4,904 results on '"left ventricular function"'
Search Results
2. Implications of myocardial strain in primary mitral regurgitation—a cardiovascular magnetic resonance study.
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Romano, Simone, Kitkungvan, Danai, Nguyen, Duc T, El-Tallawi, Carlos, Graviss, Edward A, Farzaneh-Far, Afshin, and Shah, Dipan J
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Aims Chronic primary mitral regurgitation (MR) results in progressive left ventricular (LV) remodelling. Abnormal myocardial deformation (strain) can be present despite preserved ejection fraction (EF). Cardiovascular magnetic resonance (CMR) feature-tracking techniques allow assessment of global longitudinal strain (GLS) from routine cine images. The aim of this study is to evaluate the prognostic value of CMR feature tracking–derived GLS in patients with primary MR. Methods and results Consecutive patients undergoing CMR for chronic MR from January 2012 to June 2018 were enrolled. Patients with LVEF <50% were excluded. The composite primary outcome aiming to detect decompensation related to MR comprised (i) referral for mitral surgery owing to symptoms or LV systolic dysfunction or (ii) cardiovascular death. The secondary outcome was all-cause death. A total of 422 patients were followed for a median of 2.7 years, and the primary endpoint was met in 93 patients (34 patients reported symptoms at baseline). At multivariable analysis, GLS≥ −16.6% was associated with primary outcome [hazard ratio (HR) 1.90, P = 0.01]. In moderate MR cohort, patients with GLS≥ −16.6% had worse event-free survival, whereas there was no significant difference in mild or severe MR groups. GLS≥ −16.0% remained associated with all-cause death after adjusting for other covariates including the MR severity (HR 2.24, P = 0.02). Conclusion In patients with primary MR with preserved systolic function, GLS was associated with our composite outcomes and all-cause death. GLS may serve as a marker of cardiac dysfunction in the patients with primary MR with preserved systolic function allowing identification of patients likely to decompensate during observation. [ABSTRACT FROM AUTHOR] more...
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- 2025
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3. Real-time three-dimensional transthoracic echocardiographic segmental volume analysis: a quantitative and objective tool for assessing regional left ventricle wall motion in patients with ischemic heart disease.
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Kwak, Jin-Hwan, Choi, Kang-Un, Park, Jong-Il, Nam, Jong-Ho, Lee, Chan-Hee, Kim, Ung, Park, Jong-Seon, and Son, Jang-Won
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CORONARY disease , *MYOCARDIAL ischemia , *CARDIAC patients , *MEDICAL sciences , *CORONARY angiography - Abstract
Background: Evaluation of regional left ventricle function using two-dimensional echocardiography (2DE) in patients with ischemic heart disease has limitations due to its low objectivity and qualitative nature. In addition, 2DE is limited because multiple acoustic windows are used to obtain the image, whereas three-dimensional echocardiography (3DE) uses a single window. This study aims to demonstrate the clinical utility of 3DE segmental volume analysis for evaluating regional wall motion abnormality (RWMA). Methods: This retrospective study included 33 patients with ischemic heart disease and single-vessel territory RWMA confirmed on coronary angiography. RWMA was visually assessed using 2DE, generating 17-segment bull's-eye polar maps, and 3DE. In the 3DE study, two independent observers analyzed segmental volumes and segmental volume ejection fractions (SVEFs) using QLAB 3D quantification software. The optimal SVEF cutoff value differentiating normal from abnormal was determined using receiver operating curve analysis. The accuracy of 3DE in predicting culprit coronary arteries was compared with that of 2DE using Cohen κ coefficients, which also were used for interobserver and intraobserver variability assessments. Results: Mean 3DE SVEFs were significantly lower in segments showing RWMA on 2DE. The optimal SVEF cutoff value was 44%, with sensitivity of 75.0% and specificity of 73.9% (area under the curve, 0.801; 95% CI, 0.763–0.838; P < 0.001). The reliability of 3DE-derived bull's-eye predictions of culprit coronary arteries was 81.8% (κ = 0.672; 95% CI, 0.555–0.789; P < 0.001). Interobserver and intraobserver variabilities were 97.0% (κ = 0.947; 95% CI, 0.894–1.00; P < 0.001) and 93.9% (κ = 0.897; 95% CI, 0.827–0.967; P < 0.001), respectively. Conclusions: The 3DE segmental volume analysis effectively quantified regional left ventricle function and aligned well with 2DE and coronary angiography findings in predicting culprit coronary arteries. Thus, 3DE segmental volume analysis can serve as a quantitative and objective tool for RWMA assessment in patients with ischemic heart disease. [ABSTRACT FROM AUTHOR] more...
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- 2024
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4. Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation.
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Thu, Nguyen Tai, Hai, Pham Dang, Ly, Nguyen Thi Kieu, Son, Pham Nguyen, Thanh, Nguyen Huu, and Thien, Dang Hoang
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SPECKLE tracking echocardiography , *ECHOCARDIOGRAPHY , *GLOBAL longitudinal strain , *LEFT ventricular dysfunction , *CARDIAC hypertrophy - Abstract
Background: Cirrhosis is associated with chronic cardiovascular dysfunction termed cirrhotic cardiomyopathy (CCM), characterized by myocardial hypertrophy and diastolic dysfunction. Detecting early cardiac changes is crucial, especially in patients undergoing liver transplantation. Objective: This study aims to evaluate left ventricular systolic function in cirrhotic patients undergoing liver transplantation using speckle-tracking echocardiography. Methods: A prospective observational study was conducted involving 54 cirrhotic patients who underwent liver transplantation, along with 28 age- and sex-matched healthy controls. Echocardiography, including conventional and two-dimensional speckle tracking echocardiography (2D-STE), was performed at baseline and one-month post-transplantation. Results: The mean age in the cirrhotic group was 52.2 ± 12.7 years, with no significant difference compared to the control group. Viral hepatitis was the predominant etiology of cirrhosis (68.6%). Conventional echocardiography did not reveal significant differences between groups in LV ejection fraction [62% (56–69) vs. 59% (56–62); p = 0.830]. However, in cirrhotic patients, 2D-STE demonstrated significantly lower LV global longitudinal strain (LV-GLS) [17.5 (15.5–19.1) vs 19.0 (18.0–19.7), p = 0.006]. Post-transplantation, conventional echocardiography indices remained unchanged, while 2D-STE showed remarkable improvement in LV function, with increased LV-GLS compared to pre-transplantation value. Conclusions: 2D-STE is a valuable tool for detecting and monitoring left ventricular systolic dysfunction in liver cirrhosis patients, particularly following transplantation. While conventional echocardiography may not detect subtle changes, 2D-STE reveals improvements in LV function post-transplantation, emphasizing its role in assessing cirrhotic cardiomyopathy. [ABSTRACT FROM AUTHOR] more...
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- 2024
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5. Impairment of Left Ventricular Function in Hyperthyroidism Caused by Graves' Disease: An Echocardiographic Study.
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Petrovic Djordjevic, Ivana, Petrovic, Jelena, Radomirovic, Marija, Petrovic, Sonja, Biorac, Bojana, Jemuovic, Zvezdana, Tesic, Milorad, Trifunovic Zamaklar, Danijela, Nedeljkovic, Ivana, Nedeljkovic Beleslin, Biljana, Simic, Dragan, Zarkovic, Milos, and Vujisic-Tesic, Bosiljka more...
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CARDIAC hypertrophy , *SYMPTOMS , *THYROID gland , *ECHOCARDIOGRAPHY , *DEMOGRAPHIC characteristics - Abstract
Background/Objectives: The thyroid gland has an important influence on the heart. Long-term exposure to high levels of thyroid hormones may lead to cardiac hypertrophy and dysfunction. The aim of the study was to evaluate the morphological and functional changes in the left ventricle in patients with hyperthyroidism caused by Graves' disease (GD) in comparison with healthy individuals, as well as to investigate potential differences in these parameters in GD patients in relation to the presence of orbitopathy. Methods: The prospective study included 39 patients with clinical manifestations and laboratory confirmation of GD and 35 healthy controls. All participants underwent a detailed echocardiographic examination. The groups were compared according to demographic characteristics (age and gender), heart rate and echocardiographic characteristics. Results: The patients with hyperthyroidism caused by GD had significantly higher values of left ventricular diameter, left ventricular volume and left ventricular mass compared to the healthy controls. In addition, hyperthyroidism significantly influenced the left ventricular contractility and led to the deterioration of the systolic and diastolic function, as shown together by longitudinal strain, color Doppler and tissue Doppler imaging. However, the patients with GD and orbitopathy showed better left ventricular function than those without orbitopathy. Conclusions: Besides the confirmation of previously known findings, our study indicates possible differences in echocardiographic parameters in GD patients in relation to the presence of orbitopathy. Further investigation with larger samples and meta-analyses of data focused on the evaluation of echocardiographic findings in the context of detailed biochemical and molecular analyses is required to confirm our preliminary results and their clinical significance. [ABSTRACT FROM AUTHOR] more...
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- 2024
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6. Estimation of Systolic and Diastolic Left Ventricular Blood Flow From Derivatives of Transesophageal Echocardiographic 3D Volume Curves in Cardiac Surgery Patients: A Proof-of-Concept Study.
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Jokiel, Paul-Michael, Schweizer, Thilo, Guensch, Dominik P., Berdajs, Denis, Erb, Joachim, Bolliger, Daniel, Kamber, Firmin, and Mauermann, Eckhard
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Objectives: To examine whether estimates of peak global systolic (S′) and diastolic (E′) left ventricular (LV) flow rates based on 3D echocardiographic volumes are feasible and match physiology. Methods: In this retrospective feasibility study, we included patients undergoing major cardiac surgery. S′ and E′ were derived from 190 patients by taking the first derivative of the volume-time relationship of 3D ecg-gated transesophageal echocardiography (TEE) images. To examine the quality of images upon which the estimates of flow were based we correlated intraoperative 3D TEE and preoperative 2D transthoracic echocardiography (TTE) volumes. As a proof-of-concept, we then correlated S′ flow with stroke volume and S′ and E′ were compared by valve pathology. Results: In each of the 190 images, S′ and E′ were derived. There was good correlation between 1) the ejection fraction (EF) of 3D LV images obtained intraoperatively by TEE and preoperatively by TTE (Pearson's r = 0.65) and also 2) S′ and stroke volume (Pearson's r = 0.73). Patients with aortic or mitral regurgitation showed higher S′ than patients without valve pathologies (−315 mL/s [95% CI −388 mL/s to −264 mL/s] P = 0.001, −319 mL/s [95% CI −397 mL/s to −246 mL/s] P = 0.001 vs −242 mL/s [95% CI −300 mL/s to −196 mL/s]). These patients also showed higher E′ than patients without valve pathologies (302 mL/s [95% CI 237 mL/s to 384 mL/s] P = 0.006, 341 mL/s [95%CI 227 mL/s to 442 mL/s] P = 0.001 vs 240 mL/s [95%CI 185 mL/s to 315 mL/s]). Patients with aortic stenosis showed no difference in S′ or E' (−263 mL/s [95%CI −300 mL/s to −212 mL/s] P = 0.793, 255 mL/s [95%CI 188 mL/s to 344 mL/s] P = 0.400). Conclusions: Estimates of global peak systolic and diastolic LV flow based on 3D TEE are feasible, promising, and match valve pathologies. [ABSTRACT FROM AUTHOR] more...
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- 2024
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7. Four-Dimensional Flow MRI for Cardiovascular Evaluation (4DCarE): A Prospective Non-Inferiority Study of a Rapid Cardiac MRI Exam: Study Protocol and Pilot Analysis.
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Qin, Jiaxing Jason, Gok, Mustafa, Gholipour, Alireza, LoPilato, Jordan, Kirkby, Max, Poole, Christopher, Smith, Paul, Grover, Rominder, and Grieve, Stuart M.
