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The aim is to compare whether performing muscle strengthening exercises (EF) is better than doing aerobic exercises (EA), or vice versa, to reduce pain and improve physical capacity in individuals with knee osteoarthritis. A comprehensive search of databases was conducted, and 13 relevant randomized controlled trials (RCTs) were selected, of which the quality was evaluated using the Pedro and Amstar scales. The results showed differences in the duration and type of exercise among the studies; approximately 33.33% supported the efficacy of resistance training, 26.67% aerobic training, and 40% concluded that both interventions are equally important. The importance of considering an integrated approach combining both interventions to optimize outcomes in patients with knee osteoarthritis is emphasized, as each offers complementary benefits. Strength training improves muscle strength, while aerobic exercise addresses central sensitization, both reducing pain and enhancing physical capacity. [ABSTRACT FROM AUTHOR]

Introduction: the increasing acceptance of cannabinoids for therapeutic purposes has been linked to changes in legislation, high prevalence and ineffective control of chronic pain with conventional analgesics. Objective: determine the prevalence of chronic pain, the analgesic treatment modality with herbal therapies (cannabis) in adults in southeastern Mexico. Material and methods: a cross-sectional and ethnographic study was carried out on 267 people with chronic pain and regular use of herbal medicine for analgesic purposes. Hypothesis tests were carried out to evaluate differences between average values, age and pain intensity, comparing the use of cannabis with the type of pain, gender, algological diagnoses and comorbidities. Results: an association was observed between chronic pain: diabetes, hypertension, neoplasms in women, in older adults. 46% of the participants suffered from osteoarthritis and 20.9% had other diagnoses. The preferred modality for the topical administration of cannabis was tinctures in Mezcal or alcohol and to a lesser extent macerated in oils and inhalation. Conclusions: the findings do not allow cannabis to be considered as monotherapy for chronic pain in patients with chronic pain. However, they offer a promising field in the search for analgesic alternatives that avoid the chronic consumption of opiates or non-steroidal anti-inflammatory drugs (NSAIDs). [ABSTRACT FROM AUTHOR]

The characteristics of synovial fluid (SF) in geriatric patients differ from those in younger patients. In Mexico, epidemiologic data on the incidence of different rheumatic diseases in geriatric patients are scarce. To describe the physical characteristics of geriatric SF and the prevalence of crystals in knee and other joint aspirates from patients with previously diagnosed joint disease. A retrospective study was performed with a baseline of 517 SF samples between 2011 and 2023. White blood cell count was performed by Neubauer chamber and crystals were identified by polarized light microscopy. Descriptive statistical analysis was performed and prevalence was reported as a percentage. The mean age of the adults was 73.5 ± 5.0 years, 54.4% were women and 45.6% were men. The mean SF volume was 6.3 ± 9.5 mL in older adults and 15.3 ± 24.9 mL in those younger than 65 years. The mean viscosity in older adults was 9.5 ± 4.5 mm and the mean leukocyte count was 7352 ± 16,402 leukocytes/mm3. Seventy percent of the older adults' SFs were referred to the laboratory for osteoarthritis (OA), with lower proportions for rheumatoid arthritis (RA) (14.6%) and gout (5.1%). Of the crystals observed in the geriatric population, 14.6% corresponded to monosodium urate crystals (CUM) and 18.9% to calcium pyrophosphate crystals (CPP). The characteristics of LS in older adults were smaller volume, increased viscosity, and non-inflammatory. The main diagnoses were OA, RA, and gout. The crystal content of the SF of the geriatric population corresponded mainly to CPP. [ABSTRACT FROM AUTHOR]

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Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: it is estimated that 302 million people worldwide are affected by osteoarthritis, corresponding to 60% osteoarthritis (OA) of the knee, which responsible 80% of disability in older adults, hence the importance of the association of the sign with the early inflammatory process in OA. Objective: to determine the association of digital pressure sign in patients with and without osteoarthritis of the knee. Material and methods: this was an observational, comparative cross-sectional study, carried out in patients with and without a diagnosis of knee OA, to whom the digital pressure sign was determined. The sample was calculated with the formula for two proportions, obtaining a total of 40 participants per group, obtained by non-probabilistic sampling for convenience. The statistical analysis included frequencies, percentages, χ² and OR. The bioethics regulations in force were respected. Results: the study included 80 participants, with a median age of 48.9 years (RQI 46-53.7), 73.1% were predominantly female sex (38), and a statistically significant association was found between patients with OA and the presence of digital pressure sign, χ² 4.62 and p value = 0.41, OR of 2.65. Conclusions: the presence of digital pressure sign increases the probability of having OA 2.65 times more. [ABSTRACT FROM AUTHOR]

Background: Proinflammatory diet contributes to greater symptomatology in patients with knee osteoarthritis (KOA); however, in Mexico there seems to be no evidence of the dietary inflammatory role, being a country with high prevalence of overweight and obesity with an inclination towards a Western diet. Objective: To analyze the relationship between dietary in- flammatory index (DII) and KOA symptomatology in Mexican patients. Material and methods: Analytical cross-sectional study in 100 patients aged 40 to 70 years. Pain, stiffness, and functionality were evaluated with the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the DII was calculated from the semi-quantitative food consumption frequency questionnaire (QFCFQ). For its analysis, linear regression was calculated. Results: DII was significantly associated with pain p = 0.001, R² = 0.118), functionality (p = 0.003, R² = 0.087) and WOMAC score (p = 0.001, R² = 0.099). In the second linear regression model with the dependent variable functionality, waist circumference (WC) was adjusted obtaining an R² = 0.144 and higher significance p = 0.001. Conclusions: Proinflammatory DII was related to greater pain, lower functionality and a high WOMAC score, which is why the anti-inflammatory diet could be considered as a support for the treatment of the patient with KOA. [ABSTRACT FROM AUTHOR]

Presentamos a una mujer de 42 años con antecedente de exostosis múltiple hereditaria, y dolor y limitación de la movilidad de la cadera izquierda. Los estudios radiográficos mostraron osteoartrosis y exostosis femoral con displasia bilateral de cadera y subluxación de la cabeza femoral. Se realizó una artroplastia total de cadera izquierda con un implante no cementado modular. El resultado a los 7 años fue excelente. El objetivo de este artículo es mostrar una opción alternativa de reconstrucción para las deformidades complejas.

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Copyright of Gaceta Médica de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

La osteoartritis de la base del primer metacarpiano (OA CMC-1) es una patología que afecta mayormente a mujeres posmenopáusicas. Los síntomas principales que acompañan esta patología son el dolor, la pérdida de fuerza y la disminución de capacidad motora fina. A pesar de que se ha demostrado un déficit propioceptivo en personas con OA CMC-1, no hay evidencia suficiente sobre los efectos del trabajo propioceptivo. El objetivo de este estudio es determinar la efectividad del entrenamiento propioceptivo en la recuperación funcional. Se incluyeron un total de 57 pacientes, 29 del grupo control y 28 en el experimental. Ambos grupos llevaron a cabo el programa de intervención, y al grupo experimental se le incluyó además un protocolo de trabajo propioceptivo. Las variables de estudio fueron el dolor (EVA), percepción del desempeño ocupacional (COMP), sensación de posición (SP) y sensación de fuerza (SF). Se observó una mejora estadísticamente significativa en el grupo experimental en el dolor (p < 0,05) y el desempeño ocupacional (p < 0,001) a los 3 meses de tratamiento. No se encontraron diferencias estadísticas en la sensación de posición (SP) y la sensación de fuerza (FS). La correlación de nuestros resultados y los de estudios precedentes en cuanto a la efectividad del entrenamiento propioceptivo sobre las variables de estudio nos permite afirmar que la incorporación de un protocolo de ejercicios propioceptivos disminuye el dolor y mejora notablemente el desempeño ocupacional. Osteoarthritis at the base of the thumb (CMC-1 OA) is a pathology that mainly affects postmenopausal women. The main symptoms including pain, decreased hand-thumb strength and fine motor capacity. Although a proprioceptive deficit has already been demonstrated in people with CMC-1 OA, there is insufficient evidence regarding the effects of proprioceptive training. The main objective of this study is to determine the effectiveness of proprioceptive training in functional recovery. A total of 57 patients were included in the study, 29 in the control group and 28 in the experimental group. Both groups underwent the same basic intervention programme, but the experimental group included a proprioceptive training protocol. Variables of the study were pain (VAS), perception of occupational performance (COMP), sense position (SP) and force sensation (FS). Statistically significant improvement was observed in the experimental group in pain (p <.05) and occupational performance (p <.001) after 3 months of treatment. No statistical differences were found in sense position (SP) or sensation of force (FS). The results concord with previous studies focussing on proprioception training. The incorporation of a proprioceptive exercise protocol reduces pain and significantly improves occupational performance. [ABSTRACT FROM AUTHOR]

