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Objective: This study aims to determine the etiological factors and risk factors of 100 adult patients who applied to our outpatient clinic for weight loss. Methods: Data were collected retrospectively, and age, gender, blood pressure, anthropometric measurements, and laboratory findings were analyzed. Patients with type 1 and type 2 diabetes, those using lipid-lowering drugs, patients with renal or hepatic insufficiency, pregnant individuals, or those under the age of 18 were excluded from the study. Results: 79% of the patients were female, and according to the body mass index (BMI) classification, 29% were overweight, 39% had stage 1 obesity, 23% had stage 2 obesity, and 9% had stage 3 obesity. A significant difference was found in HOMA-IR values between BMI groups (p=0.002), and as BMI increased, insulin resistance also increased. There were statistically significant differences in fasting plasma glucose (FPG), insulin, LDL, and vitamin D levels between BMI groups. However, no significant relationship was found between smoking and BMI. Conclusion: In conclusion, the study found a significant relationship between obesity, insulin resistance, and some biochemical parameters, emphasizing that these findings should be considered in the management and treatment of obesity. [ABSTRACT FROM AUTHOR]

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aims: Polycystic ovary syndrome (PCOS) is an endocrinological disease associated with hype- randrogenism and insulin resistance. Although the place of AMH in polycystic ovary syndrome has been accepted with the recently published guideline, the underlying mechanisms still remain unclear. The aim of this study is to investigate the relationship between hyperandrogenism and AMH using phenotypes A and D in PCOS and to show the place of AMH in the diagnosis of PCOS phenotype without hyperandrogenism. In addition, to reveal the relationship between insulin resistance and AMH. Material and Method: One hundred two patients with PCOS were included in this study. The patients were divided into two groups as Phenotype A and D. In addition, the patients were divided into 2 groups; with (HOMA-IR ≥2.5) and without insulin resistance (IR). The primary outcome was to measure the serum AMH levels between two groups. The secondary outcome was to compare demographic and clinical caracterics (age, BMI, laboratory values). Results: There was no significant difference in AMH values between phenotypes A and D. When patients are divided into 2 groups as PCOS with insulin resistant and without insulin resistant, AMH was found to be significantly lower in the insulin resistant PCOS (p=0.006). The cut-off value for AMH was 6.26 ng/ml, with a sensitivity of 70.4% and a specificity of 62.5%. Conclusion: As a result of our study, we think that the relationship of AMH with hyperandrogenism is not clear and reliable, as it is not a defining indicator between A and D phenotypes in PCOS, but it could be an indicator in determining insülin resistance in PCOS. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Obstetrics & Gynecology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ankara University Faculty of Medicine / Ankara Üniversitesi Tip Fakültesi Mecmuasi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Literature Pharmacy Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: In this study, it is aimed to investigate the relationship between serum adiponectin and kisspeptin levels and insulin resistance in patients with PCOS. Methods: 144 patients diagnosed with PCOS in a tertiary center, were included in the study. At the first visit, the height and weight measurements were recorded and menstrual functions were questioned. After ultrasonographic evaluation and hormonal assessment, patients were divided into groups according to insulin resistance (IR), then were compared in terms of hormonal parameters. Results: Weight and BMI were significantly higher in the insulin-resistant group (p=0.018, p=0.012). Mean fasting glucose, fasting insulin levels and HOMA indexes of the insulin-re)sistant group were significantly higher than the non-resistant group, respectively (p<0.001). LH/FSH ratios were significantly lower in the IR+ group (1.33 vs 1.58, p<0.05). No significant difference was observed between the groups in terms of adiponectin and kisspeptin levels, but the mean kisspeptin level in the IR- group was higher than the IR+ group (32.72 vs 19.36, p=0.067). Adiponectin and kisspeptin were both found to have a very weak positive relation)ship with FSH (r=0.169 and 0.171). Conclusion: Adiponectin is known to decrease in obesity and type 2 diabetes, but does not show the difference in insulin-resistant PCOS patients. Kisspeptin, which is a hypotha)lamic peptide and associated with increased LH levels in patients with PCOS, was found to be lower in the IR+ group. In order to clarify the role of kisspeptin and adiponectin in the mechanisms of PCOS and insulin resistance, it is needed to be examined in a larger sample with BMI-matched healthy controls. [ABSTRACT FROM AUTHOR]

Copyright of Androloji Bülteni (Andrology Bullettin) is the property of BAYT Ltd. Co and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: About 70% of women with polycystic ovary syndrome (PCOS) have insulin resistance and related metabolic disorders but the underlying mechanism leading to insulin resistance remain unknown. Betatrophin is a protein expressed in the liver and adipose tissue that has been found to be related to insulin resistance and ß-cell proliferation. The aim of this study is evaluate the circulating betatrophin level in PCOS cases and to investigate its relationship with obesity and insulin resistance. Methods: In this prospective cross-sectional study circulating betatrophin levels were measured in 35 PCOS cases with lean and 38 overweight/obese PCOS cases (BMI=25) using spesific enzyme-linked immunosorbent assay kits. Betatrophin levels, antropometric measurements, fasting blood glucose, 2 -hour post-glucose load blood glucose and homeostasis model assessment of insulin resistance (HOMA-IR) values were compared. Results: Circulating betatrophin levels of the lean PCOS group were found to be significantly higher than the overweight/obese PCOS group (p=0.023). There were no significant association between betatrophin and HOMA-IR levels. Conclusions: Betatrophin was found to be significantly lower in the overweight/obese group than in the lean PCOS group. Since the role of betatrophin in PCOS and insulin resistance has not been sufficiently clarified, it can be said that it is not a good predictor of insulin resistance in PCOS patients. [ABSTRACT FROM AUTHOR]

