavior. Generally, a high degree of complexity is accompanied by many monitor units (MUs), large number of segments, small sized segments, and complex segment shapes. The degree of plan delivery uncertainty can all increase with a higher detailed fluence map. Aim: This study aims to evaluate the dosimetric effects of various smoothing levels on the planning target volume (PTV) and organs at risk (OARs) for cervix cancer. Materials and Methods: IMRT treatment plans were re‑optimized by combining several values of the X and Y penalty between 0 and 100. The dose–volume histogram assessed various dosimetric indicators for PTV and OARs. Additionally, gamma passing rates were evaluated and noted as an indicator of the complex treatment plan. Results: At X = 60, Y = 60 fluence map penalty, the conformity index (CI) value reached its highest value of 0.996 ± 0.004. At X = 0, Y = 0, the homogeneity index (HI) was determined to have a maximum value of 0.0628 ± 0.0235. The highest and lowest MU values were 2424.30 ± 471.12 and 1087.80 ± 91.57, respectively, with X = 0, Y = 0 and X = 100, Y = 100. At X = 100, Y = 100, the gamma passing rate reaches its highest value of 99.28% ± 0.44% and minimum value of 85.93% ± 3.87% at X = 0, Y = 0. Conclusion: The CI and HI values showed no discernible fluctuation, and the OAR doses were barely affected as smoothing was increased. When the smoothing factor was raised, the number of MUs sharply dropped, and a decrease in the number of segments and higher gamma passing rates were also seen. [ABSTRACT FROM AUTHOR]

This study observed the effect of neutron irradiation and ageing on the microstructure, hardness, and corrosion resistance of SAV-1 (Al–Mg–Si) alloy. The investigated material was irradiated with neutrons to fluences of 1021–1026 n/m2 in the WWR-K research reactor and kept in dry storage. Long-term irradiation led to an increase in hardness of the alloy and a deterioration of pitting corrosion resistance. Post-irradiation ageing for 1 h at 100–300 °C resulted in a decrease in microhardness of the irradiated SAV-1. The effect of post-irradiation ageing on pitting corrosion was made clear through the formation of Guinier-Preston zones and secondary precipitates in the Al matrix. Ageing at 250 °C corresponded to the development of stable microstructure and the highest corrosion resistance for the irradiated samples. Mg2Si, Si, and needle-shaped β″ precipitates were formed in SAV-1 alloy that was irradiated with low fluences. β″ and clusters of rod-shaped B-type precipitates were observed in highly irradiated samples. The precipitates were similar to those seen in non-irradiated pseudo-binary Al–Mg2Si alloys with Si excess.

Laser-based light sources have fostered innovative developments in biomedical and biosensor fields. However, laser-induced damage to optical components is a limitation for designing and implementing highly sensitive biosensors, necessitating the development and characterization of suitable optical components. Microscope glass slides are among the most extensively used optical units in this field. This study investigated the laser-induced damage threshold (LIDT) of high-quality microscope glass slides obtained from three different vendors. An S-on-1 protocol following the ISO 21254 series standards was adopted to ensure a meaningful comparative analysis. Multiple laser pulses at a constant fluence (at the three laser wavelengths most widely used in biosensors) were used for LIDT tests. An automated test bench was developed and employed to minimize the influence of human factors on the test results. The fatigue damage mechanism was observed in all the samples. The findings revealed good consistency among LIDT values within and across batches from the same vendor. However, a notable discrepancy was observed when comparing the results of slides obtained from different vendors, with threshold values differing by up to two-fold. This study emphasizes the need to carefully consider the glass material source when selecting microscope glass slides for laser-sensitive applications.