Introducción: Crain, en 1961, identificó presencia de inflamación en pacientes con osteoartritis de mano utilizando para ello el término de osteoartritis inflamatoria, cinco años después Peter et al. Observó alteraciones radiográficas erosivas en algunos casos de osteoartritis de mano. Objetivos: identificar la prevalencia de Osteoartritis erosiva de mano (EHOA), sus factores de riesgo y la sensibilidad de los criterios propuestos por Anandarajah. Metodología: Descriptivo de corte transversal, se comparó 400 pacientes 22 EHOA Y 378 Osteoartritis de manos (HOA) de enero 2021 a febrero 2022 recolectada por revisión de expedientes, los criterios de Anandarajah fueron utilizados. Resultados: La prevalencia de EHOA es de 5.82% por sexo varía del 4.76 al 1.06% en mujeres y hombres respectivamente, su inicio fue abrupto, el principal factor de riesgo es obesidad con diferencia estadísticamente significativa entre los grupos estudiados, otros factores son sexo femenino, hipertensión, dislipidemia, diabetes mellitus, trabajo manual y trauma articular con valores individuales mas elevados comparados con la HOA. Los criterios diagnósticos estudiados muestran una sensibilidad del 65% Conclusiones: EHOA presentó mayor componente inflamatorio, inicio abrupto de los síntomas y asociación a factores de riesgo que le predisponen a un estado proinflamatorio crónico; consideramos que la EHOA podría tener una etiopatogenia distinta que la diferencia de la HOA, empero estudios histológicos grandes serian necesarios. Palabras clave: Osteoartritis, Osteoartritis de mano, Osteoartritis de mano erosiva, incapacidad funcional, obesidad, dolor, erosiones centrales.

Of all the diseases of the musculoskeletal system, osteoarthritis (OA) is the most common arthritis, leading to enormous costs to society and great morbidity for sufferers. It is characterized by involvement of the entire joint, including cartilage degradation, bone remodeling, osteophyte formation and inflammation of the synovial membrane. This results in pain, stiffness, swelling and loss of joint function with marked functional limitation. Management of this entity involves non-pharmacological therapy, the use of drugs for pain relief and surgery when previous measures have failed. Non-pharmacological measures include education, muscle strengthening exercises, physical therapy, weight reduction and orthoses or devices to assist ambulation. As for recommended drugs, non-steroidal anti-inflammatory drugs, both topical and oral, and intra-articular glucocorticoids are recommended. Finally, partial meniscectomy by arthroscopy has only been recommended when there is knee locking. In individuals suffering from excruciating pain or severe functional limitation due to advanced disease, total joint replacement should be considered. [ABSTRACT FROM AUTHOR]

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Fundamento: el incremento de la esperanza de vida viene aparejado con la necesidad del adulto mayor de desenvolverse en su medio y garantizar una longevidad plena.Objetivo: determinar la efectividad de la peloideterapia en adultos mayores con osteoartrosis de rodilla.Métodos: se realizó un estudio de intervención, cuasi experimental, en 30 pacientes con osteoartrosis de rodilla, seleccionados mediante aleatorización simple, quienes fueron atendidos en el área de salud de Yaguaramas (Abreus, Cienfuegos), en el período comprendido entre marzo y junio de 2021. Se realizó una encuesta general. La evolución del dolor se determinó mediante la escala de Likert, y la limitación articular se analizó mediante la medición del arco articular de la rodilla con el goniómetro.Resultados: predominaron los pacientes del grupo de edades de 66-70 años y del sexo femenino; con tiempo de evolución entre 5-10 años (60 %); y con ambas rodillas afectadas (56,7%). Los principales signos y síntomas fueron el dolor (100 %) y la limitación del movimiento articular (93,3 %), los cuales disminuyeron tras el tratamiento. El 53,3 % refirió dolor ligero antes del tratamiento; después del tratamiento el 83,3 % describió ausencia de dolor. El 76,7 % de los pacientes manifestó limitación en la flexión de la rodilla, que después del tratamiento disminuyó a 13,3 %.Conclusiones: la peloideterapia influye positivamente en los adultos mayores con osteoartrosis de rodilla, al mejorar su estado funcional e independencia personal, además de reducir las demandas de servicios médicos.

One of the most important minimally invasive treatments today in temporomandibular joint osteoarthritis (TMJOA) is the intra-articular exogenous hyaluronic acid (HA) injection, which has yielded good results in pain relief and improves mandibular function with few side effects. However, the effectiveness of HA continues to be controversial, partly due to the heterogeneity in the injection protocols in their molecular weight, viscosity and frequency of infiltration, among other properties. The aim of this review is to identify the differences in the histological and clinical effects of the different types of HA and the frequency of infiltration on TMJ-OA treatment. Materials and methods: A bibliographic search was performed in the PubMed, Web of Science and Scopus databases. The search was limited up to September 2022. Search terms included "osteoarthritis", "hyaluronic acid, "molecular weight", "concentration", "viscosity", "dose" and "temporomandibular", using AND/OR as Boolean terms. Results: Exogenous HA in its different molecular weights offers an improvement in histological and clinical characteristics. Apparently, low and medium molecular weight HA presents better results. No clinical studies related to the degree of HA viscosity were found. Respect to the frequency of infiltration, single injection, weekly injections for 3 weeks, weekly injections for 5 weeks and other protocols are used. However, their comparison is complex. There seems to be differences in the effects of the different HA preparations for the treatment of TMJ-OA, mainly in their molecular weight. However, the evidence remains scant. [ABSTRACT FROM AUTHOR]

Osteoarthritis (OA) is a multifactorial and polygenic disease, which affects joints as well as the periarticular tissue, and it represents a huge economic cost to public health systems worldwide. Numerous genes that are involved in the pathogenesis of the disease are already identified. More recently, the epigenetic mechanisms are being researched as the potential risk factors for osteoarthritis. MicroRNAs (miRNAs) are small non-coding molecules which play a role in the post-transcriptional regulation of gene expression. Their genes make up to 1-2% of the total genome and it is thought that they could potentially regulate up to 30% of the coding genes. MiRNAs have important role in the pathogenesis of some cancers, cardiovascular, autoimmune, skin and neurological diseases. Furthermore, the above mentioned molecules have an important role in the pathogenesis of osteoarthritis. Various miRNA molecules are expressed differently in the cartilage affected by osteoarthritis as compared to the healthy cartilage. Certain miRNA molecules have also been shown to regulate enzymes responsible for cartilage degradation, some were associated with the regulation of chondrocyte apoptosis and some involved in cartilage regeneration processes. Due to these findings, some of the following studies tried to prove the connection between certain single nucleotide polymorphisms of some miRNA genes and the proneness to osteoarthritis. Given that all current therapies for osteoarthritis aim at treating the consequences of the disease rather than curing the cause, further research into etiopathogenesis of osteoarthritis is required. The MiRNA molecules could play an important role in the pathogenesis of the osteoarthritis and might easily be among the potential targets for the new pharmaceutical therapies. [ABSTRACT FROM AUTHOR]

