109 results on '"van Zwet, E. W."'
Search Results
2. Funnel plots a graphical instrument for the evaluation of population performance and quality of trauma care: a blueprint of implementation
- Author
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Driessen, M. L. S., van Zwet, E. W., Sturms, L. M., de Jongh, M. A. C., and Leenen, L. P. H.
- Published
- 2023
- Full Text
- View/download PDF
3. Trends in data quality and quality indicators 5 years after implementation of the Dutch Hip Fracture Audit
- Author
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Würdemann, F. S., Krijnen, P., van Zwet, E. W., Arends, A. J., Heetveld, M. J., Trappenburg, M. C., Hegeman, J. H., and Schipper, I. B.
- Published
- 2022
- Full Text
- View/download PDF
4. Dysphagia, Fear of Choking and Preventive Measures in Patients with Huntington’s Disease: The Perspectives of Patients and Caregivers in Long-Term Care
- Author
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Kalkers, K., Schols, J. M. G. A., van Zwet, E. W., and Roos, R. A. C.
- Published
- 2022
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- View/download PDF
5. Exact Sampling from Conditional Boolean Models with Applications to Maximum Likelihood Inference
- Author
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Van Lieshout, M. N. M. and Van Zwet, E. W.
- Published
- 2001
6. Funnel plots a graphical instrument for the evaluation of population performance and quality of trauma care: a blueprint of implementation
- Author
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Cardiologie Arts-onderzoekers, Zorgeenheid Traumatologie, Infection & Immunity, Driessen, M. L. S., van Zwet, E. W., Sturms, L. M., de Jongh, M. A. C., Leenen, L. P. H., Cardiologie Arts-onderzoekers, Zorgeenheid Traumatologie, Infection & Immunity, Driessen, M. L. S., van Zwet, E. W., Sturms, L. M., de Jongh, M. A. C., and Leenen, L. P. H.
- Published
- 2023
7. A Remark on Consistent Estimation
- Author
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van Zwet, E. W., van Zwet, W. R., van de Geer, Sara, editor, and Wegkamp, Marten, editor
- Published
- 2012
- Full Text
- View/download PDF
8. Funnel plots a graphical instrument for the evaluation of population performance and quality of trauma care: a blueprint of implementation
- Author
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Driessen, M. L. S., primary, van Zwet, E. W., additional, Sturms, L. M., additional, de Jongh, M. A. C., additional, and Leenen, L. P. H., additional
- Published
- 2022
- Full Text
- View/download PDF
9. Progression of motor subtypes in Huntington’s disease: a 6-year follow-up study
- Author
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Jacobs, M., Hart, E. P., van Zwet, E. W., Bentivoglio, A. R., Burgunder, J. M., Craufurd, D., Reilmann, R., Saft, C., Roos, R. A. C., and The REGISTRY investigators of the European Huntington’s Disease Network
- Published
- 2016
- Full Text
- View/download PDF
10. Pretransplantation Donor–Recipient Pair Seroreactivity Against BK Polyomavirus Predicts Viremia and Nephropathy After Kidney Transplantation
- Author
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Wunderink, H. F., van der Meijden, E., van der Blij‐de Brouwer, C. S., Mallat, M. J. K., Haasnoot, G. W., van Zwet, E. W., Claas, E. C. J., de Fijter, J. W., Kroes, A. C. M., Arnold, F., Touzé, A., Claas, F. H. J., Rotmans, J. I., and Feltkamp, M. C. W.
- Published
- 2017
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11. Tailor-made proficiency curves in laparoscopic hysterectomy: enhancing patient safety using CUSUM analysis
- Author
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Twijnstra, A. R. H., Blikkendaal, M. D., Driessen, S. R. C., van Zwet, E. W., de Kroon, C. D., and Jansen, F. W.
- Published
- 2014
- Full Text
- View/download PDF
12. Head growth in fetuses with isolated congenital heart defects: lack of influence of aortic arch flow and ascending aorta oxygen saturation
- Author
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Jansen, F. A. R., van Zwet, E. W., Rijlaarsdam, M. E. B., Pajkrt, E., van Velzen, C. L., Zuurveen, H. R., Kragt, A., Bax, C. L., Clur, S.‐A. B., van Lith, J. M. M., Blom, N. A., and Haak, M. C.
- Published
- 2016
- Full Text
- View/download PDF
13. Cranial translation of the humeral head on radiographs in rotator cuff tear patients: the modified active abduction view
- Author
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Henseler, J. F., de Witte, P. B., de Groot, J. H., van Zwet, E. W., Nelissen, R. G. H. H., and Nagels, J.
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- 2014
- Full Text
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14. Laser surgery as a management option for twin anemia–polycythemia sequence
- Author
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Slaghekke, F., Favre, R., Peeters, S. H. P., Middeldorp, J. M., Weingertner, A. S., van Zwet, E. W., Klumper, F. J., Oepkes, D., and Lopriore, E.
- Published
- 2014
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15. The risk for hyperoxaemia after apnoea, bradycardia and hypoxaemia in preterm infants
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van Zanten, H A, Tan, R N G B, Thio, M, de Man-van Ginkel, J M, van Zwet, E W, Lopriore, E, and te Pas, A B
- Published
- 2014
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16. Early-onset thrombocytopenia in near-term and term infants with perinatal asphyxia
- Author
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Boutaybi, N., Steggerda, S. J., Smits-Wintjens, V. E. H. J., van Zwet, E. W., Walther, F. J., and Lopriore, E.
- Published
- 2014
- Full Text
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17. Cerebral injury in monochorionic twins with selective intrauterine growth restriction: a systematic review
- Author
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Inklaar, M. J., van Klink, J. M. M., Stolk, T. T., van Zwet, E. W., Oepkes, D., and Lopriore, E.
- Published
- 2014
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18. Cranial humerus translation, deltoid activation, adductor co-activation and rotator cuff disease — Different patterns in rotator cuff tears, subacromial impingement and controls
- Author
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de Witte, P. B., Henseler, J. F., van Zwet, E. W., Nagels, J., Nelissen, R. G.H.H., and de Groot, J. H.
- Published
- 2014
- Full Text
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19. Increased Metallothionein Expression Reflects Steroid Resistance in Renal Allograft Recipients
- Author
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Rekers, N. V., Bajema, I. M., Mallat, M. J. K., Anholts, J. D. H., de Vaal, Y. J. H., Zandbergen, M., Haasnoot, G. W., van Zwet, E. W., de Fijter, J. W., Claas, F. H. J., and Eikmans, M.
- Published
- 2013
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20. Increased perinatal loss after intrauterine transfusion for alloimmune anaemia before 20 weeks of gestation
- Author
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Lindenburg, I TM, van Kamp, I L, van Zwet, E W, Middeldorp, J M, Klumper, F JCM, and Oepkes, D
- Published
- 2013
- Full Text
- View/download PDF
21. A Remark on Consistent Estimation
- Author
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van Zwet, E. W., primary and van Zwet, W. R., additional
- Published
- 2011
- Full Text
- View/download PDF
22. Thrombocytopenia at birth in neonates with red cell alloimmune haemolytic disease
- Author
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Rath, M. E. A., Smits-Wintjens, V. E. H. J., Oepkes, D., van Zwet, E. W., van Kamp, I. L., Brand, A., Walther, F. J., and Lopriore, E.