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CARDIAC magnetic resonance imaging , *IMAGE analysis , *PULMONARY artery , *VOLUME measurements , *FLOW measurement - Abstract
Background: Accurate measurements of flow and ventricular volume and function are critical for clinical decision-making in cardiovascular medicine. Cardiac magnetic resonance (CMR) is the current gold standard for ventricular functional evaluation but is relatively expensive and time-consuming, thus limiting the scale of clinical applications. New volumetric acquisition techniques, such as four-dimensional flow (4D-flow) and three-dimensional volumetric cine (3D-cine) MRI, could potentially reduce acquisition time without loss in accuracy; however, this has not been formally tested on a large scale. Methods: 4DCarE (4D-flow MRI for cardiovascular evaluation) is a prospective, multi-centre study designed to test the non-inferiority of a compressed 20 min exam based on volumetric CMR compared with a conventional CMR exam (45–60 min). The compressed exam utilises 4D-flow together with a single breath-hold 3D-cine to provide a rapid, accurate quantitative assessment of the whole heart function. Outcome measures are (i) flow and chamber volume measurements and (ii) overall functional evaluation. Secondary analyses will explore clinical applications of 4D-flow-derived parameters, including wall shear stress, flow kinetic energy quantification, and vortex analysis in large-scale cohorts. A target of 1200 participants will enter the study across three sites. The analysis will be performed at a single core laboratory site. Pilot Results: We present a pilot analysis of 196 participants comparing flow measurements obtained by 4D-flow and conventional 2D phase contrast, which demonstrated moderate–good consistency in ascending aorta and main pulmonary artery flow measurements between the two techniques. Four-dimensional flow underestimated the flow compared with 2D-PC, by approximately 3 mL/beat in both vessels. Conclusions: We present the study protocol of a prospective non-inferiority study of a rapid cardiac MRI exam compared with conventional CMR. The pilot analysis supports the continuation of the study. Study Registration: This study is registered with the Australia and New Zealand Clinical Trials Registry (Registry number ACTRN12622000047796, Universal Trial Number: U1111-1270-6509, registered 17 January 2022—Retrospectively registered). [ABSTRACT FROM AUTHOR] more...
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- 2024
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8. Prevalence and progression of LV dysfunction and dyssynchrony in patients with new-onset LBBB post TAVR.
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Margulescu, Andrei D., Thomas, Dewi E., Awadalla, Magid, Shah, Parin, Khurana, Ayush, Aldalati, Omar, Obaid, Daniel R., Chase, Alexander J., and Smith, David
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GLOBAL longitudinal strain , *HEART valve prosthesis implantation , *BUNDLE-branch block , *LEFT ventricular dysfunction , *HEART diseases - Abstract
The impact of new-onset left bundle branch block (N-LBBB) developing after Transcatheter Aortic Valve Replacement (TAVR) on cardiac function and mechanical dyssynchrony is not well defined. We retrospectively screened all patients who underwent TAVR in our centre between Oct 2018 and Sept 2021 (n = 409). We identified 38 patients with N-LBBB post-operatively (of which 28 were persistent and 10 were transient), and 17 patients with chronic pre-existent LBBB (C-LBBB). We excluded patients requiring pacing post TAVR. For all groups, we retrospectively analysed stored echocardiograms at 3 time points: before TAVR (T0), early after TAVR (T1, 1.2 ± 1.1 days), and late follow-up (T2, 1.5 ± 0.8 years), comparing LV mass and volumes, indices of LV function (LV ejection fraction, LVEF; global longitudinal strain, GLS), and mechanical dyssynchrony indices (systolic stretch index, severity of septal flash). At baseline (T0), C-LBBB had worse cardiac function, and larger LV volumes and LV mass, compared with patients with N-LBBB. At T1, N-LBBB resulted in mild dyssynchrony and decreased LVEF and GLS. Dyssynchrony progressed at T2 in persistent N-LBBB but not C-LBBB. In both groups however, LVEF remained stable at T2, although individual response was variable. Patients with better LVEF at baseline demonstrated a higher proportion of developing LBBB-induced LV dysfunction at T2. Lack of improvement of LVEF immediately after TAVR predicted deteriorating LVEF at T2. In transient LBBB, cardiac function and most dyssynchrony indices returned to baseline. N-LBBB after TAVR results in an immediate reduction of cardiac function, in spite of only mild dyssynchrony. When LBBB persists, patients with better cardiac function before TAVR are more likely to have LBBB-induced LV dysfunction after TAVR. • New onset LBBB after TAVR results in an immediate reduction of cardiac function, in spite of only mild dyssynchrony. • Patients with better cardiac function at baseline have higher proportion of LBBB-induced cardiac dysfunction after TAVR. • In patients with severe cardiac dysfunction at baseline, the afterload relief of TAVR seems to overcome the impact of LBBB. • A clinical trial addressing the benefit of resynchronization therapy in this population is needed. [ABSTRACT FROM AUTHOR] more...
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- 2024
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9. Myocardial work in idiopathic premature ventricular contractions: Assessing left ventricular function and prognosis.
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Zhou, Chunrui, He, Qian, Ding, Yunchuan, Wang, Qinghui, Xian, Lini, Peng, Xin, Mao, Fuyong, Luo, Qingqing, Yang, Zefan, Yang, Ping, and Chen, Jian
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Background: Premature ventricular contractions (PVCs) can lead to impairment of left ventricular function. The noninvasive myocardial work technique, which incorporates left ventricular afterload, represents a new method for assessing left ventricular functional. Aim: The aim of this study is to explore the value of noninvasive myocardial work technique in assessing left ventricular systolic function in patients with PVCs. Methods: Compare the clinical data, two‐dimensional echocardiography parameters, and myocardial work parameters of 66 patients with PVCs and 35 healthy volunteers and explore the relevant risk factors for postoperative recurrence in patients with PVCs. Results: In patients with PVCs compared to the control group, they exhibit enlargement of left atrial diameter (LAD) and left ventricular internal dimension in diastole (LVIDd), as well as thickening of the left ventricular wall. The global work waste (GWW) increases, while the global work efficiency (GWE) decreases. There is a significant negative correlation between the PVC burden and GWE (r = −0.70, p <0.01), and a significant positive correlation between the PVC burden and GWW (r = 0.58, p <0.01). GWE is a sensitive indicator for predicting the recurrence of PVCs after radiofrequency ablation. Patients with GWE <91.5%, global longitudinal strain (GLS) <15.5%, and ejection fraction (EF) <62.5% have a higher postoperative recurrence rate. Conclusion: PVCs can cause impairment of left ventricular systolic function. GWE is the most sensitive indicator for predicting postoperative recurrence in patients with PVCs. Patients with GWE <91.5%, GLS <15.5%, and EF <62.5% have a higher postoperative recurrence rate. [ABSTRACT FROM AUTHOR] more...
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- 2024
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10. Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in patients with liver cirrhosis undergoing liver transplantation
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Nguyen Tai Thu, Pham Dang Hai, Nguyen Thi Kieu Ly, Pham Nguyen Son, Nguyen Huu Thanh, and Dang Hoang Thien
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Cirrhotic cardiomyopathy (CCM) ,Liver cirrhosis ,Liver transplantation ,Two-dimensional speckle-tracking echocardiography (2D-STE) ,Left ventricular function ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background Cirrhosis is associated with chronic cardiovascular dysfunction termed cirrhotic cardiomyopathy (CCM), characterized by myocardial hypertrophy and diastolic dysfunction. Detecting early cardiac changes is crucial, especially in patients undergoing liver transplantation. Objective: This study aims to evaluate left ventricular systolic function in cirrhotic patients undergoing liver transplantation using speckle-tracking echocardiography. Methods A prospective observational study was conducted involving 54 cirrhotic patients who underwent liver transplantation, along with 28 age- and sex-matched healthy controls. Echocardiography, including conventional and two-dimensional speckle tracking echocardiography (2D-STE), was performed at baseline and one-month post-transplantation. Results The mean age in the cirrhotic group was 52.2 ± 12.7 years, with no significant difference compared to the control group. Viral hepatitis was the predominant etiology of cirrhosis (68.6%). Conventional echocardiography did not reveal significant differences between groups in LV ejection fraction [62% (56–69) vs. 59% (56–62); p = 0.830]. However, in cirrhotic patients, 2D-STE demonstrated significantly lower LV global longitudinal strain (LV-GLS) [17.5 (15.5–19.1) vs 19.0 (18.0–19.7), p = 0.006]. Post-transplantation, conventional echocardiography indices remained unchanged, while 2D-STE showed remarkable improvement in LV function, with increased LV-GLS compared to pre-transplantation value. Conclusions 2D-STE is a valuable tool for detecting and monitoring left ventricular systolic dysfunction in liver cirrhosis patients, particularly following transplantation. While conventional echocardiography may not detect subtle changes, 2D-STE reveals improvements in LV function post-transplantation, emphasizing its role in assessing cirrhotic cardiomyopathy. more...
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- 2024
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11. Noninvasive Evaluation of Left Ventricular-Arterial Coupling: Methodologies and Clinical Relevance
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Xin Zhang, MD, Yun Yang, MD, Ruize Zhang, MD, Linyue Zhang, MD, Yuji Xie, MD, Wenqian Wu, MD, PhD, Jing Zhang, MD, PhD, Qing Lv, MD, PhD, Jing Wang, MD, PhD, Mingxing Xie, MD, PhD
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ventricular-arterial coupling ,left ventricular function ,non-invasive ,echocardiography ,Medical technology ,R855-855.5 ,Medicine - Abstract
Left ventricular-arterial coupling (VAC) is essential for understanding both cardiovascular physiology and pathophysiology. Traditionally assessed through invasive techniques, recent advancements have introduced noninvasive methods that employ imaging modalities and physiological parameters to evaluate ventricular pressure, volume, and arterial load characteristics. This review examines commonly used noninvasive VAC assessment methods, including echocardiographic single-beat method, myocardial work, wave intensity, the ratio of pulse wave velocity to global longitudinal strain, and imaging-based pressure-volume loops. These methodologies have demonstrated potential in clinical applications, such as evaluating cardiac function, personalizing treatment plans, monitoring therapeutic effects, and assessing prognosis. The incorporation of advanced imaging and computational techniques is anticipated to further enhance the accuracy and clinical relevance of VAC assessment in the management of cardiovascular diseases. more...
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- 2024
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12. Left ventricular systolic function after inhalation of beta-2 agonists in healthy athletes
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H. Persch, D. A. Bizjak, K. Takabayashi, F. Schober, K. Winkert, J. Dreyhaupt, L. C. Harps, P. Diel, M. K. Parr, M. Zügel, and J. M. Steinacker
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Beta-2 agonists ,Athlete ,Sex-specific thresholds ,Anti-doping ,Echocardiography ,Left ventricular function ,Medicine ,Science - Abstract
Abstract Inhaled beta-2 adrenoceptor agonists (iβ2A) are routinely used as bronchodilators in the treatment of asthma. However, their cardiac effects in athletes are scarcely examined. Thus, the aim of this study was to evaluate the effects of iβ2A on left ventricular (LV) systolic function (SF) by echocardiography in healthy, non-asthmatic female and male endurance athletes. A randomized, double-blinded, placebo-controlled, balanced, 4-way complete block cross-over study was conducted. Twenty-four healthy athletes (12f/12m: 22.9 ± 2.7/24.4 ± 4.6 years) randomly completed 4 study arms (placebo; salbutamol; formoterol; formoterol + salbutamol). After inhalation of the study medication, the participants performed a 10-min time trial (TT) on a bicycle ergometer. After each TT an echocardiography was performed to determine LVSF. Blood samples were collected pre, post, 3 h and 24 h post TT. In females, total serum concentrations for salbutamol and formoterol were higher. LV ejection fraction (LVEF) and LV global longitudinal strain (LVendoGLS) showed a treatment effect for the whole study group (p more...
