50 results on '"van Furth W"'
Search Results
2. Innovation in neurosurgery: less than IDEAL? A systematic review
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Muskens, I. S., Diederen, S. J. H., Senders, J. T., Zamanipoor Najafabadi, A. H., van Furth, W. R., May, A. M., Smith, T. R., Bredenoord, A. L., and Broekman, M. L. D.
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- 2017
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3. 795 Trends in Cerebrospinal Fluid Leak Rates Following the Extended Endoscopic Endonasal Approach for Anterior Skull Base Meningioma: A Meta-Analysis Over the Last 20 Years
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Zamanipoor Najafabadi, A H, primary, Khan, D Z, additional, Muskens, I S, additional, Broekman, M L D, additional, Dorward, N L, additional, van Furth, W R, additional, and Marcus, H J, additional
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- 2021
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4. Goedaardige hersentumoren
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Stalpers, L. J. A. and van Furth, W. R.
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- 2008
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5. Cerebellar haemorrhage after non-traumatic evacuation of supratentorial chronic subdural haematoma: report of two cases
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Vogels, R. L. C., Verstegen, M. J. T., and van Furth, W. R.
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- 2006
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6. Radiation-Enhanced Vascular Endothelial Growth Factor (VEGF) Secretion in Glioblastoma Multiforme Cell Lines – A Clue to Radioresistance?
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Hovinga, K. E., Stalpers, L. J. A., van Bree, C., Donker, M., Verhoeff, J. J. C., Rodermond, H. M., Bosch, D. A., and van Furth, W. R.
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- 2005
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7. Progression of vertebral fractures in long-term controlled acromegaly: a 9-year follow-up study
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Pelsma, I C M, primary, Biermasz, N R, additional, Pereira, A M, additional, van Furth, W R, additional, Appelman-Dijkstra, N M, additional, Kloppenburg, M, additional, Kroon, H M, additional, and Claessen, K M J A, additional
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- 2020
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8. “Tailored” approach to selected recurrent cranio-cervical chordomas: experience and lessons learned
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Dallan, I., primary, de Notaris, M., additional, Verstegen, M., additional, Fiacchini, G., additional, Cambi, C., additional, Seccia, V., additional, Caniglia, M., additional, and van Furth, W., additional
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- 2020
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9. Bevacizumab and dose-intense temozolomide in recurrent high-grade glioma
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Verhoeff, J. J., Lavini, C., van Linde, M. E., Stalpers, L. J., Majoie, C. B., Reijneveld, J. C., van Furth, W. R., and Richel, D. J.
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- 2010
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10. Prognostic significance of NAB2-STAT6 fusion variants and TERT promotor mutations in solitary fibrous tumors/hemangiopericytomas of the CNS: not (yet) clear
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Vogels, R, Macagno, N, Griewank, K, Groenen, P, Verdijk, M, Fonville, J, Kusters, B, Figarella-Branger, D, Wesseling, P, Bouvier, C, Flucke, U, Cornu, P, Dufour, H, Guyotat, J, Jouvet, A, Metellus, P, Mokhtari, K, Vasiljevic, A, Varlet, P, Bekers, E, Djafarihamedani, M, Kurt, E, Kusters-Vandevelde, H, Fleischeuer, R, Leenstra, Sieger, Robe, P, Spliet, W, Troost, D, van Furth, W, Radboud University Medical Center [Nijmegen], Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de Neuropathologie [AP-HM Hôpital de la Timone], Hôpital de la Timone [CHU - APHM] (TIMONE)-Assistance Publique - Hôpitaux de Marseille (APHM), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospital Essen, Stichting PAMM, Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Service d’Anatomie Pathologique et de Neuropathologie, APHM, Hôpital de la Timone, Hôpital de la Timone [CHU - APHM] (TIMONE), Aix Marseille Université (AMU), VU University Medical Center [Amsterdam], AUTRES, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Pathology, CCA - Imaging and biomarkers, and Neurosurgery
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Solitary fibrous tumor ,Medizin ,Clinical Neurology ,Nab2 stat6 ,Biology ,Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] ,medicine.disease_cause ,Pathology and Forensic Medicine ,Central Nervous System Neoplasms ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,medicine ,Humans ,Oncogene Fusion ,Promoter Regions, Genetic ,Telomerase ,Retrospective Studies ,030304 developmental biology ,0303 health sciences ,Mutation ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,Promoter ,Prognosis ,medicine.disease ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Progression-Free Survival ,3. Good health ,Clinical neurology ,Repressor Proteins ,Survival Rate ,Solitary Fibrous Tumors ,030220 oncology & carcinogenesis ,Cancer research ,Neurology (clinical) ,STAT6 Transcription Factor ,Hemangiopericytoma - Abstract
International audience; Grading of meningeal solitary fibrous tumors/hemangiopericytomas(SFTs/HPCs) of the central nervous system (CNS)is nowadays based on histologic criteria as described in therevised fourth edition of the WHO Classification of CNStumors [10] or the more recently published, updated versionof the Marseille Grading System (MGS) [11]. Histologybasedgrading of CNS SFTs/HPCs allows for discriminatingsubgroups with significant differences in prognosis. However,the often-piecemealresection of these tumors mayhamper adequate evaluation of mitotic activity and necrosis,and thereby assessment of malignancy grade. NAB2–STAT6fusion is the molecular hallmark of both soft tissue SFTs andCNS SFTs/HPCs, and the resultingfusion protein accumulatesin the nucleus and acts as a transcriptional activatorof early growth response mediated pathways with STAT6immunohistochemistry being a very sensitive and specifictool for their diagnosis [5, 8, 12, 14]. For soft tissue SFTs,particular NAB2–STAT6 fusion variants as well as telomerasereverse transcriptase (TERT) promoter mutations leadingto telomerase activity and tumor cell immortalization havebeen reported to have prognostic value. Some studies haveincluded CNS SFTs/HPCs in their cohort, but because ofsmall numbers and lack of (long term) follow-up data theprognostic value of these markers for CNS SFTs/HPCs isstill unclear.
