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The Impact of Dietary Polyphenols on COX-2 Expression in Colorectal Cancer.
- Source :
-
Nutrition & Cancer . Nov/Dec2017, Vol. 69 Issue 8, p1105-1118. 14p. - Publication Year :
- 2017
-
Abstract
- Polyphenols are natural compounds with high structural diversity whose common occurrence in plants renders them intrinsic dietary components. They are known to be secondary metabolites characterized by a wide spectrum of biological activities, and a growing body of evidence indicates they have anti-inflammatory potential. It is well known that inflammation plays a key role in many chronic diseases such as circulatory diseases, pulmonary diseases, autoimmune diseases, diabetes, cancer, and neurodegenerative diseases. Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-α, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid. Furthermore, polyphenols exhibit anti-inflammatory activity on many levels via NF-κB inhibition, and MAPK, iNOS, and growth factors regulation. This paper reviews the current state of knowledge concerning the potential of various dietary polyphenols to inhibit the effects of COX-2 in colon cancer, by examining the available evidence regarding the efficacy and safety of these compounds obtained from in vitro and animal studies. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *PREVENTION of chronic diseases
*INFLAMMATION prevention
*COLON tumor prevention
*ENZYME metabolism
*ARACHIDONIC acid
*DIET therapy for cancer patients
*CYTOKINES
*DIET
*GROWTH factors
*INTERLEUKINS
*NONSTEROIDAL anti-inflammatory agents
*POLYPHENOLS
*PROTEIN kinases
*TUMOR necrosis factors
*DNA-binding proteins
*CYCLOOXYGENASE 2
*PHARMACODYNAMICS
TUMOR prevention
RECTUM tumors
Subjects
Details
- Language :
- English
- ISSN :
- 01635581
- Volume :
- 69
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Nutrition & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 126497050
- Full Text :
- https://doi.org/10.1080/01635581.2017.1367940