Genetic causal relationship between tea intake and cerebral aneurysm: a two-sample Mendelian Randomization Study.

Background: Prior research has established a strong link between cerebral aneurysm (CA) occurrence and inflammation. Tea intake (TI) has been found to have anti-inflammatory properties through multiple mechanisms, potentially lowering CA incidence. This study aims to employ Mendelian Randomization (MR) methodology to explore the genetic causality between TI and CA. Methods: We collected Genome-wide association study (GWAS) data for CA, TI, Green tea intake (GTI), Herbal tea intake (HTI), and Rooibos tea intake (RTI). The MR analysis employed the TwoSampleMR package and utilized the inverse variance-weighted (IVW) method. Results: The findings suggest no genetic causal relationship between TI and CA (IVW: OR = 1.10, 95% CI: 0.59--2.05, P = 0.772). Similarly, there is no genetic causal association between GTI and CA (IVW: OR = 1.07, 95% CI: 0.91--1.26, P = 0.388), HTI and CA (IVW: OR = 1.00, 95% CI: 0.89--1.13, P = 0.943), or RTI and CA (IVW: OR = 1.02, 95% CI: 0.96--1.09, P = 0.472). Conclusion: There is no genetic causal relationship between TI and CA, and the different types of tea do not change this result. Further MR analysis is needed to investigate whether there is a potential genetic causal association between the quantity of TI and CA. [ABSTRACT FROM AUTHOR]