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- 2024
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13. Evaluation of changes in the global longitudinal strain for left ventricular function before and after eight weeks of taking high dose of atorvastatin in patients with coronary slow flow phenomenon
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Nakisa Khansari, Amir Mohammad Salehi, Niloofar Mohammadi, Amir Hossein Yazdi, and Zahra Sanaei
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Atorvastatin ,Global longitudinal strain ,Left ventricular function ,Slow coronary flow ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Coronary Slow Flow Phenomenon (CSFP) is a well-recognized clinical entity characterized by delayed opacification of coronary arteries in the presence of a normal coronary angiogram. The objective of this study was determined and compared left ventricle (LV)strain in patients with CSFP before and after receiving a high-dose atorvastatin. Materials and methods This cross-sectional study was conducted on 51 patients with CSFP from the beginning of 2021 to the end of September 2022. Trans-thoracic Echocardiogram (TTE) was performed by an echocardiography specialist. Thereafter, the patient’s basic information was entered into the researcher’s checklist after treatment with atorvastatin 40 mg daily for eight consecutive weeks. After eight weeks, the patients were subjected again to TTE. The data were analyzed in SPSS statistical software. Results The mean LV-GLS before taking atorvastatin was − 16.53%±3.63%. The mean LV-GLS after taking atorvastatin was 17.57%±3.53% (P.value = 0.01). The mean LV function before taking atorvastatin was 48.82%±9.19%. Meanwhile, the mean LV function after taking atorvastatin was 50.59%±7.91% (P = 0.01). There was no significantly change in left atrium volume (49.88 ± 0.68 vs. 49.9 + 0.67) after 8 weeks taking atorvastatin (P = 0.884). Conclusion The plasma ET-1 levels are elevated in CSFP patients, and atorvastatin improves coronary flow and endothelial function. As evidenced by the results of this study, the daily intake of 40 mg of oral atorvastatin during eight consecutive weeks in patients with CSFP significantly improved LV strain and LV function, however atorvastatin does not have a significant effect on improving the right ventricular function and pulmonary artery systolic pressure. more...
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- 2024
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14. Additive effect of metabolic dysfunction-associated fatty liver disease on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T cardiac magnetic resonance feature tracking study
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Xin Tang, Rui Shi, Li Jiang, Wei-Feng Yan, Pei-Lun Han, Wen-Lei Qian, Zhi-Gang Yang, and Yuan Li
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Type 2 diabetes mellitus ,Metabolic-associated fatty liver disease ,Cardiac magnetic resonance ,Left ventricular function ,Global peak strain ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Type 2 diabetes mellitus (T2DM) and metabolic-associated fatty liver disease (MAFLD) are both metabolic disorders that negatively impact the cardiovascular system. This study comprehensively analyzed the additive effect of MAFLD on left ventricular function and global strain in T2DM patients by cardiac magnetic resonance (CMR). Methods Data of 261 T2DM patients, including 109 with and 152 without MAFLD, as well as 73 matched normal controls from our medical center between June 2015 and March 2022 were retrospectively analyzed. CMR-derived parameters, including LV function and global strain parameters, were compared among different groups. Univariate and multivariate linear regression analyses were conducted to investigate the impact of various factors on LV function and global strain. Results Our investigation revealed a progressive deterioration in LV functional parameters across three groups: control subjects, T2DM patients without MAFLD, and T2DM patients with MAFLD. Statistically significant increases in left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), left ventricular mass index (LVMI) were observed, along with decreases in left ventricular ejection fraction (LVEF) and left ventricular global function index (LVGFI). Among these three groups, significant reductions were also noted in the absolute values of LV global radial, circumferential, and longitudinal peak strains (GRPS, GCPS, and GLPS), as well as in peak systolic (PSSR) and peak diastolic strain rates (PDSR). MAFLD was identified as an independent predictor of LVEF, LVMI, LVGFI, GRPS, GCPS, and GLPS in multivariate linear analysis. Besides, the incidence of late gadolinium enhancement was higher in MAFLD patients than in non-MAFLD patients (50/109 [45.9%] vs. 42/152 [27.6%], p = 0.003). Furthermore, escalating MAFLD severity was associated with a numerical deterioration in both LV function parameters and global strain values. Conclusions This study thoroughly compared CMR parameters in T2DM patients with and without MAFLD, uncovering MAFLD’s adverse impact on LV function and deformation in T2DM patients. These findings highlight the critical need for early detection and comprehensive management of cardiac function in T2DM patients with MAFLD. more...
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- 2024
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15. Diagnostic and Prognostic Role of Circulating microRNAs in Patients with Coronary Artery Disease—Impact on Left Ventricle and Arterial Function
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Loredana Iacobescu, Andrea Olivia Ciobanu, Razvan Macarie, Mihaela Vadana, Letitia Ciortan, Monica Madalina Tucureanu, Elena Butoi, Maya Simionescu, and Dragos Vinereanu
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microRNA ,myocardial infarction ,coronary artery disease ,left ventricular function ,arterial stiffness ,Biology (General) ,QH301-705.5 - Abstract
Recent studies reported that circulating microRNAs (miRNAs) can target different metalloproteases (MMPs) involved in matrix remodeling and plaque vulnerability. Consequently, they might have a role in the diagnosis and prognosis of coronary artery disease. To quantify circulating miRNAs (miRNA126, miRNA146, and miRNA21) suggested to have possible cardiovascular implications, as well as levels of MMP-1 and MMP-9, and to determine their association with left ventricular (LV) function and with arterial function, in patients with either ST-segment elevation acute myocardial infarction (STEMI) or stable ischemic heart disease (SIHD). A total of 90 patients with coronary artery disease (61% men, 58 ± 12 years), including 60 patients with STEMI and 30 patients with SIHD, were assessed within 24 h of admission, by measuring serum microRNAs, and serum MMP-1 and MMP-9. LV function was assessed by measuring ejection fraction (EF) by 2D and 3D echocardiography, and global longitudinal strain (GLS) by speckle tracking. Arterial function was assessed by echo tracking, CAVI, and peripheral Doppler. Circulating levels of miRNA146, miRNA21, and MMP1 were significantly increased in patients with STEMI vs. SIHD (p = 0.0001, p = 0.0001, p = 0.04, respectively). MiRNA126 negatively correlated with LVEF (r = −0.33, p = 0.01) and LV deformation parameters (r = −0.31, p = 0.03) in patients with STEMI and negatively correlated with ABI parameters (r = −0.39, p = 0.03, r = −0.40, p = 0.03, respectively) in patients with SIHD. MiRNA146 did not have any significant correlations, while higher values of miRNA21 were associated with lower values of GLS in STEMI patients and with higher values of GLS in SIHD patients. Both MMP1 and MMP9 correlated negatively with LVEF (r = −0.27, p = 0.04, r = −0.40, p = 0.001, respectively) and GLS in patients with STEMI, and positively with arterial stiffness in patients with SIHD (r = 0.40 and r = 0.32, respectively; both p < 0.05). MiRNA126, miRNA21, and both MMP1 and MMP9 are associated with LV and arterial function parameters in patients with acute coronary syndrome. Meanwhile, they inversely correlate with arterial function in patients with chronic atherosclerotic disease. However, further studies are needed to establish whether these novel biomarkers have diagnosis and prognosis significance. more...
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- 2024
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16. A Study to Observe the Effects of Pregnancy-Induced Hypertension and Pre-eclampsia on Left Ventricular Function by Echocardiography.
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Ghoshal, Pradip Kumar, Sinha, Abhirup, Goswami, Tanmoy Kanti, Biswas, Arunava, and Biswas, Asish
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SPECKLE tracking echocardiography , *PREGNANT women , *ECHOCARDIOGRAPHY , *DOPPLER echocardiography , *FETAL growth retardation - Abstract
Introduction: Hypertensive disorders complicating pregnancy contribute significantly to maternal and perinatal mortality and morbidity. The spectrum of disorders includes gestational hypertension, pre-eclampsia and eclampsia which are associated with poor placentation, fetal growth restriction and long term maternal cardiovascular outcomes. Cardiac manifestations are varied and can be studied by 2D and Doppler Echocardiography. Aims: To conduct a detailed clinical study of gestational hypertension and pre-eclampsia patients and to conduct echocardiographic assessment of their left ventricular function along with Speckle Tracking Echocardiography. Materials and methods: The present study was an observational, prospective, cross-sectional hospital based study. This study was conducted from April 2019 to August 2020 at Institute Of Cardiovascular Sciences, R.G. Kar Medical College and Hospital, Kolkata. Total 120 pregnant patients (greater than 20 weeks of gestation) fulfilling the inclusion and exclusion criteria were included in this study. Result: In this study, the baseline features such as age, BMI were compared between pregnancy induced hypertension (PIH) and pre-eclamptic mothers and normotensive mothers. Left ventricular ejection fraction, left ventricular end systolic volume and left ventricular end systolic values were statistically compared between the two groups. Left ventricular diastolic function was significantly impaired in PIH and Pre-eclamptic mothers. Conclusion: Echocardiography, including Tissue Doppler and Speckle-Tracking Echocardiography is applicable and helpful in detecting cardiac function changes (including sub-clinical left ventricular dysfunction) in women with pregnancy-induced hypertension and preeclampsia and can identify patients for early intervention to prevent heart failure, morbidity and mortality. [ABSTRACT FROM AUTHOR] more...
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- 2024
17. Noninvasive Left Ventricular Pressure‐Strain Loop for Quantitative Assessment of Early Left Ventricular Systolic Dysfunction in Patients With Chronic Kidney Disease.
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Wang, Qin, Wang, Jin‐Ping, Li, Yan, Zhang, Jie, Wang, Rui, and Xu, Hai‐Yun
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LEFT heart ventricle , *STATISTICAL correlation , *VENTRICULAR ejection fraction , *CREATININE , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *AGE distribution , *CARDIOVASCULAR diseases risk factors , *MYOCARDIAL injury , *CARDIAC output , *MEDICAL records , *ACQUISITION of data , *RESEARCH , *EARLY diagnosis , *SYSTOLIC blood pressure , *COMPARATIVE studies , *BLOOD pressure , *GLOBAL longitudinal strain , *ECHOCARDIOGRAPHY , *LEFT ventricular dysfunction , *HEART ventricles ,CHRONIC kidney failure complications - Abstract
Background: Patients with chronic kidney disease (CKD) possess a pronounced risk for cardiovascular events. A noninvasive left ventricular pressure‐strain loop (LV‐PSL) has recently been introduced to detect subtler changes in cardiac function. This study aims to investigate the value of LV‐PSL for quantitative assessment of myocardial work (MW) in patients with CKD. Methods: Seventy‐five patients with CKD were enrolled retrospectively (37 patients with CKD Stages 2–3, and 38 patients with CKD Stages 4–5), and 35 healthy volunteers were included as controls. All subjects underwent transthoracic echocardiography. LV‐PSL analysis was performed to estimate LV MW and efficiency. Global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) were obtained by echocardiography, and the differences among the groups were compared. Results: There was a significant increase in GWW and reduction in GWE in patients with CKD compared to normal controls (p < 0.05). No significant difference in GWI and GCW was observed among the three groups. Multiple linear regression revealed that increased GWW was significantly associated with age, serum creatinine, and systolic pressure, and decreased GWE was associated with age, serum creatinine, and GLS. Conclusion: LV‐PSL can be used for noninvasive quantitative assessment of MW in patients with CKD, providing a new sensitive approach for the clinical assessment of myocardial function. [ABSTRACT FROM AUTHOR] more...