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El objetivo de este trabajo fue determinar la presencia de lesiones articulares en tarsos de toros de razas carniceras. Se utilizaron 22 (veintidós) tarsos de toros de entre 18 meses y 6 años de edad, de razas carniceras y sus cruzas, obtenidos de frigoríficos de la localidad de Rio Tercero y Río Cuarto. El examen radiológico consistió de tres (3) proyecciones radiográficas, una Dorso- Plantar o frente, una Dorsolateral – Plantaromedial Oblicua 45° (DLPMO 45º) y una Dorsomedial – Plantarolateral Oblicua 45º (DMPLO 45º). Posteriormente, se procedió a realizar la disección anatómica convencional de cada tarso. Una vez que fueron expuestos todos los componentes óseos se realizó una inspección detallada de cada uno de ellos. Los resultados obtenidos en el estudio radiológico arrojaron que en 20 de los 22 tarsos hubo presencia de lesiones articulares, encontrándose signos de osteoartritis y osteocondritis. En cuanto a la inspección macroscópica se encontraron lesiones en los 22 tarsos estudiados. En 21 tarsos se encontraron lesiones de oteocondritis disecante, mientras que en 22 tarsos estudiados hubo lesiones compatibles con osteoartritis. Se puede concluir que los toros sufren de osteocondritis disecante y osteoartritis en sus tarsos, mientras que la osteocondritis disecante y osteoartritis asientan principalmente en la articulación tibio – talar. DOI: https://doi.org/10.5281/zenodo.7484755

Latar Belakang: Osteoartritis (OA) merupakan penyakit degeneratif sendi yang disebabkan oleh faktor biomekanik dan biokimia (stress oksidatif). Stres oksidatif dapat meningkatkan terjadinya kerusakan pada kartilago sendi. Malondialdehid merupakan biomarker stres oksidatif. Objektif: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian mesenchymal stem cell Wharton’s Jelly terhadap kadar MDA serum tikus model osteoartritis Metode: Penelitian ini merupakan penelitian eksperimental dengan posttest-only control group design. Sebanyak 24 ekor tikus dibagi menjadi empat kelomok, yaitu P1, P2, P3, dan P4. Semua kelompok diinduksi monosodium iodoacetate (MIA) secara intra-artikular pada lutut kiri tikus dan dibiarkan selama 21 hari sehingga mengalami OA. P1 dan P3 adalah kelompok tikus OA tanpa diterapi MSC-WJ selama 4 minggu dan 8 minggu. P2 dan P4 adalah kelompok tikus OA yang diterapi MSC-WJ selama 4 minggu dan 8 minggu. Pengukuran kadar MDA serum dilakukan dengan metode thiobarbituric acid reactive substances (TBARS). Analisis data menggunakan One way ANOVA dan Post Hoc Bonferroni. Hasil: Rerata kadar MDA serum pada kelompok P1 (2,78 nmol/ml), kelompok P2 (2,03 nmol/ml), kelompok P3 (3,66 nmol/ml), dan kelompok P4 (1,77 nmol/ml). Terdapat perbedaan yang bermakna pada tiap kelompok dengan p= 0,000 (p

Background: the increase in life expectancy is coupled with the elderly’s need to function in its media and guarantee full longevity. Objective: to determine the effectiveness of peloidtherapy in older adults with osteoarthritis of the knee. Method: a quasi-experimental intervention study was carried out in 30 patients with osteoarthritis of the knee, selected by simple randomization, who were treated in the health area of Yaguaramas (Abreus, Cienfuegos), between March and June of 2021. A general survey was carried out. The evolution of pain was determined using the Likert scale, and joint limitation was analyzed by measuring the knee joint arc with the goniometer. Results: there was a predominance of patients in the age group of 66-70 years old and of the female sex; with evolution time between 5-10 years (60%); and with both knees affected (56.7%). The main signs and symptoms were pain (100%) and limitation of joint movement (93.3%), which decreased after treatment. 53.3% reported light pain before treatment; after treatment, 83.3% described absence of pain. 76.7% of the patients manifested limitation in knee flexion, which after treatment decreased to 13.3%. Conclusions: peloidtherapy has a positive influence on older adults with osteoarthritis of the knee, by improving their functional status and personal independence, as well as reducing the demands for medical services. [ABSTRACT FROM AUTHOR]

To determine the disease burden and costs in patients with hip or knee OA and chronic moderate-to-severe refractory pain, receiving strong opioids in Spain. This was a 36-month longitudinal secondary analysis of the real-word OPIOIDS study. Patients aged ≥18 years with hip or knee OA and chronic moderate-to-severe refractory pain receiving strong opioids were considered. The disease burden included analgesia assessments (NRS scale), cognitive functioning (MMSE scale), basic activities of daily living (Barthel index), and comorbidities (severity and frequency). Costs due to the use of healthcare resources and productivity loss were estimated. 2832 patients were analyzed; age was 72.0 years (SD = 14.3), 76.8% were women. Patients had mainly been treated with fentanyl (n = 979; 37.6%), tapentadol (n = 625; 24.0%), oxycodone (n = 572; 22.0%), and buprenorphine (n = 425; 16.3%). Pain intensity decreased by 1 point (13.7%), with a 2.6-point decline in the cognitive scale (14.3%, with a 5.3%-increase in patients with cognitive deficit) over a mean treatment period of 384.6 days (SD: 378.8). Barthel scores decreased significantly yielding to a slightly increase in proportion of patients with severe-to-total dependency; 1.2%–2.9%. In the first year of treatment, average healthcare costs were €2013/patient, whereas the average productivity loss cost was €12,227/working-active patient. Strong opioids resulted in high healthcare costs with a limited reduction in pain, an increase in cognitive deficit, and a slight increase of patients with severe to total dependency over 36 months of treatment. [ABSTRACT FROM AUTHOR]

Introduction: osteoarthritis is one of the most prevalent chronic diseases in the world and is defined as the gradual loss of cartilage in the joints, mainly that of the knee. It is considered a cause of disability in older adults and is characterized by pain, stiffness and loss of mobility. Material and methods: observational study to evaluate the effect of the combination of non-hydrolyzed type II native collagen (CII-NH), omega-3 (Om-3) and astaxanthin (AX), in a population of 182 patients with knee osteoarthritis grade I/II. Measurements of thigh circumference, arcs of movement and pain were obtained through international scales such as the visual analogue pain scale (VAS), the Lequesne index and the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) scale. Medical check-ups were performed every 30 days for three months. The Statgraphics software (Statgraphics Technologies, Virginia) was used, the evaluation of the variables and the statistical significance were determined by t Student test and the results are shown as a mean. Results: it was shown that daily consumption increases mobility, decreases knee pain and inflammation in patients within three months. Additionally, there was a reduction in the consumption of nonsteroidal antiinflammatory drugs (NSAIDs) by the study subjects. Conclusion: the fixed combination of non-hydrolyzed type II collagen, omega-3 and astaxanthin, generates, in the short term, a decrease in inflammation and stiffness in patients with osteoarthritis. [ABSTRACT FROM AUTHOR]

