Search

Your search keyword '"suppression of lipolysis"' showing total 2 results
Start Over Descriptor "suppression of lipolysis"
2 results on '"suppression of lipolysis"'

1. Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects

Author

Elisa Fabbrini, Faidon Magkos, Caterina Conte, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, and Samuel Klein

Subjects
fatty acid kinetics, palmitate rate of appearance, adipose tissue insulin sensitivity, suppression of lipolysis, hyperinsulinemic-euglycemic clamp, stable isotope tracers, Biochemistry, QD415-436
Abstract

Insulin resistance in adipose tissue increases the release of free fatty acids into the circulation, which likely contributes to impaired insulin action in liver and skeletal muscle associated with obesity. However, reliable assessment of adipose tissue insulin resistance requires performing a hyperinsulinemic-euglycemic clamp procedure in conjunction with a fatty acid tracer infusion to determine insulin-mediated suppression of lipolytic rate. We developed a simpler method for evaluating adipose tissue insulin resistance in vivo, determined as the product of palmitate rate of appearance into the bloodstream and plasma insulin concentration during basal conditions. We validated our Adipose Tissue Insulin Resistance Index (ATIRI) by comparison with an assessment of adipose tissue insulin resistance determined by using the hyperinsulinemic-euglycemic clamp procedure in conjunction with a palmitate tracer infusion in 47 obese nondiabetic subjects (body mass index: 40.1 ± 9.3 kg/m2). We found the ATIRI correlated closely with adipose tissue insulin resistance assessed during the clamp procedure (r=−0.854, P < 0.001). These results demonstrate that the ATIRI provides a reliable index of adipose tissue insulin resistance in obese subjects.

Published
2012
Full Text
View/download PDF

2. Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects

Author

Samuel Klein, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, Faidon Magkos, Elisa Fabbrini, Caterina Conte, Fabbrini, E, Magkos, F, Conte, C, Mittendorfer, B, Patterson, B, Okunade, A, and Klein, S

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Palmitates, Adipose tissue, QD415-436, White adipose tissue, Biology, Biochemistry, adipose tissue insulin sensitivity, hyperinsulinemic-euglycemic clamp, Body Mass Index, palmitate rate of appearance, Endocrinology, Insulin resistance, Internal medicine, Methods, medicine, Humans, Obesity, chemistry.chemical_classification, fatty acid kinetics, Insulin, Fatty acid, Skeletal muscle, Settore MED/13 - ENDOCRINOLOGIA, Cell Biology, Middle Aged, Glucose clamp technique, medicine.disease, stable isotope tracers, medicine.anatomical_structure, suppression of lipolysis, Adipose Tissue, chemistry, Basal (medicine), Glucose Clamp Technique, Female, Insulin Resistance, Human
Abstract

Insulin resistance in adipose tissue increases the release of free fatty acids into the circulation, which likely contributes to impaired insulin action in liver and skeletal muscle associated with obesity. However, reliable assessment of adipose tissue insulin resistance requires performing a hyperinsulinemic-euglycemic clamp procedure in conjunction with a fatty acid tracer infusion to determine insulin-mediated suppression of lipolytic rate. We developed a simpler method for evaluating adipose tissue insulin resistance in vivo, determined as the product of palmitate rate of appearance into the bloodstream and plasma insulin concentration during basal conditions. We validated our Adipose Tissue Insulin Resistance Index (ATIRI) by comparison with an assessment of adipose tissue insulin resistance determined by using the hyperinsulinemic-euglycemic clamp procedure in conjunction with a palmitate tracer infusion in 47 obese nondiabetic subjects (body mass index: 40.1 ± 9.3 kg/m(2)). We found the ATIRI correlated closely with adipose tissue insulin resistance assessed during the clamp procedure (r =-0.854, P < 0.001). These results demonstrate that the ATIRI provides a reliable index of adipose tissue insulin resistance in obese subjects.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results