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Higher intake of carotenoid is associated with a lower risk of colorectal cancer in Chinese adults: a case-control study.
- Source :
- European Journal of Nutrition; Jun2015, Vol. 54 Issue 4, p619-628, 10p
- Publication Year :
- 2015
-
Abstract
- Purpose: The associations between specific carotenoid intake and colorectal cancer risk remain inconsistent. The aim of this study was to examine the association between specific dietary carotenoid intake with colorectal cancer risk in Chinese adults. Method: From July 2010 to October 2013, 845 eligible colorectal cancer cases and 845 frequency-matched controls (age and sex) completed in-person interviews. A validated food frequency questionnaire was used to estimate dietary intake. Multivariate logistical regression models were used to calculate the odds ratio (OR) and 95 % confidence intervals (95 % CIs) of colorectal cancer risk after adjusting for various confounders. Results: A strong inverse association was found between β-cryptoxanthin intake and colorectal cancer risk. Compared with the lowest quartile, the highest quartile intake showed a risk reduction of 77 % (OR 0.23, 95 % CI 0.17-0.33, P < 0.01) after adjustment for various confounding variables. The inverse associations were also observed for α-carotene (OR 0.50, 95 % CI 0.37-0.68, P < 0.01), β-carotene (OR 0.67, 95 % CI 0.49-0.91, P < 0.01), and lycopene (OR 0.51, 95 % CI 0.37-0.70, P < 0.01). There was no statistically significant association between lutein/zeaxanthin intake and colorectal cancer risk. These findings were consistent across cancer site, sources of controls, and smoking status. The inverse associations between dietary α-carotene, β-cryptoxanthin, and lycopene intake and colorectal cancer risk were found in both males and females, while inverse associations between β-carotene intake and colorectal cancer risk were only observed in males. Conclusions: Consumption of α-carotene, β-carotene, β-cryptoxanthin, and lycopene was inversely associated with colorectal cancer risk. No significant association was found between lutein/zeaxanthin intake and colorectal cancer risk. [ABSTRACT FROM AUTHOR]
- Subjects :
- SMOKING
RECTUM tumors
COLON tumors
DIET therapy for cancer patients
CAROTENOIDS
CHINESE people
CONFIDENCE intervals
DIET
DOSE-response relationship in biochemistry
HEALTH behavior
INTERVIEWING
LYCOPENE
MULTIVARIATE analysis
PROBABILITY theory
QUESTIONNAIRES
RESEARCH evaluation
RESEARCH funding
SEX distribution
STATISTICAL hypothesis testing
LOGISTIC regression analysis
SOCIOECONOMIC factors
STATISTICAL significance
BODY mass index
LIFESTYLES
CASE-control method
BETA carotene
PHYSICAL activity
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
TUMOR risk factors
CANCER risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 54
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 102748344
- Full Text :
- https://doi.org/10.1007/s00394-014-0743-7