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- 2024
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18. Left Ventricle Size Correlates with Peak Exercise Capacity in Pediatric Cancer Survivors Exposed to Anthracycline Chemotherapy.
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Masood, Imran Ross, Rezvan, Panteha Hayati, Lee, Kyuwan, Vervaet, Helena, Kuo, Christopher, Loss, Karla, Menteer, JonDavid, Souza, Andrew, Freyer, David, and Su, Jennifer A.
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CARDIAC magnetic resonance imaging , *AEROBIC capacity , *EXERCISE tests , *CANCER survivors , *CHILDHOOD cancer - Abstract
Cancer survivors exposed to anthracycline chemotherapy are at risk for developing cardiomyopathy, which may have delayed clinical manifestation. In a retrospective cross-sectional study, we evaluated the utility of cardiopulmonary exercise testing (CPET) for detecting early cardiac disease in 35 pediatric cancer survivors by examining the associations between peak exercise capacity (measured via percent predicted peak VO2) and resting left ventricular (LV) function on echocardiography and cardiac magnetic resonance imaging (cMRI). We additionally assessed the relationships between LV size on resting echocardiography or cMRI and percent predicted peak VO2 since LV growth arrest can occur in anthracycline-exposed patients prior to changes in LV systolic function. We found reduced exercise capacity in this cohort, with low percent predicted peak VO2 (62%, IQR: 53–75%). While most patients in our pediatric cohort had normal LV systolic function, we observed associations between percent predicted peak VO2 and echocardiographic and cMRI measures of LV size. These findings indicate that CPET may be more sensitive in manifesting early anthracycline-induced cardiomyopathy than echocardiography in pediatric cancer survivors. Our study also highlights the importance of assessing LV size in addition to function in pediatric cancer survivors exposed to anthracyclines. [ABSTRACT FROM AUTHOR] more...
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- 2024
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19. The Effectiveness of Anemia Treatment with Injectable Iron within 48 to 72 Hours before Coronary Artery Bypass Surgery on Cardiac Function and Postoperative Outcome: A Randomized Clinical Trial.
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Jebelli, Mohammad, Sadeghi, Mostafa, and Akbari, Hesam
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ANEMIA treatment ,PREVENTION of surgical complications ,LEFT heart ventricle ,POSTOPERATIVE care ,T-test (Statistics) ,FERRITIN ,STATISTICAL sampling ,BLIND experiment ,FISHER exact test ,HEMOGLOBINS ,IRON deficiency ,TREATMENT effectiveness ,PREOPERATIVE care ,HEART physiology ,DESCRIPTIVE statistics ,RANDOMIZED controlled trials ,MANN Whitney U Test ,CHI-squared test ,CORONARY artery bypass ,INJECTIONS ,INTRAOPERATIVE care ,BLOOD transfusion ,DATA analysis software ,TIME ,SUCROSE ,EVALUATION - Abstract
Background: Anemia is considered as one of the risk factors affecting the outcomes after cardiac surgery. Accordingly, the improvement of iron deficiency anemia through injection or oral may be associated with the improvement of post-procedure results, especially the improvement of cardiovascular function. This study was aimed at investigating the effectiveness of iron treatment shortly before surgery in reducing the need for blood transfusion and improving myocardial performance parameters (left ventricular ejection fraction) in coronary bypass surgery patients. Methods: This study was a single-blind randomized clinical trial. In total, 60 candidates for coronary bypass surgery having iron deficiency anemia before the operation were randomly divided into two groups treated with injectable iron supplement (iron sucrose at a dose of 200 mg/200 ml of normal saline injected in 30 minutes) 48 to 72 hours before surgery or without therapeutic intervention. The patients were examined during and after the operation in terms of surgical outcomes. Results: Treatment with injectable iron before surgery was associated with improvement in serum hemoglobin level after surgery and a significant reduction in the need for intraoperative and postoperative transfusions. Preoperative treatment of iron deficiency was associated with a reduction in the length of hospitalization of the patients after surgery. Conclusion: Treatment of iron deficiency anemia within 48 to 72 hours before surgery will improve the condition of patients’ anemia and compensate serum hemoglobin, reduce the need for blood transfusion during surgery and the length of hospitalization of the patients after surgery. [ABSTRACT FROM AUTHOR] more...
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- 2024
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20. Cardiac MRI in heart failure with preserved ejection fraction.
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Meduri, Agostino, Perazzolo, Alessio, Marano, Riccardo, Muciaccia, Massimo, Lauriero, Francesco, Rovere, Giuseppe, Giarletta, Lorenzo, Moliterno, Eleonora, and Natale, Luigi
- Abstract
Patients who have heart failure with preserved ejection fraction (HFpEF) have signs and symptoms of heart failure, yet their ejection fraction remains greater than or equal to 50 percent. Understanding the underlying cause of HFpEF is crucial for accurate diagnosis and effective treatment. This condition can be caused by multiple factors, including ischemic or nonischemic myocardial diseases. HFpEF is often associated with diastolic dysfunction. Cardiac magnetic resonance (CMR) allows for a precise examination of the functional and structural alterations associated with HFpEF through the measurement of volumes and mass, the assessment of systolic and diastolic function, and the analysis of tissue characteristics. We will discuss CMR imaging indicators that are specific to patients with HFpEF and their relation to the disease. These markers can be acquired through both established and emerging methods. [ABSTRACT FROM AUTHOR] more...
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- 2024
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21. Recovery of Left Ventricular Function and Long-Term Outcomes in Patients With Takotsubo Syndrome.
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Almendro-Delia, Manuel, López-Flores, Luis, Uribarri, Aitor, Vedia, Oscar, Blanco-Ponce, Emilia, López-Flores, María Del Carmen, Rivas-García, Antonio P., Fernández-Cordón, Clara, Sionis, Alessandro, Martín-García, Agustín C., Vazirani, Ravi, Corbí-Pascual, Miguel, Salamanca, Jorge, Pérez-Castellanos, Alberto, Martínez, Manuel, Becerra, Víctor Manuel, Aritza-Conty, David, López-País, Javier, Guillén-Marzo, Marta, and Lluch-Requerey, Carmen more...
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TREATMENT effectiveness , *SYNDROMES - Published
- 2024
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22. Evaluation of the early effect of elective percutaneous coronary intervention on left ventricular diastolic and systolic function.
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Tabatabaei, Seyed Abdolhossein, Sadeghian, Hakimeh, Taji, Ramin Negin, Abbasi, Ali, and Mostafavi, Atoosa
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GLOBAL longitudinal strain , *CORONARY artery stenosis , *PERCUTANEOUS coronary intervention , *CORONARY artery disease , *DOPPLER echocardiography , *CORONARY arteries - Abstract
BACKGROUND: Percutaneous coronary intervention (PCI) is an effective treatment for coronary artery disease. Previous studies have demonstrated the delayed effects of PCI on left ventricular diastolic and systolic function. However, the early impact on these parameters has not been systematically examined. Moreover, no study has compared the impact of revascularization on the global longitudinal (GLS) and circumferential (GCS) strains of the left ventricle. Using echocardiographic parameters, the present study aimed to investigate the reversibility of diastolic and systolic abnormalities in patients with significant coronary artery stenosis within 1 to 2 days after PCI. Additionally, this study will compare the effects on both global and longitudinal strains. METHODS: This study included 80 consecutive patients admitted to the angiography department for elective PCI with normal left ventricular function. Echocardiography was performed before PCI and 1 to 2 days post-procedure to assess left ventricular diastolic and systolic function indices in these patients. RESULTS: The mean age of the patients was 58.0±11.9 years, with a predominantly male cohort (65%). All the patients exhibited normal left ventricular systolic function and various degrees of diastolic dysfunction. One to 2 days after revascularization, significant improvements were observed in all diastolic function indices and GLS. However, no significant improvement was found in GCS. CONCLUSION: Revascularization of a significantly stenotic coronary artery can enhance diastolic function and systolic longitudinal strain of the left ventricular myocardium as early as 1 to 2 days, with no significant impact on GCS. [ABSTRACT FROM AUTHOR] more...
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- 2024
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23. Predictive value of Doppler echocardiography parameters for cardiovascular events in patients with systemic lupus erythematosus.
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Lai, Li-ping, Wang, Liang-qin, and Li, Shui-ping
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LEFT ventricular dysfunction , *DOPPLER echocardiography , *LOGISTIC regression analysis , *C-reactive protein , *VENTRICULAR dysfunction , *ECHOCARDIOGRAPHY , *SYSTEMIC lupus erythematosus - Abstract
Background and objectives: This study aimed to assess the utility of Doppler echocardiography in evaluating left ventricular diastolic function, and prognosis in patients with systemic lupus erythematosus (SLE). Patients and methods: A total of 286 SLE patients were selected along with 100 age- and gender-matched healthy individuals who underwent physical examinations. Clinical baseline characteristics were collected. Various Doppler echocardiographic parameters were measured and analyzed, including left ventricular posterior wall thickness (LVPWT), interventricular septal diameter (IVSD), left ventricular mass (LVM), LVM index (LVMI), and others. Results: Compared to the control group, SLE patients exhibited significantly higher levels of C-reactive protein and lower levels of complement (C) 3 and C4 (p <.001). Doppler echocardiographic parameters showed significant differences between SLE patients and healthy controls, including increased LVPWT, IVSD, LVM, LVMI, peak A, PWI + Tei, E/e′, TDI-Tei, and decreased e′ and E/A (p <.001). Subgroup analyses indicated more severe ventricular diastolic dysfunction in patients with higher SLE activity and those who experienced cardiovascular events. Correlation analysis revealed positive associations of PWI + Tei, TDI-Tei, and GLS with SLE activity and cardiovascular events (p <.01). Multivariate logistic regression analysis identified LVMI, PWI + Tei, TDI-Tei, and GLS as significant predictors of cardiovascular events (p <.05). Conclusion: Doppler echocardiography is a valuable tool for the early diagnosis of left ventricular diastolic dysfunction in SLE patients. Key echocardiographic parameters, including LVMI, PWI + Tei, TDI-Tei, and GLS, are effective in predicting cardiovascular events, underscoring the importance of comprehensive cardiac function assessments in these patients. [ABSTRACT FROM AUTHOR] more...
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- 2024
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24. Right parasternal echocardiographic reference values in the healthy male Iranian Shall sheep.
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Sadeghian Chaleshtori, Sirous, Mokber Dezfouli, Mohammad Reza, Vajhi, Alireza, Najd Ghahremani, Abolfazl, Sabetzadeh, Neda, and Abbasi, Javad
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STROKE volume (Cardiac output) , *MITRAL valve , *AORTIC valve , *SHEEP breeds , *SHEEP diseases , *AORTIC valve insufficiency - Abstract
Background: Among the large animals, the heart of sheep is functionally and structurally very similar to the human heart. In research, sheep are used as an animal model to study the process of cardiac disease pathogenesis and treatment. Therefore, determining the normal values of the heart structures of sheep with echocardiography is of particular emphasis. The purpose of the present research is to define the normal echocardiography values of heart in Iranian Shall breed sheep. Materials and methods: In 20 healthy Iranian Shall male sheep weighing 30–35 kg and aged 4–6 months, standing echocardiography was done from the right parasternal approach concentrated on the 3rd to 5th intercostal spaces by 2.5–5 MHz phased array transducer in the longitudinal and transverse views by B‐mode, M‐mode and Doppler systems. In M‐mode echocardiographic, the parameters of interventricular septal, left ventricular internal diameter, left ventricular free wall, right ventricular free wall and right ventricular internal diameter in diastole and systole as well as end point septal separation, ejection fraction (EF) slope, aortic root diameter, left atrial appendage, left atrial diameter/aortic valve diameter, left ventricular ejection time, fractional shortening, end‐diastolic volume, end‐systolic volume, EF, stroke volume and cardiac output and in pulsed‐wave spectral Doppler echocardiographic, the parameters of mitral valve maximum velocity (Vmax), mitral valve mean velocity (Vmean), mitral valve maximum pressure gradient (PGmax), mitral valve mean pressure gradient (PGmean), mitral valve velocity time integral (VTI), mitral valve E‐wave (MV‐E), MV‐E pressure gradient, mitral valve A‐wave (MV‐A), MV‐A pressure gradient, aortic Vmax, aortic valve Vmean, aortic valve PGmax, aortic valve PGmean, aortic valve VTI, left ventricular outflow tract (LVOT)‐Vmax, LVOT‐Vmean were measured. Results: All the sheep in this study were healthy and had no signs of heart disease. In this study, the parameters of M‐mode and spectral Doppler echocardiographic were assessed and recognized in Iranian Shall sheep. The results demonstrated the parameters of echocardiographic could be dependably determined in Shall sheep which, established normal reference values for these parameters and left ventricular function indices in healthy Shall sheep. These results can be beneficial in appropriate imagination, recognition and measuring cardiac structures. Conclusion: This study can be exerted as a reference for the assessment and diagnosis of heart diseases in sheep medicine and human cardiovascular research in sheep experimental models. [ABSTRACT FROM AUTHOR] more...