- Published
- 2012
- Full Text
- View/download PDF
23. Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
- Author
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Porcu, E. (Eleonora), Rueger, S. (Sina), Lepik, K. (Kaido), Agbessi, M. (Mawusse), Ahsan, H. (Habibul), Alves, I. (Isabel), Andiappan, A. (Anand), Arindrarto, W. (Wibowo), Awadalla, P. (Philip), Battle, A. (Alexis), Beutner, F. (Frank), Bonder, M. J. (Marc Jan), Boomsma, D. (Dorret), Christiansen, M. (Mark), Claringbould, A. (Annique), Deelen, P. (Patrick), Esko, T. (Tonu), Fave, M.-J. (Marie-Julie), Franke, L. (Lude), Frayling, T. (Timothy), Gharib, S. A. (Sina A.), Gibson, G. (Gregory), Heijmans, B. T. (Bastiaan T.), Hemani, G. (Gibran), Jansen, R. (Rick), Kahonen, M. (Mika), Kalnapenkis, A. (Anette), Kasela, S. (Silva), Kettunen, J. (Johannes), Kim, Y. (Yungil), Kirsten, H. (Holger), Kovacs, P. (Peter), Krohn, K. (Knut), Kronberg-Guzman, J. (Jaanika), Kukushkina, V. (Viktorija), Lee, B. (Bernett), Lehtimaki, T. (Terho), Loeffler, M. (Markus), Marigorta, U. M. (Urko M.), Mei, H. (Hailang), Milani, L. (Lili), Montgomery, G. W. (Grant W.), Mueler-Nurasyid, M. (Martina), Nauck, M. (Matthias), Nivard, M. (Michel), Penninx, B. (Brenda), Perola, M. (Markus), Pervjakova, N. (Natalia), Pierce, B. L. (Brandon L.), Powell, J. (Joseph), Prokisch, H. (Holger), Psaty, B. M. (Bruce M.), Raitakari, O. T. (Olli T.), Ripatti, S. (Samuli), Rotzschke, O. (Olaf), Saha, A. (Ashis), Scholz, M. (Markus), Schramm, K. (Katharina), Seppala, I. (Ilkka), Slagboom, E. P. (Eline P.), Stehouwer, C. D. (Coen D. A.), Stumvoll, M. (Michael), Sullivan, P. (Patrick), Teumer, A. (Alexander), Thiery, J. (Joachim), Tong, L. (Lin), Tonjes, A. (Anke), van Dongen, J. (Jenny), van Iterson, M. (Maarten), van Meurs, J. (Joyce), Veldink, J. H. (Jan H.), Verlouw, J. (Joost), Visscher, P. M. (Peter M.), Volker, U. (Uwe), Vosa, U. (Urmo), Westra, H.-J. (Harm-Jan), Wijmenga, C. (Cisca), Yaghootkar, H. (Hanieh), Yang, J. (Jian), Zeng, B. (Biao), Zhang, F. (Futao), Beekman, M. (Marian), Boomsma, D. I. (Dorret I.), Bot, J. (Jan), Deelen, J. (Joris), Hofman, B. A. (Bert A.), Hottenga, J. J. (Jouke J.), Isaacs, A. (Aaron), Jhamai, P. M. (P. Mila), Kielbasa, S. M. (Szymon M.), Lakenberg, N. (Nico), Luijk, R. (Rene), Mei, H. (Hailiang), Moed, M. (Matthijs), Nooren, I. (Irene), Pool, R. (Rene), Schalkwijk, C. G. (Casper G.), Slagboom, P. E. (P. Eline), Suchiman, H. E. (H. Eka D.), Swertz, M. A. (Morris A.), Tigchelaar, E. F. (Ettje F.), Uitterlinden, A. G. (Andre G.), van den Berg, L. H. (Leonard H.), van der Breggen, R. (Ruud), van der Kallen, C. J. (Carla J. H.), van Dijk, F. (Freerk), van Duijn, C. M. (Cornelia M.), van Galen, M. (Michiel), van Greevenbroek, M. M. (Marleen M. J.), van Heemst, D. (Diana), van Rooij, J. (Jeroen), Van't Hof, P. (Peter), van Zwet, E. W. (Erik. W.), Vermaat, M. (Martijn), Verbiest, M. (Michael), Verkerk, M. (Marijn), Zhernakova, D. V. (Dasha V.), Zhernakova, S. (Sasha), Santoni, F. A. (Federico A.), Reymond, A. (Alexandre), and Kutalik, Z. (Zoltan)
- Abstract
Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs, indicating their potential involvement in regulation of gene expression. Here, we propose a transcriptome-wide summary statistics-based Mendelian Randomization approach (TWMR) that uses multiple SNPs as instruments and multiple gene expression traits as exposures, simultaneously. Applied to 43 human phenotypes, it uncovers 3,913 putatively causal gene–trait associations, 36% of which have no genome-wide significant SNP nearby in previous GWAS. Using independent association summary statistics, we find that the majority of these loci were missed by GWAS due to power issues. Noteworthy among these links is educational attainment-associated BSCL2, known to carry mutations leading to a Mendelian form of encephalopathy. We also find pleiotropic causal effects suggestive of mechanistic connections. TWMR better accounts for pleiotropy and has the potential to identify biological mechanisms underlying complex traits.
- Published
- 2019
24. Sensitivity of MG‐ADL for generalized weakness in myasthenia gravis
- Author
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de Meel, R. H. P., primary, Raadsheer, W. F., additional, van Zwet, E. W., additional, Verschuuren, J. J. G. M., additional, and Tannemaat, M. R., additional
- Published
- 2018
- Full Text
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25. Systemic features of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: a monogenic small vessel disease
- Author
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Pelzer, N., primary, Hoogeveen, E. S., additional, Haan, J., additional, Bunnik, R., additional, Poot, C. C., additional, van Zwet, E. W., additional, Inderson, A., additional, Fogteloo, A. J., additional, Reinders, M. E. J., additional, Middelkoop, H. A. M., additional, Kruit, M. C., additional, van den Maagdenberg, A. M. J. M., additional, Ferrari, M. D., additional, and Terwindt, G. M., additional
- Published
- 2018
- Full Text
- View/download PDF
26. Progression of motor subtypes in Huntington's disease: a 6-year follow-up study
- Author
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Jacobs, M, Hart, E. P., van Zwet, E. W., Bentivoglio, A. R., Burgunder, J. M., Craufurd, D., Reilmann, R., Saft, C., Roos, R. A. C., The REGISTRY, investigators of the European Huntington’s Disease Network, Ferraldeschi, Michela, Ristori, Giovanni, and Romano, Silvia
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Neurology ,Clinical Neurology ,Disease ,Motor Activity ,Neuropsychological Tests ,Severity of Illness Index ,Neuropsychological assessment ,Statistics, Nonparametric ,03 medical and health sciences ,0302 clinical medicine ,Huntington's disease ,Chorea ,Internal medicine ,medicine ,Humans ,Verbal fluency test ,Longitudinal Studies ,Aged ,Original Communication ,medicine.diagnostic_test ,Cognition ,Middle Aged ,medicine.disease ,Europe ,Huntington Disease ,030104 developmental biology ,Disease Progression ,Physical therapy ,Hypokinetic ,Regression Analysis ,Female ,Neurology (clinical) ,medicine.symptom ,Cognition Disorders ,Psychology ,030217 neurology & neurosurgery ,chorea ,huntington’s disease ,hypokinetic ,neuropsychological assessment ,neurology ,neurology (clinical) ,Huntington’s disease ,Stroop effect - Abstract
The objective of this study is to investigate the progression of predominantly choreatic and hypokinetic-rigid signs in Huntington’s disease (HD) and their relationship with cognitive and general functioning over time. The motor signs in HD can be divided into predominantly choreatic and hypokinetic-rigid subtypes. It has been reported in cross-sectional studies that predominantly choreatic HD patients perform better on functional and cognitive assessments compared to predominantly hypokinetic-rigid HD patients. The course of these motor subtypes and their clinical profiles has not been investigated longitudinally. A total of 4135 subjects who participated in the European HD Network REGISTRY study were included and classified at baseline as either predominantly choreatic (n = 891), hypokinetic-rigid (n = 916), or mixed-motor (n = 2328), based on a previously used method. The maximum follow-up period was 6 years. The mixed-motor group was not included in the analyses. Linear mixed models were constructed to investigate changes in motor subtypes over time and their relationship with cognitive and functional decline. Over the 6-year follow-up period, the predominantly choreatic group showed a significant decrease in chorea, while hypokinetic-rigid symptoms slightly increased in the hypokinetic-rigid group. On the Total Functional Capacity, Stroop test, and Verbal fluency task the rate of change over time was significantly faster in the predominantly choreatic group, while on all other clinical assessments the decline was comparable for both groups. Our results suggest that choreatic symptoms decrease over time, whereas hypokinetic-rigid symptoms slightly increase in a large cohort of HD patients. Moreover, different motor subtypes can be related to different clinical profiles. Electronic supplementary material The online version of this article (doi:10.1007/s00415-016-8233-x) contains supplementary material, which is available to authorized users.