Objective: In this study, we aimed to determine the role of Triglyceride-Glucose Index (TyG) in detecting insulin resistance in hypertension (HT) patients followed up in primary care, especially in centers where blood insulin levels cannot be checked. Methods: This study is cross-sectional. The study was conducted with 458 people aged 18-65 who applied to the internal medicine outpatient clinics of the university hospital between January 2020 and January 2022. 285 of the individuals formed the patient group and 173 constituted the control group. Participants diagnosed with chronic diseases other than hypertension and receiving medical treatment due to insulin resistance were excluded from the study. Sociodemographic characteristics of the individuals, fasting blood sugar, triglyceride (TG), alanine aminotransferase test (ALT), aspartate aminotransferase test (AST), creatinine, glycated hemoglobin (HbA1c), insulin and thyroid stimulating hormone (TSH) values and anthropometric measurements were taken from the hospital automation system. Results: The mean age of 285/person HT patients and 173/person control group was 52.82±12.60 and 50.65±13.04, respectively. 60.4% of the HT patient group and 59.5% of the control group were female. In HT patients with a HOMA-IR value of =2.5, the cut-off point for TyG value was found to be =4.78, with a sensitivity of 69.1%, specificity of 74.7%, area under the ROC curve ± standard error under the ROC curve (AUC±SE)= 0.759±0.030 (p<0.001). Univariate regression analysis showed that a 1-unit increase in TyG increased the risk of hypertension 7.21-fold and this increase was statistically significant (p<0.001). Conclusion: In this study, it was determined that the TyG index can be used to calculate insulin resistance as a parameter that will affect the prognosis in patients diagnosed with hypertension. The study is important research that points out that TyG can be used as an alternative to HOMA-IR, especially in family health centers. [ABSTRACT FROM AUTHOR]

Objective: Polycystic ovary syndrome (PCOS) is a heterogeneous, systemic disease that occurs under the influence of genetic and environmental factors, clinically characterized by hyperandrogenism, menstrual irregularity and chronic anovulation, often starting in adolescence and seen in 6-20% of women of reproductive age. In this study, it was aimed to determine the clinical features of cases diagnosed with PCOS and to evaluate the relationship of PCOS with obesity and insulin resistance. Material and Method: Clinical, laboratory and radiological data of 52 cases diagnosed with PCOS were retrospectively evaluated by scanning patient files. Results: Average age of 52 patients was 16.12±1.21 years, body mass index (BMI); 26.67± 5.69 kg/m2, mean BMI SDS was found to be 1.41±1.47. The mean FGS was 10.77 ±3.64 and the FG score of 32 cases (61.5%) was found to be above 8. Total testosterone was found to be above 50 ng/dl in 48 cases (92.3%). BMI SDS and ALT, sex hormone binding globulin (SHBG) levels were found to be statistically significantly different in the insulin resistant group (p =0.001, p =0.031, p =0.005, respectively). Overweight and obese subjects (group1) were compared with normal weight and underweight subjects (group2). While HOMA-IR, ALT, triglyceride and total cholesterol were significantly higher in Group1, LH, LH/FSH ratio, estradiol (E2) and SHBG levels were significantly higher in Group2. Conclusion: Insulin resistance and obesity were absent in approximately half of the adolescent PCOS cases. Low SHBG levels were found to be associated with insulin resistance, obesity and hirsutism. In our study, SHBG levels were found to be significantly lower in group 1 when compared to overweight and obese subjects (group1) and normal weight and underweight subjects (group2). Although insulin resistance and obesity are not necessary criteria for the diagnosis of adolescent PCOS, they may have roles in the pathogenesis of PCOS. Obesity and insulin resistance may lead to hyperandrogenism by decreasing SHBG levels and increasing free androgens. [ABSTRACT FROM AUTHOR]

Objective: It has been reported that long-term growth hormone (GH) treatment may impair insulin sensitivity, hepatic glucose production, and insulin-dependent glucose utilization. In our study, we examined the effects of GH treatment on insulin sensitivity in patients with GH deficiency after one year treatment. Materials and Methods: Fifty-nine patients (22 female, 37 male) with GH deficiency who received GH therapy were included in this study. Anthropometric measurements and pubertal examination of the patients were done. Fasting plasma glucose (FPG), fasting plasma insulin (FPI), HbA1c levels were measured and oral glucose tolerance test (OGTT) (1.75 g/kg, max. 75 g) was performed before and one year after treatment. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and Matsuda indices were calculated. Result: The mean age of the patients at the start of GH treatment was 11.6±2.6 years old. The height standard deviation score (SDS) of the patients was -2.5±0.7, and the body mass index (BMI) SDS was -0.2±1.2. After one year, height SDS was -1.8±1.0 and BMI SDS was similar compared to baseline measurements. No difference was found between the initial and firstyear pubertal stages of the patients. At the end of the first year, FPG and HbA1c levels did not change. When baseline and the first year results were compared, FPI, peak insulin, and total in sulin were significantly higher at the first year (p=0.037; p=0.05; p=0.017), and the Matsuda index was found to be significantly lower (p=0.009). While HOMA-IR was higher in the first year, the difference was not significant. Conclusion: We observed that short-term GH treatment caused a decrease in insulin sensitivity, but did not reach disease-causing levels. It is important to monitor children receiving GH treatment for insulin resistance. We recommend further measurements of FPI and FPG, and performing OGTT to evaluate the degree of deterioration of glucose metabolism in risky patients. [ABSTRACT FROM AUTHOR]

