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Intake of Meat Mutagens and Risk of Prostate Cancer in a Cohort of U.S. Health Professionals.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2015 Oct; Vol. 24 (10), pp. 1557-63. Date of Electronic Publication: 2015 Jul 29. - Publication Year :
- 2015
-
Abstract
- Background: Evidence relating heterocyclic aromatic amines (HCA), associated with high-temperature cooking methods, to prostate cancer risk is inconsistent.<br />Methods: In a large U.S. cohort study, intakes of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and a meat-derived mutagenicity (MDM) index were assessed using a cooking method questionnaire administered in 1996. Until 2010, 2,770 prostate cancer cases were observed among 26,030 participants.<br />Results: Intake of PhIP from red meat was statistically significantly associated with total prostate cancer risk (top vs. bottom quintile HR, 1.18; 95% confidence intervals; CI, 1.03-1.35), but not other HCAs (MeIQx, 1.12; 0.98-1.27, PhIP from white meat, 1.08; 0.95-1.22, DiMeIQx, 1.09; 0.97-1.21) or MDM (1.13; 1.00-1.28). For high-grade (Gleason sum 7 with pattern 4+3 and Gleason sum 8-10, n = 483 cases) and advanced cancers (n = 281), we only observed positive associations for PhIP from red meat (top vs. bottom quintile: high grade: HR, 1.44; 95% CI, 1.04-1.98, Ptrend = 0.03; advanced: HR, 1.50; 95% CI, 0.99-2.26; Ptrend = 0.12), but associations for advanced cancers did not reach statistical significance. Observed associations remained similar after adjustment for total, unprocessed, or processed red meat intake.<br />Conclusion: Observed positive associations between PhIP intake from red meat and prostate cancer, particularly high-grade and possibly also advanced prostate cancer, need to be confirmed in other studies.<br />Impact: Results do not provide strong evidence that HCAs increase risk of prostate cancers.<br /> (©2015 American Association for Cancer Research.)
- Subjects :
- Adult
Aged
Benzimidazoles adverse effects
Cooking
Follow-Up Studies
Humans
Imidazoles adverse effects
Incidence
Male
Middle Aged
Mutagens chemistry
Prostatic Neoplasms epidemiology
Quinoxalines adverse effects
Reproducibility of Results
Retrospective Studies
Risk Factors
United States epidemiology
Feeding Behavior
Health Personnel statistics & numerical data
Meat analysis
Mutagens adverse effects
Prostatic Neoplasms etiology
Risk Assessment methods
Surveys and Questionnaires
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7755
- Volume :
- 24
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26224797
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-15-0068-T