Copyright of Tesla Revista Científica is the property of Puerto Madero Editorial Academica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introducción: La osteoartritis (OA) es la patología reumatológica más prevalente a nivel mundial, que produce intenso dolor crónico especialmente en las articulaciones de soporte, como es la rodilla. Dentro de las nuevas dianas terapéuticas para la OA de rodilla, se encuentra el bloqueo nervioso junto a sus diversos tipos y técnicas, que ayudan a mejorar significativamente dolor y funcionalidad integral del paciente. Objetivo: Revisar la evidencia actual sobre los tipos y técnicas del bloqueo nervioso en la osteoartritis de rodilla. Métodos: Se realizó una revisión sistemática siguiendo las directrices PRISMA, de distintos estudios según los criterios de inclusión, en la base de datos de: PubMed, MedScape, ScienceDirect, Scopus y ProQuest, desde enero del 2018 a enero del 2023. Resultados: En la búsqueda sistemática se obtuvieron 9034 artículos, tras eliminar duplicados y conforme los criterios de inclusión y exclusión se filtraron un total de 19 artículos, entre ellos 10 eran ensayos aleatorios controlados y 9 estudios observaciones, que cumplian todos los criterios de elegibilidad. Conclusión: De acuerdo a los resultados de los estudios, existe evidencia de la eficacia y seguridad del bloqueo genicular en el alivio del dolor crónico en la OA de rodilla, siendo una opcion recomendable como complemento en el abordaje terapeutico de esta patología. La tecnica que se aplique depende del contexto clínico del paciente y del profesional que realizará el procedimiento, los resultados a largo plazo no tienen diferencia significativa.

La osteoartritis de rodilla (OA) es un problema importante de salud pública porque causa dolor y limitación funcional en los pacientes. Sin embargo, el compromiso con la autogestión puede minimizar el impacto de la OA en la salud de los pacientes que padecen esta enfermedad. Para estar completamente comprometido con las actividades de autogestión, el conocimiento sobre OA es un requisito previo. Hay datos acerca de la comprensión de las personas sobre OA y sus necesidades de información sobre OA. La Educational Needs Assessment Tool -versión en español (SpENAT, por sus siglas en inglés) es un cuestionario autoinformado que evalúa las necesidades educativas (Ned) con el fin de brindar información adaptada y enfocada a pacientes con OA de rodilla. Consta de 39 preguntas agrupadas en 7 dominios: dolor, movimiento, sentimientos, osteoartritis, tratamiento médico, tratamiento no médico y ayuda. Estimar las Ned en pacientes con OA de rodilla utilizando el SpENAT. Se realizó un estudio observacional, descriptivo y transversal en 215 pacientes con diagnóstico de OA de rodilla según criterio del American College of Rheumatology que acudieron a la consulta protocolizada de patología de rodilla del servicio de Reumatología del Hospital Clínico Quirúrgico Hermanos Ameijeiras durante el período de estudio comprendido entre enero de 2017 y agosto de 2020. Se registraron datos demográficos, nivel educativo y características de la enfermedad. Todos los pacientes completaron el SpENAT y se les preguntó sobre las fuentes a las que recurrieron para obtener información sobre su enfermedad. Predominaron las mujeres mayores de 50 años y con sobrepeso con diagnóstico de OA. Se observaron mayores Ned en los dominios movimiento, ayuda, dolor, sentimiento, OA. Los pacientes mayores de 50 años, mujeres, con normopeso y trabajador activo mostraron mayor interés en el dominio del movimiento. La fuente de información más utilizada fue el reumatólogo (91,60%). Las Ned en pacientes con OA de rodilla son altas, resultando más altas en los dominios de movimiento, dolor, ayuda y sentimiento. El reumatólogo es la principal fuente de información para los pacientes con OA. Parece prudente tratar de diseñar una estrategia específica para educar a las personas sobre OA con el fin de proporcionarles, apoyarlas y prepararlas para el autocuidado. Knee osteoarthritis (KOA) is a major public health issue because it causes pain and functional limitation in patients. Engagement with self-management may, however, minimize the impact of KOA on the health of patients suffering this illness. To be fully engaged with self-management activities, knowledge about KOA is a prerequisite. There is data on people's understanding of KOA and their needs for information about KOA. The Educational Needs Assessment Tool- Spanish version (SpENAT) is a self-reported questionnaire that assesses educational needs (Ned) in order to provide information adapted and focused on patients with knee KOA. It comprises 39 questions grouped into seven domains: Pain, Movement, Feelings, Osteoarthritis, Medical treatment, Non-medical treatment, Help. To estimate the Ned in patients with knee KOA using the SpENAT. An observational, descriptive, and cross-sectional study was carried out in 215 patients with a diagnosis of knee KOA according to the criteria of the American College of Rheumatology who attended the service's protocolized consultation of knee conditions of rheumatology at the "Hermanos Ameijeiras" Surgical Clinical Hospital during the study period between January 2017 and August 2020. Demographic data, educational level and characteristics of the disease were recorded. All patients completed the SpENAT and were questioned about the sources they turn to obtain information on their disease. Women over 50 years of age and overweight with a diagnosis of OA predominated. Major Ned were observed in the domains of movement, help, pain, feeling, KOA. Patients over 50 years of age, female, normal weight, and active workers showed greater interest in the movement domain. The most used source of information was the rheumatologist (91.60%). The Ned in patients with knee KOA are high, and are higher in the domains of movement, pain, help and feeling. The rheumatologist is the main source of information for patients with KOA, it seems wise to design a targeted strategy to educate people about KOA to provide, support and prepare them for self-management. [ABSTRACT FROM AUTHOR]

Objetivo: Comparar los resultados funcionales del reemplazo total de rodilla con resuperficialización de rótula o sin resuperficialización, con dos años de seguimiento. Materiales y Métodos: Estudio observacional retrospectivo de grupos comparativos de pacientes con osteoartritis sometidos a un reemplazo total de rodilla primario con resuperficialización de rótula o sin este procedimiento, entre enero de 2014 y diciembre de 2016, dos centros de Colombia. A todos se les colocó una prótesis cementada Optetrak®. La función se evaluó previo cirugía y a los dos años mediante las escalas Knee Society Score (KSS), Hospital for Special Surgery (HSS) y Oxford Knee Score (OKS). Resultados: Se incluyeron 206 reemplazos totales de rodilla: 94 (grupo con resuperficialización) y 112 (grupo sin resuperficialización). La media de la edad en la cohorte de estudio era de 66.9 ± 9.7 años y el 76,7% (n = 155) eran mujeres. El tiempo quirúrgico fue más prolongado en el grupo con resuperficialización (mediana 100 min, RIC 90-110) que en el otro grupo (mediana 85 min, RIC 70-90; p

Introduction: Overweight negatively impacts the cardiovascular system and osteomyoarticular, promoting pain in the joints of the lower limbs. Therefore, strategies have been applied to reduce overweight through lifestyle changes. Objective: to investigate the effects of two multidisciplinary intervention programs on the health-related physical fitness of obese women with pain symptoms in the knees. Methods: Women between 40 and 59 years of age with obesity (n=59) were evaluated in the pre- and post-intervention time regarding anthropometry, body composition, physical fitness, level of disability in the knee and hip, and health-related quality of life. A randomized clinical trial of parallel groups was conducted, using two resistance exercise programs and food re-education, for eight weeks. All participants received the same nutritional intervention content and for physical exercises were randomized into two groups, G1 being the "strength group" using machines (n=30), and G2 being the "functional training" group (n=29). Twenty-eight women (G1=18 + G2=10) were included in the final analyses. The groups and time were evaluated by two-way analysis of variance, with repeated measures. A p < 0.05 was assumed for all analyses. Results: a time effect was identified, with higher values for maximum isometric lumbar-traction strength (MILTS), after the intervention period in both groups (p < 0.05). However, for the other variables investigated, no significant differences were identified (p > 0.05). Conclusion: The absence of significant results for all variables, except FIMTL, may be justified by the moderate adherence of the participants to interventions (~59% to 66%) since the study was conducted during the period of social isolation (COVID-19). However, it is believed that the intervention models were positive in maintaining the variables studied.