Purpose: Seborrheic dermatitis (SD) is a chronic inflammatory skin disorder with an unknown etiology. Data from studies show that the prevalence of SD is higher in individuals with obesity. Insulin resistance (IR) is a metabolic condition characterized by high levels of insulin required to balance blood glycemia, and obesity is one of its clinical manifestations. This study presents one of the first prospective studies revealing the relationship between IR and SD in the literature. Materials and Methods: In this case-control study, a total of 71 participants were included: 35 SD patients (15 males/20 females) and 36 controls (15 males/21 females). All participants were clinically evaluated for the presence or absence of seborrheic dermatitis by the same dermatologist. Parameters including HOMA-IR, insulin levels, serum lipid levels, waist circumference, and BMI were measured in both groups. Results: HOMA-IR, insulin, total cholesterol, LDL cholesterol, waist circumference and BMI levels were higher in SD patients compared to the control group. Significant positive correlations were found between HOMA-IR and waist circumference, BMI, diastolic blood pressure, and triglyceride levels. Conclusion: This study suggests that IR could be a new comorbid factor in seborrheic dermatitis. A substantial association was observed between SD and insulin resistance, possibly due to shared inflammatory pathogenesis. Consequently, individuals with SD should be monitored for insulin resistance-related conditions, emphasizing the importance of maintaining a healthy lifestyle. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Van Health Sciences Journal / Van Sağlık Bilimleri Dergisi is the property of Van Yuzuncu Yil University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Bosphorus Medical Journal / Boğaziçi Tıp Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Son yıllarda polikistik over sendromu (PKOS) etiyopatogenezinde insülin direncinin rolünün ortaya konmuş ve obezite, tip 2 diabetes mellitus, hipertansiyon, dislipidemi, iskemik kalp hastalıkları, obstruktif uyku apnesi, endometrium kanseri ve mood bozuklukları gibi uzun dönem sağlık riskleriyle ilişkisi gösterilmiştir. İrisin ise yeni tanımlanmış bir myokin olup, insülin direnci ve metabolik sendromla ilişkili bulunmuştur. Biz bu çalışmamızda 18-28 yaş arası PKOS’lu olan ve olmayan gruplarda klinik, biyokimyasal, hormonal parametrelerle serum irisin düzeylerini karşılaştırdık. Gereç ve Yöntem: Erzincan Binali Yıldırım Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum polikliniğine başvuran 18-28 yaş arası, Rotterdam 2003 kriterlerine göre PKOS tanısı alan 64 hasta ve 60 kontrol grubu çalışmaya dahil edildi. Hastalara pelvik ultrasonografi yapıldı. Kilo, boy, tansiyon ölçüldü. HDL, LDL, trigliserid, total kolesterol, açlık insulin, LH, FSH, estradiol, total testesteron, serbest testesteron, homosistein, CRP, TSH, prolaktin, açlık glukoz, DHEAS, AMH, ALT, AST, HbA1c ve irisin düzeylerine bakıldı. Vücut kitle indeksleri ve HOMA-IR değerleri hesaplandı.Bulgular:PKOS’lu hastalar ve kontrol grubu klinik özellikler açısından karşılaştırıldığında her iki grup arasında yaş, boy, HDL, trigliserit, açlık insulin, FSH, LH, estradiol, TSH, prolaktin, ALT, AST, HOMA-IR indeks arasında istatistiksel olarak anlamlı bir fark izlenmedi. Kilo, vücut kitle indeksi, tansiyon, LDL, total kolesterol, total testesteron, serbest testesteron, homosistein, CRP, açlık glukoz, DHEAS, HbA1c değerleri açısından PKOS grubundaki hastalarda istatistiksel anlamlı olarak daha yüksek izlendi (p

Aim: This study aimed to evaluate the relationship between vitamin D levels and insulin resistance parameters in children with overweight and obesity. Material and Methods: A total of 174 children, 64.4% (n=112) female, and 35.6% (n=62) male, aged between 6-17 years were included in the study. The participants were divided into three groups as normal (29.9%, n=52), overweight (23.6%, n=41), and obesity (46.5%, n=81) based on the criteria of the World Health Organization body mass index (BMI) classification. The insulin resistance status of the participants was evaluated by homeostatic model assessment of insulin resistance (HOMA-IR), fasting glucose to insulin ratio (FGIR), and quantitative insulin sensitivity check index (QUICKI). Results: HOMA-IR was found higher in the obesity group (3.2±2.1) compared to the overweight (2.2±1.0) and the normal weight (1.5±1.0) groups (p

Purpose: The presence of a potential relationship between metabolic diseases and hormones and the intestinal flora has recently gained attention. Levels of asprosin and trimethylamine oxide (TMAO) may be associated with polycystic over syndrome (PCOS), which is a metabolic disease. The present study aims to investigate the potential relationship of PCOS with serum asprosin and TMAO levels. Materials and Methods: This cross-sectional study included 30 PCOS patients on metformin, 30 PCOS patients not receiving treatment, and 30 healthy controls. The demographic, glucose, insulin resistance, lipid, and hormone profiles of the participants were analyzed. Serum asprosin and TMAO levels were investigated with the ELISA method. Results: Patients with PCOS had higher BMI, serum glucose, triglyceride, ALT, insulin levels, and HOMA-IR scores compared with controls. The serum testosterone level was 28.1 ng/dl in the control group, 33.3 ng/dl in the PCOS group receiving metformin and 48.0 ng/dl in the untreated PCOS group, and there was a statistically significant difference. Neither serum asprosin nor TMAO levels were significantly different when compared between the three groups. Conclusion: Serum asprosin and TMAO levels of individuals with PCOS and healthy controls were not significantly different. The receipt of metformin treatment by PCOS patients did not have a significant relationship with serum asprosin and TMAO levels. [ABSTRACT FROM AUTHOR]

Copyright of Firat Universitesi Sağlik Bilimleri Tip Dergisi is the property of Firat Universitesiu, Saglik Bilimleri Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

ÖZET Amaç: Polikistik over sendromlu (PKOS) kadınlardaki insülin direnci ile serum copeptin düzeyi arasındaki olası ilişkiyi ortaya koymaktır. Yöntem: Benzer yaş ve vücut kitle indeksine (VKİ) sahip 44 PKOS’lu ve 44 sağlıklı kadın çalışmaya dahil edildi. Kadınların demografik, klinik ve laboratuvar bilgileri dosyalarından elde edildi. Adetin 2-4. günleri arası alınan örnekte serum copeptin düzeyi ölçüldü. PKOS ve sağlıklı kadınların verileri karşılaştırıldı. Serum copeptin düzeyinin anlamlı çıkan değişkenlerle korelasyonu değerlendirildi. Bulgular: PKOS’lu kadınlarda, klinik açıdan infertilite, hirşutizm, akne, ciltte yağlanma ve saç dökülmesi daha fazla, Ferriman-Gallwey Skoru (FGS) daha yüksek, adetler arası süre daha uzundu (bütün değişkenlerde p

Introduction: Meteorin-like (Metrnl), also known as subfatin is a newly discovered adipokine of adipocyte origin that may play a role in obesity and insulin resistance. The current study aimed to investigate the association between subfatin and biochemical values, demographic characteristics, and insulin resistance in obese patients and healthy controls.Methods: This cross-sectional study included 59 obese patients with sex and age-matched group of 41 healthy controls. An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Subfatin (Metrnl), and the correlations of Metrnl level with anthropometric parameters, HOMA index, and biochemical measurements were assessed.Results: The levels of BMI (p lt;0.001), insulin (p=0.002), and HOMA-IR score (p lt;0.001) were significantly higher in obese patients than controls. The serum levels of Subfatin were found to be lower in obese patients (1.85 [1.35–5.51] ng/ml) compared to the healthy controls (21.82 [12.61–27.76] ng/ml) (p lt;0.001). Subfatin had a significantly negative relationship with age (r =-0.250, p=0.012), weight (r =-0.373, p=0.001), BMI (r =-0.492, p=0.001), HbA1c (r =-0.209, p=0.037), LDL (r =-0.264, p=0.008), HOMA-IR (r =-0.223, p=0.026), and glucose (r =-0.376, p lt;0.001). There was a significantly positive correlation between subfatin and height (r=0.321, p=0.001).Conclusion: These results show that levels of subfatin were decreased in obese patients. There is a relationship between circulating amounts of subfatin hormone and age, weight, height, LDL-cholesterol, glucose, hbA1c, and HOMA-IR. Subfatin might be a new biomarker of obesity and insulin resistance.Keywords: Meteorin-like/subfatin, adiposity, insulin resistance, adipokines, biomarkers, diabetes mellitus type 2