- Published
- 2016
27. Sensitivity of MG‐ADL for generalized weakness in myasthenia gravis.
- Author
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de Meel, R. H. P., Raadsheer, W. F., Verschuuren, J. J. G. M., Tannemaat, M. R., and van Zwet, E. W.
- Subjects
MYASTHENIA gravis ,ACTIVITIES of daily living ,NEUROMUSCULAR diseases - Abstract
Background and purpose: Myasthenia gravis activities of daily living (MG‐ADL) is a commonly used questionnaire in MG trials. To investigate whether MG‐ADL is equally sensitive to oculobulbar and generalized weakness, its correlation with the oculobulbar and generalized domain of the quantitative myasthenia gravis (QMG) score was analyzed (QMGob and QMGgen, respectively). To test whether the sensitivity of MG‐ADL for generalized weakness could be improved, the additional value of ACTIVLIM on top of MG‐ADL in the prediction QMGgen in was investigated. Methods: MG‐ADL, QMG and ACTIVLIM, an ADL questionnaire focusing on generalized weakness, were analyzed in a prospective cohort of 112 MG patients. A generalized linear model was used to calculate the correlation of MG‐ADL with QMGob and QMGgen and to assess the additional value of ACTIVLIM on top of MG‐ADL for its correlation with QMGgen. Results: MG‐ADL had a higher correlation with QMGob than with QMGgen (B = 0.68, P < 0.001, and B = 0.38, P < 0.001, respectively). A similar trend was found for changes in the scores (B = 0.68, P = 0.132, and B = 0.39, P = 0.492, respectively). ACTIVLIM had a significant additional value on top of MG‐ADL in the prediction of QMGgen, both cross‐sectionally (B = −0.61, P < 0.001) and for changes within individual patients (B = −0.93, P = 0.041). Conclusion: MG‐ADL has a lower sensitivity for generalized weakness than for oculobulbar weakness. Adding questions on generalized weakness would improve the sensitivity of the MG‐ADL for generalized weakness. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
28. Fetuses with Isolated Congenital Heart Defects Show Normal Cerebral and Extracerebral Fluid Volume Growth: A 3D Sonographic Study in the Second and Third Trimester.
- Author
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Jansen, F.A.R., van Zwet, E.W., Everwijn, S.M.P., Teunissen, A.K.K., Rozendaal, L., van Lith, J.M.M, Blom, N.A., Haak, M.C., van Zwet, E W, and van Lith, J M M
- Subjects
CONGENITAL heart disease ,ULTRASONIC imaging ,THIRD trimester of pregnancy ,NEURAL development ,CEREBRAL atrophy - Abstract
Objective: The aim of our study is to explore whether the cerebral growth is delayed in fetuses with congenital heart defects (CHD) in the second and early third trimester.Methods: A prospective cohort study was conducted in 77 CHD cases, with 75 healthy controls. 3D cerebral volume acquisition was performed sequentially. The volumes of the fetal hemicerebrum and extracerebral fluid were compared by linear regression analysis, and the Sylvian fissure was measured.Results: Between 19 and 32 weeks of gestation, 158 measurements in cases and 183 measurements in controls were performed (mean 2.2/subject). The volume growth of the hemicerebrum (R2 = 0.95 vs. 0.95; p = 0.9) and the extracerebral fluid (R2 = 0.84 vs. 0.82, p = 0.9) were similar. Fetuses with abnormal oxygen delivery to the brain have a slightly smaller brain at 20 weeks of gestation (p = 0.02), but this difference disappeared with advancing gestation. CHD cases demonstrated a slightly shallower Sylvian fissure (mean ratio 0.146 vs. 0.153; p = 0.004).Conclusions: Our study shows no differences in cerebral growth, studied in an unselected cohort, with successive cases of isolated CHD. Even in the severest CHD cases, cerebral size is similar in the early third trimester. The cause and meaning of a shallower Sylvian fissure is unclear; possibly, it is a marker for delayed cerebral maturation or it might be an expression of decreasing amount of extracerebral fluid. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
29. Systemic features of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: a monogenic small vessel disease.
- Author
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Pelzer, N., Hoogeveen, E. S., Haan, J., Bunnik, R., Poot, C. C., van Zwet, E. W., Inderson, A., Fogteloo, A. J., Reinders, M. E. J., Middelkoop, H. A. M., Kruit, M. C., van den Maagdenberg, A. M. J. M., Ferrari, M. D., and Terwindt, G. M.
- Subjects
RAYNAUD'S disease ,ETIOLOGY of diseases ,RETROLENTAL fibroplasia ,URINALYSIS ,THYROID diseases ,EARLY death - Abstract
Background: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a small vessel disease caused by C-terminal truncating TREX1 mutations. The disease is typically characterized by vascular retinopathy and focal and global brain dysfunction. Systemic manifestations have also been reported but not yet systematically investigated.Methods: In a cross-sectional study, we compared the clinical characteristics of 33 TREX1 mutation carriers (MC+) from three Dutch RVCL-S families with those of 37 family members without TREX1 mutation (MC-). All participants were investigated using personal interviews, questionnaires, physical, neurological and neuropsychological examinations, blood and urine tests, and brain MRI.Results: In MC+, vascular retinopathy and Raynaud's phenomenon were the earliest symptoms presenting from age 20 onwards. Kidney disease became manifest from around age 35, followed by liver disease, anaemia, markers of inflammation and, in some MC+, migraine and subclinical hypothyroidism, all from age 40. Cerebral deficits usually started mildly around age 50, associated with white matter and intracerebral mass lesions, and becoming severe around age 60-65.Conclusions: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations is a rare, but likely underdiagnosed, systemic small vessel disease typically starting with vascular retinopathy, followed by multiple internal organ disease, progressive brain dysfunction, and ultimately premature death. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
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30. Influence of coronary vessel dominance on short- and long-term outcome in patients after ST-segment elevation myocardial infarction
- Author
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Veltman, C. E., primary, van der Hoeven, B. L., additional, Hoogslag, G. E., additional, Boden, H., additional, Kharbanda, R. K., additional, de Graaf, M. A., additional, Delgado, V., additional, van Zwet, E. W., additional, Schalij, M. J., additional, Bax, J. J., additional, and Scholte, A. J. H. A., additional
- Published
- 2014
- Full Text
- View/download PDF
31. Neonatal Thrombocytopenia after Perinatal Asphyxia Treated with Hypothermia: A Retrospective Case Control Study
- Author
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Boutaybi, N., primary, Razenberg, F., additional, Smits-Wintjens, V. E. H. J., additional, van Zwet, E. W., additional, Rijken, M., additional, Steggerda, S. J., additional, and Lopriore, E., additional
- Published
- 2014
- Full Text
- View/download PDF
32. Early-onset thrombocytopenia in near-term and term infants with perinatal asphyxia
- Author
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Boutaybi, N., primary, Steggerda, S. J., additional, Smits-Wintjens, V. E. H. J., additional, van Zwet, E. W., additional, Walther, F. J., additional, and Lopriore, E., additional
- Published
- 2013
- Full Text
- View/download PDF
33. Cranial translation of the humeral head on radiographs in rotator cuff tear patients: the modified active abduction view
- Author
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Henseler, J. F., primary, de Witte, P. B., additional, de Groot, J. H., additional, van Zwet, E. W., additional, Nelissen, R. G. H. H., additional, and Nagels, J., additional
- Published
- 2013
- Full Text
- View/download PDF
34. Postdural puncture headache in migraineurs and nonheadache subjects: A prospective study
- Author
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van Oosterhout, W. P. J., primary, van der Plas, A. A., additional, van Zwet, E. W., additional, Zielman, R., additional, Ferrari, M. D., additional, and Terwindt, G. M., additional
- Published
- 2013
- Full Text
- View/download PDF
35. Thrombocytopenia at birth in neonates with red cell alloimmune haemolytic disease
- Author
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Rath, M. E. A., primary, Smits‐Wintjens, V. E. H. J., additional, Oepkes, D., additional, van Zwet, E. W., additional, van Kamp, I. L., additional, Brand, A., additional, Walther, F. J., additional, and Lopriore, E., additional
