1. Cortical sources of resting state electroencephalographic rhythms probe brain function in naïve HIV individuals
- Author
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Laura Gianserra, Raffaele Ferri, Lorenzo Ciullini, Paolo Onorati, Maria Teresa Pascarelli, Antonio Aceti, Gloria Crocetti, Giuseppe Noce, Valentina Catania, Claudio Babiloni, Claudio Del Percio, Paolo Roma, Ginevra Toma, Elisabetta Teti, Paolo Capotosto, Francesco Di Campli, Andrea Soricelli, Alfredo Pennica, Massimo Andreoni, Valentina Correr, Loredana Sarmati, Stefano Ferracuti, and Elisa Piccinni
- Subjects
0301 basic medicine ,Male ,HIV Infections ,Audiology ,Electroencephalography ,Neuropsychological Tests ,0302 clinical medicine ,Cognition ,Neuropsychological assessment ,EEG ,Cerebral Cortex ,medicine.diagnostic_test ,human immunodeficiency virus ,Neuropsychology ,low-resolution brain electromagnetic source tomography ,Human immunodeficiency virus (HIV) ,LORETA ,HIV ,neuropsychological assessment ,resting-state electroencephalography ,sensory systems ,neurology ,physiology ,Resting-state electroencephalography (EEG) ,Female ,Low-resolution brain electromagnetic source tomography (LORETA) ,Sensory Systems ,Neurology ,Neurology (clinical) ,Physiology (medical) ,medicine.symptom ,Adult ,medicine.medical_specialty ,Settore MED/17 - Malattie Infettive ,Rest ,Asymptomatic ,03 medical and health sciences ,Rhythm ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,Humans ,Resting state fMRI ,business.industry ,medicine.disease ,030104 developmental biology ,business ,030217 neurology & neurosurgery - Abstract
Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS).EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0 years ± 2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest.Widespread sources of delta (4 Hz) and alpha (8-12 Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p 0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70-75%).Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level.This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits.
- Published
- 2018