Introduction: osteoarthritis is a chronic degenerative joint disease, with an inflammatory component included, its characterized by degeneration and progressive loss of hyaline cartilage and subchondral bone and also for synovial tissue damage. Objective: to describe the clinical and epidemiological aspects of patients diagnosed with osteoarthritis at the Provincial Hospital of Zaire in the Republic of Angola, from September 2021 to September 2022. Method: a descriptive, longitudinal cohort study was carried out using the data gathered from the Department of Orthopedics and Traumatology of the institution. The universe consisted of 489 patients and the study sample consisted of n꓿167. Bivariate correlation tests were performed using the Pearson's correlation coefficient analysis. Results: the predominant age group was 61 to 70 years old (28.7%), with women sex as predominant (58.1%), with an evolution time of more than 5 years (35.9%), and the knee was the most affected joint (observed in 62 patients). A considerable positive correlation between the time of the disease evolution and the degree of disability was demonstrated using the Pearson's coefficient value (0.407), value that shows a great statistical significance. Conclusions: osteoarthritis is a degenerative disease of varied etiology that occurs at early ages, more frequently in the female sex associated with the knee joint, and there is a correlation between the time of evolution and the degree of disability produces by the disease.

Copyright of Revista de Investigación en Salud VIVE is the property of Revista de Investigacion en Salud VIVE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The tarsus is a highly predisposed structure to present various injuries, with osteoarthritis being one of the main causes of pathology at the joint level. Several factors related to joint damage have been considered; the most common are external trauma, joint instability, ossification alterations, infections and iatrogenesis. In the diagnosis, conventional radiography is established as a diagnostic aid of wide value, commonly finding lesions such as osteophytes, decreased joint space, sclerosis, bone proliferation, periosteal reaction and bone lysis. The objective of this investigation is to determine the frequency of radiological findings in the tarsus, for which a retrospective descriptive study is carried out, in which a database of 53 horses of the Colombian Creole breed was evaluated, of which, according to the criteria of selection, n = 23 animals were obtained, for a total of 46 tarsus radiographs. The variables to be determined are the presence of arthrophytes, decreased joint space, bone proliferation, sclerosis, periosteal reaction, bone lysis, osteophytes and enthesophytes, of which it was found that the arthrophyte is the most common finding, with 56.52% (26/46), followed by the decrease in joint space, with 30.43% (14/46). It was also determined that the most affected anatomical structures were the intertarsal joints, being the distal intertarsal the one with the highest frequency of presentation, with 67.4% (31/46), and the proximal intertarsal, with 58.66 (27/46). [ABSTRACT FROM AUTHOR]

Osteoarthritis is a disease that is increasingly present in the population due to the pandemic of obesity, formerly attributed exclusively to obesity by weight load as the only factor that injured the joints, especially weight-bearing joints, This concept has been confirmed by research and evidence that weight gain alone is not an exclusive etiological factor, since the study of adipose tissue and its endocrine action, such as the production of leptin, has demonstrated its participation in the destruction of weight-bearing and non-weight-bearing joint structures. [ABSTRACT FROM AUTHOR]

Copyright of Revista Argentina de Antropología Biológica is the property of Revista Argentina de Antropologia Biologica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Closing wedge high tibial osteotomy (CW-HTO) is a surgical option for active patients with medial knee pain and mild-moderate osteoarthritis with varus limb deformity. Despite its good reported results, this technique has been losing popularity. The aim of this study was to analyse the survival rate, clinical functional outcomes and radiological results of CW-HTO., Methods: It is a retrospective case series study. Seventy patients with primary knee osteoarthritis, operated on between 2010 and 2020 in a single Spanish tertiary hospital using the CW-HTO technique and with a minimum follow-up of 2 years were analysed., Results: Survival rate was 87.6% and 75.5% after a follow-up of 5 and 10 years respectively. Functional outcomes were good-to-excellent (KSS 77.7/100 and OKS 35.6/48) and good pain control (VAS 3.9/10) and high satisfaction (7.2/10) were achieved. Limb varus malalignment was significantly corrected (mean postoperative HKA angle 177.6° and MPTA 90.7°). However, 30% of patients presented hypocorrection, which was associated with inferior survival, functionality and satisfaction., Conclusion: CW-HTO technique can be useful for patients with knee osteoarthritis and varus limb. It allows to correct varus malalignment while achieving good-to-excellent functional outcomes, good pain control, high patient satisfaction and acceptable medium-long term survival rate. However, it is associated with a non-negligible risk of hypocorrection or medial hinge disruption., (Copyright © 2023 SECOT. Publicado por Elsevier España, S.L.U. All rights reserved.)

Introducción: la osteoartritis de rodilla (OR) se define como una enfermedad crónica, inflamatoria, degenerativa y progresiva, caracterizada por el deterioro del cartílago articular. Tiene manifestaciones clínicas y etiológicas diferentes según el grupo etario y se encuentra asociada con múltiples factores que intervienen en la fisiopatología, entre los que están: edad, raza, sexo, sobrepeso, obesidad y síndrome metabólico. Objetivo: determinar los factores de riesgo que influyen en el proceso degenerativo de la OR en la adultez temprana y tardía. Materiales y métodos: revisión sistemática de la literatura científica en diferentes bases de datos que incluyeron estudios de cohorte, transversales, casos y controles, evaluando los factores de riesgo predisponentes. Resultados: se seleccionaron 50 artículos que cumplieron con los criterios, identificando diferentes factores que afectan el desarrollo o progresión de la OR como las alteraciones metabólicas, sistémicas y estilo de vida que influyen en esta patología, además de factores modificables y no modificables. Conclusión: la OR es una afección de carácter multifactorial, donde la obesidad, la hipertensión arterial (HTA), el índice de masa corporal (IMC) elevado, los niveles altos de LDL, la debilidad muscular e incluso la profesión del paciente, son los principales factores predisponentes para desarrollar o aumentar su progresión.

Copyright of Revista Latinoamericana de Hipertension is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

