1. Influence of bushenhuoxue on primary visual cortex' BDNF damage in rat model of chronic elevated intraocular pressure
- Author
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Xiang Li, Hong-Jian Guo, Xiao-Xia Wen, Zhao Xie, Xue-Jun Xie, Xue-Jing Lu, Yi Wang, and Jing Zhang
- Subjects
glaucoma ,rat model of chronic elevated intraocular pressure ,TCM of bushenhuoxue ,primary visual cortex ,nissl bodies ,ultrastructure of neuron cell ,Ophthalmology ,RE1-994 - Abstract
AIM: To observe the effect of traditional Chinese medicine(TCM)of bushenhuoxue on primary visual cortex(PVC)brain-derived neurotrophic factor(BDNF)in rat model of chronic elevated intraocular pressure(EIOP), and explore the mechanism of it initially. METHODS: The rat model of chronic EIOP was established by unilaterally cauterizing 3 episcleral veins, then 30 rats were divided into 3 groups randomly: control group, model group, and treatment group. After given drugs or normal saline for 8 weeks, the rats were put to death. The effect of intraocular pressure(IOP), expression of BDNF and ultrastructure of neuron cell in the PVC was observed. RESULTS: Unilaterally cauterizing episcleral veins increased IOP of the rat model obviously, there was significant difference compared with pre-operation(P
- Published
- 2013
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