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- 2019
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11. Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients
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Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., Kusters, Benno, Pathology, and CCA - Cancer Treatment and quality of life
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0301 basic medicine ,Oncology ,Male ,Solitary fibrous tumor ,medicine.medical_treatment ,Cohort Studies ,0302 clinical medicine ,Meningeal Neoplasms ,Research Articles ,Aged, 80 and over ,Univariate analysis ,General Neuroscience ,Marseille Grading System ,Middle Aged ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Prognosis ,Progression-Free Survival ,Solitary Fibrous Tumors ,Cohort ,Female ,medicine.medical_specialty ,Poor prognosis ,Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] ,Malignancy ,Disease-Free Survival ,Pathology and Forensic Medicine ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,solitary fibrous tumor ,hemangiopericytoma ,Aged ,Neoplasm Staging ,Retrospective Studies ,Hemangiopericytoma ,Chemotherapy ,business.industry ,Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,Reproducibility of Results ,prognostic factors ,grading ,medicine.disease ,central nervous system ,Radiation therapy ,Repressor Proteins ,030104 developmental biology ,MGS ,Neurology (clinical) ,business ,STAT6 Transcription Factor ,030217 neurology & neurosurgery - Abstract
Item does not contain fulltext The finding that meningeal solitary fibrous tumors (SFTs) and meningeal hemangiopericytomas (HPCs) are both characterized by NAB2-STAT6 gene fusion has pushed their inclusion in the WHO 2016 Classification of tumors of the central nervous system (CNS) as different manifestations of the same entity. Given that the clinical behavior of the CNS SFT/HPC spectrum ranges from benign to malignant, it is presently unclear whether the grading criteria are still adequate. Here, we present the results of a study that analyzed the prognostic value of an updated version of the Marseille Grading System (MGS) in a retrospectively assembled cohort of 132 primary meningeal SFTs/HPCs with nuclear overexpression of STAT6. The median patient follow-up was 64 months (range 4-274 months); 73 cases (55%) were MGS I, 50 cases (38%) MGS II and 9 cases (7%) were MGS III. Progression-free survival (PFS) and disease-specific survival (DSS) were investigated using univariate analysis: the prognostic factors for PFS included MGS, extent of surgery, radiotherapy, chemotherapy and mitotic activity >/=5/10 high-power field (HPF). Moreover, MGS, radiotherapy, mitotic activity >/=5/10 HPF, and necrosis were the prognostic factors measured for DSS. In multivariate analysis, extent of surgery, mitotic activity >/=5/10 HPF, MGS I and MGS III were the independent prognostic factors measured for PFS while necrosis, MGS III and radiotherapy were the independent prognostic factors for DSS. In conclusion, our results show that assessing the malignancy risk of SFT/HPC should not rely on one single criterion like mitotic activity. Therefore, MGS is useful as it combines the value of different criteria. In particular, the combination of a high mitotic activity and necrosis (MGS III) indicates a particularly poor prognosis.
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- 2019
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12. Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients
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Pathologie Pathologen staf, Neurochirurgie, Brain, Cancer, Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., Kusters, Benno, Pathologie Pathologen staf, Neurochirurgie, Brain, Cancer, Macagno, Nicolas, Vogels, Rob, Appay, Romain, Colin, Carole, Mokhtari, Karima, Bouvier, Corinne, Cornu, Philippe, Dufour, Henry, Figarella-Branger, Dominique, Guyotat, Jacques, Jouvet, Anne, Metellus, Philippe, Vasiljevic, Alexandre, Varlet, Pascale, Vogels, R., Flucke, U., Kusters, B., Groenen, P., Wesseling, P., Bekers, E., Verdijk, M., Djafarihamedani, M., Kurt, E., Kusters-Vandevelde, H., Fleischeuer, R., Leenstra, S., Robe, P., Spliet, W., Troost, D., van Furth, W., and Kusters, Benno
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- 2019
13. P05.65 The caregiver burden in meningioma: long-term results and its effects on caregiver’s health-related quality of life, anxiety and depression
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Zamanipoor Najafabadi, A H, van der Meer, P B, Boele, F W, Reijneveld, J C, Taphoorn, M J B, Klein, M, van Furth, W R, Dirven, L, and Peerdeman, S M
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Poster Presentations - Abstract
BACKGROUND: Various studies in oncological/neurological patients highlight that informal caregivers suffer from a significant disease burden. We aimed to assess the meningioma caregiver burden, and its effects on caregiver’s health-related quality of life (HRQoL), and levels of anxiety and depression. MATERIAL AND METHODS: In a multicentre cross-sectional study informal caregivers of intracranial meningioma patients at a median of 10 years after their last anti-tumour therapy were included. Informal caregivers were family members or close friends and completed the caregiver disease burden scale, SF-36 (HRQoL) and the Hospital Anxiety and Depression Scale. Caregiver burden was assessed as an independent determinant for caregiver’s HRQoL, and levels of anxiety and depression with multivariable analysis correcting for relevant confounders. Participant recruitment is still in progress. RESULTS: 110 informal caregivers were included (mean age: 64.5, female: 37.2%). Informal caregivers reported any caregiver burden in 35.2% of cases, and clinically relevant burden in 15.7%. More specifically, 20.4% of caregivers suffered from stress, 11.2% from social isolation, 13.0% from feelings of disappointment, 21.0% from emotional problems, and 12.0% from environmental factors complicating the care for the patient. The total caregiver burden score was significantly associated with decreased HRQoL on 6/8 scales and 2/2 component scores: physical function (β=-6.53, p=0.071), role limitation due to physical problems (β=-13.62, p=0.041), bodily pain (β=-13.11, p=0.014), social function (β=-11.87, p=0.001), mental health (β=-14.32, p
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- 2018
14. THE CAREGIVER BURDEN IN MENINGIOMA: LONG-TERM RESULTS AND ITS EFFECTS ON CAREGIVER'S HEALTH-RELATED QUALITY OF LIFE, ANXIETY AND DEPRESSION
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Najafabadi, A. H. Zamanipoor, van der Meer, P. B., Boele, F. W., Reijneveld, J. C., Taphoorn, M. J. B., Klein, M., van Furth, W. R., Dirven, L., Peerdeman, S. M., Medical psychology, CCA - Imaging and biomarkers, CCA - Treatment and quality of life, Neurology, Rheumatology, Neurosurgery, and CCA - Cancer biology and immunology
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- 2018
15. OS4.2 The long-term disease burden of meningioma patients: results on health-related quality of life, cognitive function, anxiety and depression
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Zamanipoor Najafabadi, A H, van der Meer, P B, Boele, F W, Reijneveld, J C, Taphoorn, M J B, Klein, M, van Furth, W R, Dirven, L, and Peerdeman, S M
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Oral Presentations - Abstract
BACKGROUND: Recent systematic reviews reported that meningioma patients have an impaired health-related quality of life (HRQoL) and cognitive function up to 5 years after intervention. We aimed to assess the long-term disease burden of meningioma patients. MATERIAL AND METHODS: In this multicentre cross-sectional study, intracranial meningioma patients at least 5 years (median: 9.9 years) after anti-tumour therapy were included. HRQoL was measured with the generic SF-36 (8 scales and 2 component scores) and the disease-specific EORTC QLQ-BN20 (11 scales/items), and anxiety and depression with the Hospital Anxiety and Depression Scale (HADS: ≤11/21 points is indicative for probable anxiety or depression). Six domains of cognitive function were assessed with a standardised neuropsychological test battery (z-score
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- 2018
16. P05.78 Improving quality of care of meningioma patients: initial evaluation of issues in care trajectories according to the Plan-Do-Study-Act Cycle
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Zamanipoor Najafabadi, A H, primary, van de Mortel, J P M, additional, Lobatto, D J, additional, Brandsma, D, additional, Peul, W C, additional, Taphoorn, M J B, additional, Dirven, L, additional, and van Furth, W R, additional
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- 2018
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17. Innovation in neurosurgery: less than IDEAL? A systematic review
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Brain, ZL Algemene en Acute Nec Medisch, ZL Neuro-Oncologie Medisch, Epi Infectieziekten Team 3, Cancer, JC onderzoeksprogramma Kanker, Medische Geschiedenis, Child Health, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Muskens, I. S., Diederen, S. J.H., Senders, J. T., Zamanipoor Najafabadi, A. H., van Furth, W. R., May, A. M., Smith, T. R., Bredenoord, A. L., Broekman, M. L.D., Brain, ZL Algemene en Acute Nec Medisch, ZL Neuro-Oncologie Medisch, Epi Infectieziekten Team 3, Cancer, JC onderzoeksprogramma Kanker, Medische Geschiedenis, Child Health, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Muskens, I. S., Diederen, S. J.H., Senders, J. T., Zamanipoor Najafabadi, A. H., van Furth, W. R., May, A. M., Smith, T. R., Bredenoord, A. L., and Broekman, M. L.D.
