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2 results on '"low-resolution brain electromagnetic source tomography"'

1. Cortical sources of resting state electroencephalographic rhythms probe brain function in naïve HIV individuals

Author

Laura Gianserra, Raffaele Ferri, Lorenzo Ciullini, Paolo Onorati, Maria Teresa Pascarelli, Antonio Aceti, Gloria Crocetti, Giuseppe Noce, Valentina Catania, Claudio Babiloni, Claudio Del Percio, Paolo Roma, Ginevra Toma, Elisabetta Teti, Paolo Capotosto, Francesco Di Campli, Andrea Soricelli, Alfredo Pennica, Massimo Andreoni, Valentina Correr, Loredana Sarmati, Stefano Ferracuti, and Elisa Piccinni

Subjects
0301 basic medicine, Male, HIV Infections, Audiology, Electroencephalography, Neuropsychological Tests, 0302 clinical medicine, Cognition, Neuropsychological assessment, EEG, Cerebral Cortex, medicine.diagnostic_test, human immunodeficiency virus, Neuropsychology, low-resolution brain electromagnetic source tomography, Human immunodeficiency virus (HIV), LORETA, HIV, neuropsychological assessment, resting-state electroencephalography, sensory systems, neurology, physiology, Resting-state electroencephalography (EEG), Female, Low-resolution brain electromagnetic source tomography (LORETA), Sensory Systems, Neurology, Neurology (clinical), Physiology (medical), medicine.symptom, Adult, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, Rest, Asymptomatic, 03 medical and health sciences, Rhythm, Acquired immunodeficiency syndrome (AIDS), medicine, Humans, Resting state fMRI, business.industry, medicine.disease, 030104 developmental biology, business, 030217 neurology & neurosurgery
Abstract

Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS).EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest.Widespread sources of delta (4 Hz) and alpha (8-12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70-75%).Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level.This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.

Published
2018

2. Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index

Author

Nicole Donato, Francesco Di Campli, Stefano Ferracuti, Elisabetta Teti, Alfredo Pennica, Antonio Aceti, Claudio Del Percio, Giuseppe Noce, Cristina Limatola, Paolo Onorati, Susanna Cordone, Claudio Babiloni, Massimo Andreoni, Magdalena Viscione, Chiara Muratori, Laura Gianserra, and Andrea Soricelli

Subjects
Male, medicine, HIV Infections, Pilot Projects, Audiology, Electroencephalography, delta/alpha power density, 0302 clinical medicine, EEG, Cerebral Cortex, Delta/alpha power density, Human immunodeficiency virus (HIV), Low-resolution brain electromagnetic source tomography (LORETA), Resting-state electroencephalography (EEG), Z-score, Adult, Humans, Viral Load, Rest, human immunodeficiency virus, medicine.diagnostic_test, 05 social sciences, low-resolution brain electromagnetic source tomography, LORETA, Sensory Systems, medicine.anatomical_structure, Neurology, Cerebral cortex, Psychology, Viral load, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, resting-state electroencephalography, Alpha (ethology), Standard score, 050105 experimental psychology, 03 medical and health sciences, Rhythm, Physiology (medical), 0501 psychology and cognitive sciences, Resting state fMRI, HIV, adult, cerebral cortex, electroencephalography, HIV infections, humans, male, pilot projects, viral load, rest, sensory systems, neurology, physiology, Standard error, Neurology (clinical), Neuroscience, 030217 neurology & neurosurgery
Abstract

This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (4 Hz) and alpha (8-13 Hz) electroencephalographic (EEG) rhythms with reference to a control group of sex-, age-, and education-matched healthy individuals. Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values were expected to show worse cognitive status.Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p0.05). Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values exhibited lower mini mental state evaluation (MMSE) score, higher CD4 count, and lower viral load (p0.05).This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.

Published
2016

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