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- 2024
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25. Strain imaging as a prognostic indicator for complications in COVID-19 patients.
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Devera, Justin L., Wee, Choo P., and Sohn, Jina
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The goal of this study was to determine the potential for right ventricular (RV) and left ventricular (LV) strain to predict cardiopulmonary complications of COVID-19. We identified 276 patients with COVID-19 who underwent transthoracic echocardiography within 30 days of COVID-19 diagnosis at our institution. Patients were excluded if they had a history of any primary outcomes before COVID-19 diagnosis or insufficient imaging. LV global longitudinal strain (GLS) and RV GLS were obtained using 2-dimensional speckle-tracking echocardiography. Primary outcomes were death, pulmonary embolism, congestive heart failure (CHF), cardiomyopathy, pulmonary fibrosis, pulmonary hypertension, acute respiratory distress syndrome (ARDS), and myocardial infarction (MI) occurring after COVID-19 diagnosis. In the final analysis of 163 patients, mean RV GLS and LV GLS were reduced, and 43.6% developed at least one primary outcome. There were significant differences in LV GLS distribution in terms of CHF, cardiomyopathy, and MI in bivariate analysis. However, LV GLS was not significantly associated with CHF after adjusting for LV ejection fraction and RV fractional area change, nor with MI after adjusting for troponin T. RV GLS was significantly associated with ARDS after adjusting for other variables. In the risk stratification of patients with COVID-19, strain imaging can provide incremental prognostic information, as worsened RV GLS is associated with the development of ARDS. [ABSTRACT FROM AUTHOR] more...
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- 2024
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26. Additive effect of metabolic dysfunction-associated fatty liver disease on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T cardiac magnetic resonance feature tracking study.
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Tang, Xin, Shi, Rui, Jiang, Li, Yan, Wei-Feng, Han, Pei-Lun, Qian, Wen-Lei, Yang, Zhi-Gang, and Li, Yuan
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CARDIAC magnetic resonance imaging , *TYPE 2 diabetes , *FATTY liver , *VENTRICULAR ejection fraction , *METABOLIC disorders - Abstract
Background: Type 2 diabetes mellitus (T2DM) and metabolic-associated fatty liver disease (MAFLD) are both metabolic disorders that negatively impact the cardiovascular system. This study comprehensively analyzed the additive effect of MAFLD on left ventricular function and global strain in T2DM patients by cardiac magnetic resonance (CMR). Methods: Data of 261 T2DM patients, including 109 with and 152 without MAFLD, as well as 73 matched normal controls from our medical center between June 2015 and March 2022 were retrospectively analyzed. CMR-derived parameters, including LV function and global strain parameters, were compared among different groups. Univariate and multivariate linear regression analyses were conducted to investigate the impact of various factors on LV function and global strain. Results: Our investigation revealed a progressive deterioration in LV functional parameters across three groups: control subjects, T2DM patients without MAFLD, and T2DM patients with MAFLD. Statistically significant increases in left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), left ventricular mass index (LVMI) were observed, along with decreases in left ventricular ejection fraction (LVEF) and left ventricular global function index (LVGFI). Among these three groups, significant reductions were also noted in the absolute values of LV global radial, circumferential, and longitudinal peak strains (GRPS, GCPS, and GLPS), as well as in peak systolic (PSSR) and peak diastolic strain rates (PDSR). MAFLD was identified as an independent predictor of LVEF, LVMI, LVGFI, GRPS, GCPS, and GLPS in multivariate linear analysis. Besides, the incidence of late gadolinium enhancement was higher in MAFLD patients than in non-MAFLD patients (50/109 [45.9%] vs. 42/152 [27.6%], p = 0.003). Furthermore, escalating MAFLD severity was associated with a numerical deterioration in both LV function parameters and global strain values. Conclusions: This study thoroughly compared CMR parameters in T2DM patients with and without MAFLD, uncovering MAFLD's adverse impact on LV function and deformation in T2DM patients. These findings highlight the critical need for early detection and comprehensive management of cardiac function in T2DM patients with MAFLD. [ABSTRACT FROM AUTHOR] more...
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- 2024
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27. Machine Learning-Enabled Fully Automated Assessment of Left Ventricular Volume, Ejection Fraction and Strain: Experience in Pediatric and Young Adult Echocardiography.
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Li, Ling, Homer, Paul, Craft, Mary, Kutty, Shelby, Putschoegl, Adam, Marshall, Amanda, Danford, David, and Yetman, Anji
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GLOBAL longitudinal strain , *YOUNG adults , *VENTRICULAR ejection fraction , *ECHOCARDIOGRAPHY , *IMAGE analysis - Abstract
Background: Left ventricular (LV) volumes, ejection fraction (EF), and myocardial strain have been shown to be predictive of clinical and subclinical heart disease. Automation of LV functional assessment overcomes difficult technical challenges and complexities. We sought to assess whether a fully automated assessment of LV function could be reliably used in children and young adults. Methods: Fifty normal volunteers (22/28, female/male) were prospectively recruited for research echocardiography. LV volumes, EF, and strain were measured both manually and automatically. An experienced sonographer performed all the manual analysis and recorded the analysis timing. The fully automated analyses were accomplished by 5 groups of observers with different knowledge and medical background. AutoLV and AutoSTRAIN (TomTec) were employed for the fully automated LV analysis. The LV volumes, EF, strain, and analysis time were compared between manual and automated methods, and among the 5 groups of observers. Results: Software-determined endocardial border detection was achievable in all subjects. The analysis times of the experienced sonographer were significantly shorter for AutoLV and AutoSTRAIN than manual analyses (both p < 0.001). Strong correlations were seen between conventional EF and AutoLV (r = 0.8373), and between conventional three view global longitudinal strain (GLS) and AutoSTRAIN (r = 0.9766). The volumes from AutoLV and three view GLS from AutoSTRAIN had strong correlations among different observers regardless of level of expertise. EF from AutoLV analysis had moderately strong correlations among different observers. Conclusion: Automated pediatric LV analysis is feasible in normal hearts. Machine learning-enabled image analysis saves time and produces results that are comparable to traditional methods. [ABSTRACT FROM AUTHOR] more...
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- 2024
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28. Artificial intelligence-assisted echocardiographic monitoring in pediatric patients on extracorporeal membrane oxygenation
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Weiling Chen, Jinhui Wu, Zhenxuan Zhang, Zhifan Gao, Xunyi Chen, Yu Zhang, Zhou Lin, Zijian Tang, Wei Yu, Shumin Fan, Heye Zhang, and Bei Xia
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artificial intelligence ,echocardiography ,critical monitoring ,ECMO ,pediatrics ,left ventricular function ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundPercutaneous extracorporeal membrane oxygenation (ECMO) is administered to pediatric patients with cardiogenic shock or cardiac arrest. The traditional method uses focal echocardiography to complete the left ventricular measurement. However, echocardiographic determination of the ejection fraction (EF) by manual tracing of the endocardial borders is time consuming and operator dependent. The standard visual assessment is also an inherently subjective procedure. Artificial intelligence (AI) based machine learning-enabled image analysis might provide rapid, reproducible measurements of left ventricular volumes and EF for ECMO patients.ObjectivesThis study aims to evaluate the applicability of AI for monitoring cardiac function based on Echocardiography in patients with ECMO.Materials and methodsWe conducted a retrospective study involving 29 hospitalized patients who received ECMO support between January 2017 and December 2021. Echocardiogram was performed for patients with ECMO, including at pre-ECMO, during cannulation, during ECMO support, during the ECMO wean, and a follow up within 3 months after weaning. EF assessment of all patients was independently evaluated by junior physicians (junior-EF) and experts (expert-EF) using Simpson's biplane method of manual tracing. Additionally, raw data images of apical 2-chamber and 4-chamber views were utilized for EF assessment via a Pediatric ECMO Quantification machine learning-enabled AI (automated-EF).ResultsThere was no statistically significant difference between the automated-EF and expert-EF for all groups (P > 0.05). However, the differences between junior-EF and automated-EF and expert-EF were statistically significant (P more...
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- 2024
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29. Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function
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Wil Lieberman-Cribbin, PhD, Irene Martinez-Morata, MD, PhD, Arce Domingo-Relloso, PhD, Jason G. Umans, MD, PhD, Shelley A. Cole, PhD, Marcia O’Leary, RN, Maria Grau-Perez, PhD, Gernot Pichler, MD, PhD, MSc, Richard B. Devereux, MD, Anne E. Nigra, ScM, PhD, Allison Kupsco, PhD, and Ana Navas-Acien, PhD more...
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American Indian populations ,cardiac geometry ,left ventricular function ,uranium ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Background: Uranium is a potentially cardiotoxic, nonessential element commonly found in drinking water throughout the United States. Objectives: The purpose of this study was to evaluate if urinary uranium concentrations were associated with measures of cardiac geometry and function among American Indian young adults from the Strong Heart Family Study. Methods: Urinary uranium was measured among 1,332 participants free of diabetes, cardiovascular disease, and more...
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- 2024
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30. Recovery of left ventricular function after surgery for aortic and mitral regurgitation with heart failure
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Wei-Tsung Lai, I-Chen Chen, Ming-Chon Hsiung, Ting-Chao Lin, Kuan-Chih Huang, Chung-Yi Chang, and Jeng Wei
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Heart failure with reduced ejection fraction ,Left ventricular function ,Aortic regurgitation ,Mitral regurgitation ,Mixed valvular heart disease ,Valve surgery ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Severe aortic regurgitation (AR) and mitral regurgitation (MR) can lead to left ventricular (LV) systolic dysfunction; however, there are limited data about recovery of LV after surgery for AR or MR. Little is known to guide the management of combined AR and MR (mixed valvular heart disease [VHD]). This study is sought to investigate the predictors of postoperative LV function recovery in left-sided regurgitant VHD with reduced left ventricular ejection fraction (LVEF), especially for mixed VHD. Methods: From 2010 to 2020, 2053 adult patients underwent aortic or mitral valve surgery at our center. The patients with valvular stenosis, infective endocarditis, concomitant revascularization, and preoperative LVEF ≥40 % were excluded. A total of 127 patients were included in this study: 22 patients with predominant AR (AR group), 64 with predominant MR (MR group), and 41 with combined AR and MR (AMR group). Results: The mean preoperative LVEF was 32.4 %, 30.7 %, and 30.2 % (p = 0.44) in the AR, MR, and AMR groups, respectively. The AR group was more likely to have postoperative LVEF recovery. The cut-point of left ventricular end-systolic diameter (LVESD) for better recovery was 49 mm for the MR group and 58 mm for the AMR group. Conclusion: LV dysfunction due to combined AR and MR has similar remodeling reserve as AR, and better recoverability than MR. Thus, double-valve surgery is recommended before the LVESD is > 58 mm. more...