- Published
- 2011
- Full Text
- View/download PDF
36. Depressive symptoms during the different phases of a migraine attack: A prospective diary study.
- Author
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de Vries Lentsch, S, Louter, MA, van Oosterhout, WPJ, van Zwet, EW, van Noorden, MS, Terwindt, GM, Louter, M A, van Zwet, E W, van Noorden, M S, and Terwindt, G M
- Subjects
- *
MENTAL depression , *MIGRAINE , *MIGRAINE aura , *LONGITUDINAL method , *PRIMARY headache disorders , *SYMPTOMS , *RESEARCH , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *AFFECTIVE disorders , *HEADACHE - Abstract
Background: The relationship between migraine and depression has been thoroughly investigated, indicating a bidirectional comorbidity. The exact temporal relationship between acute depressive symptoms (mood changes) and the various phases of the migraine attack has not yet been examined.Methods: We performed a prospective diary study in n = 487 participants with migraine. Participants filled out a daily diary on migraine and acute depressive symptoms during a 1-month period. We randomly selected one migraine attack per participant, consisting of six days around an attack, including the interictal, premonitory, ictal, and postdromal phases. Acute depressive symptoms covered five major items from the DSM-5 classification. Primary analysis was performed using a mixed model with post-hoc testing. We also tested whether lifetime depression influenced the presence of acute depressive symptoms.Results: During a migraine headache day, patients scored higher on acute depressive symptoms than on all other days of the migraine attack (p < 0.001). There were no early warning signs for an upcoming headache attack through acute depressive symptomatology. Migraine patients with lifetime depression scored overall higher during the migraine attack than those without lifetime depression (p < 0.001).Limitations: Migraine attacks were based on self-reported migraine and one migraine attack per patient was randomly selected.Conclusion: We now clearly demonstrate that during the migraine headache phase, but not in the prodromal phase, patients report increased depressive symptomatology. No evidence was found for mood changes as an early warning sign for an upcoming migraine attack. [ABSTRACT FROM AUTHOR]- Published
- 2022
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37. Detoxification in medication-overuse headache, a retrospective controlled follow-up study: Does care by a headache nurse lead to cure?
- Author
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Pijpers, J. A., Louter, M. A., de Bruin, M. E., van Zwet, E. W., Zitman, F. G., Ferrari, M. D., and Terwindt, G. M.
- Subjects
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HEADACHE treatment , *DETOXIFICATION (Substance abuse treatment) , *DRUG abuse , *MULTIVARIATE analysis , *TEMPERANCE , *PHYSIOLOGY , *DRUG withdrawal symptoms , *HEADACHE , *LONGITUDINAL method , *SUBSTANCE abuse , *RETROSPECTIVE studies - Abstract
Aim: J.A.P. and M.A.L. contributed equally to this manuscript.The aim of this article is to determine whether support by a headache nurse in the treatment of medication-overuse headache (MOH) increases successful withdrawal, and to study determinants of response to withdrawal therapy.Methods: A retrospective, controlled follow-up study was performed with 416 MOH patients. All patients were treated with outpatient withdrawal therapy, with two treatment arms: with or without the support of a specialised headache nurse. The outcome measures were: i) successful withdrawal, defined as discontinuation of all headache medication according to the study protocol; and ii) the responder rate, defined as the percentage of patients with ≥ 50% reduction in headache days after successful withdrawal and iii) relative reduction in headache days after successful withdrawal.Results: Successful withdrawal percentages were significantly higher in the group supported by the headache nurse than in the group without support (73.1% vs. 60.7%; p = 0.008), which was confirmed in multivariate analysis (OR 1.73, 95% CI 1.11-2.71, p = 0.016). Support by a headache nurse was not associated with response. The underlying primary headache diagnosis, determined after withdrawal, was significantly correlated with response.Conclusion: The support by a headache nurse results in an increased adherence to detoxification. [ABSTRACT FROM AUTHOR]- Published
- 2016
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38. Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
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Mills, Melinda C., Tropf, Felix C., Brazel, David M., van Zuydam, Natalie, Vaez, Ahmad, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johannes, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Lehtimäki, Terho, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthias, Nivard, Michel G., Penninx, Brenda W. J. H., Perola, Markus, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashis, Scholz, Markus, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Teumer, Alexander, Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Võsa, Urmo, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Isaacs, Aaron, Pool, René, Jan Hottenga, Jouke, van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Zhernakova, Sasha, Tigchelaar, Ettje F., Beekman, Marian, Deelen, Joris, van Heemst, Diana, van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., Akimova, Evelina T., Bergmann, Sven, Boardman, Jason D., Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey-Smith, George, Davies, Gail, Deary, Ian J., Franco, Oscar, Gaskins, Audrey J., de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Grabe, Hans Jörgen, Gunderson, Erica P., Harris, Kathleen Mullan, Hartwig, Fernando P., He, Chunyan, Hill, W. David, Homuth, Georg, Horta, Bernando Lessa, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Johannesson, Magnus, Kamali, Zoha, Kavousi, Maryam, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, McQueen, Matthew B., Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Missmer, Stacey A., Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nolte, Ilja M., Noordam, Raymond, Peters, Annette, Power, Chris, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Waldenberger, Melanie, Wareham, Nicholas J., Willemsen, Gonneke, Zhao, Jing Hau, Pers, Tune H., Snieder, Harold, Perry, John R. B., Ong, Ken K., den Hoed, Marcel, Barban, Nicola, Day, Felix R., Mills, M. C., Tropf, F. C., Brazel, D. M., van Zuydam, N., Vaez, A., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A. K., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Jan Bonder, M., Boomsma, D. I., Christiansen, M. W., Claringbould, A., Deelen, P., Esko, T., Fave, M. -J., Franke, L., Frayling, T., Gharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg, J., Kukushkina, V., Kutalik, Z., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Montgomery, G. W., Muller-Nurasyid, M., Nauck, M., Nivard, M. G., Penninx, B. W. J. H., Perola, M., Pervjakova, N., Pierce, B. L., Powell, J., Prokisch, H., Psaty, B. M., Raitakari, O. T., Ripatti, S., Rotzschke, O., Rueger, S., Saha, A., Scholz, M., Schramm, K., Seppala, I., Slagboom, E. P., Stehouwer, C. D. A., Stumvoll, M., Sullivan, P., 't Hoen, P. A. C., Teumer, A., Thiery, J., Tong, L., Tonjes, A., van Dongen, J., van Iterson, M., van Meurs, J., Veldink, J. H., Verlouw, J., Visscher, P. M., Volker, U., Vosa, U., Westra, H. -J., Wijmenga, C., Yaghootkar, H., Yang, J., Zeng, B., Zhang, F., van Greevenbroek, M. M. J., Schalkwijk, C. G., Deelen, J., van Heemst, D., van