Copyright of Ahi Evran Medical Journal is the property of Ahi Evran University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Chronic inflammation in obesity is the main factor that increases insulin resistance by causing changes in insulin sensitivity. Our study aimed to investigate the relationship between insulin resistance and C-reactive protein (CRP), uric acid, and fibrinogen levels in different body mass indexes (BMI). Material and Methods: In our study, patients who applied to our hospital with the complaint of overweight in 2021-2022 were retrospectively analyzed, and 149 women aged 20 and over were included in the study. Glucose, uric acid, total cholesterol, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglyceride (TG), CRP, insulin, fibrinogen results, which were measured simultaneously with the height and weight measurements of the patients, were obtained from the laboratory information system. Results: The patients included in the study were 25 normal weight, 56 overweight, 53 obese and 15 morbidly obese according to BMI. The uric acid and TG levels of the overweight group were found to be significantly higher than the normal group (respectively; p=0.012, p=0.031), the CRP level of the morbidly obese group was found to be significantly higher than the normal, overweight, and obese groups (respectively; p<0.001, p<0.001, p=0.006). A significant positive correlation was found between Homeostatic Model Assessment for Insulin Resistance and CRP and uric acid (respectively; r=0.219, p=0.009; r=0.353, p<0,001). Conclusion: We think that uric acid levels in the early stage of obesity and CRP levels in the advanced stage may be a guide for insulin resistance and obesity-related diseases. [ABSTRACT FROM AUTHOR]

Aim: This study aimed to evaluate the relationship between vitamin D levels and insulin resistance parameters in children with overweight and obesity. Material and Methods: A total of 174 children, 64.4% (n=112) female, and 35.6% (n=62) male, aged between 6-17 years were included in the study. The participants were divided into three groups as normal (29.9%, n=52), overweight (23.6%, n=41), and obesity (46.5%, n=81) based on the criteria of the World Health Organization body mass index (BMI) classification. The insulin resistance status of the participants was evaluated by homeostatic model assessment of insulin resistance (HOMA-IR), fasting glucose to insulin ratio (FGIR), and quantitative insulin sensitivity check index (QUICKI). Results: HOMA-IR was found higher in the obesity group (3.2±2.1) compared to the overweight (2.2±1.0) and the normal weight (1.5±1.0) groups (p<0.001). It was observed that QUICKI values of the overweight (0.34±0.03) and the obesity (0.33±0.03) groups were lower than the normal weight (0.37±0.03) group (p<0.001). FGIR was noticed as higher in the normal weight (16.8±10.4) group compared to the overweight (10.6±6.0) and the obesity (8.5±5.5) groups (p<0.001). The mean serum 25-hydroxyvitamin D [25(OH)D] levels of the children and adolescents were 19.6±10.7 ng/mL, and no statistically significant difference was found between the groups (p=0.153). A significant weak negative correlation between serum 25(OH)D and HOMA-IR values was found (r=-0.170, p=0.025). Additionally, a weak positive statistically significant correlation was found between serum 25(OH)D level and QUICKI and FGIR values (r=0.173, p=0.022, and r=0.173, p=0.023, respectively). Conclusion: Vitamin D levels can affect insulin resistance parameters. [ABSTRACT FROM AUTHOR]

Copyright of Hamidiye Medical Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: Polycystic ovary syndrome (PCOS) is a heterogenous disease that is characterized with chronic anovulation, menstrual irregularities and hyperandrogenism. In the present study we aimed to compare the metabolic features of PCOS' subgroups based on revised Rotterdam diagnostic criterias. Materials and Methods: Ninety-five women with PCOS were enrolled into the study and divided into four groups. Group 1; oligomenorrhea and/or anovulation with biochemical hyperandrogenemia and/or hyperandrogenism, group 2; biochemical hyperandrogenemia and/or hyperandrogenism with polycystic ovaries, group 3; oligomenorrhea and/or anovulation with polycystic ovaries and group 4; polycystic ovaries with oligomenorrhea and/or anovulation with biochemical hyperandrogenaemia and/or hyperandrogenism. Body mass indeces (kg/m2) and waist to hip ratios were calculated in all study patients. Fasting glucose, lipid levels, kidney and liver function tests were measured after 12 hours fasting. Oral glucose tolerance test (OGTT) was performed to evaluate the responses of glucose and insülin. Hormone levels were measured during the follicular phase of the menstrual cycle. Adrenocorticotrophic hormone (ACTH) (0.5 mg Synacthen IM) and gonadotrophin-releasing hormone agonist (buserelin) tests were performed in order to evaluate adrenal and ovarian hyperandrogenemia. Ovarian ultrasonography was performed on all study patients to define PCO morphology. Results: The frequency of the classical PCOS phenotype was higher than the non-classical PCOS phenotype (74.7% and 25.2%, respectively). Body mass indexes, waist-hip ratios, serum total, LDL and HDL-cholesterol levels were similar in all groups. Serum triglyceride levels were found to be significantly lower in group 2 compared to other groups (p< 0.01). Peak insulin and AUC insulin levels were significantly lower in group 2 (p< 0.05). The prevalence of impaired fasting glucose and impaired glucose tolerance was similar in all groups. Free testosterone and androstenedione levels were significantly lower in group 3 compared to group 4. Conclusion: Metabolic disturbances of patients with PCOS without hyperandrogenism (OA+PCO; group 3) were similar to the classical PCOS groups contrary to the expectations. The metabolic disturbances found in patients with PCOS without menstrual dysfunction (HA+PCO; group 2) were found to be milder in terms of lipid levels and insulin resistance. These findings support that newly developed HA+PCO and OA+PCO groups are the part of wide PCOS spectrum and also it supports that PCO morphology is one of the diagnostic criterias of PCOS. [ABSTRACT FROM AUTHOR]

