1. Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss
- Author
-
Silvia Cases-Cunillera, Karen M J van Loo, Julika Pitsch, Anne Quatraccioni, Sugirthan Sivalingam, Paolo Salomoni, Valeri Borger, Dirk Dietrich, Susanne Schoch, and Albert J Becker
- Subjects
Proto-Oncogene Proteins B-raf ,Cancer Research ,MTOR protein, human ,genetics [Proto-Oncogene Proteins B-raf] ,metabolism [TOR Serine-Threonine Kinases] ,epileptogenicity ,Mice ,metabolism [Proto-Oncogene Proteins B-raf] ,physiology [Signal Transduction] ,Animals ,Humans ,ddc:610 ,pediatric tumor ,Ganglioglioma ,dysplastic neuron ,Brain Neoplasms ,TOR Serine-Threonine Kinases ,genetics [TOR Serine-Threonine Kinases] ,metabolism [Brain Neoplasms] ,genetics [Brain Neoplasms] ,Oncology ,Mutation ,metabolism [Proto-Oncogene Proteins c-akt] ,genetics [Ganglioglioma] ,genetics [Proto-Oncogene Proteins c-akt] ,Neurology (clinical) ,neoplastic astroglia ,Proto-Oncogene Proteins c-akt ,Signal Transduction - Abstract
Neuro-Oncology 24(5), 741-754 (2022). doi:10.1093/neuonc/noab268, Published by Oxford Univ. Press, Oxford
- Published
- 2022
- Full Text
- View/download PDF