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- 2024
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31. Comparative evaluation of a novel [18F] F-Labeled PET tracer XTR004 against [13N] ammonia in myocardial perfusion imaging for coronary artery disease
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Wang, Peipei, Ren, Chao, Wang, Liang, Qian, Hao, Li, Fang, Su, Xinhui, Shen, Zhujun, Hsu, Bailing, and Huo, Li
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- 2024
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32. Echocardiographic Assessment in Patients with Vascular Ehlers-Danlos Syndrome: Insights from an Unexplored Field
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Buso, Giacomo, Paini, Anna, Agabiti-Rosei, Claudia, Bertacchini, Fabio, Stassaldi, Deborah, Capellini, Sara, Aggiusti, Carlo, Salvetti, Massimo, De Ciuceis, Carolina, Ritelli, Marco, Venturini, Marina, Colombi, Marina, and Muiesan, Maria Lorenza more...
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- 2024
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33. Three-dimensional speckle tracking echocardiography for evaluation of ventricular function in patients with systemic lupus erythematosus: relationship between duration of lupus erythematosus and left ventricular dysfunction by using global longitudinal strain
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Nehzat Akiash, Somayeh Abbaspour, Karim Mowla, Amir Moradi, Shahla Madjidi, Parisa Sharifi, and Mahboubeh Pazoki
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Systemic lupus erythematous ,Speckle tracking echocardiography ,Left ventricular function ,Global longitudinal strain ,3D echocardiography ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Cardiovascular diseases are leading causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Cardiac involvement in SLE can often go undetected. Three-dimensional (3D) speckle tracking echocardiography (STE) is a noninvasive imaging technique that can assess the function of the heart’s ventricles in an accurate and reproducible way. This makes it an attractive option for detecting early signs of heart disease in SLE patients. By identifying these subclinical cardiac abnormalities, 3D-STE may help reduce the negative impact of cardiovascular diseases in SLE population. Therefore, this study aimed to compare the left ventricular (LV) function between patients with SLE compared to age- and gender-matched controls using two-dimensional (2D) and 3D-STE. Results The current study found no significant differences in left ventricle ejection fraction, left ventricle end-diastolic volume, left ventricle end-systolic volume, left ventricle end-diastolic mass, and left ventricle end-systolic mass between the two groups. However, the SLE group exhibited a significantly lower LV global longitudinal strain (GLS) compared to the control group according to all types of echocardiographic assessments, including 3D and 2D long-axis strain, apical 2-chamber, and apical 4-chamber assessments (all P values more...
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- 2024
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34. Fractal analysis of left ventricular trabeculae in heart failure with preserved ejection fraction patients with multivessel coronary artery disease
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Zi-Yi Gu, Bing-Hua Chen, Lei Zhao, Dong-Aolei An, Chong-Wen Wu, Song Xue, Wei-Bo Chen, Shan Huang, Yong-Yi Wang, and Lian-Ming Wu
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Heart failure ,Left ventricular function ,Magnetic resonance imaging ,Fractal analysis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Objectives Endocardial trabeculae undergo varicose changes and hyperplasia in response to hemodynamic influences and are a variable phenotype reflecting changes in disease. Fractal analysis has been used to analyze the complexity of endocardial trabeculae in a variety of cardiomyopathies. The aim of this paper was to quantify the myocardial trabecular complexity through fractal analysis and to investigate its predictive value for the diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients with multivessel coronary artery disease (CAD). Methods The retrospective study population consisted of 97 patients with multivessel CAD, 39 of them were diagnosed with HFpEF, while 46 healthy volunteers were recruited as controls. Fractal dimension (FD) was obtained through fractal analysis of endocardial trabeculae on LV short-axis cine images. Logistic regression analyses were used to confirm the predictors and compare different prediction models. Results Mean basal FD was significantly higher in patients with HFpEF than in patients without HFpEF or in the healthy group (median: 1.289; IQR: 0.078; p more...
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- 2024
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35. Continuous monitoring of left ventricular function in postoperative intensive care patients using artificial intelligence and transesophageal echocardiography
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Jinyang Yu, Anders Austlid Taskén, Erik Andreas Rye Berg, Tomas Dybos Tannvik, Katrine Hordnes Slagsvold, Idar Kirkeby-Garstad, Bjørnar Grenne, Gabriel Kiss, and Svend Aakhus
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Transesophageal echocardiography ,Deep learning ,Left ventricular function ,Hemodynamic monitoring ,Mitral annular plane systolic excursion ,Critical care ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Continuous monitoring of mitral annular plane systolic excursion (MAPSE) using transesophageal echocardiography (TEE) may improve the evaluation of left ventricular (LV) function in postoperative intensive care patients. We aimed to assess the utility of continuous monitoring of LV function using TEE and artificial intelligence (autoMAPSE) in postoperative intensive care patients. Methods In this prospective observational study, we monitored 50 postoperative intensive care patients for 120 min immediately after cardiac surgery. We recorded a set of two-chamber and four-chamber TEE images every five minutes. We defined monitoring feasibility as how often the same wall from the same patient could be reassessed, and categorized monitoring feasibility as excellent if the same LV wall could be reassessed in ≥ 90% of the total recordings. To compare autoMAPSE with manual measurements, we rapidly recorded three sets of repeated images to assess precision (least significant change), bias, and limits of agreement (LOA). To assess the ability to identify changes (trending ability), we compared changes in autoMAPSE with the changes in manual measurements in images obtained during the initiation of cardiopulmonary bypass as well as before and after surgery. Results Monitoring feasibility was excellent in most patients (88%). Compared with manual measurements, autoMAPSE was more precise (least significant change 2.2 vs 3.1 mm, P more...
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- 2024
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36. Non‐dilated left ventricular cardiomyopathy vs. dilated cardiomyopathy: clinical background and outcomes
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Yuko Eda, Takeru Nabeta, Saeko Iikura, Yu Takigami, Teppei Fujita, Yuichiro Iida, Yuki Ikeda, Shunsuke Ishii, and Junya Ako
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Cardiomyopathy ,Heart failure ,Prognosis ,Left ventricular function ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Non‐dilated left ventricular cardiomyopathy (NDLVC) was proposed as a new category of cardiomyopathy that included patients with non‐left ventricular (LV) dilatation, LV wall motion abnormality, or LV scar. However, the clinical background and event rates of NDLVC were unclear. The aim of this study was to examine the characteristics and event rates of patients with NDLVC and reduced LV ejection fraction (NDLVC–REF) in comparison with those with dilated cardiomyopathy (DCM). Methods and results We retrospectively included 363 patients with newly diagnosed non‐ischaemic cardiomyopathy and reduced LV ejection fraction ( more...
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- 2024
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37. Editorial to 'Performance of the novel ANTWERP score in predicting heart function improvement after atrial fibrillation ablation in Asian patients with heart failure'
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Yasushi Mukai
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atrial fibrillation ,heart failure ,left ventricular function ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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38. A comparative study on the effect of coronary angioplasty on left ventricular function in post myocardial infarction among patients with and without type-2 diabetes mellitus.
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Gopal, Sava Nanda, Yallanki, Hanumath Prasad, Priya, Kaldindu Lakshmi, and R., Kannan
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PATIENT compliance , *TYPE 2 diabetes , *MYOCARDIAL infarction , *PEOPLE with diabetes , *DIABETES , *VENTRICULAR ejection fraction , *STRESS echocardiography - Abstract
Background and objectives. Coronary angioplasty is a common intervention for improving cardiac function postmyocardial infarction. However, the impact of this procedure in patients with type-2 diabetes mellitus (T2DM) compared to those without diabetes remains less understood. Material and methods. This study included 50 patients who underwent coronary angioplasty post-myocardial infarction. Patients were divided into two groups based on the presence (Group A) or absence (Group B) of T2DM, with 6 patients in each group. We assessed left ventricular function using echocardiography, focusing on ejection fraction and wall motion score, at baseline, and at 1, 3, and 6 months post-angioplasty. Additional data on clinical outcomes, functional status, cardiac biomarkers, medication use, comorbid condition management, and hemodynamic measurements were also collected. Results. Both groups showed improvement in left ventricular function post-angioplasty, with no significant difference in ejection fraction and wall motion score between the two groups at each follow-up. Clinical outcomes, functional status, and biomarker levels were comparable between groups. Medication compliance was high in both groups. The control of comorbid conditions and hemodynamic stability post-angioplasty were similarly maintained in both diabetic and nondiabetic patients. Conclusion. Coronary angioplasty positively impacts left ventricular function in post-myocardial infarction patients, irrespective of the presence of T2DM. Both diabetic and non-diabetic patients demonstrated similar improvements in cardiac function and overall clinical outcomes, suggesting that angioplasty is an effective intervention for post-myocardial infarction patients regardless of their diabetes status. Further studies with larger sample sizes are recommended to validate these findings. [ABSTRACT FROM AUTHOR] more...
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- 2024
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39. Immediate Changes of Left Ventricular Function after Total Occlusion Opening of Artery Rich in Collaterals Versus in Artery without Collaterals.
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El Sedawy, Hossam El Din Mohamed, Shokry, Khaled A. Azem, Saleh, Omar M., Oraby, Mohamed Ahmed, and Aly, Hesham Hegazy
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CORONARY circulation , *CHRONIC total occlusion , *COLLATERAL circulation , *AEROBIC capacity , *CORONARY angiography - Abstract
Background: For ischemic patients, left ventricular function is essential to their quality of life, and the major goal of coronary interventions is to keep the myocardium's blood supply productive. Thus, the complete cessation of blood flow to the myocardium for a prolonged duration is the obstacle to chronic total occlusion (CTO). Effective CTO coronary interventions improve the quality of life for the patient by improving LV systolic function, reducing angina, and increasing exercise capacity. Aim: This study aimed to compare the immediate changes that occur in the left ventricular systolic function in patients with CTO after successful revascularization in presence or absence of collateral circulation. Subjects and methods: This was an analytical cross-sectional study that was conducted at the Military Hospitals (Air Force, Maadi and Kobri El Koba Hospitals). Patients were recruited from the Cardiology Department from January 2023 to December 2023. Two groups were included: Group 1 included forty patients with CTO in any coronary artery more than 2.5 mm in its diameter with presence of ipsilateral or contralateral collateral circulation based on coronary angiography. Group 2 included other forty patients with CTO in any coronary artery more than 2.5 mm in its diameter with no collateral circulation based on the coronary angiography. Trans- thoracic echocardiography was done for all patients including both conventional (M-mode and 2D) and tissue Doppler strain rate studies 24 hours before PCI and two weeks after successful CTO PCI with final TIMI III flow. Results: Strain rate statistically significantly improved in group 1 compared to group 2 in terms of the septal and inferior wall segments 2 weeks after CTO opening. Conclusion: In CTO interventions, the presence of collateral circulation predicts immediate improvement in left ventricular systolic function as assessed by tissue Doppler intervention (TDI) using strain rate technique despite the lack of significant effect on conventional left ventricular systolic parameters as wall motion score index measurements. [ABSTRACT FROM AUTHOR] more...
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- 2024
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40. Childhood Obesity Is Associated With Subclinical Left Ventricular Dysfunction Detected by Speckle Tracking Echocardiography.