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- 2017
18. MNGI-24. PREDICTORS OF VISUAL OUTCOMES IN SPHENO-ORBITAL MENINGIOMA SURGERY ENDORSE EARLY MAXIMUM SAFE SURGERY AND INTENSIVE FOLLOW-UP OF PATIENTS WITH MULTIPLE MENINGIOMA
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van Furth, W., S. Genders, and Amir H Zamanipoor Najafabadi
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Cancer Research ,medicine.medical_specialty ,genetic structures ,business.industry ,medicine.disease ,Safe surgery ,eye diseases ,Surgery ,Meningioma ,Abstracts ,Text mining ,Oncology ,medicine ,Neurology (clinical) ,business - Abstract
OBJECTIVE: Most Spheno-Orbital Meningioma (SOM) series include patients over a period of multiple decades, while surgical techniques have improved over the years. In addition, predictors of visual outcomes and progression free survival (PFS) have not yet been systemically assessed. The aim of this study was to assess predictors of visual outcomes and PFS in a recent SOM cohort. METHODS: Consecutive patients operated by a team of a neurosurgeon and orbital surgeon in the Leiden University Medical Center between June 2015-December 2017 were included. Pre- and postoperative visual acuity (Snellen chart), visual field deficit (Humphrey field analyser, in decibel [dB]), and relative proptosis (exophthalmometry) were compared with the Wilcoxon signed-rank test. Predictors of visual outcomes were assessed with linear regression analysis. Predictors of PFS (definition: need for reintervention) with the log-rank test. RESULTS: Eight patients presented with impaired visual acuity, which improved in 88% (preoperative: 0.8, postoperative: 1.1, p=0.012). All 16 patients presented with visual field deficits, which improved in 86% (preoperative: -8.4dB, postoperative: -3.8dB, p=0.008). Also all patients presented with proptosis, which improved in 86% (preoperative: 4.5mm, postoperative: 2.9mm, p=0.013) Strongest predictors for postoperative visual acuity, visual field deficits and persistent proptosis were preoperative visual acuity (p=0.001), visual field (p
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- 2018
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19. Industrial of medical tool with steering cables
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Breedveld, P., Henselmans, P.W.J., Arkenbout, E.A., Van Furth, W., and Gerboni, G.
- Abstract
Instrument provided with cables extending between a first portion and a second portion of the instrument at opposite sides of its longitudinal axis and disposed at predefined angles with respect to said axis, which instrument has one or more sets of cables, each set of cables comprising in combination a first cable running parallel to the longitudinal axis, a second cable running at a first predefined angle with respect to said longitudinal axis, and a third cable running at a second predefined angle with respect to said longitudinal axis and having a sign that is opposite to the sign of the first predefined angle so as to arrange that the second and third cables cross each other. The instrument is preferably a joystick or a surgical instrument, such as a laparoscopic tool.
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- 2015
20. P11.01 Patient-reported outcome measures in meningioma research - lack of the patients perspective
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Zamanipoor Najafabadi, A. H., primary, Dirven, L., additional, Broekman, M. L. D., additional, Peul, W. C., additional, Taphoorn, M. J. B., additional, and van Furth, W. R., additional
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- 2016
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21. P11.02 Health-related quality of life in meningioma patients - a systematic review
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Zamanipoor Najafabadi, A. H., primary, Peeters, M. C. M., additional, Dirven, L., additional, Broekman, M. L. D., additional, Peul, W. C., additional, Taphoorn, M. J. B., additional, and van Furth, W. R., additional
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- 2016
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22. Industrial of medical tool with steering cables
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Breedveld, P. (author), Henselmans, P.W.J. (author), Arkenbout, E.A. (author), Van Furth, W. (author), Gerboni, G. (author), Breedveld, P. (author), Henselmans, P.W.J. (author), Arkenbout, E.A. (author), Van Furth, W. (author), and Gerboni, G. (author)
- Abstract
Instrument provided with cables extending between a first portion and a second portion of the instrument at opposite sides of its longitudinal axis and disposed at predefined angles with respect to said axis, which instrument has one or more sets of cables, each set of cables comprising in combination a first cable running parallel to the longitudinal axis, a second cable running at a first predefined angle with respect to said longitudinal axis, and a third cable running at a second predefined angle with respect to said longitudinal axis and having a sign that is opposite to the sign of the first predefined angle so as to arrange that the second and third cables cross each other. The instrument is preferably a joystick or a surgical instrument, such as a laparoscopic tool., Biomechanical Engineering, Mechanical, Maritime and Materials Engineering
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- 2015
23. Subtiele huidafwijkingen in de mediaanlijn als aanduiding van een neurodermaal sluitingsdefect
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Bleeker, F. E., van Furth, W. R., van der Horst, C. M. A. M., Majoie, C. B. L. M., Koot, R. W., Other departments, Amsterdam Neuroscience, Neurosurgery, Amsterdam Cardiovascular Sciences, Other Research, Plastic, Reconstructive and Hand Surgery, and Radiology and Nuclear Medicine
- Abstract
Three patients, aged 2, 2.5 and 24 years, presented with a skin lesion in the median or paramedian area at the nose, in the lumbar region and between the shoulders, respectively. The first patient suffered from recurrent infection, the skin lesion of the second patient was a coincidental finding, and the third patient had cosmetic problems. Although there were no signs of neurological deficits, neurodermal closing defects were found by MRI. Two patients underwent surgery to prevent infection and neurological complaints in the future. It is stressed that even if there are no neurological signs or infections, congenital dermal lesions situated in the midline should be considered as possible neural tube defects and therefore analysed by MRI. Ifa neurodermal dysraphism is found, patients should be referred to a neurosurgical centre. A good clinical assessment of the neural lesion, clinical signs and age will determine whether surgical resection is indicated to prevent or resolve neurological problems, infections or cosmetic complaints
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- 2006
24. Quality of life in extended endonasal approaches for skull base tumours
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Georgalas, C, primary, Badloe, R, additional, van Furth, W, additional, Reinartz, S, additional, and Fokkens, WJ, additional
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- 2012
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25. Surgical treatment of sphenoorbital meningiomas
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Saeed, P., primary, van Furth, W. R., additional, Tanck, M., additional, Freling, N., additional, van der Sprenkel, J. W. B., additional, Stalpers, L. J. A., additional, van Overbeeke, J. J., additional, and Mourits, M. P., additional
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- 2011
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26. Endogenous opioids are differentially involved in appetitive and consummatory aspects of sexual behavior of male rats
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Van Furth, W. R., primary, Wolterink-Donselaar, I. G., additional, and van Ree, J. M., additional
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- 1994
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27. Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme
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Richel Dirk J, van Linde Myra E, Stalpers Lukas JA, Claes An, van Tellingen Olaf, Verhoeff Joost JC, Leenders William PJ, and van Furth Wouter R
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The relevance of angiogenesis inhibition in the treatment of glioblastoma multiforme (GBM) should be considered in the unique context of malignant brain tumours. Although patients benefit greatly from reduced cerebral oedema and intracranial pressure, this important clinical improvement on its own may not be considered as an anti-tumour effect. Discussion GBM can be roughly separated into an angiogenic component, and an invasive or migratory component. Although this latter component seems inert to anti-angiogenic therapy, it is of major importance for disease progression and survival. We reviewed all relevant literature. Published data support that clinical symptoms are tempered by anti-angiogenic treatment, but that tumour invasion continues. Unfortunately, current imaging modalities are affected by anti-angiogenic treatment too, making it even harder to define tumour margins. To illustrate this we present MRI, biopsy and autopsy specimens from bevacizumab-treated patients. Moreover, while treatment of other tumour types may be improved by combining chemotherapy with anti-angiogenic drugs, inhibiting angiogenesis in GBM may antagonise the efficacy of chemotherapeutic drugs by normalising the blood-brain barrier function. Summary Although angiogenesis inhibition is of considerable value for symptom reduction in GBM patients, lack of proof of a true anti-tumour effect raises concerns about the place of this type of therapy in the treatment of GBM.