El uso de cohortes de osteoartritis bien caracterizadas es obligatorio para estudiar y profundizar en el conocimiento en esta enfermedad. En España no existe actualmente ninguna cohorte prospectiva en este ámbito; por ello, el objetivo de este trabajo es describir la primera cohorte de osteoartritis en España: la PROCOAC (PROspective COhort of A Coruña). El Servicio de Reumatología del Hospital Universitario de La Coruña inició un estudio de seguimiento prospectivo en el año 2006. Los criterios de inclusión fueron: a) pacientes mayores de 55 años a los que se les realizó una radiografía abdominal que permitiese estudiar ambas caderas; b) pacientes diagnosticados de osteoartritis radiográfica de mano según los criterios ACR; c) pacientes diagnosticados de osteoartritis radiográfica de rodilla o cadera según los criterios ACR. Se realizó seguimiento cada 2 años y se recogió información clínica, analítica, genética y radiográfica. La cohorte consta de 937 individuos; 873 tienen osteoartritis radiográfica de rodilla, 783 de cadera y 679 de mano. La edad media de la población es 63,9 ± 8,9 años y el IMC promedio de 29,6 ± 5,1. Más de la mitad de la población tiene hipertensión arterial y el 17%, diabetes. La osteoartritis predominante en la mano es la nodular (78,1%), seguida de la rizartrosis (55,3%) y la erosiva (18,4%). El 21,4% y el 43,1% tienen sanas la rodilla y la cadera, respectivamente. Se observa un grado 1 en el 26% y 37%; un grado 2 en el 26,7% y 11,5%; un grado 3 en el 14,9% y 4%; y un grado 4 en el 9,4% y 3,7%, respectivamente. El 44,1% de la población tiene una articulación afectada, el 39,9% tiene 2 y el 13,4% tiene las 3 articulaciones afectadas. La edad (OR = 1,11; p < 0,001), el IMC (OR = 1,11; p = 0,002) y el WOMAC total (OR = 1,03; p = 0,005) son los únicos factores de riesgo si comparamos la afectación de una sola ubicación frente a 3. También se detectó una discrepancia entre el dolor y el daño radiográfico articular en pacientes con grado KL ≤ 2, de modo que un porcentaje significativamente mayor de pacientes con osteoartritis de rodilla experimentaron dolor (66,1%) en comparación con los pacientes de cadera (21,1%) (p < 0,001). La cohorte PROCOAC es un instrumento que permite realizar estudios de incidencia y progresión en la osteoartritis de mano, rodilla y cadera, así como conocer factores que se asocian con los diferentes fenotipos de osteoartritis. The use of well characterized osteoarthritis cohorts is mandatory for the study and knowledge of this disease. Currently, there is no prospective cohort in this pathology in Spain. The objective of this work is to describe the first osteoarthritis cohort in Spain, PROCOAC (Cohort PROspectiva de A Coruña). The Unit of Rheumatology of the University Hospital of A Coruña started a prospective follow-up study in 2006. The patient inclusion criteria were: a) patients older than 55 years who underwent an abdominal x-ray to study both hips; b) patients diagnosed with radiographic hand osteoarthritis according to ACR criteria; c) patients diagnosed with radiographic knee or hip osteoarthritis according to ACR criteria. Follow-up was performed every 2 years collecting clinical, analytical, genetic and radiographic information. The cohort consists of 937 patients, 873 have radiographic knee osteoarthritis, 783 hip osteoarthritis and 679 hand osteoarthritis. The mean age of the population is 63.9 ± 8.9 years and the average BMI is 29.6 ± 5.1. More than half of the population has high blood pressure and 17% diabetes. The predominant osteoarthritis in the hand is nodular (78.1%), followed by trapeziometacarpal (55.3%) and erosive (18.4%). Of them, 21.4% and 43.1% are healthy at knee and hip level respectively; observing a grade 1 in 26% and 37%; a grade 2 in 26.7% and 11.5%; a grade 3 in 14.9% and 4%; and a grade 4 in 9.4% and 3.7%, respectively. Of the population, 44.1% has only one joint affected, 39.9% has 2 and 13.4% has 3 joints affected. Age (OR = 1.11; P <.001), BMI (OR = 1.11; P =.002) and total WOMAC (OR = 1.03; P =.005) are the only risk factors if we compare the involvement of a single location versus 3. A discrepancy between pain and radiographic damage at the joint level was also detected in patients with KL ≤ 2 grade, and therefore a significantly higher percentage of patients with knee osteoarthritis experienced pain (66.1%) compared to patients with osteoarthritis hip (21.1%) (P <.001). The PROCOAC cohort is an instrument that allows studies of incidence and progression in hand, knee and hip osteoarthritis; as well as determining factors that are associated with the different osteoarthritis phenotypes. [ABSTRACT FROM AUTHOR]

Knee osteoarthritis usually affects almost all people above 80 years old, pain and decrease of mobility is one of the main reasons for consultation of these patients. The consequences of this joint disorder are a decrease in the quality of life and an increased risk of falls. Nowadays, surgery is indicated in cases where medical treatment (kinesiology, NSAIDs, infiltrations, etc) did not have beneficial results, our questioning is whether subjetin an older adult to the risks of mayor surgery improves the quality of life and reduces complications to the adverse effects that medical treatment may have. To settle the question, we analyzed the available literature to reach a conclusion. After the analysis we can conclude that total knee joint replacement surgery showed an improvement in quality of life, with a decrease in pain in 100% of the patients, reducing the risk of falls. Complications, although they exist, have a low incidence. [ABSTRACT FROM AUTHOR]

Copyright of Revista Latinoamericana de Hipertension is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

La osteoartritis (OA) es considerada como la enfermedad articular degenerativa más frecuente en la población adulta, siendo una causa importante de discapacidad a nivel mundial, y su prevalencia va en aumento asociada a diferentes factores entre ellos la obesidad. La obesidad junto con el síndrome metabólico se han asociado con un estado pro inflamatorio debido a la liberación de citocinas que inducen cambios en el metabolismo del cartílago. La quemerina es una adipocina secretada principalmente por adipocitos, y tiene como acción final, el aumento de la producción de IL-6, IL-8, IL-1b, TNF-a y metaloproteinasas por parte de macrófagos, células dendríticas y condrocitos, las cuales son encargadas del daño del cartílago articular. Esta es una de las razones por la que se ha relacionado la obesidad y la inflamación con la OA. El objetivo principal de este estudio consiste en determinar si las concentraciones de quemerina en suero de un grupo de pacientes con OA primaria son mayores al compararlos con individuos controles sanos; y adicionalmente determinar la relación entre la presencia de obesidad/sobrepeso con la severidad de la enfermedad medida por una escala radiológica. Se realizó un estudio de corte transversal analítico donde se cuantificaron los niveles de quemerina en suero mediante ensayo por inmunoadsorción ligado a enzimas (ELISA), en pacientes con OA primaria de cadera, rodilla y mano con criterios del American College Of Reumathology (ACR) y controles sanos. Se analizaron los estudios radiológicos de los pacientes y controles para determinar la severidad del compromiso articular aplicando el sistema de clasificación de Kellgren y Lawrence (KL). Se verificó la significación estadística de la diferencia de los valores de quemerina sérica entre los dos grupos y se analizó la correlación entre las variables de índice de masa corporal (IMC) con severidad radiológica, número de regiones articulares y niveles de quemerina sérica. Durante el período de julio de 2015 a julio de 2016 fueron recolectadas muestras de suero y radiografías de las articulaciones comprometidas de 40 pacientes con OA primaria que cumplieron los criterios de inclusión, así como muestras de suero de 20 controles sanos. La concentración promedio de quemerina fue más alta en el grupo de pacientes con OA comparado con el con el grupo control, siendo de 373 ng/ml y 175,55 ng/ml respectivamente (p < 2,2 × 10−16). No se encontraron asociaciones significativas entre los diferentes grados severidad de la enfermedad medida por escala radiológica KL como con el número de regiones articulares comprometidas y el IMC. En un grupo de pacientes con OA primaria de mano, rodilla o cadera, los valores de quemerina fueron superiores a los encontrados en los controles sanos, sin asociación significativa con la severidad de la enfermedad establecida radiológicamente por escala K/L, el número de regiones articulares comprometidas y el IMC. Osteoarthritis (OA) is considered the most common degenerative joint pathology in the adult population, being an important cause of disability worldwide, and its prevalence is increasingly associated with different factors, including obesity. Obesity together with metabolic syndrome have been associated with a pro-inflammatory state due to the release of cytokines that induce changes in cartilage metabolism. Chemerin is an adipokine secreted mainly by adipocytes and its final action is to increase the production of IL-6, IL-8, IL-1b, TNF-α and metalloproteinases by macrophages, dendritic cells and chondrocytes, which are responsible for damage to the articular cartilage. This is one of the reasons that obesity and inflammation have been linked to OA. The main objective of this study is to determine whether the serum chemerin concentrations of a group of patients with primary OA are higher when compared with control individuals. A further purpose of the study is to determine the relationship between the presence of obesity/overweight with the severity of the disease measured by a radiological scale. An analytical cross-sectional study was carried out where serum chemerin levels were quantified by enzyme-linked immunoadsorption assay (ELISA), in patients with primary OA of the hip, knee and hand with criteria from the American College Of Rheumatology (ACR) and controls. Radiological studies of patients and controls were analysed to determine the severity of joint involvement using the Kellgren and Lawrence (KL) classification system. The statistical significance of the difference in serum chemerin values between the two groups was verified and the correlation between the variables of body mass index (BMI) with radiological severity, number of joint regions and serum chemerin levels was analysed. During the period from July 2015 to July 2016, serum samples and radiographs of compromised joints were collected from 40 patients with primary OA who met the inclusion criteria, as well as serum samples from 20 controls. The average concentration of chemerin was higher in the group of patients with OA compared to that of the control group, being 373 ng / ml and 175.55 ng / ml respectively (p<2.2×10−16). No significant associations were found between the different degrees of disease severity measured by the KL radiological scale, such as the number of involved joint regions and BMI. In a group of patients with primary OA of the hand, knee or hip, the values of chemerin were higher than those found in controls, without significant association with the severity of the disease established radiologically by K/L scale, the number of involved joint regions, and the BMI. [ABSTRACT FROM AUTHOR]