Aim: To investigate the effects of metformin therapy on hyperandrogenism and menstrual functions in adolescent patients with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Materials and Methods: In this study, 50 adolescents with PCOS were included. Hormonal and ultrasonographic assessments were done at the early follicular phase. On the day of 19-21 of the cycle, progesterone levels were measured and patients were questioned for menstrual periods. Body-mass-indexes (BMI), waist-hip ratios, and Ferriman-Gallwey scores were calculated for all patients. IR is diagnosed according to HOMA index and insulin-resistant patients were instructed to use 1500 mg/day metformin for 3 months. After treatment ended, measurements were repeated by the same researcher. Results: Mean age and BMI values were similar between groups. Although the values of BMI and waist/hip ratio decreased after treatment, the decrement didn't reach the values of the IR- group. Free testosterone levels were significantly higher in IR+ subjects compared to IR negatives and significantly decreased after treatment. Sex hormone-binding globulin levels were increased with metformin treatment and as a result, free androgen indexes were decreased. 17 OH progesterone levels were significantly higher in the IR+ group and regressed to similar levels with IR negatives after treatment. While mean levels of fasting insulin were 19.21IU/ml in the IR+ group, it regressed to 13.14IU/ml after treatment. Also fasting glucose/insulin ratios were increased as expected. Finally, a significant improvement in the treatment group was observed at menstrual irregularity. Conclusion: Consequently, this study supports the conclusion that metformin reduces hyperandrogenism and improves menstrual and ovulatory functions.

Introduction: The visceral adiposity index is a reliable indicator of visceral adipose tissue dysfunction. The aim of this research was to determine the cut-off points of the visceral adiposity index in predicting metabolic syndrome, insulin resistance, type 2 diabetes mellitus, and hypertension at specific age ranges and in both sexes separately.Methods: This research is both descriptive and analytical. The research was conducted with 951 participants aged 18 and over between July 2019 and July 2020. 51 participants that did not meet study criteria were excluded from the research. The research was completed with a total of 900 participants, 577 females and 373 males. A physical examination and anthropometric measurements (height, weight, waist circumference, and blood pressure) of all participants were conducted. After 12 hours of fasting, the HDL, TG, glucose, and insulin levels of participants were measured. The blood pressure of participants was measured after 15 minutes of rest. Adult treatment panel 3 criteria were used for the diagnosis of metabolic syndrome. A homeostatic model assessment was calculated. The visceral adiposity index is calculated in the entire population for the prediction of metabolic syndrome, insulin resistance, diabetes, and hypertension: women, men, age groups 18–30, 31–40, 41–50, 51–65, 66 and over.Results: Cut-off points of the visceral adiposity index in predicting metabolic syndrome were 4.53 in the total population and males, 4.28 in females, 4.76 in the 18-30 age range, 4.96 in the 31-40 age range, 4.87 in the 41-50 age range, 5.04 in the 51-65 age range, and 4.59 in the age range 66 and above. Cut-off points of the visceral adiposity index in predicting insulin resistance were 4.24 in the total population and females, 4.68 in males, 3.45 in the 18-30 age range, 4.15 in the 31-40 age range, 4.66 in the 41-50 age range, and 4.87 in the 51-65 age range. Cut-off points of the visceral adiposity index in predicting type 2 diabetes mellitus were 4.89 in the total population, 6.43 in females, 7.02 in the 31-40 age range, 7.29 in the 41-50 age range, and 5.98 in the 51-65 age range. Cut-off points of the visceral adiposity index in predicting hypertension were 4.26 in the total population, 4.07 in females, 4.64 in the 18–30 age range, and 4.43 in the 51–65 age range.Conclusions: The visceral adiposity index can be used to predict metabolic syndrome, insulin resistance, type 2 diabetes mellitus and hypertension.

Amaç: GDM’lu ve sağlıklı gebelerde anne serumunda YKL-40 düzeyini ölçerek bu gebelerdeki insülin direnci üzerindeki rolünü açıklığa kavuşturmaktır. Yöntem: Haziran 2012 ile Haziran 2013 tarihleri arasında Cerrahpaşa Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı'nda takip edilen 40 GDM ve 40 sağlıklı term gebe çalışmaya dahil edildi. Gebelere ait demografik ve klinik parametreler hasta dosyalarından alındı. Bu gebelerde açlık glukoz, HbA1C, açlık insülin ve YKL-40 düzeyi ölçüldü. HOMA-IR değeri hesaplandı. GDM’li ve sağlıklı gebelerdeki parametreler karşılaştırıldı. Serum YKL-40 düzeyinin insülin direnci parametreleriyle ilişkisi araştırıldı. Bulgular: GDM’lu ve sağlıklı gebeler arasında yaş, sistolik ve diyastolik kan basıncı, gebelik haftası, doğum ağırlığı, lökosit sayısı ve açlık glukoz düzeyi açısından istatistiksel bir fark saptanmadı (tümü için p > 0.05). GDM'lu gebelerin VKİ, HbA1c, açlık insülin düzeyi, HOMA-IR değeri ve YKL-40 düzeyi istatiksel açıdan anlamlı olacak şekilde yüksek saptandı ( sırasıyla, 31.8 ± 4.3, 28.1 ± 2.4, p:0,001; 5.86 ± 1.85, 5.11 ± 0.25, p:0,001; 12.74 ± 6.52, 7.44 ± 2.12, p:0,001, 3.12 ± 1.94, 1.81 ± 0.48, p:0,001). Serum YKL-40 düzeyi VKİ, HbaA1C, açlık insülin,ve HOMA-IR değeri ile pozitif korele saptandı(sırasıyla, r:0,507, p:0,001; r:0,668, p:0,001; r:0,556, p:0,001; r:0,379, p:0,009). Sonuç: GDM’lu gebelerde serum YKL-40 düzeyinin arttığı ve bu düzeyin insülin direnci parametreleriyle pozitif korele olduğu tespit edilmiştir.