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- 2009
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28. Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice
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Haveman Jaap, Van Noorden Cornelis JF, Lavini Cristina, Koedooder Kees, Coumou Annet W, Stalpers Lukas JA, Verhoeff Joost JC, Vandertop William P, and van Furth Wouter R
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background High-dose radiotherapy is standard treatment for patients with brain cancer. However, in preclinical research external beam radiotherapy is limited to heterotopic murine models– high-dose radiotherapy to the murine head is fatal due to radiation toxicity. Therefore, we developed a stereotactic brachytherapy mouse model for high-dose focal irradiation of experimental intracerebral (orthotopic) brain tumors. Methods Twenty-one nude mice received a hollow guide-screw implanted in the skull. After three weeks, 5 × 105 U251-NG2 human glioblastoma cells were injected. Five days later, a 2 mCi iodine-125 brachytherapy seed was inserted through the guide-screw in 11 randomly selected mice; 10 mice received a sham seed. Mice were euthanized when severe neurological or physical symptoms occurred. The cumulative irradiation dose 5 mm below the active iodine-125 seeds was 23.0 Gy after 13 weeks (BEDtumor = 30.6 Gy). Results In the sham group, 9/10 animals (90%) showed signs of lethal tumor progression within 6 weeks. In the experimental group, 2/11 mice (18%) died of tumor progression within 13 weeks. Acute side effects in terms of weight loss or neurological symptoms were not observed in the irradiated animals. Conclusion The intracerebral implantation of an iodine-125 brachytherapy seed through a stereotactic guide-screw in the skull of mice with implanted brain tumors resulted in a significantly prolonged survival, caused by high-dose irradiation of the brain tumor that is biologically comparable to high-dose fractionated radiotherapy– without fatal irradiation toxicity. This is an excellent mouse model for testing orthotopic brain tumor therapies in combination with radiation therapy.
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- 2007
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29. Mental state as a predictor of outcome in spinal stenosis surgery: Four quadrants model integrating patient satisfaction and functional outcome.
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van Grafhorst J, van Furth W, and Vleggeert-Lankamp C
- Abstract
Introduction: Mental status, characterised by anxiety and depression, significantly influences physical well-being, particularly in patients with spinal stenosis symptoms., Research Question: The prevalence of depression and anxiety in our cohort. The correlation between psychological distress and physical outcome after surgery, including postoperative recovery and satisfaction., Materials and Methods: Questionnaires evaluating anxiety and depression (HADS), functionality (ODI), quality of life (EQ-5D), and perceived recovery (Likert-scale) were sent to a randomly selected cohort of 450 lumbar spinal stenosis patients, with or without spondylolisthesis, who underwent surgery between 2007 and 2013. Results are presented, dichotomised by HADS score (score ≥8 indicating psychologically impaired) and in a Four Quadrants Model integrating functional outcomes and perceived recovery separately for psychologically impaired and non-impaired cases., Results: Among the 147 included patients, 32 (22%) exhibited anxiety and/or depression (impaired cases). Satisfactory outcome (perceived recovery) was reported in 29.0% of the impaired cases and 78.3% of the non-impaired cases (p < 0.001). The mean postoperative functionality score of the impaired cases was 42.46 ± 16.24, in contrast to 18.48 ± 18.25 for the non-impaired cases (p < 0.001). In the impaired group, only 12.5% achieved both a good functional outcome (ODI ≤24) and satisfactory perceived recovery, compared with 58.4% in the non-impaired group., Discussion and Conclusion: Patients reporting anxiety and/or depression demonstrate an inferior long-term outcome after spinal stenosis surgery compared to non-impaired patients. This clinically relevant difference underscores the importance of addressing depression and anxiety in preoperative counselling to optimize patient satisfaction and functional outcomes., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests.Dr. Vleggeert-Lankamp reports a relationship with 10.13039/100002718Cervical Spine Research Society that includes: board membership and funding grants. Dr. Vleggeert-Lankamp reports a relationship with Netherlands Neurosurgical Society (NVvN) that includes: board membership. Dr. Vleggeert-Lankamp reports a relationship with EUROSPINE The Spine Society of Europe that includes: board membership. Dr. Vleggeert-Lankamp reports a relationshiigsp with Advisory Board Rijndam Rehabilitation that includes: consulting or advisory. Dr. Vleggeert-Lankamp reports a relationship with Covidien that includes: funding grants. Dr. Vleggeert-Lankamp reports a relationship with YM Fund that includes: funding grants. Dr. Vleggeert-Lankamp reports a relationship with Achmea Health Insurance that includes: funding grants. Dr. Vleggeert-Lankamp reports a relationship with Nuvasive that includes: speaking and lecture fees. Dr. Vleggeert-Lankamp reports a relationship with Stryker Spine that includes: speaking and lecture fees. Dr. van Furth reports a relationship with Sella Therapies that includes: Co-Founder/CEO., (© 2024 The Authors. Published by Elsevier B.V. on behalf of EUROSPINE, the Spine Society of Europe, EANS, the European Association of Neurosurgical Societies.)
- Published
- 2024
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30. Relationships of the vidian nerve and internal carotid artery: MRI and intraoperative surgical evaluation.
