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Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2006 Jul 19; Vol. 106 (3), pp. 321-6. Date of Electronic Publication: 2006 Mar 06. - Publication Year :
- 2006
-
Abstract
- The purpose of this study was to examine the effect of single and repeated oral administration of the aqueous extract of Carum carvi L. fruits at a dose of (20mg/kg) on lipid metabolism in normal and streptozotocin-induced diabetic rats (STZ). After a single oral administration, Carum carvi extract produced a significant decrease on triglycerides levels in normal rats (p<0.05). In STZ diabetic rats, cholesterol levels were decreased significantly 6h after Carum carvi treatment (p<0.05). On the other hand, repeated oral administration of Carum carvi extract exhibited a significant hypotriglyceridemic and hypocholesterolemic activities in both normal (p<0.01 and <0.001 respectively) and STZ diabetic rats (p<0.001) 15 days after Carum carvi treatment. We conclude that the aqueous extract of Carum carvi (20mg/kg) exhibits a potent lipid lowering activity in both normal and severe hyperglycemic rats after repeated oral administration of Carum carvi aqueous extract.
- Subjects :
- Administration, Oral
Animals
Anticholesteremic Agents administration & dosage
Anticholesteremic Agents therapeutic use
Diabetes Mellitus, Experimental blood
Diabetes Mellitus, Experimental chemically induced
Dose-Response Relationship, Drug
Fruit
Lipid Metabolism drug effects
Male
Plant Extracts administration & dosage
Plant Extracts therapeutic use
Rats
Rats, Wistar
Streptozocin
Anticholesteremic Agents pharmacology
Carum
Cholesterol blood
Phytotherapy
Plant Extracts pharmacology
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 0378-8741
- Volume :
- 106
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 16567073
- Full Text :
- https://doi.org/10.1016/j.jep.2006.01.033