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Regulatory efficacy of fermented plant extract on the intestinal microflora and lipid profile in mildly hypercholesterolemic individuals.
- Source :
-
Journal of food and drug analysis [J Food Drug Anal] 2017 Oct; Vol. 25 (4), pp. 819-827. Date of Electronic Publication: 2016 Dec 03. - Publication Year :
- 2017
-
Abstract
- In recent years, the use of fermented plant products to protect against various metabolic syndromes has been increasing enormously. The objective of this study was to check the regulatory efficacy of fermented plant extract (FPE) on intestinal microflora, lipid profile, and antioxidant status in mildly hypercholesterolemic volunteers. Forty-four mildly hypercholesterolemic individuals (cholesterol 180-220 mg/dL) were recruited and assigned to two groups: experimental or placebo. Volunteers were requested to drink either 60 mL of FPE or placebo for 8 weeks. Anthropometric measurements were done in the initial, 4 <superscript>th</superscript> , 8 <superscript>th</superscript> , and 10 <superscript>th</superscript> weeks. The anthropometric parameters such as body weight, body fat, and body mass index were markedly lowered (p<0.05) on FPE intervention participants. Moreover, the total antioxidant capacity and total phenolics in plasma were considerably increased along with a reduction (p<0.05) in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) after FPE supplementation. Participants who drank FPE showed a pronounced increase (p<0.05) in the number of beneficial bacteria such as Bifidobacterium spp. and Lactobacillus spp., whereas the number of harmful bacteria such as Escherichia coli and Clostridium perfringens (p<0.05) were concomitantly reduced. Furthermore, the lag time of LDL oxidation was substantially ameliorated in FPE-administered group, thus indicating its antioxidative and cardioprotective properties. Treatment with FPE substantially improved the intestinal microflora and thereby positively regulated various physiological functions by lowering the anthropometric parameters, TC, and LDL-c, and remarkably elevated the antioxidant capacity and lag time of LDL oxidation. Therefore, we recommended FPE beverage for combating hypercholesterolemia.<br /> (Copyright © 2016. Published by Elsevier B.V.)
- Subjects :
- Adult
Anticholesteremic Agents administration & dosage
Anticholesteremic Agents chemistry
Bacteria classification
Bacteria genetics
Bacteria metabolism
Female
Fermentation
Humans
Hypercholesterolemia metabolism
Intestinal Mucosa metabolism
Male
Middle Aged
Plant Extracts chemistry
Plant Extracts metabolism
Bacteria isolation & purification
Gastrointestinal Microbiome
Hypercholesterolemia microbiology
Intestines microbiology
Lipids chemistry
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2224-6614
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of food and drug analysis
- Publication Type :
- Academic Journal
- Accession number :
- 28987358
- Full Text :
- https://doi.org/10.1016/j.jfda.2016.10.008