- Author
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Dallan I, Verstegen M, Canovetti S, Turri-Zanoni M, Georgalas C, Fiacchini G, Cambi C, Prevedello D, and van Furth W
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Young Adult, Aged, Abducens Nerve anatomy & histology, Abducens Nerve diagnostic imaging, Skull Base diagnostic imaging, Skull Base anatomy & histology, Skull Base surgery, Adolescent, Carotid Artery, Internal diagnostic imaging, Carotid Artery, Internal anatomy & histology, Magnetic Resonance Imaging methods
- Abstract
Objective: Skull base anatomy around the internal carotid artery (ICA) is extremely complex. Among anatomical landmarks studied, the vidian canal has been thoroughly evaluated, unlike the vidian nerve (VN). Our aim is to evaluate the VN-ICA relationships, and understand their role in terms of surgical planning., Methods: Fifty MRI examinations of 100 healthy petro-spheno-clival regions were reviewed in order to evaluate the relationship between the vidian nerve axis (VNA) and the petrous ICA. Twenty-seven cases of expanded endonasal approaches to petrous apex region were evaluated to check the VN-ICA relationship intraoperatively., Results: MRI evaluations showed that, in 23% of cases, the VNA was below the edge of the ICA, in 45% it was at the edge of the ICA and in 32% it ended up above the edge of the ICA. Surgically speaking, in 9 of 28 petrous apex approaches, the VN ended above the inferior edge of the petrous carotid., Conclusions: MRI evaluation adds useful information in planning the surgical approach to petro-spheno-clival regions, even if the identification of VNA, in these cases, may not be radiologically possible. Surgical experience confirms the importance of VN identification in guiding the surgeon in complex cases, and also outline the possible risks of relying only on this landmark., (Copyright © 2024 Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy.)
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- 2024
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31. Endoscopic-assisted transorbital surgery: Where do we stand on the scott's parabola? personal considerations after a 10-year experience.
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Dallan I, Cristofani-Mencacci L, Fiacchini G, Turri-Zanoni M, van Furth W, de Notaris M, Picariello M, Alexandre E, Georgalas C, and Bruschini L
- Abstract
Transorbital approaches are genuinely versatile surgical routes which show interesting potentials in skull base surgery. Given their "new" trajectory, they can be a very useful adjunct to traditional routes, even being a valid alternative to them in some cases, and add valuable opportunities in selected patients. Indications are constantly expanding, and currently include selected intraorbital, skull base and even intra-axial lesions, both benign and malignant. Given their relatively recent development and thus unfamiliarity among the skull base community, achieving adequate proficiency needs not only a personalized training and knowledge but also, above all, an adequate case volume and a dedicated setting. Current, but mostly future, applications should be selected by genetic, omics and biological features and applied in the context of a truly multidisciplinary environment., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Dallan, Cristofani-Mencacci, Fiacchini, Turri-Zanoni, van Furth, de Notaris, Picariello, Alexandre, Georgalas and Bruschini.)
- Published
- 2022
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32. Hypophysitis: A comprehensive overview.
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de Vries F, van Furth WR, Biermasz NR, and Pereira AM
- Subjects
- Autoimmune Hypophysitis diagnosis, Autoimmune Hypophysitis etiology, Diabetes Insipidus etiology, Endocrine System Diseases diagnosis, Endocrine System Diseases etiology, Erdheim-Chester Disease complications, Histiocytosis, Langerhans-Cell complications, Humans, Hypophysitis diagnosis, Hypophysitis diagnostic imaging, Hypophysitis therapy, Immune Checkpoint Inhibitors adverse effects, Immunoglobulin G, Immunoglobulin G4-Related Disease complications, Pituitary Gland diagnostic imaging, Symptom Assessment methods, Xanthomatosis complications, Hypophysitis etiology
- Abstract
Hypophysitis is defined as inflammation of the pituitary gland. It is a heterogeneous condition as it can originate from different parts of the pituitary gland, can be caused by different pathophysiological processes, and can be isolated or the manifestation of a underlying systemic disease. Hypophysitis usually presents with endocrine deficiencies, including diabetes insipidus, with varying patterns. A subset of patients presents with mass effects. The last decades major progress has been made in the understanding of this disease. New forms are now recognized, new diagnostics are being developed, and specific treatments are proposed. This review provides an overview of the current knowledge on hypophysitis using an aetiology-based approach and provides the clinician with a stepwise approach to the patient with (suspected) hypophysitis., (Copyright © 2021. Published by Elsevier Masson SAS.)
- Published
- 2021
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33. International Consensus Statement: Spontaneous Cerebrospinal Fluid Rhinorrhea.
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Georgalas C, Oostra A, Ahmed S, Castelnuovo P, Dallan I, van Furth W, Harvey RJ, Herman P, Kombogiorgas D, Locatelli D, Meco C, Palmer JN, Piltcher O, Sama AM, Saleh H, Sindwani R, Van Zele T, and Woodworth BA
- Subjects
- Cerebrospinal Fluid Leak, Humans, Rhinorrhea, Cerebrospinal Fluid Rhinorrhea diagnosis, Cerebrospinal Fluid Rhinorrhea surgery, Intracranial Hypertension, Pseudotumor Cerebri
- Abstract
Background: The association between spontaneous cerebrospinal fluid (CSF) leak/rhinorrhea and idiopathic intracranial hypertension (IIH) has been increasingly recognized over the last years. However, considerable variability of opinion regarding the assessment, investigations, and management of patients with spontaneous CSF rhinorrhea remains., Methods: A consensus group was formed from experts from Europe, Asia, Australia, South and North America. Following literature review and open discussions with members of the panel, a set of 61 statements was produced. A modified Delphi method was used to refine expert opinion with 3 rounds of questionnaires and a consensus group meeting in Santo-Rhino meeting in September 2019., Results: Fifty statements (82% of total) on spontaneous CSF leak and IIH reached consensus. In 38 of 50 statements, the median response was 7 (strongly agree) and in the 12 remaining statements the median response was 6 (agree). Eleven statements were excluded because they did not reach consensus and one new statement was added during SantoRhino meeting. The final statements refer to patient history and clinical examination ("History taking should include presence of headache, tinnitus and visual defects"), investigations (role of Thin Slice Computed Tomography and CISS/FLAIR sequences in Magnetic Resonance Imaging), principles of management (watchful waiting or measures to reduce ICP are supplementary but cannot subsitute surgical closure), surgical technique, intraoperative, early postoperative and long term management., Conclusion: We present fifty consensus statements on the diagnosis, investigation, and management of spontaneous CSF rhinorrhea based on the currently available evidence and expert opinion. Although by no means comprehensive and final, we believe they can contribute to the standardization of clinical practice. Early diagnosis, prompt surgical closure of the defect, assesment for and treatment of potentially co-existing idiopathic intracranial hypertension in a comprehensive multidisciplinary approach are essential in order to successfully manage spontaneous CSF rhinorrhea, reduce associated morbidity and prevent recurrence., (© 2020 ARS-AAOA, LLC.)
- Published
- 2021
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34. Pituitary Adenoma Apoplexy in an Adolescent: A Case Report and Review of the Literature.
