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Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats.

Authors :
Lemhadri A
Hajji L
Michel JB
Eddouks M
Source :
Journal of ethnopharmacology [J Ethnopharmacol] 2006 Jul 19; Vol. 106 (3), pp. 321-6. Date of Electronic Publication: 2006 Mar 06.
Publication Year :
2006

Abstract

The purpose of this study was to examine the effect of single and repeated oral administration of the aqueous extract of Carum carvi L. fruits at a dose of (20mg/kg) on lipid metabolism in normal and streptozotocin-induced diabetic rats (STZ). After a single oral administration, Carum carvi extract produced a significant decrease on triglycerides levels in normal rats (p<0.05). In STZ diabetic rats, cholesterol levels were decreased significantly 6h after Carum carvi treatment (p<0.05). On the other hand, repeated oral administration of Carum carvi extract exhibited a significant hypotriglyceridemic and hypocholesterolemic activities in both normal (p<0.01 and <0.001 respectively) and STZ diabetic rats (p<0.001) 15 days after Carum carvi treatment. We conclude that the aqueous extract of Carum carvi (20mg/kg) exhibits a potent lipid lowering activity in both normal and severe hyperglycemic rats after repeated oral administration of Carum carvi aqueous extract.

Details

Language :
English
ISSN :
0378-8741
Volume :
106
Issue :
3
Database :
MEDLINE
Journal :
Journal of ethnopharmacology
Publication Type :
Academic Journal
Accession number :
16567073
Full Text :
https://doi.org/10.1016/j.jep.2006.01.033