Duijn, C. M., Hofman, B. A., Isaacs, A., Uitterlinden, A. G., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Bot, J., Zhernakova, D. V., Luijk, R., Bonder, M. J., Swertz, M. A., van Zwet, E. W., Akimova, E. T., Bergmann, S., Boardman, J. D., Buring, J. E., Cesarini, D., Chasman, D. I., Chavarro, J. E., Cocca, M., Concas, M. P., Davey-Smith, G., Davies, G., Deary, I. J., Gaskins, A. J., de Geus, E. J. C., Gieger, C., Girotto, G., Grabe, H. J., Gunderson, E. P., Harris, K. M., Hartwig, F. P., He, C., Homuth, G., Horta, B. L., Jan Hottenga, J., Huang, H., Hyppӧnen, E., Ikram, M. A., Johannesson, M., Kamali, Z., Kavousi, M., Kraft, P., Kuhnel, B., Langenberg, C., Study, L. C., Lind, P. A., Luan, J., Magi, R., Magnusson, P. K. E., Mahajan, A., Martin, N. G., Mbarek, H., Mccarthy, M. I., Mcmahon, G., Mcqueen, M. B., Medland, S. E., Meitinger, T., Metspalu, A., Mihailov, E., Missmer, S. A., Mollegaard, S., Mook-Kanamori, D. O., Morgan, A., van der Most, P. J., de Mutsert, R., Noordam, R., Power, C., Redmond, P., Rich-Edwards, J. W., Ridker, P. M., Rietveld, C. A., Ring, S. M., Rose, L. M., Rueedi, R., Stefansson, K., Stockl, D., Strauch, K., Thurik, A. R., Timpson, N. J., Turman, C., Wareham, N. J., Willemsen, G., Zhao, J. H., Pers, T. H., Snieder, H., Perry, J. R. B., Ong, K. K., den Hoed, M., Barban, N., Day, F. R., Mills, Melinda C, Tropf, Felix C, Brazel, David M, van Zuydam, Natalie, Vaez, Ahmad, Pers, Tune H, Snieder, Harold, Perry, John RB, Ong, Ken K, den Hoed, Marcel, Barban, Nicola, Day, Felix R, Hyppӧnen, Elina, eQTLGen Consortium, BIOS Consortium, Human Reproductive Behaviour Consortium, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Consortium, eQTLGen, Consortium, BIOS, Consortium, Human Reproductive Behaviour, Mahajan, A, McCarthy, MI, Mills, Melinda C., Tropf, Felix C., Brazel, David M., Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexi, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johanne, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Lehtimäki, Terho, Loeffler, Marku, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthia, Nivard, Michel G., Penninx, Brenda W. J. H., Perola, Marku, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashi, Scholz, Marku, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Teumer, Alexander, Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Võsa, Urmo, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Isaacs, Aaron, Pool, René, Jan Hottenga, Jouke, van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Zhernakova, Sasha, Tigchelaar, Ettje F., Beekman, Marian, Deelen, Jori, van Heemst, Diana, van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Nooren, Irene, Moed, Matthij, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., Akimova, Evelina T., Bergmann, Sven, Boardman, Jason D., Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey-Smith, George, Davies, Gail, Deary, Ian J., Franco, Oscar, Gaskins, Audrey J., de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Grabe, Hans Jörgen, Gunderson, Erica P., Harris, Kathleen Mullan, Hartwig, Fernando P., He, Chunyan, Hill, W. David, Homuth, Georg, Horta, Bernando Lessa, Huang, Hongyang, Ikram, M. Arfan, Johannesson, Magnu, Kamali, Zoha, Kavousi, Maryam, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, McQueen, Matthew B., Medland, Sarah E., Meitinger, Thoma, Metspalu, Andre, Mihailov, Evelin, Missmer, Stacey A., Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nolte, Ilja M., Noordam, Raymond, Peters, Annette, Power, Chri, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Stefánsson, Kári, Stöckl, Dori, Strauch, Konstantin, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Waldenberger, Melanie, Wareham, Nicholas J., Willemsen, Gonneke, Zhao, Jing Hau, Pers, Tune H., Perry, John R. B., Ong, Ken K., Day, Felix R., Sociology [until 2010], Biological Psychology, APH - Methodology, Sociology and Social Gerontology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Management and Organisation, Urology, Medical Informatics, Department of Marketing Management, Epidemiology, Internal Medicine, Radiology & Nuclear Medicine, Neurology, Applied Economics, and Life Course Epidemiology (LCE)
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Male ,demography ,genetic variants ,reproductive biology ,externalising behavior ,environmental effects ,Disease ,Genome-wide association studies ,Behavioral Neuroscience ,0302 clinical medicine ,genetics ,media_common ,fertility ,0303 health sciences ,Reproduction ,Incidence (epidemiology) ,Coitus ,Age Factors ,Longevity ,sexual intercourse ,health ,Spermatid differentiation ,Single Nucleotide ,Reproduction/genetics ,3. Good health ,Behavioural genetics ,Parturition/genetics ,Female ,infertility ,Infertility ,genetic variant ,Adolescent ,Social Psychology ,media_common.quotation_subject ,Experimental and Cognitive Psychology ,Polymorphism, Single Nucleotide ,Article ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Reproductive biology ,medicine ,Humans ,Polymorphism ,behavioural genetics ,first sexual intercourse ,Genetic Association Studies ,Demography ,030304 developmental biology ,Parturition ,Coitus/physiology ,medicine.disease ,externalising behaviour ,Sexual intercourse ,Fertility ,age ,030217 neurology & neurosurgery ,first birth - Abstract
Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.
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- 2021
39. Quantitative electroencephalography in cerebral amyloid angiopathy.
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van der Plas MC, Rasing I, Geraedts VJ, Tromp SC, Terwindt GM, van Dort R, Kaushik K, van Zwet EW, Tannemaat MR, and Wermer MJH
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- Humans, Male, Female, Aged, Middle Aged, Magnetic Resonance Imaging, Cognition physiology, Siderosis physiopathology, Siderosis diagnosis, Aged, 80 and over, Electroencephalography methods, Cerebral Amyloid Angiopathy physiopathology, Cerebral Amyloid Angiopathy diagnostic imaging
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Objective: We investigated whether quantitative electroencephalography (qEEG) correlates with cognition and cortical superficial siderosis (cSS) in cerebral amyloid angiopathy., Methods: We included patients with sporadic (sCAA) and hereditary Dutch-type CAA (D-CAA). Spectral measures and the phase lag index (PLI) were analyzed on qEEG. Cognition was assessed with the MoCA and cSS presence was scored on 3T-MRI. Linear regression analyses were performed to investigate these qEEG measures and cognition. Independent samples T-tests were used to analyze the qEEG measure differences between participants with and without cSS., Results: We included 92 participants (44 D-CAA; 48 sCAA). A lower average peak frequency (β[95 %CI] = 0.986[0.252-1.721]; P = 0.009) and a higher spectral ratio (β[95 %CI] = -0.918[-1.761--0.075]; P = 0.033) on qEEG correlated with a lower MoCA score, irrespective of a history of symptomatic intracerebral hemorrhage (sICH). The PLI showed no correlation to the MoCA. qEEG slowing was not different in those with or without cSS., Conclusions: Spectral qEEG (but not PLI) reflects cognitive performance in patients with CAA with and without a history of sICH. We found no association between qEEG slowing and cSS., Significance: qEEG could be a valuable biomarker, especially in challenging cognitive testing situations in CAA, and a potential predictive tool in future studies., (Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
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- 2024
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40. Striped occipital cortex and intragyral hemorrhage: Novel magnetic resonance imaging markers for cerebral amyloid angiopathy.