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Zijlker H, Schagen S, Wit JM, Biermasz N, van Furth W, and Oostdijk W
- Subjects
- Adolescent, Humans, Male, Adenoma complications, Pituitary Apoplexy etiology, Pituitary Neoplasms complications
- Abstract
We present a 13-year-old boy who was admitted with complaints of a state of progressive sleepiness and a sudden headache with vomiting and fever. Laboratory testing showed hypoglycemia, multiple pituitary hormonal deficiencies, and an elevated C-reactive protein level. A cranial magnetic resonance imaging (MRI) showed an opaque sphenoid sinus and an intrasellar mass suggesting hemorrhage, so that we suspected pituitary apoplexy (PA) originating from a non-functioning adenoma, although a pituitary abscess could not completely be excluded. The boy was treated with antibiotics, hydrocortisone, and levothyroxine. Due to his rapid clinical improvement, no surgery was performed and we considered the diagnosis of PA as confirmed. At follow-up, the MRI scan showed a small residual lesion. Pituitary deficiencies of growth hormone, adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone, and vasopressin persisted. A literature search of all well-documented cases of PA in children or adolescents (n=30, 13 boys and 17 girls) indicated that this condition is rare below 20 years of age but must be considered when a patient experiences headache with or without visual disturbances, even in the presence of clinical and laboratory signals suggestive of pituitary abscess. MRI neuroimaging is helpful in the differential diagnosis. In both conditions, the possibility of ACTH deficiency should always be considered, investigated, and treated. In cases without severe neuro-ophthalmological deficits and/or with a rapid and positive response to acute medical management, one can abstain from surgical treatment.
- Published
- 2017
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35. Extended endoscopic endonasal skull base surgery: from the sella to the anterior and posterior cranial fossa.
- Author
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Oostra A, van Furth W, and Georgalas C
- Subjects
- Adenoma surgery, Chordoma surgery, Cranial Fossa, Anterior surgery, Cranial Fossa, Posterior surgery, Cranial Nerve Neoplasms surgery, Craniopharyngioma surgery, Humans, Meningeal Neoplasms surgery, Meningioma surgery, Pituitary Neoplasms surgery, Sella Turcica surgery, Central Nervous System Neoplasms surgery, Natural Orifice Endoscopic Surgery methods, Skull Base surgery
- Abstract
Skull base surgery has gone through significant changes with the development of extended endoscopic endonasal approaches over the last decade. Initially used for the transphenoidal removal of hypophyseal adenomas, the endoscopic transnasal approach gradually evolved into a way of accessing the whole ventral skull base. Improved visualization, avoidance of brain retraction, the ability to access directly tumours with minimal damage to critical neurosurgical structures as well lack of external scars are among its obvious benefits. However, it presents the surgeons with a number of challenges, including the need to deal endoscopically with potential arterial bleeding, complicated reconstruction requirements as well as the need for a true team approach. In this review drawing from our experience as well as published series, we present an overview of current indications, challenges and limitations of the expanded endonasal approaches to the skull base., (© 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.)
- Published
- 2012
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36. [Children with obesity and declining linear growth curve: Cushing's disease?].
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van Wezel EM, van Santen HM, van Furth W, Reneman L, Bisschop PH, and van Trotsenburg AS
- Subjects
- Adenoma blood, Adenoma diagnosis, Adenoma surgery, Child, Cushing Syndrome blood, Cushing Syndrome surgery, Dexamethasone, Diagnosis, Differential, Female, Humans, Pituitary Neoplasms blood, Pituitary Neoplasms diagnosis, Pituitary Neoplasms surgery, Treatment Outcome, Body Height physiology, Cushing Syndrome diagnosis, Obesity diagnosis
- Abstract
We describe two children who presented with extreme weight gain and failure to grow in height, and who were both diagnosed with Cushing's disease. Following preoperative metyrapone treatment, both children successfully underwent curative transsphenoidal surgery. While obesity is a common and increasing problem in childhood, Cushing's disease is rare. The combination of weight gain and growth failure in a child is an alarming sign in which underlying endocrine disease must be ruled out.
- Published
- 2012
37. [Diagnosis and treatment of brain tumours].
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Stalpers LJ, Dieleman EM, van Westing BR, Postma TJ, and van Furth WR
- Subjects
- Adult, Aged, 80 and over, Brain Neoplasms complications, Brain Neoplasms mortality, Child, Preschool, Combined Modality Therapy, Female, Humans, Male, Neoplasm Metastasis, Palliative Care methods, Prognosis, Survival Analysis, Time Factors, Antineoplastic Agents therapeutic use, Brain Neoplasms diagnosis, Brain Neoplasms therapy, Radiotherapy methods
- Abstract
Primary brain tumours are relatively rare, but brain metastases are a frequent complication of the most common cancers elsewhere in the body (breast, lung, melanoma). Loss of function and excitation of brain nerves i.e. sensory loss, paralysis and pain in the head-and-neck region are specific features in base of skull tumours: meningioma, glomus tumours, vestibular Schwannoma, meningeal metastases by breast cancer, melanoma, and leukaemia, melanoma. In the diagnosis and treatment of brain tumours, special attention is required for rare complications in the head and neck region.
- Published
- 2009
38. Salivary gland-like tumor of the sella.
- Author
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van Furth W, Smyth HS, Horvath E, Kovacs K, Salehi F, and Cusimano MD
- Subjects
- Angioplasty, Balloon, Coronary, Aortic Aneurysm pathology, Carcinoma, Acinar Cell complications, Diabetes Insipidus etiology, Diagnosis, Differential, Humans, Hypernatremia etiology, Immunohistochemistry, Magnetic Resonance Imaging, Male, Microscopy, Electron, Transmission, Middle Aged, Myocardial Infarction pathology, Myocardial Infarction surgery, Pituitary Neoplasms pathology, Salivary Gland Neoplasms pathology, Skull Neoplasms complications, Stomach Ulcer pathology, Carcinoma, Acinar Cell pathology, Carcinoma, Acinar Cell physiopathology, Sella Turcica pathology, Skull Neoplasms pathology, Skull Neoplasms physiopathology
- Published
- 2007
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39. [Subtle skin lesions in the midline as an indication of a neurodermal closing defect].
- Author
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Bleeker FE, van Furth WR, van der Horst CM, Majoie CB, and Koot RW
- Subjects
- Adult, Child, Preschool, Dermatologic Surgical Procedures, Female, Humans, Magnetic Resonance Imaging methods, Male, Neural Tube Defects complications, Neural Tube Defects pathology, Skin Diseases pathology, Skin Diseases surgery, Skin pathology, Skin Diseases diagnosis
- Abstract
Three patients, aged 2, 2.5 and 24 years, presented with a skin lesion in the median or paramedian area at the nose, in the lumbar region and between the shoulders, respectively. The first patient suffered from recurrent infection, the skin lesion of the second patient was a coincidental finding, and the third patient had cosmetic problems. Although there were no signs of neurological deficits, neurodermal closing defects were found by MRI. Two patients underwent surgery to prevent infection and neurological complaints in the future. It is stressed that even if there are no neurological signs or infections, congenital dermal lesions situated in the midline should be considered as possible neural tube defects and therefore analysed by MRI. Ifa neurodermal dysraphism is found, patients should be referred to a neurosurgical centre. A good clinical assessment of the neural lesion, clinical signs and age will determine whether surgical resection is indicated to prevent or resolve neurological problems, infections or cosmetic complaints.