To determine the comorbidities associated with disability in patients with OA in Mexico (2013–2015). A cross-sectional, retrospective and multicentre IMPACTAR study (n = 7703) in Mexican patients (2013–2015). Comorbidities associated with disability were identified in 4971 patients diagnosed with OA from the IMPACTAR registry (n = 7073). An adjusted logistic regression analysis was carried out by demographic, economic, clinical and medical variables. Mean age was 63 years; and 75% of the patients were women. Subjects with OA and presence of comorbidities are 42% more likely to develop disabilities than patients without associated comorbidity, considering age, sex, family income, OA diagnosis duration, and education level. The highest rate of people with disability (28.9%) was concentrated in Region 7, which corresponds to Mexico City. There are also significant differences between median family incomes, when the income of persons with disability is under $13 000 (IQR: 9000–16 000) Mexican pesos, compared to patients without disability. Almost half of the subjects (49.6%) reported having at least one comorbidity. Arterial hypertension was the risk factor with a statistically significant difference (32.8%) among those with disability (34.7%). Programs and interventions for OA patients should take into consideration comorbidity factors, being female, family income, and the region of residence as variables that may increase the possibility of developing an OA-associated disability. [ABSTRACT FROM AUTHOR]

La Sociedad Española de Reumatología elaboró en el año 2000 el estudio EPISER2000 para conocer la prevalencia de la artrosis y otras enfermedades reumáticas en España. Los cambios sociodemográficos y en los hábitos de vida ocurridos en los últimos años en España justifican actualizar los datos de las enfermedades reumáticas (EPISER2016). Estimar la prevalencia de artrosis sintomática de columna cervical, columna lumbar, cadera, rodilla y mano, en población adulta en España. Estudio transversal de base poblacional. Se realizó un muestreo aleatorizado polietápico estratificado y por conglomerados. Los participantes fueron contactados por teléfono para cumplimentar un cuestionario de cribado de artrosis. El reumatólogo confirmaba o descartaba el diagnóstico. Se utilizaron los criterios-clínicos-ACR para diagnosticar artrosis de manos y los criterios clínico-radiológicos-ACR para diagnosticar la artrosis de rodilla y cadera. La prevalencia de artrosis en España en una o más de las localizaciones estudiadas fue de 29,35%. La prevalencia de artrosis-cervical fue del 10,10% y de artrosis-lumbar del 15,52%. Ambas son más frecuentes en mujeres y a mayor edad, así como en personas con niveles de estudios bajos y obesidad. La prevalencia de artrosis de cadera fue del 5,13% y la de artrosis de rodilla del 13,83%; estas se asocian con el sexo femenino, sobrepeso y obesidad, menor frecuencia en nivel de estudios alto y con la edad. La prevalencia de la artrosis de mano fue del 7,73%. Es más frecuente en mujeres, obesas, con bajo nivel de estudios y mayor edad. El estudio EPISER2016 es el primero que analiza la prevalencia de artrosis sintomática en 5 localizaciones (columna cervical, lumbar, rodilla, cadera y manos) en España. La artrosis de la columna lumbar es la más prevalente. The Spanish Society of Rheumatology carried out the EPISER2000 study in 2000 to determine the prevalence of osteoarthritis and other rheumatic diseases in the Spanish population. Recent sociodemographic changes and lifestyle habits in Spain justified updating the epidemiological data on osteoarthritis and other rheumatic diseases (EPISER2016-study). To estimate the prevalence of symptomatic osteoarthritis of the cervical spine, lumbar spine, hip, knee and hand in the adult population in Spain. Cross-sectional population-based study. A multistage and stratified random cluster sampling was carried out. The participants were contacted by telephone to complete an osteoarthritis screening questionnaire. A rheumatologist confirmed or discarded the diagnosis. The ACR-clinical-criteria were used to diagnose hand-osteoarthritis and the ACR-clinical-radiological criteria to diagnose knee- and hip-osteoarthritis. To estimate the prevalence and its 95% confidence interval, weights were calculated according to the probability of selection in each of the sampling stages. The prevalence of osteoarthritis in Spain in one or more of the locations studied was 29.35%. The prevalence of cervical-osteoarthritis was 10.10% and of lumbar-osteoarthritis 15.52%. Both are more frequent in women and at older ages, as well as in people with low levels of education and obesity. The prevalence of hip-osteoarthritis was 5.13%, that of knee-osteoarthritis 13.83%, these are associated with female sex, overweight and obesity. The prevalence of hand osteoarthritis was 7.73%. It is more frequent in women, who are obese, with a low educational level and who are older. The EPISER2016 study is the first to analyse the prevalence of symptomatic osteoarthritis in 5 locations (cervical, lumbar, knee, hip and hands) in Spain. Lumbar spine osteoarthritis is the most prevalent. [ABSTRACT FROM AUTHOR]

Amaç: Farklı kemik mineral yoğunluğu (KMY) olan kadın ve erkek erken ve geç evre osteoartritli (OA) yaşlılarda, vitamin D düzeyinin OA ve KMY üzerine etkisini ve ayrıca D vitamini ve diz fonksiyon skorları arasındaki ilişkiyi belirlemeyi amaçladık.Gereç ve Yöntem: Çalışmaya diz OA olan yüz kırk iki kadın ve yüz otuz beş erkek hasta alındı. Diz OA erken ve geç evre olarak sınıflandırıldı. Western Ontario ve McMaster Universities Osteoarthritis indexi (WOMAC) indeksi, Knee Injury ve Osteoarthritis Outcome Skoru (KOOS) hesaplandı ayrıca KMY ve D vitamini düzeyleri ölçüldü. Bulgular: Kadın OA de D vitamini düzeyleri erkek OA grubuna göre istatistiksel olarak anlamlı derecede düşüktü. Kadın OA hastalarında kalsiyum ve fosfor düzeyleri erkek OA grubuna göre anlamlı olarak daha yüksekti. Osteoporoz, osteopeni ve normal KMY olan erken ve geç dönem OA hastalarında vitamin D, vitamin B12, kalsiyum, fosfor, WOMAC indeksi ve KOOS skorları arasında fark yoktu. Osteoporozlu erken evre ve geç evre OA olan erkek hastalarda osteopenisi ve normal KMY olanlara göre WOMAC indexi anlamlı olarak daha yüksekti. Kadın OA olan hastalarda yaş odds oranı (OR) 1,047 (% 95 CI = 1,009-1,086), erkek OA olan hastalarda OR = 1.090 (% 95 CI = 1,021-1,163) idi.Sonuç: D vitamini takviyesinin, osteoporozun ilerlemesini yavaşlattığı, ağrıyı azalttığı, KMY arttırdığı söylenebilir, ancak OA progresyonu ve diz fonksiyon skorları üzerinde hiçbir etkisi yoktur.