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Introduction: Nowadays, children's exposure to the obesogenic environment can lead to obesity and insulin resistance in the early period. However, it is suggested that the risk of developing health problems such as obesity, insulin resistance, and type 2 diabetes may decrease with increasing adherence to the Mediterranean diet. This study was aimed to evaluate the relationship between insulin resistance and the Mediterranean Diet Quality Index (KIDMED) in children and adolescents. Materials and Methods: A total of 174 children and adolescents (35.6% boys, 64.4% girls) with a mean age of 11.6±3.17 years were included in the study. The data were collected by a questionnaire containing individuals' socio-demographic information, anthropometric measurements, KIDMED, and 24-hour food consumption records. According to World Health Organization criteria, the body mass index z-scores of the participants were evaluated, and participants were divided into three groups as normal weight (29.9%), overweight (23.6%), and obesity (46.5%). Results: This study's findings were: mean KIDMED score was 5.7±2.62 points in the normal weight group, 5.4±2.39 points in the overweight group, and 4.6±2.70 points in the obesity group which was significantly lower than the normal weight group (p<0.05). Additionally, the mean KIDMED score of children with insulin resistance (4.3±2.72) was lower than those without insulin resistance (5.4±2.57) (p<0.05). A negative, moderate, and significant correlation was found between the participants' KIDMED scores and the homeostatic model assessment of insulin resistance value (r=-0.338, p<0.001). Conclusion: The low level of adherence to the Mediterranean diet was associated with the risk of developing insulin resistance. [ABSTRACT FROM AUTHOR]

Purpose: Many studies show that obesity is associated with increased serum thyrotropin [TSH] but the relationship between obesity, free thyroid hormones (including free triiodothyronine [FT3] and free thyroxin [FT4] is still unclear. The aim of this studywas to evaluate the effects of thyroid homeostasis, insulin resistance and blood parameters on weight loss in an obesity center. Materials and Methods: Of 3918 patients applied to an obesity center between November 1st, 2018 and March 13th, 2020, 417 were found suitable and accepted in this obesity prevention program and retrospective, descriptive, cross-sectional study. Results: A total of 417 patients were interviewed, 383 were female in this study. The mean age of participants was 48.20±11.03 years. In the group who lost weight; TSH, FT3, BMI, WC, HC, HbA1c and HOMA-IR index values were significantly lower in the sixth month. According to these results, the blood parameters, TSH, FT3 and insülin resistance of the patients are decreased who lose weight. Hip circumference, BMI, BFP, FT3, HbA1c and FBG were important determinants of weight loss in our univariate analyses. FT3 (odds ratio [OR]: 1.854; 95% CI: [1.223-2.811]; p=0.004), BMI (OR: 0.948; 95% CI: [0.914-0.984]; p=0.005) and FBG (OR: 0.984; 95% CI: [0.973-0.996]; p=0.007) were defined as multivariate predictors affecting weight loss. Conclusion: This study advises that lower BMI and FBG levels, and higher fT3 concentrations are related with a better potential to lose weight in obese patients.

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Amaç: Bu çalışmada gestasyonel diyabet mellitus (GDM) tanısı alan gebelerin serum kartonektin (CTRP-3) sevilerinin sağlıklı kontrol gebe grubu ile karşılaştırılması ve Kartonektin düzeyinin gebelerin biyokimyasal parametreleri ile ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Kesitsel tipte tasarlanan araştırma Haziran 2016 ile Ocak 2017 tarihleri arasında yürütülmüştür. Çalışmaya 24-32 haftalık 30 GDM ve 30 sağlıklı gebe dahil edildi. Tüm katılımcılardan 12 saat açlık sonrası kan şekeri, lipid paneli, insulin, c-peptid ve kartonektin düzeyleri elde edilmiştir. Bulgular: Gestasyonel diyabeti olan katılımcıların Glikoz, HbA1C, İnsulin, C-peptid, HOMA-IR, Trigliserit, VLDL, HDL düzeyleri istatistiksel olarak kontrol grubundan yüksek saptandı. Kontrol grubunun kartonektin (CTRP-3) düzeyi 7.68±4.29 (ng/mL), GDM grubunun ortalama kartonektin düzeyi 6.95±4.02 (ng/mL) saptandı ve iki grup arasında istatistiksel anlamlı bir fark saptanmadı Sonuç: GDM’lu hasta grubunda glikoz, HbA1c, insulin, HOMA-IR, C-peptid, trigliserit ve VLDL düzeylerinin yükseldiği saptanmıştır. Gestasyonel diyabetli hastalarda kartonektin ile glikoz ve insülin düzeyleri arasında negatif korelasyon saptanmıştır.

tion between insulin resistance (IR) measured by using different methods and heart failure (HF). In recent years, the triglyceride glucose (TyG) index has been used to measure IR, and there are several reports showing that the TyG index indicates conditions such as metabolic syndrome (MetS) and atherosclerotic process. However, there is no study investigating the association of the TyG index with HF. Therefore, we aimed to evaluate the role of the TyG index in HF presence and its relationship with HF severity in this study. Materials and Methods: Sixty-nine subjects matched for age and gender were analyzed retrospectively. The TyG index was used to measure IR and was calculated by the formula Ln [fasting triglycerides (mg/dl) x fasting glucose (mg/dl)/2]. The severity of HF was assessed by New York Heart Association (NYHA) functional class, left ventricular ejection fraction (LVEF) and N- terminal prohormone brain natriuretic peptide (NT-proBNP). Results: HF patients had higher TyG index (9.11±0.59 vs. 8.55±0.55; p<0.001) but there was no correlation between TyG index with HF severity identified by NYHA functional class, LVEF and NT-proBNP. The ROC curve showed the cut-off point of the TyG index in determining HF as 9.19 with 71% sensitivity and 51% specificity (AUC:0.745, p<0.001). Conclusion: TyG index may be a useful marker for diagnosis of HF, but is not correlated with HF severity. [ABSTRACT FROM AUTHOR]

Objective: Among screen-addicted children, there is a risk of insulin resistance (IR), obesity, hypertriglyceridemia and diabetes mellitus type 2 due to decreased physical activity and irregular eating habits. Most recently, relations of screen addiction (SA) and attention-deficit hyperactivity disorder (ADHD) with obesity have been reported. Herein, we aimed to investigate the presence of IR and dependent factors in screen-addicted children with and without obesity. Method: A total of 108 children in the age range of 11-17 years were included in the study. Cases were divided into three groups according to ADHD and SA scale scores. In these three groups, there were equal numbers of obese and non-obese patients. Homeostasis model assessment for insulin resistance (HOMA-IR) of the patients was assessed at baseline. Body fat analysis was performed with TANITA BC-420 MA body composition analyzers. All cases wore pedometers for 3 days to determine their basal metabolic rates (BMR) during active and sedentary periods. Carbohydrate, fat and calorie consumption was calculated using a professional nutrition program. Results: There were no statistically significant differences between the SA and non-SA groups on the energy consumption, BMR and fat mass and dietary contents. There was no effect of ADHD and SA on HOMA-IR values. Conclusion: We did not find any association between SA and IR. Also dependent factors were similar between groups. New studies are needed to determine how SA affects obesity. [ABSTRACT FROM AUTHOR]