- Published
- 2006
40. Hyaluronate receptors mediating glioma cell migration and proliferation.
- Author
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Akiyama Y, Jung S, Salhia B, Lee S, Hubbard S, Taylor M, Mainprize T, Akaishi K, van Furth W, and Rutka JT
- Subjects
- Antibodies, Monoclonal pharmacology, Astrocytoma metabolism, Astrocytoma pathology, Blotting, Western, Brain Neoplasms pathology, Cell Division, Cell Movement, Extracellular Matrix metabolism, Extracellular Matrix Proteins immunology, Ganglioglioma metabolism, Ganglioglioma pathology, Glioblastoma metabolism, Glioblastoma pathology, Glioma pathology, Hyaluronan Receptors immunology, Medulloblastoma metabolism, Medulloblastoma pathology, Microscopy, Fluorescence, Molecular Weight, Neoplasm Proteins immunology, Tumor Cells, Cultured, Brain Neoplasms metabolism, Extracellular Matrix Proteins physiology, Glioma metabolism, Hyaluronan Receptors physiology, Hyaluronic Acid metabolism, Neoplasm Invasiveness physiopathology, Neoplasm Proteins physiology
- Abstract
The extracellular matrix (ECM) of the central nervous system (CNS) is enriched in hyaluronate (HA). Ubiquitous receptors for HA are CD44 and the Receptor for HA-Mediated Motility known as RHAMM. In the present study, we have investigated the potential role of CD44 and RHAMM in the migration and proliferation of human astrocytoma cells. HA-receptor expression in brain tumor cell lines and surgical specimens was determined by immunocytochemistry and western blot analyses. The ability of RHAMM to bind ligand was determined through cetylpyridinium chloride (CPC) precipitations of brain tumor lysates in HA-binding assays. The effects of HA, CD44 blocking antibodies, and RHAMM soluble peptide on astrocytoma cell growth and migration was determined using MTT and migration assays. Our results show that the expression of the HA-receptors, CD44, and RHAMM, is virtually ubiquitous amongst glioma cell lines, and glioma tumor specimens. There was a gradient of expression amongst gliomas with high grade gliomas expressing more RHAMM and CD44 than did lower grade lesions or did normal human astrocytes or non-neoplastic specimens of human brain. Specific RHAMM variants of 85- and 58-kDa size were shown to bind avidly to HA following CPC precipitations. RHAMM soluble peptide inhibited glioma cell line proliferation in a dose-dependent fashion. Finally, while anti-CD44 antibodies did not inhibit the migration of human glioma cells, soluble peptides directed at the HA-binding domain of RHAMM inhibited glioma migration both on and off an HA-based ECM. These data support the notion that HA-receptors contribute to brain tumor adhesion, proliferation, and migration, biological features which must be better understood before more effective treatment strategies for these tumors can be found.
- Published
- 2001
- Full Text
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41. Endogenous opioids and reward.
- Author
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Van Ree JM, Niesink RJ, Van Wolfswinkel L, Ramsey NF, Kornet MM, Van Furth WR, Vanderschuren LJ, Gerrits MA, and Van den Berg CL
- Subjects
- Animals, Behavior drug effects, Behavior physiology, Behavior, Animal drug effects, Behavior, Animal physiology, Humans, Reinforcement, Psychology, Self Stimulation, Endorphins physiology, Reward
- Abstract
The discovery of endogenous opioids has markedly influenced the research on the biology of addiction and reward brain processes. Evidence has been presented that these brain substances modulate brain stimulation reward, self-administration of different drugs of abuse, sexual behaviour and social behaviour. There appears to be two different domains in which endogenous opioids, present in separate and distinct brain regions, are involved. One is related to the modulation of incentive motivational processes and the other to the performance of certain behaviours. It is concluded that endogenous opioids may play a role in the vulnerability to certain diseases, such as addiction and autism, but also when the disease is present, such as alcoholism.
- Published
- 2000
- Full Text
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42. Colloid cysts.
- Author
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de Witt Hamer PC, Verstegen MJ, van Furth WR, and Bosch DA
- Subjects
- Brain Diseases physiopathology, Cysts physiopathology, Death, Sudden etiology, Decision Making, Fourth Ventricle surgery, Humans, Treatment Outcome, Brain Diseases surgery, Cysts surgery
- Published
- 2000
43. Appetitive sexual behavior in male rats: 1. The role of olfaction in level-changing behavior.
- Author
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Van Furth WR and Van Ree JM
- Subjects
- Animals, Female, Male, Rats, Rats, Wistar, Motivation, Motor Activity physiology, Sexual Behavior, Animal physiology, Smell physiology
- Abstract
Level-changing behavior is a form of anticipatory behavior of a male rat, when tested in a bilevel testbox. The male explores the testcage prior to introduction of a female. The female is introduced after 5 min. The number of level changes displayed by the male in this period reflects appetitive aspects of sexual behavior and it was suggested that analysis of this level-changing behavior may function as assessment of sexual motivation. In this study the increase of anticipatory level changes over repeated weekly tests was dependent upon (sexual) olfactory stimulation. The number of anticipatory level changes was reliably reduced by administration of the opioid antagonist naloxone, suggesting that endogenous opioids facilitate this behavior. These results suggest that the increase of anticipatory level changes over repeated tests is a response to olfactory stimuli and reflects appetitive aspects of sexual behavior, which are stimulated by endogenous opioids. These results are in accordance with the concept that analysis of anticipatory level-changing behavior can be used to assess sexual motivation.
- Published
- 1996
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44. Appetitive sexual behavior in male rats: 2. sexual reward and level-changing behavior.
- Author
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Van Furth WR and Van Ree JM
- Subjects
- Animals, Female, Male, Rats, Rats, Wistar, Motivation, Motor Activity physiology, Reward, Sexual Behavior, Animal physiology
- Abstract
Anticipatory level-changing behavior is a form of appetitive sexual behavior displayed by male rats prior to introduction of a female in a bilevel testbox. Analysis of this level-changing behavior may serve as assessment of sexual motivation. Because ejaculation affects appetitive aspects of sexual behavior, measures purporting to assess sexual motivation should be effected by ejaculation. We observed that ejaculation prior to testing reduced the number of anticipatory level changes of a male rat. This reduction was greater when tested after two than after one ejaculation. Our results support the concept that analysis of anticipatory level-changing behavior can be used to measure sexual motivation.
- Published
- 1996
- Full Text
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45. Sexual motivation: involvement of endogenous opioids in the ventral tegmental area.