Background: As individuals age, the prevalence of osteoarthritis tends to increase gradually. α-Klotho is a hormone renowned for its anti-aging properties. However, the precise role of serum α-Klotho in osteoarthritis is still not fully comprehended., Methods: We conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016. Serum α-Klotho levels were measured using an enzyme-linked immunosorbent assay (ELISA). Osteoarthritis was assessed through self-reported questionnaires. Through univariate and multivariate logistic regression analyses, smooth curve fitting, threshold effect analysis, and subgroup analyses, we delved into the potential association between them., Results: The study encompassed a cohort of 10,265 participants. In fully adjusted models of multivariate logistic regression analysis, we identified a negative correlation between serum ln α-Klotho and OA (OR = 0.77, 95% CI: 0.65-0.91, p = 0.003). When stratifying serum α-Klotho levels into tertiles, individuals in the highest tertile exhibited a 26% reduced risk of OA compared to those in the lowest tertile (OR = 0.84, 95% CI: 0.73-0.97, p = 0.014). Subsequent analyses indicated a linearly negative association. In subgroup analyses, we explored the relationship between serum ln α-Klotho and osteoarthritis across diverse populations, revealing the persistence of this association in the majority of subgroups., Conclusion: Serum α-Klotho levels exhibit a significant negative linear correlation with the prevalence of osteoarthritis in middle-aged and elderly populations in the United States., (Copyright © 2024 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.)

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There is limited data that characterizes osteoarthritis (OA) patients who experience moderate to severe pain despite analgesic treatment in Mexico. In this study, we estimate the real-world prevalence of inadequate pain relief (IPR) among individuals with knee and/or hip OA who have been prescribed analgesic therapy and characterize this patient population for each country separately. This is a multinational, multi-site, cross-sectional, observational study. Participating physicians enrolled patients over 50 years of age with diagnosed knee and/or hip OA who had been prescribed topical and/or oral pain medication for at least 30 days prior to study visit, extracted data from their medical charts, and collected patient data using established questionnaires. 301 patients treated by 35 physicians in Mexico were enrolled in the study. More than half of the patients (53%) met the definition of IPR. Patients with IPR were significantly older (66.8 vs. 63.5 years, p = 0.002) and were more likely to be obese (24.2% vs. 11.9%, p = 0.006). Patients in the IPR group were more likely to report moderate/severe problems across all 5 dimensions of the EQ-5D and reported higher scores, indicating worse outcomes, on all three WOMAC subscales. Patients in the IPR group also reported reduced work productivity and greater treatment dissatisfaction compared to patients without IPR. IPR is highly prevalent among individuals with knee and/or hip OA in Mexico. Patients with IPR experience decreased health-related quality of life HRQoL and work productivity, impaired function, and poor treatment satisfaction. Health care professionals need to be aware of the high prevalence of IPR, work toward improving OA patient management, and facilitate early intervention or changes in drug and other treatment modalities. [ABSTRACT FROM AUTHOR]

Osteoarthritis is a complex degenerative disease with several factors contributing to joint damage. Objective: To compare the potential effect of hyaluronic acid (HA) and triamcinolone acetonide (TA), alone or combined, on the in vitro chondrogenic differentiation process of mesenchymal stem cells (MSCs). Methods: MSCs were divided into four groups: Control, HA, TA, and HA/TA combined. Each treatment group was cultured for 14 days in chondrogenic differentiation medium. The chondrogenic differentiation potential was assessed by histology and immunohistochemistry. Results: The HA and HA/TA-treated MSCs presented histological characteristics similar to native chondrocytes. The extracellular matrix (ECM) of TA-treated MSCs was compact and organized. Glycosaminoglycan staining was intense in Control, moderate in TA, slight in HA/TA, and undetectable in HA. Type II collagen immunoreactivity was high in the TA-treated ECM and MSCs. Conclusions: Histological analysis shows that HA influences morphological development similar to chondrocytes of the MSCs, but with low expression of specific cartilage molecules. The TA promotes formation of a compact and organized ECM. [ABSTRACT FROM AUTHOR]

Introduction: Osteoarthritis in Mexico is one of the ten most frequent causes of disability. Early diagnosis and detection of risk factors are determinant for treatment. The institutional organization establishes therapeutic guidelines according to each level of care, but eff ective management is not achieved. Material and methods: A prospective, pilot, interventional, clinical study was conducted, which included patients diagnosed with different degrees of knee osteoarthritis in the first, second and third level of care, with an integrative model that includes a group of professionals for the intervention of nutritional, physiotherapeutic, social and psychological evaluation from the first level. Results: The intervention of a multidisciplinary care group allows a correct evaluation and assignment of the level of care, optimizing human and material resources. The participation of diff erent disciplines in nutrition, psychology, social work, physiotherapy and rehabilitation modifies the global lifestyle by involving the patients themselves in their treatment. The intervention group had improvements in the visual analog pain scale, mobility arcs, low body mass index and improvement in the psychological aspect. Conclusions: The proposed model of care demonstrates that implementation in the institution and in each clinical care unit should be considered to improve outcomes. [ABSTRACT FROM AUTHOR]

El objetivo de este estudio fue determinar la confiabilidad del cuestionario The Osteoarthritis Knee and Hip Quality of Life en población adulta mayor colombiana con osteoartritis de rodilla y cadera. El enfoque metodológico de este estudio es cuantitativo, con un diseño de corte transversal. Los participantes diligenciaron el cuestionario con un lapso entre mediciones entre 5 a 8 días. Las propiedades psicométricas de reproducibilidad, consistencia interna y nivel de acuerdo del cuestionario se determinaron a través del coeficiente de correlación intraclase, el coeficiente alfa de Cronbach y el análisis gráfico de Bland y Altman, respectivamente. Sesenta y dos adultos mayores con osteoartritis de rodilla y cadera, con edad entre los 57 y 82 años respondieron el cuestionario. Se encontró una reproducibilidad casi perfecta (CCI = 0,89) para el dominio de actividad física; y sustancial (CCI = 0,62-0,77) para los dominios de dolor, salud mental y actividades. También se obtuvo una consistencia interna muy satisfactoria en los dominios de salud mental y actividad física (alfa = 0,9-0,94), mientras que la de dolor fue adecuada (alfa = 0,89). En cuanto a lo encontrado con el nivel de acuerdo, el promedio de las diferencias de los dominios de actividad física, dolor y salud mental fue de –7, –8 y –6,9 puntos, respectivamente. El cuestionario The Osteoarthritis Knee and Hip Quality of Life mostró buenas propiedades psicométricas en los dominios de actividad física, dolor y salud mental, principalmente. Este cuestionario puede ser utilizado en el ámbito clínico, pero requiere ajustes para ser utilizado en investigación. The aim of this study was to determine the reliability of The Osteoarthritis Knee and Hip Quality of Life questionnaire in a Columbian older adult population with knee and hip osteoarthritis. The methodological approach of this study was quantitative, with a cross-sectional design. Respondents completed the questionnaire with a period of 5 to 8 days between measurements. The psychometric properties of reproducibility, internal consistency and level of agreement of the questionnaire were determined using the intraclass correlation coefficient, Cronbach's alpha coefficient and Bland-Altman graphical analysis, respectively. Sixty-two older adults with osteoarthritis of the knee and hip aged between 57 and 82 responded to the questionnaire. Almost perfect reproducibility (CCI =.89) was found for the domain of physical activity, and substantial reproducibility (CCI =.62-.77) for the domains of pain, mental health and activities. A very satisfactory internal consistency was also obtained for the domains of mental health and physical activity (alpha =.90-.94), while that for pain was adequate (alpha =.89). As soon as the level of agreement was established, the mean of the differences in the domains of physical activity, main and mental health was –7.0, –8.0 and –6.9 points, respectively. The Osteoarthritis Knee and Hip Quality of Life questionnaire showed good psychometric properties principally in the domains of physical activity, pain and mental health. This questionnaire can be used in the clinical setting, but requires adjustment to be used in research. [ABSTRACT FROM AUTHOR]