Objective: There is a lot of study in adults investigating the Triglyceride-Glucose (Ty-G) index. However, a limited study has been searched in the pediatric age group. Moreover, to the best of our knowledge, there is no study on Turkish children. The aim of this study, to investigate the usability of the triglyceride-glucose index as an indicator of insulin resistance in obese adolescents and to calculate the cut-off values. Method: Six hundred twenty-three pubertal obese adolescents (266 boys, and 357 girls) were retrospectively evaluated. Ty-G index and HOMA-IR levels were calculated. ROC analysis was used for the estimations of the Ty-G index cutoff value. Results: There was positive correlation between HOMA-IR and Ty-G index in boys (r=0.255, p<0.001), in girls (r=0.402, p<0.001), and all study groups (r=0.323, p<0.001). Ty-G index cutoff value for insülin resistance in pubertal obese adolescents was calculated as 8.42 with 70.1 % sensitivity and 59.3 % specificity for all study groups; 8,38 with 71.1 % sensitivity, and 48.3 % specificity for boys; 8,27 with 80% sensitivity, and 52.9% specificity for girls. Conclusions: Ty-G index may be a reliable indicator for insülin resistance in pubertal obese adolescents. More attention should be given fort his marker with prospective studies. [ABSTRACT FROM AUTHOR]

Obesity is an increasing health problem all over the world. Angiopoietinrelated growth factor (AGF, ANGPTL6) is a hepatocyte that directly regulates lipid, glucose and energy metabolism independent of angiogenic effects. In this study, we investigated circulating AGF levels in relation to kidney function, type 2 diabetes mellitus and insulin resistance. Angiopoietin-related growth factor was determined by enzyme-linked immunosorbent assay in subjects with a normal glomerular filtration rate (n = 44, 22 diabetic and 22 nondiabetic) and in patients on chronic hemodialysis (CD; n = 44, 22 diabetic and 22 nondiabetic). Median serum AGF levels were 176,6± 96,6 µg/L inpatients who underwent dialysis and 186,0±81,7 µg/L in patients not on dialysis. There was no statistically significant difference between the mean serum AGF levels of the patients who underwent dialysis and those who did not(p>0.05). AGF serum levels were significantly increased in diabetic patients (222,56±90,61 µg/L) as compared with non-diabetic patients (140,12 ± 66,06 µg/L) (P <0.05). In addition, we evaluated the relationship between biochemical parameters and anthropometric measurements of the patients and AGF in our study. BMI, HOMA, waist/hip circumference ratios positively correlated with circulating AGF in all patients. Our results suggest that T2DM is positively associated with AGF serum levels. We think that this study will be useful to explain the pathogenesis of AGF in insulin resistance. Further studies are needed to better elucidate the physiologic significance of circulating AGF in human. [ABSTRACT FROM AUTHOR]

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Giriş ve Amaç: Prediyabet, bozulmuş açlık glikozu (BAG) ve bozulmuş glikoz toleransı (BGT) ile Diyabet Mellitus (DM) riskinin arttığı durumdur. Çalışmalar DM’un D vitamini ve Paratiroid Hormon (PTH) düzeyleri ile ilişkili olduğunu göstermektedir. Bu çalışmada prediyabetik hastalarda D vitamini ve PTH düzeyi ile insülin duyarlılığının değerlendirilmesi amaçlandı. Gereç ve Yöntem: Bu kesitsel araştırma 1 Haziran 2017 ve 30 Kasım 2017 arasında prediyabet olan 17-87 yaş arası 100 kişi ile yapıldı. Prediyabet durumu çalışmanın bağımlı değişkeni iken, vitamin D düzeyleri, homeostasis model assesment (HOMA) ve biyokimyasal parametreler bağımsız değişkeni olarak belirlendi. Ölçümle belirlenen verilerin analizinde student-T, sayımla belirlenen verilerin analizinde ki- kare, korelasyon testi için Spearman Korelasyon Analizi uygulanarak prediyabetlilerde vitamin D ve PTH düzeylerinin glikoz düzeyi ve HOMA üzerindeki etkisi analiz edildi (anlamlılık düzeyi için P lt;0.05 alındı). Bulgular: Hastaların %27’si erkek, %73’ü kadın, yaş ortalaması 50,50±14,90’ idi. Kadınlarda PTH, erkeklerde vitamin D ve Hb değerleri daha yüksek idi. Kadın ve erkeklerde optimal vitamin D düzeyi (≥ 30ng/ml) oranı çok düşük olup sırası ile %3,7 ve %5,5 idi. Vitamin D eksikliği olanların %45,8’inde insülin direnci var iken, vitamin D optimal olanlarda insülin %20’da insülin direnci vardı. Vitamin D düzeyleri ile VKİ ve HOMA-IR açısından anlamlı fark yoktu (P=0.861). BAG olanlarda BGT olanlara göre glikoz, insülin ve HOMA-IR anlamlı yüksek iken (P lt;0.05), BGT olanlarda yaş anlamlı şekilde daha yüksekti (P lt;0.05). Sonuç: Sonuç olarak prediyabetiklerin takip ve tedavisinin sürdürülmesinde vitamin D düzeyleri dikkate alınmalı gereğinde optimal düzeyler sağlanmalıdır