In this study, a new approach for laser beam oscillations in welding is proposed. Commonly frequency is used as the principal process parameter when driving beam oscillation but often leads to a suboptimal fluence distribution. If velocity is modulated this presents significant opportunity for enhancing thermal distribution within welds. Controlling galvanometer velocity instead of the frequency will create 'trajectory' dependent fluence distribution opportunities. Here we investigate the use of Lissajous curves for this purpose since these allow rapid parametric design adaptation. Fluence profiles are obtained, analysed and presented. Using this method key melt pool characteristics can be modulated including temperature difference within weld, max temperature achieved and the cooling rate. To illustrate this, we present a series of remelted surfaces which show the effect of modulated fluence on weld morphology. [ABSTRACT FROM AUTHOR]

Phenol is a recalcitrant anthropogenic compound whose presence has been reported in both wastewater and drinking water; human exposure to phenolic substances can lead to health problems. The degradation of phenol (measured as COD decrease) through solar heterogeneous photocatalysis with immobilized TiO2 was performed in two different reactors: a flat-plate reactor (FPR) and a compound parabolic collector (CPC). A 23 full factorial experimental design was followed. The variables were the presence of TiO2, H2O2 addition, and the type of reactor. Data were fitted to the pseudo-first-order reaction-rate-kinetics model. The rate constant for photocatalytic phenol degradation with 1 mM of H2O2 was 6.6 × 10−3 min−1 for the FPR and 5.9 × 10−3 min−1 in the CPC. The calculated figures of merit were analyzed with a MANCOVA, with UV fluence as a covariate. An ANCOVA showed that the type of reactor, H2O2 addition, or fluence had no statistically significant effect on the results, but there was for the presence of TiO2. According to the MANCOVA, fluence and TiO2 presence were significant (p < 0.05). The CPC was on average 17.4% more efficient than the FPR when it came to collector area per order (ACO) by heterogeneous photocatalysis and 1 mM H2O2 addition. [ABSTRACT FROM AUTHOR]

Multiple wavelength devices are now available for photobiomodulation (PBM) treatments, but their dosimetry for individual or combinatorial use remains unclear. The present work investigated the effects of 447, 532, 658, 810, 980 and 1064 nm wavelengths on odontoblast differentiation at 10 mW/cm2 using either equal treatment time for conventional fluence (300 seconds for 3 J/cm2) or varying times to adjust for individual wavelength photon fluence (4.6 p.J/cm2). Both 447 and 810 nm significantly increased alkaline phosphatase (ALP) activity, while 1064 nm showed reduced ALP activity at 3 J/cm2. However, ALP induction was significantly improved when equivalent photon fluence dosing was used. Other wavelengths did not show significant changes compared to untreated controls. The data suggest that accounting for wavelength‐specific photon energy transfer during PBM dosing could improve clinical safety and efficacy. [ABSTRACT FROM AUTHOR]

Tomas M Grippo,1,2 Facundo G Sanchez,1,3 Joan Stauffer,4 George Marcellino4 1Department of Glaucoma, Grippo Glaucoma & Cataract Center, Buenos Aires, Argentina; 2Department of Ophthalmology, Hospital Alemán, Buenos Aires, Argentina; 3Glaucoma Research, Legacy Devers Eye Institute, Portland, OR, USA; 4Glaucoma, Iridex Corp., Mountain View, CA, USACorrespondence: Tomas M GrippoDepartment of Glaucoma, Grippo Glaucoma & Cataract Center, Av. Luis Maria Campos 250, 1st Floor, Suite O, Buenos Aires, ArgentinaTel +54 11 4774-9004Email tomasgrippo@yahoo.comAbstract: Since the first peer-reviewed publication on MicroPulse® Transscleral Laser Therapy (MP-TLT) in 2010, authors worldwide have used a wide range of treatment parameter combinations with varying clinical efficacy in terms of the magnitude of intraocular pressure reduction, success rate, durability, and safety profile. This has made it difficult to determine the proper parameters necessary to optimize efficacy and safety, and has made comparison of results from one investigation to another difficult. The first goal of this paper is to explain and highlight the impact of the choices of exposure time and the number of sweeps per hemisphere in terms of “sweep velocity” on energy delivery to the eye. These treatment parameters are underreported in the literature. The second goal is to introduce fluence as a “dose” metric, that combines all the treatment parameters and constants into a single number. Fluence may be a better light-dose metric and a more reliable indicator of clinical outcomes compared to total energy.Keywords: micropulse, glaucoma, fluence, total energy, sweep velocity