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Dehghan, Bahar, Sedighi, Mohsen, Rostampour, Noushin, Hashemi, Elham, Hovsepian, Silva, Sabri, Mohammad Reza, Ghaderian, Mehdi, Mahdavi, Chehreh, Ahmadi, Alireza, and Esnaashari, Azadeh
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CROSS-sectional method , *BODY mass index , *T-test (Statistics) , *RESEARCH funding , *AGE distribution , *CHI-squared test , *MULTIVARIATE analysis , *LONGITUDINAL method , *STATURE , *ROUTINE diagnostic tests , *ANALYSIS of variance , *CHILDHOOD obesity , *DATA analysis software , *BLOOD pressure , *LEFT ventricular dysfunction , *ECHOCARDIOGRAPHY , *NONPARAMETRIC statistics , *REGRESSION analysis , *DISEASE complications - Abstract
Childhood obesity is related to cardiac structural and functional changes, increasing the risk of heart disease. Sixty normotensive children were assigned based on body mass index (BMI) into normal weight, overweight, and obese groups and examined by two-dimensional speckle tracking echocardiography (2D-STE). Weight (P =.001) and BMI (P =.001) differed significantly among the 3 groups. Left ventricular (LV) strain (P =.001) and strain rate (P =.002) in overweight and obese children (P =.001) were significantly lower compared to normal weight group. LV mass in obese children was notably larger compared to overweight children (P =.047). LV strain was associated with age (P =.031), weight (P =.001), and height (P =.022). There was an association between LV strain rate with weight (P =.001) and between left atrial area and height of children (P =.007). Obesity in normotensive obese children is associated with subclinical alteration of LV dimension and myocardial longitudinal strain recognized by 2D-STE. [ABSTRACT FROM AUTHOR] more...
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- 2024
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41. Three-dimensional speckle tracking echocardiography for evaluation of ventricular function in patients with systemic lupus erythematosus: relationship between duration of lupus erythematosus and left ventricular dysfunction by using global...
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Akiash, Nehzat, Abbaspour, Somayeh, Mowla, Karim, Moradi, Amir, Madjidi, Shahla, Sharifi, Parisa, and Pazoki, Mahboubeh
- Abstract
Background: Cardiovascular diseases are leading causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Cardiac involvement in SLE can often go undetected. Three-dimensional (3D) speckle tracking echocardiography (STE) is a noninvasive imaging technique that can assess the function of the heart's ventricles in an accurate and reproducible way. This makes it an attractive option for detecting early signs of heart disease in SLE patients. By identifying these subclinical cardiac abnormalities, 3D-STE may help reduce the negative impact of cardiovascular diseases in SLE population. Therefore, this study aimed to compare the left ventricular (LV) function between patients with SLE compared to age- and gender-matched controls using two-dimensional (2D) and 3D-STE. Results: The current study found no significant differences in left ventricle ejection fraction, left ventricle end-diastolic volume, left ventricle end-systolic volume, left ventricle end-diastolic mass, and left ventricle end-systolic mass between the two groups. However, the SLE group exhibited a significantly lower LV global longitudinal strain (GLS) compared to the control group according to all types of echocardiographic assessments, including 3D and 2D long-axis strain, apical 2-chamber, and apical 4-chamber assessments (all P values < 0.05). Furthermore, a good inter-rater reliability and intra-rater reliability were observed regarding the LVGLS measurement with 3D-STE. Additionally, the study identified a significant correlation between LVGLS and SLE duration (r (50) = 0.46, P < 0.001). The use of prednisolone and nephrology disorders was also found to impact LVGLS measurements. Conclusions: Despite a normal LVEF in patients with SLE, LVGLS measurements indicated that LV systolic dysfunction was observed more frequently in SLE patients compared to their healthy counterparts. Therefore, advanced 3D-STE techniques may be useful in identifying subtle abnormalities in LV function in SLE patients. [ABSTRACT FROM AUTHOR] more...
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- 2024
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42. Fractal analysis of left ventricular trabeculae in heart failure with preserved ejection fraction patients with multivessel coronary artery disease.
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Gu, Zi-Yi, Chen, Bing-Hua, Zhao, Lei, An, Dong-Aolei, Wu, Chong-Wen, Xue, Song, Chen, Wei-Bo, Huang, Shan, Wang, Yong-Yi, and Wu, Lian-Ming
- Abstract
Objectives: Endocardial trabeculae undergo varicose changes and hyperplasia in response to hemodynamic influences and are a variable phenotype reflecting changes in disease. Fractal analysis has been used to analyze the complexity of endocardial trabeculae in a variety of cardiomyopathies. The aim of this paper was to quantify the myocardial trabecular complexity through fractal analysis and to investigate its predictive value for the diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients with multivessel coronary artery disease (CAD). Methods: The retrospective study population consisted of 97 patients with multivessel CAD, 39 of them were diagnosed with HFpEF, while 46 healthy volunteers were recruited as controls. Fractal dimension (FD) was obtained through fractal analysis of endocardial trabeculae on LV short-axis cine images. Logistic regression analyses were used to confirm the predictors and compare different prediction models. Results: Mean basal FD was significantly higher in patients with HFpEF than in patients without HFpEF or in the healthy group (median: 1.289; IQR: 0.078; p < 0.05). Mean basal FD was also a significant independent predictor in univariate and multivariate logistic regression (OR: 1.107 and 1.043, p < 0.05). Furthermore, adding FD to the prediction model improved the calibration and accuracy of the model (c-index: 0.806). Conclusion: The left ventricular FD obtained with fractal analysis can reflect the complexity of myocardial trabeculae and has an independent predictive value for the diagnosis of HFpEF in patients with multivessel CAD. Including FD into the diagnostic model can help improve the diagnosis. Critical relevance statement: Differences show in the complexity of endocardial trabeculae in multivessel coronary artery disease patients, and obtaining fractal dimensions (FD) by fractal analysis can help identify heart failure with preserved ejection fraction (HFpEF) patients. Key Points: The complexity of myocardial trabeculae differs among patients with multivessel coronary artery disease. Left ventricular fractal dimensions can reflect the complexity of the myocardial trabecular. Fractal dimensions have predictive value for the diagnosis of heart failure with preserved ejection fraction. [ABSTRACT FROM AUTHOR] more...
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- 2024
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43. Continuous monitoring of left ventricular function in postoperative intensive care patients using artificial intelligence and transesophageal echocardiography.
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Yu, Jinyang, Taskén, Anders Austlid, Berg, Erik Andreas Rye, Tannvik, Tomas Dybos, Slagsvold, Katrine Hordnes, Kirkeby-Garstad, Idar, Grenne, Bjørnar, Kiss, Gabriel, and Aakhus, Svend
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INTENSIVE care patients , *POSTOPERATIVE care , *ARTIFICIAL intelligence , *SIMULATED patients , *TRANSESOPHAGEAL echocardiography , *CARDIOPULMONARY bypass , *CARDIAC surgery - Abstract
Background: Continuous monitoring of mitral annular plane systolic excursion (MAPSE) using transesophageal echocardiography (TEE) may improve the evaluation of left ventricular (LV) function in postoperative intensive care patients. We aimed to assess the utility of continuous monitoring of LV function using TEE and artificial intelligence (autoMAPSE) in postoperative intensive care patients. Methods: In this prospective observational study, we monitored 50 postoperative intensive care patients for 120 min immediately after cardiac surgery. We recorded a set of two-chamber and four-chamber TEE images every five minutes. We defined monitoring feasibility as how often the same wall from the same patient could be reassessed, and categorized monitoring feasibility as excellent if the same LV wall could be reassessed in ≥ 90% of the total recordings. To compare autoMAPSE with manual measurements, we rapidly recorded three sets of repeated images to assess precision (least significant change), bias, and limits of agreement (LOA). To assess the ability to identify changes (trending ability), we compared changes in autoMAPSE with the changes in manual measurements in images obtained during the initiation of cardiopulmonary bypass as well as before and after surgery. Results: Monitoring feasibility was excellent in most patients (88%). Compared with manual measurements, autoMAPSE was more precise (least significant change 2.2 vs 3.1 mm, P < 0.001), had low bias (0.4 mm), and acceptable agreement (LOA − 2.7 to 3.5 mm). AutoMAPSE had excellent trending ability, as its measurements changed in the same direction as manual measurements (concordance rate 96%). Conclusion: Continuous monitoring of LV function was feasible using autoMAPSE. Compared with manual measurements, autoMAPSE had excellent trending ability, low bias, acceptable agreement, and was more precise. [ABSTRACT FROM AUTHOR] more...
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- 2024
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44. Role of Left Ventricular Dysfunction in Systemic Sclerosis-Related Pulmonary Hypertension.
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Lui, Justin K., Cozzolino, Matthew, Winburn, Morgan, Trojanowski, Marcin A., Wiener, Renda Soylemez, LaValley, Michael P., Bujor, Andreea M., Gopal, Deepa M., and Klings, Elizabeth S.
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LEFT ventricular dysfunction , *PULMONARY hypertension , *GLOBAL longitudinal strain , *SPECKLE tracking echocardiography , *PULMONARY arterial hypertension , *CARDIAC catheterization - Abstract
In systemic sclerosis (SSc), pulmonary hypertension remains a significant cause of morbidity and mortality. Although conventionally classified as group 1 pulmonary arterial hypertension, systemic sclerosis-related pulmonary hypertension (SSc-PH) is a heterogeneous disease. The contribution of left-sided cardiac disease in SSc-PH remains poorly understood. How often does left ventricular (LV) dysfunction occur in SSc among patients undergoing right heart catheterization and how does coexistent LV dysfunction with SSc-PH affect all-cause mortality in this patient population? We conducted a retrospective, observational study of 165 patients with SSc who underwent both echocardiography and right heart catheterization. LV dysfunction was identified using LV global longitudinal strain (GLS) on speckle-tracking echocardiography based on a defined threshold of > −18%. SSc-PH was defined by a mean pulmonary artery pressure > 20 mmHg. Among patients with SSc who have undergone right heart catheterization, LV dysfunction occurred in 74.2% with SSc-PH and 51.2% without SSc-PH. The median survival of patients with SSc-PH and LV dysfunction was 67.9 (95% CI, 38.3-102.0) months, with a hazard ratio of 12.64 (95% CI, 1.73-92.60) for all-cause mortality when adjusted for age, sex, SSc disease duration, and FVC compared with patients with SSc without pulmonary hypertension with normal LV function. LV dysfunction is common in SSc-PH. Patients with SSc-PH and LV dysfunction by LV GLS have increased all-cause mortality. This suggests that LV GLS may be helpful in identifying underlying LV dysfunction and in risk assessment of patients with SSc-PH. [Display omitted] [ABSTRACT FROM AUTHOR] more...
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- 2024
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45. Non‐dilated left ventricular cardiomyopathy vs. dilated cardiomyopathy: clinical background and outcomes.
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Eda, Yuko, Nabeta, Takeru, Iikura, Saeko, Takigami, Yu, Fujita, Teppei, Iida, Yuichiro, Ikeda, Yuki, Ishii, Shunsuke, and Ako, Junya
- Subjects
DILATED cardiomyopathy ,CARDIAC arrest ,ATRIAL fibrillation ,HEART failure ,VENTRICULAR ejection fraction - Abstract
Aims: Non‐dilated left ventricular cardiomyopathy (NDLVC) was proposed as a new category of cardiomyopathy that included patients with non‐left ventricular (LV) dilatation, LV wall motion abnormality, or LV scar. However, the clinical background and event rates of NDLVC were unclear. The aim of this study was to examine the characteristics and event rates of patients with NDLVC and reduced LV ejection fraction (NDLVC–REF) in comparison with those with dilated cardiomyopathy (DCM). Methods and results: We retrospectively included 363 patients with newly diagnosed non‐ischaemic cardiomyopathy and reduced LV ejection fraction (<50%) between December 2004 and January 2018. Patients who did not have LV dilatation (LV dimension index of ≦31 mm/m2 in men and ≦34 mm/m2 in women) were categorized as NDLVC–REF (n = 80, 22.2%), and the remaining patients were categorized as DCM. Cardiac events were defined as sudden cardiac death and rehospitalization for heart failure. Patients with NDLVC–REF had a higher prevalence of atrial fibrillation and a higher LV ejection fraction than those with DCM at baseline. LV ejection fraction was higher and LV end‐diastolic diameter was smaller in patients with NDLVC–REF than in those with DCM at all time points after diagnosis. During the median follow‐up period of 68.8 months (interquartile range: 33.0–93.7 months), 44 patients experienced cardiac events. The Kaplan–Meier curves showed no significant differences in the probability of cardiac events among NDLVC–REF and DCM patients (P = 0.349). However, patients with NDLVC–REF and LV dilatation after diagnosis (14%) had a higher risk of cardiac events than those with NDLVC–REF without LV dilatation (P = 0.049). Conclusions: There was no significant difference in the incidence of cardiac events between NDLVC–REF and DCM. Among NDLVC–REF patients, 18% of patients who showed LV dilatation after diagnosis had poor outcomes. Therefore, both NDLVC–REF and DCM patients may require equivalent attention to follow‐up and regular assessment of LV function. [ABSTRACT FROM AUTHOR] more...