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Objective: The objective of the study is to investigate sleep disorders in patients with polycystic ovary syndrome (PCOS) and determine the relationship of sleep disorders with the metabolic and psychogenic aspects of PCOS. Materials and Methods: This case-control study was conducted between October 1, 2019, and March 1, 2020, at the gynaecology and neurology outpatient clinics of a tertiary hospital. The study included 73 patients diagnosed with PCOS and 63 healthy women volunteers. Testosterone, fasting glucose and fasting insulin levels of all the participants were measured. All study participants completed Beck's depression inventory (BDI), Beck's anxiety inventory (BAI), Epworth Sleepiness scale (ESS), Berlin questionnaire (BQ), insomnia severity index (ISI), and Pittsburgh sleep quality index (PSQI). The presence of restless legs syndrome (RLS) was assessed according to the international RLS study group criteria. Results: According to PSQI scores, 61.6% of patients with PCOS and 34.9% of healthy controls had a poor sleep quality (p=0.003). The PCOS group had significantly higher PSQI, ESS, ISI, BAI, BDI, and BQ scores than the control group (p=0.002, p=0.001, p<0.001, p<0.001, p<0.001, p<0.001, respectively). Although 23.3% of patients with PCOS met the RLS criteria, this rate was only 6.3% in the control group (p=0.013). There was a positive correlation between insulin resistance and PSQI (r=0.320, p=0.006). Conclusion: This study's results indicate that PCOS may be a risk factor for several sleep disorders. In addition, the cumulative impact of both the organic and psychogenic changes caused by PCOS may lead to sleep disorders. [ABSTRACT FROM AUTHOR]

Objective: Lacunae in literature persist regarding the mechanisms connected with the progression from metabolic syndrome (MetS) to Type 2 diabetes and cardiovascular disease (CVD). To validate heart rate variability (HRV), as a tool for progression of CVD in patients visiting cardiovascular outpatient clinic. Material and Methods: This crosssectional study involved screening of 126 patients for the presence of one or more cardiometabolic risk factors and followed with HRV measurement after categorizing them as MetS+ or control MetS-. Results: Time domain analysis showed a significant reduction between male and female of MetS- and MetS+ While frequency domain analysis in MetS+ male showed no difference, MetS+ female showed significant difference in TP and HF indices. With increasing number of metabolic components, the MetS+ males exhibited significant decrease in the time domain and increase in frequency domain indices of HRV. Body mass index (BMI), waist circumference (WC), high-density lipoprotein (HDL), and triglyceride (TG) were associated with time and frequency domain of HRV among MetS+ and MetS- males and females. Low density lipoprotein (LDL) was a significant predictor of SDNN, RRSSD, and NN50 in patients with MetS+ while HDL was a significant predictor of Standard deviation of normal-to-normal intervals (SDNN) and pNN50. BMI was significant predictor of SDNN and pNN50 in MetS-patients and NN50 in MetS+ patients. In MetS+, the significant predictor of HF was WC, TG, HDL and LDL and that of LF were TG and LDL while in MetS-, WC was significant predictor of LF and HDL of LF/HF. Conclusion: MetS+ females showed lower vagal activity and decreased sympathetic predominance as compared to MetS males suggesting greater cardiovascular risk. [ABSTRACT FROM AUTHOR]

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Objectives: Bee propolis is a natural substance that is used in traditional medicine due to its versatile pharmacological actions. This study evaluates whether short term use of bee propolis supplementation could have an impact on glycemic control in healthy individuals. Materials and Methods: A single daily dose of 1000 mg of bee propolis was administered orally to a total of 34 healthy individuals for 60 days. Body weight, body mass index (BMI), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and insulin resistance were measured in all participants before and after the use of bee propolis. Results: The results of this study showed that bee propolis was associated with a significant increase in body weight and BMI of healthy volunteers. Bee propolis supplementation decreased FBG and HbA1c, but did not affect insulin resistance. Conclusion: Based on these results, bee propolis supplementation has a potential effect on glycemic control in healthy individuals and this should be considered when using this supplement in medical conditions. [ABSTRACT FROM AUTHOR]

Objectives: It was aimed to compare the rate of insulin resistance (IR) in patients with chronic hepatitis B virus (CHB) infection with the general population. Materials and Methods: The files of the patients were retrospectively examined. Patients testing for insulin and fasting blood glucose were included. For detecting IR, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index was used. All patients were divided into 2 groups in terms of HOMA-IR. All data were compared between two groups. The rate of IR was compared with the general population. Results: Forty-seven were female and the mean age was 38. Seventy-one had hepatitis B e antigen (HBeAg)-negative CHB infection, 44 had CHB and 5 had HBeAg-positive CHB infection. IR was detected in 47 patients. The rates of IR were similar between females and males. The rates of IR was 38% in HBeAg negative CHB infection, 36.4% in CHB and 80% in HBeAg positive CHB infection. The rate of IR in patients with CHB infection was found to be 39% in our study. Conclusion: This study showed higher rate of IR in patients with CHB infection than in the general population and thus these patients should be carefully monitored in terms of the occurrence of IR and diabetes mellitus. [ABSTRACT FROM AUTHOR]

Background and Design: Post-adolescent acne has been defined as acne that persists or whose onset starts beyond the age of 25 years. The presence of hyperandrogenemia, polycystic ovary syndrome (PCOS), dyslipidemia, and insulin sensitivity play a role in etiopathogenesis of post-adolescent acne in women as shown in previous studies. This study was conducted to investigate these relationships. Materials and Methods: We included 45 female patients with post-adolescent acne and 30 age, sex, and body mass index-matched healthy controls. Demographic characteristics, clinical signs of hyperandrogenemia, pelvic ultrasound scan, and hormonal assessment including the [total testosterone (TT), sex hormone binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2)] and fasting plasma glucose, and insulin and lipid levels were recorded. Results: Woman with post-adolescent acne had the marked presence of menstrual abnormalities (37.7%), hirsutism (13.3%), androgenetic alopecia (11.1%), metabolic syndrome (MS) (32.4%), and PCOS (22.2%). Pelvic ultrasound scans showed that 17.8% of the patients had polycystic ovaries. In addition, the percentage of current smokers was significantly higher in the patient group than the controls (p=0.001). TT and LH were significantly higher in post-adolescent acne patients than the controls (p=0.048, and p=0.012, respectively). No significant differences were observed between patients and controls in terms of SHBG, DHEAS, FSH, PRL, E2, and total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels. No correlations were observed between these parameters and the severity of acne. Conclusion: Although laboratory hormonal assessment showed no significant difference, post-adolescent acne patients had marked menstrual irregularities, polycystic ovaries, androgenetic alopecia, hirsutism, and MS. However, insulin resistance and dyslipidemia may not play a major role in the pathogenesis of post-adolescent female acne. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Ankara University Faculty of Medicine / Ankara Üniversitesi Tip Fakültesi Mecmuasi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)