- Author
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van Furth WR and van Ree JM
- Subjects
- Animals, Female, Male, Rats, Rats, Wistar, Sexual Behavior, Animal drug effects, Statistics as Topic, Ventral Tegmental Area drug effects, Motivation, Naloxone pharmacology, Narcotic Antagonists pharmacology, Sexual Behavior, Animal physiology, Ventral Tegmental Area physiology, beta-Endorphin pharmacology
- Abstract
The sexual motivation and performance of male rats were observed in a bilevel testing chamber after bilateral infusion of 40 pmol beta-endorphin, 2.75 nmol naloxone or saline into the ventral tegmental area for four succeeding, weekly tests. In the 5 min prior to introduction of the female rat, the male rat explores the bilevel testing chamber. It was previously shown that the increase over tests of these anticipatory level changes is sexually motivated and a response to olfactory stimuli. Naloxone infusion into the VTA prevented the increase of anticipatory level changes. beta-Endorphin failed to affect the anticipatory level-changing behavior. The sexual performance was unaffected by naloxone or beta-endorphin treatment, but the number of ejaculating rats decreased with repeated testing after naloxone treatment. It is concluded that endogenous opioid systems in the ventral tegmental area contribute to the stimulation of sexual motivation and/or reward, presumably by stimulating the mesolimbic dopamine system in response to sex-related olfactory stimuli.
- Published
- 1996
- Full Text
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46. Regulation of masculine sexual behavior: involvement of brain opioids and dopamine.
- Author
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van Furth WR, Wolterink G, and van Ree JM
- Subjects
- Animals, Brain Chemistry physiology, Male, Dopamine physiology, Opioid Peptides physiology, Sexual Behavior, Animal physiology
- Abstract
In recent years much has become known about the substrates in the brain involved in the regulation of masculine sexual behavior and the involvement of specific neurochemicals in these brain areas. In the present paper the experimental data concerning the involvement of a number of brain areas in sexual behavior are reviewed, in relation to an incentive motivational theory of sexual behavior. The review is restricted to the involvement of opioids and dopamine, of which the role in sexual motivation and behavior is best documented. Opioids in the medial preoptic area (mPOA) impair sexual performance, although the endogenous opioids systems may be quiescent in normal, sexually active rats. Dopamine in the mPOA has a facilitative role in the masculine sexual performance. The corticomedial amygdala is involved in processing of sensory information, especially olfactory stimuli, which are subsequently directed towards the mPOA. Local beta-endorphin infusion interferes with this processing. Endogenous opioids in the ventral tegmental area activate the mesoaccumbens dopamine system and stimulate the sexual motivation. Increased dopamine transmission in the nucleus accumbens correlates with increased sexual motivation and vice versa. The basolateral amygdala plays an essential role in the association of environmental stimuli with reward and therefore in the expression of conditioned sexual motivation. Finally, the reviewed data are integrated and a comprehensive view on the relations between various neural substrates is composed.
- Published
- 1995
- Full Text
- View/download PDF
47. Opioids and sexual behavior of male rats: involvement of the medial preoptic area.
- Author
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van Furth WR, van Emst MG, and van Ree JM
- Subjects
- Animals, Brain Mapping, Female, Male, Neural Inhibition physiology, Rats, Rats, Wistar, beta-Endorphin physiology, Copulation physiology, Opioid Peptides physiology, Preoptic Area physiology, Sexual Behavior, Animal physiology
- Abstract
Local infusion of beta-endorphin (beta-END) into the medial preoptic area (MPOA) dose-dependently impaired the gating of the copulatory response and the execution of the sexual performance of sexually experienced, intact male rats. Local naloxone treatment prevented the impairment of the sexual response by beta-END, but failed to facilitate unimpaired copulation. Local infusion into the MPOA of equimolar doses of alpha-endorphin, dynorphin-A-(1-17) or met-enkephalin were less effective than beta-END. It is suggested that endogenous opioid systems in the MPOA are normally quiescent, and increased activity may be related to disrupted or inhibited male sexual behavior.
- Published
- 1995
- Full Text
- View/download PDF
48. Endogenous opioids and sexual motivation and performance during the light phase of the diurnal cycle.
- Author
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van Furth WR and van Ree JM
- Subjects
- Animals, Copulation drug effects, Female, Light, Male, Motivation, Naloxone pharmacology, Rats, Rats, Wistar, Refractory Period, Electrophysiological drug effects, Sexual Behavior, Animal drug effects, Circadian Rhythm physiology, Endorphins physiology, Sexual Behavior, Animal physiology
- Abstract
The sexual motivation and performance of sexually experienced male rats were tested during the light phase of the diurnal cycle after treatment with saline or 1 mg.kg-1 naloxone in a bilevel testing box. The sexual motivation during the light phase, as assessed by the increase in anticipatory level changes prior to introduction of a receptive female on subsequent weekly sessions, was comparable to that during the dark phase. Opioid blockade reduced the increase of level changes, suggesting that endogenous opioids are involved in sexual motivation. The sexual performance was impaired during the light phase. Naloxone treatment failed to affect the sexual performance, other than that the post ejaculatory refractory period was increased. This increased latency to re-initiate copulation may be an expression of the reduced sexual motivation. It is concluded that endogenous opioids are not involved in the regulation of the impaired sexual performance during the light phase of the diurnal cycle. In contrast, the sexual motivation, which displays no marked diurnal variation, may be stimulated by endogenous opioids.
- Published
- 1994
- Full Text
- View/download PDF
49. [A little less sodium is not without hazard].
- Author
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van Furth WR and Eelkman Rooda SJ
- Subjects
- Diagnosis, Differential, Female, Humans, Hyponatremia chemically induced, Hyponatremia diagnosis, Male, Middle Aged, Osmolar Concentration, Hyponatremia etiology, Inappropriate ADH Syndrome complications, Spironolactone adverse effects
- Published
- 1993
50. The grasping response in rats: interaction between gamma-type endorphins and haloperidol.
- Author
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Van Furth WR, Wiegant VM, Bruning JW, and Van Ree JM
- Subjects
- Animals, Antibodies, Monoclonal immunology, Brain Chemistry drug effects, Endorphins immunology, Injections, Intraventricular, Male, Rats, Rats, Inbred Strains, beta-Endorphin antagonists & inhibitors, gamma-Endorphin, Behavior, Animal drug effects, Endorphins pharmacology, Haloperidol pharmacology
- Abstract
gamma-Type endorphins mimic neuroleptics in inducing a grasping response in rats. It was studied whether the haloperidol-induced grasping response was altered after blockade of gamma-type endorphin activity in the rat brain. To achieve this blockade rats were injected i.c.v. with gamma-endorphin antiserum or with a monoclonal anti-idiotype desenkephalin-gamma-endorphin antibody, which may bio-inactivate the gamma-type endorphins or block the putative receptors for gamma-type endorphins, respectively. The results showed that both treatments attenuated the haloperidol-induced grasping response, particularly 3 h after haloperidol treatment. The influence of these antibodies appeared to be specific, since other sera were without effect. Thus there may be an interaction between the endogenous gamma-type endorphin activity and the haloperidol-induced grasping response.
- Published
- 1991
- Full Text
- View/download PDF
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