Potential benefits of high-added-value compounds from aquaculture and fish side streams on human gut microbiota.

Human gut microbiota dysbiosis has been linked to a higher risk of non-communicable diseases (NCDs) such us inflammatory disorders, allergy and obesity. Specific dietary strategies, including the use of specific food supplements targeted to microbiota modulation, have been suggested to be especially relevant in reducing the risk of NCDs. In this regard, marine environment is considered as a pivotal source of nutrients and bioactive compounds such as polyunsaturated fatty acids, polysaccharides and active peptides. These compounds, including algae- (alginate, fucoidan) and animal-derived polysaccharides (chitin, chitosan), among others, have been widely studied. The use of these active substances from marine organisms as a food supplements has been reported to affect human health. This review provides the evidence-base information on the potential effects of various active substances from marine organisms, including fatty acids, proteins and polysaccharides, on the structure of gut microbiota and their effects on host health. These compounds could regulate the gut microbiota structure and thus, intestinal and systemic level with potential human health benefits. The exploration and evaluation of the relationship between these substances and gut microbiota may provide a new direction for further exploration of the influence of high-added-value components on gut microbiota with potential health effects. These high-added-value compounds have been explored to not only improve the utilization rate of aquatic products, but also reduce waste and contribute to the environment and economy sustainability. Meanwhile, it is possible to expand the commercial applications of these products by the industry. • High-added-value compounds (HAVC) from aquaculture could affect gut microbiota (GM). • HAVC may reduce the risk of some non-communicable diseases by modulating GM. • Different types of HAVC have different effects on GM composition and activity. • ω-3 PUFA improves intestinal homeostasis and influences metabolic dysfunction. • Protein and carbohydrate can regulate the GM composition and its SCFAs production. [ABSTRACT FROM AUTHOR]