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Koemans EA, Voigt S, Rasing I, Jolink W, van Harten TW, van der Grond J, van Rooden S, Schreuder F, Freeze WM, van Buchem MA, van Zwet EW, van Veluw SJ, Terwindt GM, van Osch M, Klijn C, van Walderveen M, and Wermer M
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- Aged, Cerebral Hemorrhage diagnostic imaging, Humans, Magnetic Resonance Imaging, Middle Aged, Occipital Lobe diagnostic imaging, Cerebral Amyloid Angiopathy complications, Cerebral Amyloid Angiopathy diagnostic imaging, Stroke
- Abstract
Background and Aim: To investigate whether a striped occipital cortex and intragyral hemorrhage, two markers recently detected on ultra-high-field 7-tesla-magnetic resonance imaging in hereditary cerebral amyloid angiopathy (CAA), also occur in sporadic CAA (sCAA) or non-sCAA intracerebral hemorrhage (ICH)., Methods: We performed 7-tesla-magnetic resonance imaging in patients with probable sCAA and patients with non-sCAA-ICH. Striped occipital cortex (linear hypointense stripes perpendicular to the cortex) and intragyral hemorrhage (hemorrhage restricted to the juxtacortical white matter of one gyrus) were scored on T
2 *-weighted magnetic resonance imaging. We assessed the association between the markers, other CAA-magnetic resonance imaging markers and clinical features., Results: We included 33 patients with sCAA (median age 70 years) and 29 patients with non-sCAA-ICH (median age 58 years). Striped occipital cortex was detected in one (3%) patient with severe sCAA. Five intragyral hemorrhages were found in four (12%) sCAA patients. The markers were absent in the non-sCAA-ICH group. Patients with intragyral hemorrhages had more lobar ICHs (median count 6.5 vs. 1.0), lobar microbleeds (median count >50 vs. 15), and lower median cognitive scores (Mini Mental State Exam: 20 vs. 28, Montreal Cognitive Assessment: 18 vs. 24) compared with patients with sCAA without intragyral hemorrhage. In 12 (36%) patients, sCAA diagnosis was changed to mixed-type small vessel disease due to deep bleeds previously unobserved on lower field-magnetic resonance imaging., Conclusion: Whereas a striped occipital cortex is rare in sCAA, 12% of patients with sCAA have intragyral hemorrhages. Intragyral hemorrhages seem to be related to advanced disease and their absence in patients with non-sCAA-ICH could suggest specificity for CAA.- Published
- 2021
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41. Effects of hospital preference for endovascular repair on postoperative mortality after elective abdominal aortic aneurysm repair: analysis of the Dutch Surgical Aneurysm Audit.
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Lijftogt N, Vahl AC, Karthaus EG, van der Willik EM, Amodio S, van Zwet EW, and Hamming JF
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- Hospitals, High-Volume, Humans, Postoperative Complications, Risk Factors, Time Factors, Treatment Outcome, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis Implantation adverse effects, Endovascular Procedures
- Abstract
Background: Increased use of endovascular aneurysm repair (EVAR) and reduced open surgical repair (OSR), has decreased postoperative mortality after elective repair of abdominal aortic aneurysms (AAAs). The choice between EVAR or OSR depends on aneurysm anatomy, and the experience and preference of the vascular surgeon, and therefore differs between hospitals. The aim of this study was to investigate the current mortality risk difference (RD) between EVAR and OSR, and the effect of hospital preference for EVAR on overall mortality., Methods: Primary elective infrarenal or juxtarenal aneurysm repairs registered in the Dutch Surgical Aneurysm Audit (2013-2017) were analysed. First, mortality in hospitals with a higher preference for EVAR (high-EVAR group) was compared with that in hospitals with a lower EVAR preference (low-EVAR group), divided by the median percentage of EVAR. Second, the mortality RD between EVAR and OSR was determined by unadjusted and adjusted linear regression and propensity-score (PS) analysis and then by instrumental-variable (IV) analysis, adjusting for unobserved confounders; percentage EVAR by hospital was used as the IV., Results: A total of 11 997 patients were included. The median hospital rate of EVAR was 76.6 per cent. The overall mortality RD between high- and low-EVAR hospitals was 0.1 (95 per cent -0.5 to 0.4) per cent. The OSR mortality rate was significantly higher among high-EVAR hospitals than low-EVAR hospitals: 7.3 versus 4.0 per cent (RD 3.3 (1.4 to 5.3) per cent). The EVAR mortality rate was also higher in high-EVAR hospitals: 0.9 versus 0.7 per cent (RD 0.2 (-0.0 to 0.6) per cent). The RD following unadjusted, adjusted, and PS analysis was 4.2 (3.7 to 4.8), 4.4 (3.8 to 5.0), and 4.7 (4.1 to 5.3) per cent in favour of EVAR over OSR. However, the RD after IV analysis was not significant: 1.3 (-0.9 to 3.6) per cent., Conclusion: Even though EVAR has a lower mortality rate than OSR, the overall effect is offset by the high mortality rate after OSR in hospitals with a strong focus on EVAR., (© The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd.)
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- 2021
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42. Cold extremities in migraine: a marker for vascular dysfunction in women.
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Linstra KM, Perenboom MJL, van Zwet EW, van Welie FC, Fronczek R, Tannemaat MR, Wermer MJH, Maassenvandenbrink A, and Terwindt GM
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- Adult, Aged, Case-Control Studies, Extremities, Female, Humans, Male, Middle Aged, Risk Factors, Young Adult, Migraine Disorders complications, Migraine Disorders epidemiology, Stroke
- Abstract
Background and Purpose: Migraine is recognized as a vascular risk factor, especially in women. Presumably, migraine, stroke and cardiovascular events share pathophysiological mechanisms. Self-reported cold extremities were investigated as a marker for vascular dysfunction in migraine. Secondly, it was hypothesized that suffering from cold extremities affects sleep quality, possibly exacerbating migraine attack frequency., Methods: In this case-control study, a random sample of 1084 migraine patients and 348 controls (aged 22-65 years) from the LUMINA migraine cohort were asked to complete questionnaires concerning cold extremities, sleep quality and migraine., Results: A total of 594 migraine patients and 199 controls completed the questionnaires. In women, thermal discomfort and cold extremities (TDCE) were more often reported by migraineurs versus controls (odds ratio 2.3, 95% confidence interval 1.4-3.7; P < 0.001), but not significantly so in men (odds ratio 2.5, 95% confidence interval 0.9-6.9; P = 0.09). There was no difference in TDCE comparing migraine with or without aura. Female migraineurs who reported TDCE had higher attack frequencies compared to female migraineurs without TDCE (4 vs. 3 attacks per month; P = 0.003). The association between TDCE and attack frequency was mediated by the presence of difficulty initiating sleep (P = 0.02)., Conclusion: Women with migraine more often reported cold extremities compared with controls, possibly indicating a sex-specific vascular vulnerability. Female migraineurs with cold extremities had higher attack frequencies, partly resulting from sleep disturbances. Future studies need to demonstrate whether cold extremities in female migraineurs are a predictor for cardiovascular and cerebrovascular events., (© 2020 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
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- 2020
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43. Outcome of Carpal Tunnel Release and the Relation With Depression.