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- 2024
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46. Analysis of risk factors for changes of left ventricular function indexes in Chinese patients with gout by echocardiography.
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Wantai Dang, Danling Luo, Jing Hu, Hui Luo, Xiaohui Xu, and Jian Liu
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GLOBAL longitudinal strain ,CHINESE people ,FACTOR analysis ,GOUT ,CARDIOVASCULAR disease diagnosis - Abstract
Background: Echocardiographic data investigating the association between left ventricular (LV) function and gout is still limited. Purpose: To analyze the association of echocardiographic parameters based on two-dimentional speckle tracking analysis with clinically related indicators in patients with gout, and to provide a clinical basis for the early diagnosis and treatment of cardiovascular disease in patients with gout. Methods: This study collected gout patients who visited the outpatient and inpatient departments of the first affiliated hospital of chengdu medical college from November 2019 to December 2020. Spearman correlation test was performed to analyze the correlation coefficients between the laboratorial indicators with echocardiographic parameters. And the logistic regression analysis was performed to evaluate the independent effects. Results: The results of multivariate logistic regression showed that fasting plasma glucose (FPG) was a risk factor for the decrease in absolute value of global longitudinal strain [GLS (OR = 2.34; 95% CI, 1.01-5.39; p = 0.04)], Urea was a risk factor for absolute reduction in GCS (OR = 1.40; 95% CI, 1.07-1.85; p = 0.02), age (OR = 1.09, 95% CI, 1.04-1.16; p = 0.001), and hypertension (OR = 8.35; 95% CI, 1.83-38.02; p = 0.006) were risk factors for increased E/Em. High urea levels were significantly related with high risks of LVH (OR = 1.59, 95% CI, 1.04-2.43; p = 0.03) and enlargement of LAVI (OR = 1.68, 95% CI, 1.01-2.80; p = 0.04). Conclusion: Our study found that elevated urea and FPG were risk factors for subclinical LV myocardial dysfunction in patients with gout, which might provide a theoretical basis for the early diagnosis and treatment of heart disease in clinical practice. [ABSTRACT FROM AUTHOR] more...
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- 2024
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47. Right parasternal echocardiographic reference values in the healthy male Iranian Shall sheep
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Sirous Sadeghian Chaleshtori, Mohammad Reza Mokber Dezfouli, Alireza Vajhi, Abolfazl Najd Ghahremani, Neda Sabetzadeh, and Javad Abbasi
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echocardiography ,Iranian Shall sheep ,left ventricular function ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Among the large animals, the heart of sheep is functionally and structurally very similar to the human heart. In research, sheep are used as an animal model to study the process of cardiac disease pathogenesis and treatment. Therefore, determining the normal values of the heart structures of sheep with echocardiography is of particular emphasis. The purpose of the present research is to define the normal echocardiography values of heart in Iranian Shall breed sheep. Materials and methods In 20 healthy Iranian Shall male sheep weighing 30–35 kg and aged 4–6 months, standing echocardiography was done from the right parasternal approach concentrated on the 3rd to 5th intercostal spaces by 2.5–5 MHz phased array transducer in the longitudinal and transverse views by B‐mode, M‐mode and Doppler systems. In M‐mode echocardiographic, the parameters of interventricular septal, left ventricular internal diameter, left ventricular free wall, right ventricular free wall and right ventricular internal diameter in diastole and systole as well as end point septal separation, ejection fraction (EF) slope, aortic root diameter, left atrial appendage, left atrial diameter/aortic valve diameter, left ventricular ejection time, fractional shortening, end‐diastolic volume, end‐systolic volume, EF, stroke volume and cardiac output and in pulsed‐wave spectral Doppler echocardiographic, the parameters of mitral valve maximum velocity (Vmax), mitral valve mean velocity (Vmean), mitral valve maximum pressure gradient (PGmax), mitral valve mean pressure gradient (PGmean), mitral valve velocity time integral (VTI), mitral valve E‐wave (MV‐E), MV‐E pressure gradient, mitral valve A‐wave (MV‐A), MV‐A pressure gradient, aortic Vmax, aortic valve Vmean, aortic valve PGmax, aortic valve PGmean, aortic valve VTI, left ventricular outflow tract (LVOT)‐Vmax, LVOT‐Vmean were measured. Results All the sheep in this study were healthy and had no signs of heart disease. In this study, the parameters of M‐mode and spectral Doppler echocardiographic were assessed and recognized in Iranian Shall sheep. The results demonstrated the parameters of echocardiographic could be dependably determined in Shall sheep which, established normal reference values for these parameters and left ventricular function indices in healthy Shall sheep. These results can be beneficial in appropriate imagination, recognition and measuring cardiac structures. Conclusion This study can be exerted as a reference for the assessment and diagnosis of heart diseases in sheep medicine and human cardiovascular research in sheep experimental models. more...
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- 2024
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48. Safety and efficacy of angiotensin receptor neprilysin inhibitor in improving cardiac function and blood pressure in dialysis patients
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Kai Zhou, Qiuyue Zhang, Wen Dong, Xin Li, Yimiao Sun, and Ying Zhang
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angiotensin receptor neprilysin inhibitor ,cardiac function ,blood pressure ,dialysis patients ,left ventricular function ,Medicine (General) ,R5-920 - Abstract
BackgroundThe efficacy of the angiotensin receptor neprilysin inhibitor (ARNI) sacubitril/valsartan (SV) in patients with chronic kidney disease (CKD) has been established. Two meta-analyses have demonstrated its significant role in enhancing ventricular remodeling. However, the effectiveness and safety of its use in patients with end-stage renal disease (ESRD) remain unclear.Methods and resultsUp to October 2023, we searched the PubMed, Embase, and Web of Science databases for studies involving ESRD patients treated with ARNI. The quality of the included studies was evaluated using the Newcastle-Ottawa Scale. Effect sizes were reported as mean differences (MD) with 95% confidence intervals (CIs). We included 10 studies, encompassing 649 patients. ARNI was associated with improvements in blood pressure and left ventricular (LV) function in ESRD patients, including systolic blood pressure (SBP) (MD −12.76 mmHg; 95% CI, −18.03 to −7.5 mmHg), diastolic blood pressure (DBP) (MD −6.41 mmHg; 95% CI, −8.10 to −4.72 mmHg), and left ventricular ejection fraction (LVEF) (MD, 4.61%; 95% CI, 1.78%−7.44%). Hemoglobin levels improved, but there were no significant statistical differences in other biomarkers for dialysis. Sacubitril/valsartan was generally well tolerated in ESRD patients. Improved indices of left ventricular function were noted at 6 months and were more pronounced at 12 months. A linear relationship between LVEF and left ventricular end-diastolic volume (LVEDV) was observed, as indicated by a high correlation coefficient (r-value).ConclusionARNI effectively reduces blood pressure and enhances left ventricular function in dialysis patients, with early treatment associated with greater benefits. ARNI also demonstrates a favorable safety profile in this population. Further prospective studies are required to fully understand the long-term efficacy and safety of sacubitril/valsartan in dialysis patients. more...
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- 2024
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49. Effect of residual myocardial ischemia on recovery of left ventricular function after primary percutaneous coronary intervention
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Mohamed Aly Abdelhafez, Karim M. E. Aly, and Amr A. A. Youssef
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2-D speckle tracking ,Primary percutaneous coronary intervention ,Left ventricular function ,Residual myocardial ischemia ,GLS-A2C ,GLS-AVG ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background It is unknown whether the existence of severe bystander damage will affect left ventricular (LV) healing following primary percutaneous coronary intervention (PPCI). The aim of the present analysis was to follow LV recovery using 2D speckle tracking echocardiography (2-D STE) in cases with single versus multiple vessel disease with acute myocardial infarction (AMI) who underwent PPCI and to assess major adverse cardiovascular events (MACEs) within 3 months. Patients and methods This work was conducted at Assiut University Heart Hospital. Of 1026 screened subjects with AMI needing PPCI and assessed for eligibility, only 89 cases fulfilled the inclusion criteria. They were classified into Group A: single vessel and Group B: multiple vessel (≥ 2 vessels) disease. Their data were obtained on admittance and after 90 days. Results In group A compared to group B, there was a statistically preferable value at baseline in the global longitudinal strain- Apical 2 chamber (GLS-A2C) (-12.05 ± 3.57 vs. -10.38 ± 3.92, P = 0.039). At follow-up, the improvement was in all 2-D STE variables, including GLS-long axis (GLS-LAX) (-13.09 ± 3.84 vs.-10.75 ± 3.96, P = 0.006), GLS- apical 4 chamber (GLS-A4C) (-13.23 ± 3.51 vs.-10.62 ± 4.08, P = 0.002), GLS-A2C (-13.85 ± 3.41 vs-10.93 ± 3.97, P more...
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- 2024
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50. The worsening effect of paroxysmal atrial fibrillation on left ventricular function and deformation in type 2 diabetes mellitus patients: a 3.0 T cardiovascular magnetic resonance feature tracking study
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Xue-Ming Li, Wei-Feng Yan, Ke Shi, Rui Shi, Li Jiang, Yue Gao, Chen-Yan Min, Xiao-Jing Liu, Ying-Kun Guo, and Zhi-Gang Yang
- Subjects
Type 2 diabetes mellitus ,Atrial fibrillation ,Cardiovascular magnetic resonance ,Feature tracking ,Left ventricular function ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Atrial fibrillation (AF) has been linked to an increased risk of cardiovascular death, overall mortality and heart failure in patients with type 2 diabetes mellitus (T2DM). The present study investigated the additive effects of paroxysmal AF on left ventricular (LV) function and deformation in T2DM patients with or without AF using the cardiovascular magnetic resonance feature tracking (CMR-FT) technique. Methods The present study encompassed 225 T2DM patients differentiated by the presence or absence of paroxysmal AF [T2DM(AF+) and T2DM(AF−), respectively], along with 75 age and sex matched controls, all of whom underwent CMR examination. LV function and global strains, including radial, circumferential and longitudinal peak strain (PS), as well as peak systolic and diastolic strain rates (PSSR and PDSR, respectively), were measured and compared among the groups. Multivariable linear regression analysis was used to examine the factors associated with LV global strains in patients with T2DM. Results The T2DM(AF+) group was the oldest, had the highest LV end‑systolic volume index, lowest LV ejection fraction and estimated glomerular filtration rate compared to the control and T2DM(AF−) groups, and presented a shorter diabetes duration and lower HbA1c than the T2DM(AF−) group. LV PS-radial, PS-longitudinal and PDSR-radial declined successively from controls through the T2DM(AF−) group to the T2DM(AF+) group (all p more...
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- 2024
- Full Text
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