This paper demonstrates the fabrication of a thin film of Zinc Oxide (ZnO) by RF sputtering on Indium Tin Oxide (ITO) substrate for Resistive Random-Access Memory (RRAM) application. The fabricated ZnO/ITO sample was bombarded with Swift Heavy Ion (SHI) of Ag9+ ions at 100 MeV with the fluence of 1 × 1013 ions/cm2 to study the effect of ion irradiation on the resistive switching of ZnO based RRAM. The resistance ratio of Au/ZnO/ITO-based devices was measured after ion irradiation. Enhancement of more than 100% in resistance ratio was observed in I-V measurements, while in pristine sample approximately linear switching was observed. The fabricated samples were characterized using Atomic Force Microscopy (AFM) and X-Ray Diffraction (XRD) to study the structural and morphological properties. The chemical composition of the ZnO/ITO substrate was studied using Rutherford Backscattering Spectrometry (RBS) spectrum analysis. The current study demonstrates that ion irradiation improves the performance of ZnO-based RRAM devices significantly. The ZnO based RRAM with enhanced resistive switching can find applications in memory devices for low power scalable devices.

• Finding solar release times of SEP events using velocity dispersion analysis. • For low CME speeds, difference between SEP and CME origin times is larger. • Proton peak flux - SF peak flux correlation falls with rise in particle energy. Properties and association of Solar Energetic Particle (SEP) events with their solar sources during the 24th solar cycle were examined. SEPs observed by SOHO ERNE were used. SEP properties include solar release time, peak proton flux and total fluence in different energy channels. Solar release times of SEP events were found out using Velocity Dispersion Analysis (VDA). It is observed that for low Coronal Mass Ejection (CME) velocities, the difference between SEP and CME release times is larger compared to that for high velocities. For SEPs associated with C class Solar Flares (SF), the average time difference in the release times is around 78 min, whereas in M and X class flares the time differences are 38 and 31 min respectively. Correlation analysis of proton peak flux with the CME speed and SF peak flux reveals that the coefficients decrease with increase in particle energy in both the cases. The correlation coefficient between total proton fluence of SEP and the peak flux of SF is moderate and decrease with increase in energy and tends to increase beyond 60 MeV. The correlation between total proton fluence and CME speed is high and it increases initially and then decrease with increase in energy. The analysis of H/He ratio of SEP events shows that the average value of the ratio extends from 16 to 837. [ABSTRACT FROM AUTHOR]

Femtosecond laser processing is a non-thermal process with less heat effect on a target material and is applied to dielectric and difficult-to-machine materials, such as titanium alloy and diamond. Femtosecond laser processing has been used for 3-dimensional shape generation in recent years, and increasing accuracy and productivity are required for such generation by femtosecond lasers. However, a 2.5-dimensional computer-aided manufacturing (CAM) system, which is mainly used in femtosecond laser processing, does not satisfy the requirement for complicated 3-dimensional shape generation. Therefore, there is a need for the development of a 3-dimensional CAM system for high-precision and productive 3-dimensional processing. Furthermore, for the 3-dimensional CAM system, quantitative identification of a 3-dimensional removal shape through ablation is necessary. This study proposes the development of a simulation method to accurately predict the 3-dimensional removal shape through femtosecond laser processing, including the piecewise approximation of the ablation rate and absorptance correction. At the same time, a similar 3-dimensional shape as that found through the experimental results was obtained during the simulation by considering the mechanical errors of the laser processing machine in the simulation model. Furthermore, an on-machine measurement system was developed to efficiently identify the ablation parameters. • A simulation method to predict 3-dimensional shape through ablation was developed. • A piecewise approximation of ablation rate improved accuracy of the simulation. • An absorptance correction enhanced the simulation accuracy. • Mechanical errors were applied to the simulation for accurate prediction. • On-machine measurement system was developed for identifying ablation parameters. [ABSTRACT FROM AUTHOR]