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Datema M, Tannemaat MR, Hoitsma E, van Zwet EW, Smits F, van Dijk JG, and Malessy MJA
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- Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multivariate Analysis, Pain etiology, Pain Measurement, Patient Outcome Assessment, Prospective Studies, Psychiatric Status Rating Scales, Surveys and Questionnaires, Carpal Tunnel Syndrome complications, Carpal Tunnel Syndrome surgery, Depression complications
- Abstract
Purpose: To examine the relation between depressive symptoms and outcome of carpal tunnel release (CTR)., Methods: Prospective study in a general hospital with data collection at baseline and 3 and 12 months after CTR. We quantified depressive symptoms using the Center for Epidemiologic Studies Depression (CES-D) scale and performed multivariable analyses on 2 outcome measures: (1) carpal tunnel syndrome (CTS) symptoms (Boston Carpal Tunnel Questionnaire [BCTQ]) and (2) palmar pain, focusing on preoperative CES-D and BCTQ score, sex, age, alcohol use, diabetes, and severity of nerve conduction abnormalities., Results: We included 227 patients. Before surgery, patients with depression had a higher BCTQ score than patients without depression. After 1 year, depressed patients had a higher BCTQ score and more palmar pain. The CES-D decreased by a median of 2 points from baseline to 1 year. This correlated with the decrease in BCTQ score. Multivariable analyses showed that preoperative depression had a small but statistically significant influence on palmar pain, but not on postoperative BCTQ score., Conclusions: Depression is not an independent predictor of residual CTS symptoms 1 year after CTR. Depressive symptoms in patients with CTS decrease after CTR, along with a decrease in CTS symptoms. The nature of this relationship is unknown. Patients with CTS and depression may expect a somewhat higher degree of palmar pain after CTR, the clinical relevance of which is small., Type of Study/level of Evidence: Prognostic II., (Copyright © 2018 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
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44. Adjusted Hospital Outcomes of Abdominal Aortic Aneurysm Surgery Reported in the Dutch Surgical Aneurysm Audit.
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Lijftogt N, Vahl AC, Wilschut ED, Elsman BHP, Amodio S, van Zwet EW, Leijdekkers VJ, Wouters MWJM, and Hamming JF
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- Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal mortality, Aortic Rupture diagnostic imaging, Aortic Rupture mortality, Benchmarking, Elective Surgical Procedures, Female, Hospital Mortality, Humans, Male, Medical Audit, Netherlands, Quality Indicators, Health Care, Registries, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Aortic Aneurysm, Abdominal surgery, Aortic Rupture surgery, Blood Vessel Prosthesis Implantation adverse effects, Blood Vessel Prosthesis Implantation mortality, Endovascular Procedures adverse effects, Endovascular Procedures mortality, Hospitals
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Objective/background: The Dutch Surgical Aneurysm Audit (DSAA) is mandatory for all patients with primary abdominal aortic aneurysms (AAAs) in the Netherlands. The aims are to present the observed outcomes of AAA surgery against the predicted outcomes by means of V-POSSUM (Vascular-Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity). Adjusted mortality was calculated by the original and re-estimated V(physiology)-POSSUM for hospital comparisons., Methods: All patients operated on from January 2013 to December 2014 were included for analysis. Calibration and discrimination of V-POSSUM and V(p)-POSSUM was analysed. Mortality was benchmarked by means of the original V(p)-POSSUM formula and risk-adjusted by the re-estimated V(p)-POSSUM on the DSAA., Results: In total, 5898 patients were included for analysis: 4579 with elective AAA (EAAA) and 1319 with acute abdominal aortic aneurysm (AAAA), acute symptomatic (SAAA; n = 371) or ruptured (RAAA; n = 948). The percentage of endovascular aneurysm repair (EVAR) varied between hospitals but showed no relation to hospital volume (EAAA: p = .12; AAAA: p = .07). EAAA, SAAA, and RAAA mortality was, respectively, 1.9%, 7.5%, and 28.7%. Elective mortality was 0.9% after EVAR and 5.0% after open surgical repair versus 15.6% and 27.4%, respectively, after AAAA. V-POSSUM overestimated mortality in most EAAA risk groups (p < .01). The discriminative ability of V-POSSUM in EAAA was moderate (C-statistic: .719) and poor for V(p)-POSSUM (C-statistic: .665). V-POSSUM in AAAA repair overestimated in high risk groups, and underestimated in low risk groups (p < .01). The discriminative ability in AAAA of V-POSSUM was moderate (.713) and of V(p)-POSSUM poor (.688). Risk adjustment by the re-estimated V(p)-POSSUM did not have any effect on hospital variation in EAAA but did in AAAA., Conclusion: Mortality in the DSAA was in line with the literature but is not discriminative for hospital comparisons in EAAA. Adjusting for V(p)-POSSUM, revealed no association between hospital volume and treatment or outcome. Risk adjustment for case mix by V(p)-POSSUM in patients with AAAA has been shown to be important., (Copyright © 2017 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
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45. Symptom dimensions of affective disorders in migraine patients.
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Louter MA, Pijpers JA, Wardenaar KJ, van Zwet EW, van Hemert AM, Zitman FG, Ferrari MD, Penninx BW, and Terwindt GM
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- Adult, Affect, Anxiety complications, Anxiety epidemiology, Anxiety psychology, Arousal, Cohort Studies, Depression complications, Depression epidemiology, Depression psychology, Female, Humans, Hyperalgesia complications, Hyperalgesia etiology, Hyperalgesia psychology, Male, Mental Disorders complications, Mental Disorders epidemiology, Middle Aged, Migraine Disorders complications, Migraine Disorders epidemiology, Mood Disorders complications, Mood Disorders etiology, Netherlands epidemiology, Socioeconomic Factors, Surveys and Questionnaires, Migraine Disorders psychology, Mood Disorders psychology
- Abstract
Objective: A strong association has been established between migraine and depression. However, this is the first study to differentiate in a large sample of migraine patients for symptom dimensions of the affective disorder spectrum., Methods: Migraine patients (n=3174) from the LUMINA (Leiden University Medical Centre Migraine Neuro-analysis Program) study and patients with current psychopathology (n=1129), past psychopathology (n=477), and healthy controls (n=561) from the NESDA (Netherlands Study of Depression and Anxiety) study, were compared for three symptom dimensions of depression and anxiety. The dimensions -lack of positive affect (depression specific); negative affect (nonspecific); and somatic arousal (anxiety specific)- were assessed by a shortened adaptation of the Mood and Anxiety Symptom Questionnaire (MASQ-D30). Within the migraine group, the association with migraine specific determinants was established. Multivariate regression analyses were conducted., Results: Migraine patients differed significantly (p<0.001) from healthy controls for all three dimensions: Cohen's d effect sizes were 0.37 for lack of positive affect, 0.68 for negative affect, and 0.75 for somatic arousal. For the lack of positive affect and negative affect dimensions, migraine patients were predominantly similar to the past psychopathology group. For the somatic arousal dimension, migraine patients scores were more comparable with the current psychopathology group. Migraine specific determinants for high scores on all dimensions were high frequency of attacks and cutaneous allodynia during attacks., Conclusion: This study shows that affective symptoms in migraine patients are especially associated with the somatic arousal component., (Copyright © 2015 Elsevier Inc. All rights reserved.)
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- 2015
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46. Implementing the Laparoscopic Hysterectomy, Is the Vaginal Approach at Risk?
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Driessen S, Twijnstra A, Van Zwet EW, and Jansen FW
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- 2015
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47. Correlation between veno-venous anastomoses, TTTS and perinatal mortality in monochorionic twin pregnancies.
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de Villiers SF, Zhao DP, Cohen D, van Zwet EW, Duan T, Oepkes D, and Lopriore E
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- Female, Humans, Infant, Newborn, Netherlands epidemiology, Pregnancy, Twins, Monozygotic, Fetofetal Transfusion epidemiology, Perinatal Mortality, Placenta blood supply, Pregnancy, Twin statistics & numerical data, Vascular Fistula epidemiology
- Abstract
Introduction: The clinical significance of veno-venous (VV) anastomoses in monochorionic (MC) placentas remains inconclusive and controversial. The purpose of this study was to investigate the correlation between the presence of VV anastomoses and clinical outcome in a large cohort of MC twin pregnancies., Methods: All MC placentas injected with colored dye from 2002 to 2014 were included in the study. We excluded MC pregnancies managed with fetoscopic laser surgery., Results and Discussion: A total of 384 MC placentas were analyzed. VV anastomoses were detected in 27% (104/384) of MC placentas. The prevalence of twin-twin transfusion syndrome (TTTS) in MC placentas with VV anastomoses was significantly higher compared to MC placentas without VV anastomoses, 20% (21/104) versus 10% (29/280), respectively (P = .01). The overall perinatal mortality in MC twins with and without VV anastomoses was 16% versus 10%, respectively (P = .02). Risk factor analysis showed the presence of VV anastomoses was associated with perinatal mortality (P = .02; odds ratio (OR): 1.76; 95% confidence interval (CI): 1.11-2.79), but was not an independent risk factor for perinatal mortality (P = .26, OR: .66; 95% CI: .33-1.35) in MC twin pregnancies. However, VV anastomoses was associated with and was an independent risk factor for TTTS (P = .00, OR: 3.59; 95% CI: 1.72-7.47). VV anastomoses-related perinatal mortality may be due to the high rate of TTTS in MC twins with VV anastomoses., Conclusion: The presence of VV anastomoses is correlated with TTTS and perinatal mortality, but is not an independent risk factor for perinatal mortality in MC twin pregnancies., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
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- 2015
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48. Quantitative MRI and strength measurements in the assessment of muscle quality in Duchenne muscular dystrophy.
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Wokke BH, van den Bergen JC, Versluis MJ, Niks EH, Milles J, Webb AG, van Zwet EW, Aartsma-Rus A, Verschuuren JJ, and Kan HE
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- Adipose Tissue pathology, Adolescent, Adrenal Cortex Hormones therapeutic use, Child, Humans, Hypertrophy pathology, Hypertrophy physiopathology, Image Processing, Computer-Assisted, Magnetic Resonance Imaging methods, Male, Muscle Strength, Muscular Dystrophy, Duchenne drug therapy, Organ Size, Quadriceps Muscle pathology, Quadriceps Muscle physiopathology, Leg, Muscle, Skeletal pathology, Muscle, Skeletal physiopathology, Muscular Dystrophy, Duchenne pathology, Muscular Dystrophy, Duchenne physiopathology
- Abstract
The purpose of this study was to assess leg muscle quality and give a detailed description of leg muscle involvement in a series of Duchenne muscular dystrophy patients using quantitative MRI and strength measurements. Fatty infiltration, as well as total and contractile (not fatty infiltrated) cross sectional areas of various leg muscles were determined in 16 Duchenne patients and 11 controls (aged 8-15). To determine specific muscle strength, four leg muscle groups (quadriceps femoris, hamstrings, anterior tibialis and triceps surae) were measured and related to the amount of contractile tissue. In patients, the quadriceps femoris showed decreased total and contractile cross sectional area, attributable to muscle atrophy. The total, but not the contractile, cross sectional area of the triceps surae was increased in patients, corresponding to hypertrophy. Specific strength decreased in all four muscle groups of Duchenne patients, indicating reduced muscle quality. This suggests that muscle hypertrophy and fatty infiltration are two distinct pathological processes, differing between muscle groups. Additionally, the quality of remaining muscle fibers is severely reduced in the legs of Duchenne patients. The combination of quantitative MRI and quantitative muscle testing could be a valuable outcome parameter in longitudinal studies and in the follow-up of therapeutic effects., (Copyright © 2014 Elsevier B.V. All rights reserved.)
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- 2014
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49. Intracorporeal knot tying in a box trainer: how proficient is in vitro evaluation in laparoscopic experts?
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Twijnstra AR, Hiemstra E, van Zwet EW, Balkema EI, Dankelman J, and Jansen FW
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- Female, Humans, In Vitro Techniques, Operative Time, Postoperative Complications, Clinical Competence, Hysterectomy methods, Laparoscopy methods, Suture Techniques
- Abstract
Objective: To determine the applicability of motion analysis parameters of intracorporeal knot tying in box trainers in experts as predictors of surgical outcome., Design: Consecutive series of 1534 advanced laparoscopic hysterectomies (Canadian Task Force classification II-2)., Intervention: Time, path length, and motion in depth of a standardized intracorporeal knot-tying task were compared with mean risk-adjusted primary clinical outcomes for each participant., Results: Although a large variety in proficient knot tying and surgical skills factors was observed; after correction for patient mix in 50 expert surgeons, motion analysis of intracorporeal knot tying could not significantly determine surgical outcome skills in advanced laparoscopic surgery., Conclusion: Levels of proficiency in advanced laparoscopic surgery cannot be appropriately determined using motion analysis in box trainers. Therefore, box trainer assessments do not adequately differentiate proficient from suboptimal clinical performance., (Copyright © 2014 AAGL. Published by Elsevier Inc. All rights reserved.)
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- 2014
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50. Increased perinatal loss after intrauterine transfusion for alloimmune anaemia before 20 weeks of gestation.
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Lindenburg IT, van Kamp IL, van Zwet EW, Middeldorp JM, Klumper FJ, and Oepkes D
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- Anemia, Hemolytic immunology, Anemia, Hemolytic mortality, Erythroblastosis, Fetal immunology, Erythroblastosis, Fetal mortality, Female, Fetal Mortality, Humans, Hydrops Fetalis etiology, Infant Mortality, Infant, Newborn, Logistic Models, Multivariate Analysis, Pregnancy, Retrospective Studies, Risk Factors, Severity of Illness Index, Survival Rate, Anemia, Hemolytic therapy, Blood Transfusion, Intrauterine mortality, Erythroblastosis, Fetal therapy, Gestational Age, Perinatal Mortality, Pregnancy Trimester, Second
- Abstract
Objectives: To evaluate and compare perinatal outcome after intrauterine transfusions (IUT) performed before and after 20 weeks of gestation. To analyse contributing factors., Design: Retrospective analysis., Setting: The Dutch referral centre for fetal therapy., Population: IUTs for fetal alloimmune anaemia., Methods: Fetuses were divided into two groups: fetuses requiring the first IUT before 20 weeks of gestation (Group 1) and those in which the IUTs started after 20 weeks (Group 2). The cause of perinatal loss was classified as procedure-related (PR) or not procedure-related (NPR). The cohort was divided into two periods to describe the change of perinatal loss over time., Main Outcome Measures: Perinatal loss of fetuses requiring the first IUT before 20 weeks of gestation, compared with perinatal loss later in gestation., Results: A total of 1422 IUTs were performed in 491 fetuses. Perinatal loss rate in Group 1 was higher (7/29 24% versus 35/462 8%, P = 0.002). Especially NPR was higher for IUTs performed before 20 weeks (4/37 11% versus 19/1385 1%, P < 0.001). Kell alloimmunisation was overrepresented in Group 1 (7/29 24% versus 52/462 11%, P = 0.04). In a multivariate regression analysis, only hydrops was independently associated with perinatal loss (P = 0.001). In recent years, a decline in total perinatal loss was found (36/224 16% versus 6/267 2%, P < 0.001), but perinatal loss in Group 1 did not decline (4/224 1.8% versus 3/267 1.1%, P = 0.5)., Conclusions: Perinatal loss after IUT performed before 20 weeks of gestation is increased compared with loss after IUT performed later in gestation. In addition, we confirmed earlier observations that hydrops is a major contributor to adverse outcome. Early and timely detection and treatment may prevent hydrops and improve outcome., (© 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.)
- Published
- 2013
- Full Text
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